CN107349471A - A kind of complex tissue repair materials of carried medicine sustained-release and preparation method thereof - Google Patents

A kind of complex tissue repair materials of carried medicine sustained-release and preparation method thereof Download PDF

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Publication number
CN107349471A
CN107349471A CN201710456675.0A CN201710456675A CN107349471A CN 107349471 A CN107349471 A CN 107349471A CN 201710456675 A CN201710456675 A CN 201710456675A CN 107349471 A CN107349471 A CN 107349471A
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medicine
release
repair materials
tissue repair
complex tissue
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张剑
周海洋
胡志前
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Shanghai Zhuoruan Medical Technology Co Ltd
Zhuo Ruan Medical Technology (suzhou) Co Ltd
Second Military Medical University SMMU
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Shanghai Zhuoruan Medical Technology Co Ltd
Zhuo Ruan Medical Technology (suzhou) Co Ltd
Second Military Medical University SMMU
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Priority to CN201710456675.0A priority Critical patent/CN107349471A/en
Publication of CN107349471A publication Critical patent/CN107349471A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to complex tissue repair materials of a kind of carried medicine sustained-release and preparation method thereof, the repair materials include the material with three-dimensional structure, porosity and permeability, medicine or load medicine medium.The present invention can realize the sustained release of contained medicine, and release profiles are controllable, do not change materials microstructure compatibility and host material immune response type, possess the characteristics of bio-compatible, nontoxic, help to be lifted the biology performance and specific function of repair materials, potential applicability in clinical practice is good.

Description

A kind of complex tissue repair materials of carried medicine sustained-release and preparation method thereof
Technical field
The invention belongs to complex tissue repair materials and its preparation field, more particularly to a kind of complex tissue of carried medicine sustained-release Repair materials and preparation method thereof.
Background technology
Feature by carrying medicine reinforcing material is one of possible approaches for improveing biomaterial.According to the use of repair materials Functional drug is pointedly added on way, and curative effect is lifted while tissue repair is realized, while maintaining active drug concentration Medicine dosage is reduced, reduces Side effect, mitigates adverse reaction.In addition, the load medicine repair materials that can be sustained may be used also To avoid the trouble of medication repeatedly, dressing, and suitable for the position of inconvenient direct drug injection.The optional wide variety of medicine, can be Unsuitable Formulations for systemic administration needs to improve the local, medicine of Targeting delivery, such as antibacterial medicines, anticoagulation medicine, immunoregulation medicament Deng.
Tridimensional network based on biomaterial, possess certain thickness, penetrability and porosity, can be formed with medicine Film controlling type and matrix type structure, slow down the release of medicine.On the one hand, biomaterial porosity is high, possesses certain thickness, aperture Irregularly, it can be used as pellicle, insoluble drug release is slowed down with dissolving, diffusion.Wrapped by medicine or after carrying the combination of medicine medium Wrap up in into biomaterial, body fluid or intercellular washing fluids infiltrating material after implanting, drug molecule is through dissolving, diffusing through hole And spread in material internal, it is discharged into finally through material in body fluid, the rate of release of medicine is depending on the medicine inside and outside material Concentration difference, material thickness, hole property etc..On the other hand, the three-dimensional netted supporting structure of the ultra micro of biomaterial or medium, is rich in Viscous composition, it is easy to adsorb various drug molecules, medicine can be slowed down with dissolving, corrosion as the framework material of insoluble drug release Thing discharges.By medicine or carry after medicine medium combined with material and to implant, medicine dissolves, diffuse to material internal and with material or Medium is with intermolecular force or chemical bonds, and with the degraded of framework material, medicine progressively discharges, the rate of release of medicine Depending on the degradation time of material, three-dimensional structure, hole property etc..
