CN104667337A - Medical wound surface coating film and producing method thereof - Google Patents
Medical wound surface coating film and producing method thereof Download PDFInfo
- Publication number
- CN104667337A CN104667337A CN201510103494.0A CN201510103494A CN104667337A CN 104667337 A CN104667337 A CN 104667337A CN 201510103494 A CN201510103494 A CN 201510103494A CN 104667337 A CN104667337 A CN 104667337A
- Authority
- CN
- China
- Prior art keywords
- overlay film
- coating film
- layer
- medicine
- film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a medical wound surface coating film and a producing method thereof. The producing method comprises steps as follows: S1: dehydrating and drying fresh human body placenta amnion layers, and removing fat and protein on surfaces of the amnion layers to obtain semi-finished film bases; S2: applying or spraying an antibiotic medicine with the concentration accounting for 0.01%-0.04% of the volume concentration to surfaces of the semi-finished film bases; S3: performing single-layer connection or multi-layer overlapping composition on films, meanwhile, drying and shaping the films to prepare a single-layer or multi-layer-composited medicine-containing coating film with a certain area; S4: perforating the medicine-containing coating film to prepare a porous medicine-containing coating film with adjacent hole distances ranging from 10 mm to 30 mm and hole diameters ranging from 1 mm to 4 mm. The coating film has good randomness and adhesion and can realize effects of isolating external bacteria, resisting bacteria, killing bacteria, preventing infection and preventing epidermal water, electrolytes and protein from losing. The coating film falls off automatically after a wound surface is healed, and the healed surface is smooth, flat and free of pigmentation. The coating film is a medical product which is convenient to operate, safe and reliable.
Description
Technical field
The invention belongs to department of dermatologry, surgical field, be specifically related to a kind of Medical wounded surface overlay film and manufacture method thereof.
Background technology
In people's daily life, burn, the meeting of scald often occur, and cause the wound surface that various concentration is different, and very easily cause infection, cause various complication.Wound surface is the clinical multidisciplinary treatment difficult problem faced for a long time, protects wound surface, is not infected by bacterial, and the closed environment causing to be hedged off from the outer world, is the central aspects promoting that wound surface one of fully recovering early is very important.
Existing overlay film comprises: with Corii Sus domestica, Corii Bovis seu Bubali, Corium Gallus domesticus and the overlay film with the synthesis such as chitosan and Corii Sus domestica, or with the overlay film of the Polymer Synthesizings such as acrylic acid, this artificial epithelium needs to adopt special film balance masking in processing, and the film made still has some deficits in randomness, adhesiveness, intensity is also lower, easily produces and breaks; With acrylic acid, acrylic acid ethyl ester and ethyl acetate as substrate; using ethanol, acetone and ethyl acetate as solvent; a kind of solvent based polymer produced using benzoyl peroxide as initiator, the protection for burn wound surface; but this product; though have randomness and adhesiveness, because being with film forming behind affected part, glue applicator surface, there is breathability and poisture-penetrability is poor; production method also relative complex, cost is high, uses the deficiencies such as inconvenience.
Summary of the invention
One of the object of the invention is to solve the problem in background technology, provides a kind of adhesiveness good, breathability and the strong Medical wounded surface overlay film of poisture-penetrability and manufacture method thereof.
The invention provides a kind of Medical wounded surface overlay film manufacture method, step comprises:
S1: by fresh human body placenta amnion pull-up water, drying slough fat, the protein on described rete layer surface, obtain the substrate of thin film semi-finished product;
S2: to apply or spray concentration is the antibiotic medicine of 0.01% ~ 0.04% of volumetric concentration in the leaching of described thin film semi-finished product substrate surface;
S3: described thin film is carried out drying, shaping through monolayer connection or multiple-layer overlapped compound simultaneously, makes and there is certain area, the pastille overlay film of single or multiple lift compound;
S4: described pastille overlay film is made adjacent holes apart from being 10 ~ 30mm through punching, and aperture is the porose pastille overlay film of 1 ~ 4mm.
