CN104688705B - 一种α‑硫辛酸缓释片及其制备方法 - Google Patents
一种α‑硫辛酸缓释片及其制备方法 Download PDFInfo
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- CN104688705B CN104688705B CN201510068008.6A CN201510068008A CN104688705B CN 104688705 B CN104688705 B CN 104688705B CN 201510068008 A CN201510068008 A CN 201510068008A CN 104688705 B CN104688705 B CN 104688705B
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- lipoic acid
- alpha
- sustained release
- release tablets
- hydroxypropyl
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- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 title claims abstract description 302
- 229960002663 thioctic acid Drugs 0.000 title claims abstract description 166
- 235000019136 lipoic acid Nutrition 0.000 title claims abstract description 165
- 239000007939 sustained release tablet Substances 0.000 title claims abstract description 127
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 36
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims abstract description 33
- 239000007888 film coating Substances 0.000 claims abstract description 31
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- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 51
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 51
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 51
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 15
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- 238000000034 method Methods 0.000 claims description 12
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 8
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 8
- 239000008117 stearic acid Substances 0.000 claims description 8
- 235000013312 flour Nutrition 0.000 claims description 6
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 5
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- 244000248349 Citrus limon Species 0.000 claims 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
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- IZFHEQBZOYJLPK-UHFFFAOYSA-N dihydrolipoic acid Chemical compound OC(=O)CCCCC(S)CCS IZFHEQBZOYJLPK-UHFFFAOYSA-N 0.000 description 2
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- Medicinal Preparation (AREA)
Abstract
Description
Claims (10)
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CN201510068008.6A CN104688705B (zh) | 2015-02-09 | 2015-02-09 | 一种α‑硫辛酸缓释片及其制备方法 |
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CN104688705B true CN104688705B (zh) | 2017-07-25 |
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CN111053758A (zh) * | 2018-10-17 | 2020-04-24 | 江苏恒正合生命科学有限公司 | 一种75%的alpha硫辛酸及其微囊化加工工艺 |
CN110420193A (zh) * | 2019-09-04 | 2019-11-08 | 西安科力康医药科技有限公司 | 一种α-硫辛酸缓控释片制备方法 |
CN113181129B (zh) * | 2020-01-14 | 2022-07-22 | 亚宝药业集团股份有限公司 | 一种稳定的硫辛酸片的制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1370072A (zh) * | 1999-01-13 | 2002-09-18 | 锡德克斯公司 | 以磺基烷基醚环糊精为基础的控释固体药物制剂 |
CN1868463A (zh) * | 2006-06-15 | 2006-11-29 | 南方医科大学珠江医院 | 一种α-硫辛酸或其衍生物的缓释制剂及其制备方法 |
CN102469807A (zh) * | 2009-07-14 | 2012-05-23 | 希尔氏宠物营养品公司 | 包括持续释放的硫辛酸的宠物食品组合物及其制造和使用方法 |
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ITMI20061024A1 (it) * | 2006-05-25 | 2007-11-26 | Eurand Pharmaceuticals Ltd | Pellet a base di acido lipoico |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1370072A (zh) * | 1999-01-13 | 2002-09-18 | 锡德克斯公司 | 以磺基烷基醚环糊精为基础的控释固体药物制剂 |
CN1868463A (zh) * | 2006-06-15 | 2006-11-29 | 南方医科大学珠江医院 | 一种α-硫辛酸或其衍生物的缓释制剂及其制备方法 |
CN102469807A (zh) * | 2009-07-14 | 2012-05-23 | 希尔氏宠物营养品公司 | 包括持续释放的硫辛酸的宠物食品组合物及其制造和使用方法 |
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