Certain drug can be easily implanted into by possessing above-mentioned characteristic biomaterial, represent the hair of improvement tissue renovation material Exhibition prospect.In this respect, biological enzyme, chitosan derivatives or Chinese invention patent with antibacterial action are utilized The antibacterial metal particle such as Nano Silver, silver ion infiltration acellular matrix disclosed in CN102014790A and CN101623518A difference Biomaterial, it can improve the anti-infection property of biomaterial.Antimicrobial test and results of animal, which show to reduce, to be taken off carefully Cytoplasmic matrix biomaterial infection rate, improve pollution wound repair success rate.This improvement biological sticking patch anti-infection effect makes us full Meaning, but because antimicrobial component is only to be adsorbed to material network structure, with reference to more loosely, release is a large amount of in the short time after the implantation Antimicrobial component, cause reparation area's later stage antibacterial effect poor.Chinese invention patent CN103751844A discloses a kind of antibacterial and resisted The pig intestinal mucosa acellular matrix preparation method and applications of degraded.The invention is handled with Geniposide, dopamine and Nano Silver Pig intestinal mucosa acellular matrix prepare the anti-degradation biological material of antibacterial, dopamine has viscosity, can pass through chemical bond Antimicrobial component is tied to collagenous fibres support by effect, and experiment confirms its anti-degradation property and anti-microbial property both with respect to natural Pig intestinal mucosa acellular matrix significantly increases, and can be applied in high stress site tissue reparation.But cross-linked material is more non- When cross-linked material is applied to polluted surface, significantly repairs area's infection rate and rise, this is probably because crosslinking can reduce material Hole, too small hole is unfavorable for cell intrusion and realizes early stage vascularization, and be easy to bacteria planting, form bacterial biof iotalm. Chinese invention patent CN101810883A discloses a kind of high tissue compatibility, long-acting anti-infectious bio-derived material, its group Dividing includes acellular matrix and absorbable anti-infection nano particulate, and absorbable anti-infection nano particulate is dashed forward in a short time after implanting Release the drug thing, is rapidly reached valid density, and effectively haemoconcentration continues 2 weeks~March.Chinese invention patent CN102172418A is public A kind of acellular matrix material of the sustained release growth factor is opened, its component includes degradable hydrophobic polymer, the life of revascularization The long factor and acellular matrix, the compound growth factor into acellular matrix, being sustained out of nano controlled-release system is still effectively protected Biological characteristics is held, sustained release process is long and steady.But the preparation process for the nano-particle that this two patents are related to is complicated, and biology Security is unknown, the less nano-particle of particle diameter (<Certain cytotoxicity 50nm) is there may be, lacks potential applicability in clinical practice.Cause This, the medicine-carrying method of biomaterial still urgently improves.
The content of the invention
The technical problems to be solved by the invention are to provide complex tissue repair materials and its preparation of a kind of carried medicine sustained-release Method, the semi-membrance effect and three-dimensional structure of the material being related to can realize the sustained release of contained medicine, and release profiles are controllable, no Change materials microstructure compatibility and host-material immune response type, possess the characteristics of bio-compatible, nontoxic, help It is good in the biology performance and specific function of lifting repair materials, potential applicability in clinical practice.
The present invention a kind of carried medicine sustained-release complex tissue repair materials, the repair materials include with three-dimensional structure, The material of porosity and permeability, medicine or load medicine medium；Wherein medicine or carry medicine medium wrap or be coated on material interlayer or Surface, carried medicine sustained-release is realized by the semi-membrance effect with three-dimensional structure, porosity and permeability material.
Medicine carries medicine medium and wraps or be coated on material interlayer or surface is：Medicine individually can wrap or be coated on material Interlayer or surface, or medicine are combined with medium and are prepared as wrapping or be coated on material interlayer or surface after carrying medicine medium.
The described material with three-dimensional structure, porosity and permeability, its number of plies is unlimited, and the specific number of plies should be according to application Depending on the release profiles of Shi Suoxu mechanical strengths and contained medicine, medicine, load medicine medium can be distributed or wrap in arbitrary levels material Between material or surface.The material with three-dimensional structure, porosity and permeability is extracellular matrix/acellular matrix, collagen Albumen, fibrin, chitosan, hyaluronic acid, chondroitin sulfate, collagen, gelatin, polyalcohol hydrogel and with electrostatic One or more in biomaterial or synthetic material prepared by spinning, 3D printing, foaming technique.
Material with three-dimensional structure, porosity and permeability, wherein porosity are 0%-98%, and permeability is material pair Some predetermined substances possess through effect.
Extracellular matrix/the acellular matrix is from the hollow organ submucosa of people or mammal, tissue Basilar memebrane, corium, pericardium, peritonaeum, pleura or amnion, crosslink material degree are 0%~100%.
Medicine in the medicine, load medicine medium is antiseptic, antibioticses, rush organization healing class, anticoagulation class, anti-inflammatory One or more in class, immunological regulation class medicine and contain the nano particle of mentioned component, microballoon etc..
The antiseptic is the one or more in Nano Silver, silver ion, triclosan, chlorohexidene, bismuth compound；Antibiotic Class medicine is the one or more in vancomycin, gentamicin, Rimactazid；Promote organization healing class medicine as growth One or more in the factor, cell factor, chemotactic factor (CF), nucleic acid, polypeptide；Anticoagulants are heparin and/or hirudin； Anti-inflammatory drug is the one or more in brufen, paracetamol, COX-2 receptor antagonists.