Further, the optional levofloxacin of described antibiotic medicine, ciprofloxacin, gentamycin and amikacin.
The present invention also provides a kind of Medical wounded surface overlay film, comprise: by the thin film semi-finished product substrate obtained after the process of fresh human body placenta amnion layer, the leaching of described overlay film surface is applied or sprayed has concentration to be the antibiotic medicine of 0.01% ~ 0.04% of volumetric concentration, described overlay film surface is provided with adjacent holes apart from being 10 ~ 30mm, and aperture is some apertures of 1 ~ 4mm.
Beneficial effect of the present invention is; the protective tectorial membrane for surfaces of wound using a kind of Medical wounded surface overlay film of making of the inventive method to make, poor transparent; not only there are good randomness and adhesiveness; also there is certain breathability and poisture-penetrability; through drug treating, can play isolating exterior antibacterial, antibacterial, sterilize, the effect of protect from infection, prevent transepidermal water, electrolyte and protein loss, non-stimulated, ease the pain; promote that wound surface is fully recovered early, also clearly can observe the healing state of wound surface.After wound surface recovery from illness, self falling, healed surface is smooth, non-pigment is calm.Different according to wound site, can be made into the pastille overlay film of all size, is a kind of easy to operate, safe and reliable medical supplies.
Detailed description of the invention
Hereafter will describe the present invention in detail in conjunction with specific embodiments.It should be noted that the combination of technical characteristic or the technical characteristic described in following embodiment should not be considered to isolated, they can mutually be combined thus be reached better technique effect.
The invention provides a kind of Medical wounded surface overlay film manufacture method, step comprises:
S1: by fresh human body placenta amnion pull-up water, drying slough fat, the protein on described rete layer surface, obtain the substrate of thin film semi-finished product;
S2: to apply or spray concentration is the antibiotic medicine of 0.01% ~ 0.04% of volumetric concentration in the leaching of described thin film semi-finished product substrate surface;
S3: described thin film is carried out drying, shaping through monolayer connection or multiple-layer overlapped compound simultaneously, makes and there is certain area, the pastille overlay film of single or multiple lift compound;
S4: described pastille overlay film is made adjacent holes apart from being 10 ~ 30mm through punching, and aperture is the porose pastille overlay film of 1 ~ 4mm.
Further, the optional levofloxacin of described antibiotic medicine, ciprofloxacin, gentamycin and amikacin.The present invention also provides a kind of Medical wounded surface overlay film, comprise: by the thin film semi-finished product substrate obtained after the process of fresh human body placenta amnion layer, the leaching of described overlay film surface is applied or sprayed has concentration to be the antibiotic medicine of 0.01% ~ 0.04% of volumetric concentration, described overlay film surface is provided with adjacent holes apart from being 10 ~ 30mm, and aperture is some apertures of 1 ~ 4mm.
Embodiment:
1. cleaning and degreasing
Get the rete layer of the fresh human placenta of people's term labor, with distilled water cleaning extremely without blood and slime, defat 6 ~ 10 hours in immersion 1.5 ~ 2.5% sodium hydrate aqueous solutions.
2. deproteinization
Rete layer distilled water after defat is washed till neutrality, put scraping surface impurity on the table, then immerse 1.5 ~ 2.5% sodium-chloride water solutions to soak 12 ~ 22 hours, slough the protein on surface, then the process of leaching medicine is entered, or after the leaching chrome tanning system of first carrying out strengthening membrane intensity and film not easily being dissolved by wound surface hydrops, then carry out the process of leaching medicine.
3. soak chrome tanning system
This procedure extends film at the effective protecting time of wound surface to increase film strength, makes it be unlikely and dissolved by wound surface hydrops.Concrete operation to slough the amniotic membrane of albumen, with distilled water cleaning 3 ~ 5 times, removal superfluous water is hindered, immerse tanning more than 20 hours in 1.2 ~ 1.5% chrome liquors and 0.5% formaldehyde mixed liquor, and then put into sodium bicarbonate aqueous solution immersion taking-up after 3 ~ 6 hours, be washed till neutrality with distilled water, then use distilled water flushing 3 times.
