CN104644941A - Eye drop - Google Patents

Abstract

The invention discloses an eye drop, and belongs to the technical field of medicines. The eye drop is prepared by the following steps: respectively weighing raw concha haliotidis, ginkgo leaf, chrysanthemum, wolfberry fruit, arecanut powder, buerger pipewort flower, sunflower leaf, buddleja officinalis an borneol; crushing and mixing evenly; adding the mixed medicine powder into an extraction tank; adding water, and air-tightly boiling until the medicine powder in the extraction tank is carbonized; opening the extraction tank, and collecting the discharged gas; dissolving the gas into water to prepare a water phase; simultaneously dissolving polylactic acid into dichloromethane to prepare an organic phase; mixing the prepared water phase with the organic phase evenly under the ultrasonic wave action to obtain a mixed liquid; adding polyvinyl alcohol to the mixed liquid, stirring evenly, standing, precipitating and centrifuging; and adding the obtained sediments into a solution prepared from polyacrylic acid hydroxypropyl methyl cellulose, stirring evenly, and then adjusting the pH value to be 5.0. The eye drop disclosed by the invention has a good curative effect on glaucoma.

Description

Collyrium

Technical field

The invention belongs to field of pharmaceutical technology, particularly relate to a kind of collyrium.

Background technology

Glaucoma refers to that intraocular pressure is interrupted or continues a kind of oculopathy of raising, and lasting Bulbi hypertonia bring infringement can to eyeball each several part tissue and visual function, and as treated not in time, the visual field can total loss and arrive blind.Glaucoma is one of three large diseases causing blindnesses causing the mankind blind, and total crowd's sickness rate is 1%, within 45 years old, is 2% later.

Glaucomatous kind mainly contains four kinds: congenital glaucoma, primary glaucoma, secondary glaucoma, mixed glaucoma.

Summary of the invention

The invention provides a kind of collyrium, this collyrium has good curative effect to glaucoma.

In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is:

A kind of collyrium, be made up of the raw material of following parts by weight: Concha Haliotidis 100 parts ~ 120 parts, Folium Ginkgo 90 parts ~ 100 parts, Flos Chrysanthemi 60 parts ~ 75 parts, Fructus Lycii 58 parts ~ 65 parts, Semen Arecae 45 parts ~ 55 parts, Flos Eriocauli 100 parts ~ 120 parts, 50 parts ~ 58 parts, Folium Helianthi, Flos Buddlejae 80 parts ~ 86 parts and Borneolum Syntheticum 5 parts ~ 8 parts;

Its preparation method comprises the following steps:

A, by above-mentioned parts by weight, take Concha Haliotidis respectively, Folium Ginkgo, Flos Chrysanthemi, Fructus Lycii, Semen Arecae part, Flos Eriocauli, Folium Helianthi, Flos Buddlejae and Borneolum Syntheticum are also pulverized, the whole medicated powder mix homogeneously then will obtained;

B, mixed powder obtained for steps A is put into extraction pot, add 2 ~ 3 times of water wherein, then seal boiling to the medicated powder carbonization in extraction pot, then open extraction pot, collect expellant gas;

C, make aqueous phase by water-soluble for gas obtained for step B, polylactic acid is dissolved in dichloromethane simultaneously and makes organic facies; By ratio mix homogeneously under ul-trasonic irradiation that obtained aqueous phase and organic facies are 1:5 by volume, obtained mixed liquor;

Add the polyvinyl alcohol accounting for described mixeding liquid volume 0.25% in D, the mixed liquor that obtains to step C, stir, standing sedimentation, centrifugal;

The ratio that it is 1:2 by volume that E, the precipitate obtained by step D join by polyacrylic acid and hydroxypropyl emthylcellulose mixes in obtained solution, stirs, then regulates its pH value to 5.0, obtained.

Due to adopt technique scheme, the beneficial effect that the present invention obtains is: the present invention is according to Traditional Chinese medical theory, by scientific compatibility, and through experiment for many years grope exploitation obtain; The curative effect time of this collyrium is long, and drug bioavailability is high.

Detailed description of the invention

Below in conjunction with specific embodiment, the invention will be further described, and protection scope of the present invention is not only confined to following examples.

Embodiment 1

A kind of preparation method of collyrium comprises the following steps:

A, take Concha Haliotidis 100g respectively, Folium Ginkgo 100g, Flos Chrysanthemi 60g, Fructus Lycii 58g, Semen Arecae g45g, Flos Eriocauli 120g, Folium Helianthi 58g, Flos Buddlejae 86g and Borneolum Syntheticum 5g also pulverizes, the whole medicated powder mix homogeneously then will obtained;

B, mixed powder obtained for steps A is put into extraction pot, add 2 ~ 3 times of water wherein, then seal boiling to the medicated powder carbonization in extraction pot, then open extraction pot, collect expellant gas;

C, make aqueous phase by water-soluble for gas obtained for step B, polylactic acid is dissolved in dichloromethane simultaneously and makes organic facies; By ratio mix homogeneously under ul-trasonic irradiation that obtained aqueous phase and organic facies are 1:5 by volume, obtained mixed liquor;

Add the polyvinyl alcohol accounting for described mixeding liquid volume 0.25% in D, the mixed liquor that obtains to step C, stir, standing sedimentation, centrifugal;

The ratio that it is 1:2 by volume that E, the precipitate obtained by step D join by polyacrylic acid and hydroxypropyl emthylcellulose mixes in obtained solution, stirs, then regulates its pH value to 5.0, obtained.