The medium carried in medicine medium is the aqueous solution, organic solvent, chitosan, hyaluronic acid, chondroitin sulfate, collagen One or more in albumen, gelatin, polyalcohol hydrogel.
Medicine addition should according to the purposes of repair materials, known conventional dosage and application when required drug release patterns and It is fixed, such as Nano Silver.
For insoluble drug release according to clinical treatment needs, the release of wherein medicine can in the complex tissue repair materials of carried medicine sustained-release To be adjusted to as needed 1-48 days.
Repair materials optionally increase the hole or release groove through material, 1~5mm of diameter, 0.5~5cm of spacing.
A kind of preparation method of the complex tissue repair materials of carried medicine sustained-release of the present invention：With three-dimensional structure, porosity Tied up with the material of permeability with medicine or medicine/load medicine medium by adhesive bonding, medical degradable suture, vacuum layer Pressure, in constant temperature hot pressing or other can be by one kind or more in physics, chemistry or biological method that multilayer material is fixed as one Kind.
The present invention has three-dimensional structure, the material of porosity and permeability and medicine or carries medicine medium, and preparation method is will Medicine/load medicine medium wraps or is coated on material interlayer or surface, and overall knot is formed by adhesive, suture or vacuum lamination Structure.
Beneficial effect
(1) the contained medicine of slow-release controlled-release：The present invention is mainly real by the film controlling type based on biomaterial and matrix type structure Releasing for existing contained medicine is slow.On the one hand, biomaterial porosity is high, possesses certain thickness, and aperture is irregular, can be used as semi-transparent Film uses, and slows down insoluble drug release with dissolving, diffusion.Wrap up into biomaterial, plant by medicine or after carrying the combination of medicine medium Body fluid or intercellular washing fluids infiltrating material after entering in vivo, drug molecule through dissolving, diffusing through hole and spread in material internal, Be discharged into finally through material in body fluid, the drug concentration that the rate of release of medicine is depended on inside and outside material is poor, material thickness, hole Gap property etc..On the other hand, the three-dimensional netted supporting structure of the ultra micro of biomaterial or medium, rich in viscous composition, it is easy to adsorb Various drug molecules, insoluble drug release can be slowed down with dissolving, corrosion as the framework material of insoluble drug release.By medicine or load Medicine medium is combined with material implant after, medicine dissolving, diffuse to material internal and with material or medium with intermolecular interaction Power or chemical bonds, with the degraded of framework material, medicine progressively discharges, and the rate of release of medicine depends on the degraded of material Time, three-dimensional structure, hole property etc..By taking extracellular matrix biomaterial as an example, its through effect it is strong and weak with it is tissue-derived, De- cellular processes and the degree of cross linking are closely related；Change the processing technology and porosity, the thickness/layer for increasing material of material Number, the release of the controllable medicine of application level of regulating drug.
On the other hand, the delivery vector of material and medium as medicine, there is secondary membrane control and skeleton function, ancillary drug Sustained release.Its compositing monomer of the present invention selects material or medium all should have certain reactivity, such as carry a certain amount of The groups such as aldehyde radical, amino, double bond.The present invention relates to material or medium should be complete or partial biodegradable, the biology of addition The good medicine of compatibility, which can be in a liquid state, is free on the gap of network structure, or is formed with molecule and be covalently or non-covalently connected, such as Containing double bond, the isostructural beneficiating ingredient of aldehyde radical with can form chemical bond with amino, the intermolecular of aldehyde radical isoreactivity group, Network structure surface is attached to, the medicine of two kinds of states reaches certain dynamic equilibrium.After being implanted into organism, material or Jie Matter can be by the crosslinking intercommunication network structure of mesh, and in early stage, release is largely free on the medicine in network structure gap with liquid Thing, middle and later periods are grown into host cell and tissue, and medium is slowly degraded, while continuation discharges remaining medicine.Therefore, may be used With by change concentration of medium, material and medium porosity, medicine the regulating medicine such as addition release.
(2) histocompatbility is good：The containing of material and medium ensure that is directly exposed to body group without heavy dose of medicine Knit, do not change materials microstructure compatibility and host-material immune response type, do not cause allergic reaction.And this part is given The mode of medicine, it can maintain to reduce medicine dosage while active drug concentration, reduce Side effect, mitigate bad Reaction.