4. soak drug of topical application thing
By the amniotic membrane of purification process, be immersed in containing in antibiotic medicine solution, hospital, pharmacy or pharmaceutical factory can be adopted to produce the antibiotic solution sold; Or with the solution stirred containing levofloxacin 200,000 unit and ciprofloxacin 1 gram, normal saline 200ml, the solution that other antibiotic are prepared also can be adopted.
5. monolayer connects and multiple-layer overlapped compound
By not of uniform size, the amniotic membrane of not shaping is layered on smooth working plate, and edge is fitted and connected, and one deck has spread, can repave second layer or more layer as required, be driven away by the bubble between rete with bamboo scraper.
6. dry, correction of the flank shape
Monolayer is connected or the pastille overlay film of multiple-layer overlapped compound, send drying chamber to dry, dried amniotic membrane is taken off, carry out correction of the flank shape, according to size and the position of wound surface, make the pastille overlay film of all size.When wound surface needs drain more deeply, then evenly get pitch-row 10 ~ 30mm by puncher at pastille overlay film, the water conservancy diversion circular hole of diameter 1 ~ 4mm.
7, encapsulation, sterilizing
Qualified products are loaded in aluminium foil bag by specification classification and seals, with γ ray sterilization, or ethylene oxide sterilizing.
The pastille overlay film of leaching chrome tanning process can be adopted to carry out covering treatment for heavier wound surface.
For lighter wound surface, can adopt and not carry out covering treatment by the pastille overlay film of leaching chrome tanning process.
The protective tectorial membrane for surfaces of wound using a kind of Medical wounded surface overlay film of making of the inventive method to make, poor transparent; not only there are good randomness and adhesiveness; also there is certain breathability and poisture-penetrability; through drug treating; can play isolating exterior antibacterial, antibacterial, sterilize, the effect of protect from infection, prevent transepidermal water, electrolyte and protein loss; non-stimulated, ease the pain, promote wound surface fully recover early, also clearly can observe the healing state of wound surface.After wound surface recovery from illness, self falling, healed surface is smooth, non-pigment is calm.Different according to wound site, can be made into the pastille overlay film of all size, is a kind of easy to operate, safe and reliable medical supplies.
Although give some embodiments of the present invention, it will be understood by those of skill in the art that without departing from the spirit of the invention herein, can change embodiment herein.Above-described embodiment is exemplary, should using embodiment herein as the restriction of interest field of the present invention.
Claims (3)
1. a Medical wounded surface overlay film manufacture method, is characterized in that, step comprises:
S1: by fresh human body placenta amnion pull-up water, drying slough fat, the protein on described rete layer surface, obtain the substrate of thin film semi-finished product;
S2: to apply or spray concentration is the antibiotic medicine of 0.01% ~ 0.04% of volumetric concentration in the leaching of described thin film semi-finished product substrate surface;
S3: described thin film is carried out drying, shaping through monolayer connection or multiple-layer overlapped compound simultaneously, makes and there is certain area, the pastille overlay film of single or multiple lift compound;
S4: described pastille overlay film is made adjacent holes apart from being 10 ~ 30mm through punching, and aperture is the porose pastille overlay film of 1 ~ 4mm.
2. a kind of Medical wounded surface overlay film manufacture method as claimed in claim 1, is characterized in that, the optional levofloxacin of described antibiotic medicine, ciprofloxacin, gentamycin and amikacin.