Embodiment 2

A kind of preparation method of collyrium comprises the following steps:

A, take Concha Haliotidis 120g respectively, Folium Ginkgo 90g, Flos Chrysanthemi 75g, Fructus Lycii 65g, Semen Arecae g45g, Flos Eriocauli 100g, Folium Helianthi 50g, Flos Buddlejae 80g and Borneolum Syntheticum 8g also pulverizes, the whole medicated powder mix homogeneously then will obtained;

B, mixed powder obtained for steps A is put into extraction pot, add 2 times of water wherein, then seal boiling to the medicated powder carbonization in extraction pot, then open extraction pot, collect expellant gas;

C, make aqueous phase by water-soluble for gas obtained for step B, polylactic acid is dissolved in dichloromethane simultaneously and makes organic facies; By ratio mix homogeneously under ul-trasonic irradiation that obtained aqueous phase and organic facies are 1:5 by volume, obtained mixed liquor;

Add the polyvinyl alcohol accounting for described mixeding liquid volume 0.25% in D, the mixed liquor that obtains to step C, stir, standing sedimentation, centrifugal;

The ratio that it is 1:2 by volume that E, the precipitate obtained by step D join by polyacrylic acid and hydroxypropyl emthylcellulose mixes in obtained solution, stirs, then regulates its pH value to 5.0, obtained.

Embodiment 3

A kind of preparation method of collyrium comprises the following steps:

A, take Concha Haliotidis 110g respectively, Folium Ginkgo 95g, Flos Chrysanthemi 70g, Fructus Lycii 61g, Semen Arecae g50g, Flos Eriocauli 110g, Folium Helianthi 55g, Flos Buddlejae 84g and Borneolum Syntheticum 7g also pulverizes, the whole medicated powder mix homogeneously then will obtained;

B, mixed powder obtained for steps A is put into extraction pot, add 3 times of water wherein, then seal boiling to the medicated powder carbonization in extraction pot, then open extraction pot, collect expellant gas;

C, make aqueous phase by water-soluble for gas obtained for step B, polylactic acid is dissolved in dichloromethane simultaneously and makes organic facies; By ratio mix homogeneously under ul-trasonic irradiation that obtained aqueous phase and organic facies are 1:5 by volume, obtained mixed liquor;

Add the polyvinyl alcohol accounting for described mixeding liquid volume 0.25% in D, the mixed liquor that obtains to step C, stir, standing sedimentation, centrifugal;

The ratio that it is 1:2 by volume that E, the precipitate obtained by step D join by polyacrylic acid and hydroxypropyl emthylcellulose mixes in obtained solution, stirs, then regulates its pH value to 5.0, obtained.

Clinical case is reported

Clinical trial glaucoma patient is totally 200 examples, wherein each 100 examples of men and women, oldest 75 years old, minimum 50 years old; The collyrium that the present invention of these patient's drops every day obtains, after half a year, has 190 routine patients to reach healing, has the symptom of 8 routine patients obviously to be taken a turn for the better, but do not cure completely, have 2 routine patients not cure.

Owing to can find out that collyrium of the present invention has good curative effect to treatment glaucoma.

Claims (1)

1. a collyrium, its feature is made at the raw material by following parts by weight:

Concha Haliotidis 100 parts ~ 120 parts, Folium Ginkgo 90 parts ~ 100 parts, Flos Chrysanthemi 60 parts ~ 75 parts, Fructus Lycii 58 parts ~ 65 parts, Semen Arecae 45 parts ~ 55 parts, Flos Eriocauli 100 parts ~ 120 parts, 50 parts ~ 58 parts, Folium Helianthi, Flos Buddlejae 80 parts ~ 86 parts and Borneolum Syntheticum 5 parts ~ 8 parts;

Its preparation method comprises the following steps:

A, by above-mentioned parts by weight, take Concha Haliotidis respectively, Folium Ginkgo, Flos Chrysanthemi, Fructus Lycii, Semen Arecae part, Flos Eriocauli, Folium Helianthi, Flos Buddlejae and Borneolum Syntheticum are also pulverized, the whole medicated powder mix homogeneously then will obtained;

B, mixed powder obtained for steps A is put into extraction pot, add 2 ~ 3 times of water wherein, then seal boiling to the medicated powder carbonization in extraction pot, then open extraction pot, collect expellant gas;

C, make aqueous phase by water-soluble for gas obtained for step B, polylactic acid is dissolved in dichloromethane simultaneously and makes organic facies; By ratio mix homogeneously under ul-trasonic irradiation that obtained aqueous phase and organic facies are 1:5 by volume, obtained mixed liquor;

Add the polyvinyl alcohol accounting for described mixeding liquid volume 0.25% in D, the mixed liquor that obtains to step C, stir, standing sedimentation, centrifugal;

The ratio that it is 1:2 by volume that E, the precipitate obtained by step D join by polyacrylic acid and hydroxypropyl emthylcellulose mixes in obtained solution, stirs, then regulates its pH value to 5.0, obtained.