(3) it is not easy drug resistance：For different defects, several functions medicine preparation is used in combination according to a certain percentage For personalized sticking patch, mitigate postoperative pain, reduction infection risk, raising curative effect, quickening organization healing and other effects so as to reach.
Brief description of the drawings
The scanning electron microscope diagram of Fig. 1 embodiments 1；Wherein the multiplication factor of a figures is 50000 times, and the multiplication factor of b figures is 100000 times；
The antiseptic In-vitro release curves of Fig. 2 embodiments 1.
Embodiment
With reference to specific embodiment, the present invention is expanded on further.It should be understood that these embodiments are merely to illustrate the present invention Rather than limitation the scope of the present invention.In addition, it is to be understood that after the content of the invention lectured has been read, people in the art Member can make various changes or modifications to the present invention, and these equivalent form of values equally fall within the application appended claims and limited Scope.
Embodiment 1
Trees-Osima jacoti, Osima excavata acellular matrix (SIS) and SIS fluid compositions are prepared, the latter adds 10mM antibacterials Agent, to carry medicine medium.SIS is prepared as area as 10 × 10cm in a manner of staggeredly splicing2Lamella, carry medicine medium upper and lower surface Respectively 2 layers of SIS lamellas of covering, interlayer are integrated by vacuum lamination, the pressing of -200mmHg pressure.Scanning electron microscope diagram can be with It was observed that material internal ultra microstructure, antiseptic is combined with SIS collagenous fibres.
Release in vitro：Complex tissue repair materials are cut into 1cm × 1cm to be placed in agarose culture dish, cultivate 1-24 My god, extraction agarose, the concentration of identification release medicine, the results showed that complex tissue repair materials can maintain the stabilization of at least 14 days Release, burst size is about 30% (Fig. 1) of total drug content.
Cytotoxicity：The complex tissue repair materials for being cut to 1cm × 1cm are fixed to culture dish bottom, add 1 thereon ×105/ mLNIH3T3 pattern cells, 37 DEG C, 5%CO2Cultivate 72h.Mtt assay measure cell survival rate is 92.6%.Material it is thin Cellular toxicity is 0 grade.
Blood compatibility：Contact group rat back loses hair or feathers, and smears the enzymolysis product that concentration is 50 μ g/mL, smears 1 daily It is secondary, continuously smear 20d；Oral 1mL leaching liquors every other day are orally ingested in group 7d, are taken in 4 times altogether；Intramuscular injection group and intravenous injection Injection concentration is 0.15mL leaching liquors every other day in group 7d, each to inject 4 times.Put to death and move respectively at contamination the 30th day and 90 days two batches Thing, extracting vein blood are used to test.Hemolysis rate is calculated by following equation：Hemolysis rate (%)=(sample absorbance-negative extinction Degree)/(positive absorbance-negative absorbance) × 100%.Repair materials hemolysis rate≤5%.
Animal model：Abdominal-wall defect is built with severe bacterial infection canine model, with repair materials reparation.Postoperative 1,3,7, 14th, severe abdominal cavity infection does not occur for 30 days observation animals, and secretion bacterial number is suppressed.

Claims (10)

  1. A kind of 1. complex tissue repair materials of carried medicine sustained-release, it is characterised in that：The repair materials include with three-dimensional structure, The material of porosity and permeability, medicine or load medicine medium；Wherein medicine or carry medicine medium wrap or be coated on material interlayer or Surface.
  2. A kind of 2. complex tissue repair materials of carried medicine sustained-release according to claim 1, it is characterised in that：Tied with three-dimensional The number of layers of structure, porosity and permeability is unlimited, and the specific number of plies should be according to required mechanical strength during application and contained medicine Depending on release profiles.
  3. A kind of 3. complex tissue repair materials of carried medicine sustained-release according to claim 1, it is characterised in that：It is described to have three Tie up structure, the material of porosity and permeability is extracellular matrix/acellular matrix, collagen, fibrin, chitosan, Hyaluronic acid, chondroitin sulfate, collagen, gelatin, polyalcohol hydrogel and with electrostatic spinning, 3D printing, foaming technique One or more in the biomaterial or synthetic material of preparation.
  4. A kind of 4. complex tissue repair materials of carried medicine sustained-release according to claim 1, it is characterised in that：It is described extracellular Matrix/acellular matrix is from the hollow organ submucosa of people or mammal, Tissue Base film, corium, pericardium, abdomen Film, pleura or amnion, crosslink material degree are 0%~100%.