3. a Medical wounded surface overlay film, it is characterized in that, comprise: by the thin film semi-finished product substrate obtained after the process of fresh human body placenta amnion layer, the leaching of described overlay film surface is applied or sprayed has concentration to be the antibiotic medicine of 0.01% ~ 0.04% of volumetric concentration, described overlay film surface is provided with adjacent holes apart from being 10 ~ 30mm, and aperture is some apertures of 1 ~ 4mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510103494.0A CN104667337A (en) | 2015-03-10 | 2015-03-10 | Medical wound surface coating film and producing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510103494.0A CN104667337A (en) | 2015-03-10 | 2015-03-10 | Medical wound surface coating film and producing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104667337A true CN104667337A (en) | 2015-06-03 |
Family
ID=53303268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510103494.0A Pending CN104667337A (en) | 2015-03-10 | 2015-03-10 | Medical wound surface coating film and producing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104667337A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107349471A (en) * | 2017-06-16 | 2017-11-17 | 卓阮医疗科技（苏州）有限公司 | A kind of complex tissue repair materials of carried medicine sustained-release and preparation method thereof |
| CN110124085A (en) * | 2019-05-21 | 2019-08-16 | 广东普洛宇飞生物科技有限公司 | A kind of amnion or microlayer model contain combine dressing of drug and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088118A (en) * | 1992-12-15 | 1994-06-22 | 吕平 | Medical protective tectorial membrane for surfaces of wound |
| CN101041090A (en) * | 2007-04-17 | 2007-09-26 | 何伟 | Amnion slice material and the preparing method and the application |
-
2015
- 2015-03-10 CN CN201510103494.0A patent/CN104667337A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088118A (en) * | 1992-12-15 | 1994-06-22 | 吕平 | Medical protective tectorial membrane for surfaces of wound |
| CN101041090A (en) * | 2007-04-17 | 2007-09-26 | 何伟 | Amnion slice material and the preparing method and the application |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107349471A (en) * | 2017-06-16 | 2017-11-17 | 卓阮医疗科技（苏州）有限公司 | A kind of complex tissue repair materials of carried medicine sustained-release and preparation method thereof |
| CN110124085A (en) * | 2019-05-21 | 2019-08-16 | 广东普洛宇飞生物科技有限公司 | A kind of amnion or microlayer model contain combine dressing of drug and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104257639B (en) | A kind of liniment for Wound treating and preparation method thereof | |
| CN103341203B (en) | Medical dressing, preparation method of medical dressing and preparation method of dressing plaster | |
| CN103948960A (en) | Nano-silver porous silicone rubber/polyurethane-containing double-layer artificial skin and preparation method thereof | |
| KR101429455B1 (en) | Hydrogel patch for wound-healing using self-assembled chitosan and preparation method thereof | |
| US20210393680A1 (en) | Use of an antimicrobial composition | |
| CN101658690A (en) | Officinal volatile argyi leaf oil dressing and preparation method thereof | |
| CN107233617A (en) | A kind of wound dressing of liquid chitosan and its preparation and application | |
| CN104667337A (en) | Medical wound surface coating film and producing method thereof | |
| CN105903059A (en) | Bacteriostatic medical functional dressing | |
| CN106139239A (en) | Full-service fluid dressing and preparation method thereof | |
| CN110876814A (en) | Liquid band-aid rich in antibacterial peptide and preparation method thereof | |
| CN105078651A (en) | Multifunctional wet medical wound dressing and preparation method thereof | |
| CN101947330A (en) | Silver ion antibacterial medicinal dressing and preparation method thereof | |
| RU2616239C2 (en) | Method for erosive and ulcerative skin lesions treatment | |
| CN1088118A (en) | Medical protective tectorial membrane for surfaces of wound | |
| RU100724U1 (en) | ATRAUMATIC BANDING AGENT WITH NANOPARTICLES OF ASEPTICA SILVER | |
| CN104367507A (en) | Skincare solution and preparation method thereof | |
| CN104548194A (en) | Medical high-performance binding agent | |
| CN108619560A (en) | A kind of preparation method of tissue adhension hemostatic and antibacterial nanometer film | |
| CN106879607B (en) | Biological pesticide for preventing and treating apple tree canker | |
| CN107961395A (en) | A kind of medical films with antibacterial functions and preparation method thereof | |
| CN103623455A (en) | Preparation method of biological wound protecting film | |
| CN106619739B (en) | Artificial collection method of giant salamander surface mucus | |
| RU71068U1 (en) | BANDING KIT | |
| CN107998071B (en) | Method for improving stability of phenytoin silver and phenytoin silver external preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150603 |
|
| RJ01 | Rejection of invention patent application after publication |