  5. A kind of 5. complex tissue repair materials of carried medicine sustained-release according to claim 1, it is characterised in that：The medicine, The medicine carried in medicine medium is antiseptic, antibioticses, rush organization healing class, anticoagulation class, anti-inflammatory class, immunological regulation class medicine In one or more；Carry medicine medium in medium for the aqueous solution, organic solvent, chitosan, hyaluronic acid, chondroitin sulfate, One or more in collagen, gelatin, polyalcohol hydrogel.
  6. A kind of 6. complex tissue repair materials of carried medicine sustained-release according to claim 5, it is characterised in that：The antiseptic For the one or more in Nano Silver, silver ion, triclosan, chlorohexidene, bismuth compound；Antibiotics be vancomycin, One or more in gentamicin, Rimactazid；It is growth factor, cell factor, chemotactic to promote organization healing class medicine One or more in the factor, nucleic acid, polypeptide；Anticoagulants are heparin and/or hirudin；Anti-inflammatory drug is cloth Lip river One or more in sweet smell, paracetamol, COX-2 receptor antagonists.
  7. A kind of 7. complex tissue repair materials of carried medicine sustained-release according to claim 1, it is characterised in that：Carried medicine sustained-release Insoluble drug release is adjusted as needed according to clinical treatment needs, effective release of wherein anti-infectives in complex tissue repair materials Save as 1-48 days.
  8. A kind of 8. complex tissue repair materials of carried medicine sustained-release according to claim 7, it is characterised in that：Medicament slow release is Realized by the semi-membrance effect with three-dimensional structure, porosity and permeability material.
  9. A kind of 9. complex tissue repair materials of carried medicine sustained-release according to claim 1, it is characterised in that：Repair materials increase Add the hole or release groove through material, 1~5mm of diameter, 0.5~5cm of spacing.
  10. 10. a kind of preparation method of the complex tissue repair materials of carried medicine sustained-release as described in claim 1-9 is any, its feature It is：Material and medicine or medicine/load medicine medium with three-dimensional structure, porosity and permeability passes through adhesive bonding, doctor Tied up with degradable suture, vacuum lamination, one kind in constant temperature hot pressing are fixed.
CN201710456675.0A 2017-06-16 2017-06-16 A kind of complex tissue repair materials of carried medicine sustained-release and preparation method thereof Pending CN107349471A (en)

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Cited By (14)

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WO2018227550A1 (en) * 2017-06-16 2018-12-20 卓阮医疗科技（苏州）有限公司 Sustained release drug-loading compound tissue repair material and preparation method thereof
CN109125799A (en) * 2018-09-05 2019-01-04 张强 GelMA hydrogel people takes off the preparation method of the three-dimensional double-deck auxiliary material of cell amnion
CN109157676A (en) * 2018-08-31 2019-01-08 谭亚 A kind of preparation method for remolding compound bio amnion
CN109331228A (en) * 2018-11-26 2019-02-15 陈德夫 A kind of preparation method of anti-infectious submucous layer of small intestine biomaterial
CN111603609A (en) * 2020-05-25 2020-09-01 医工瑞思(福建)工程研究中心有限公司 Bionic tissue engineering scaffold and preparation method thereof
CN112203702A (en) * 2018-02-26 2021-01-08 圣埃斯皮里图联邦大学 Decellularized bone biomaterial rich in decellularized bone extracellular matrix hydrogel
CN112494723A (en) * 2020-12-03 2021-03-16 广东省医疗器械研究所 Piezoelectric support and preparation method and application thereof
CN112587731A (en) * 2020-12-03 2021-04-02 广东省医疗器械研究所 Composite stent and preparation method and application thereof
CN112604030A (en) * 2020-12-03 2021-04-06 广东省医疗器械研究所 Acellular matrix, bone repair scaffold and preparation method thereof
CN112891365A (en) * 2019-11-19 2021-06-04 广州溯原生物科技有限公司 Preparation and application of 3D bionic cell implant capable of releasing microRNA nucleic acid drug
CN114306746A (en) * 2021-12-20 2022-04-12 四川大学 Preparation method of anticoagulant acellular dermal matrix
CN115869453A (en) * 2021-09-26 2023-03-31 中国科学院理化技术研究所 Double-layer antibacterial dressing loaded with antibacterial molecules, preparation and application
CN115887733A (en) * 2022-11-28 2023-04-04 天津中医药大学 3D printing silver-loaded antibacterial traditional Chinese medicine dressing and preparation method thereof
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Application publication date: 20171117