CN1895552A - Preparation of compound mixture and its inspection - Google Patents
Preparation of compound mixture and its inspection Download PDFInfo
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- CN1895552A CN1895552A CNA2006100109508A CN200610010950A CN1895552A CN 1895552 A CN1895552 A CN 1895552A CN A2006100109508 A CNA2006100109508 A CN A2006100109508A CN 200610010950 A CN200610010950 A CN 200610010950A CN 1895552 A CN1895552 A CN 1895552A
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Abstract
A Chinese medicine for treating myopia, glaucoma, early-or middle-phase cataract, blurred vision, etc is prepared from 24 Chinese-medicinal materials including chrysanthemum flower, ginseng, wolfberry fruit, dodder seed, etc. Its preparing process and discrimination method are also disclosed.
Description
Technical field: the invention belongs to a kind of preparation method of Chinese patent medicine compound mixture and the method for inspection of this mixture.
Background technology: press the explanation of Chinese Pharmacopoeia, the sheet of recovering lost eyesight is coated tablet (WS3-B-2385-97).The dissolution rate of tablet Chinese traditional medicine is slower, and its bioavailability is poor; Child and coma patient are difficult for swallowing; The sheet developing agent storage that contains volatile ingredient for a long time the time content descend.
Summary of the invention: the objective of the invention is to change the sheet of recovering lost eyesight into mixture, improve bioavailability; Be easy to the child and coma patient is swallowed; Volatile ingredient is store back content for a long time and can not descended.
Another object of the present invention provides a kind of method of inspection of compound mixture.
The present invention is achieved like this, by Cornu Saigae Tataricae: Fructus Tribuli: Herba Equiseti Hiemalis: Flos Chrysanthemi: Semen Plantaginis: Spica Prunellae: Semen Cassiae: Radix Ginseng: Fructus Corni (system): Herba Dendrobii: Fructus Lycii: Semen Cuscutae: Fructus Ligustri Lucidi: Concha Haliotidis: Rhizoma Coptidis: Flos Eriocauli: Caulis Akebiae: Radix Rehmanniae Preparata: Rhizoma Dioscoreae: Rhizoma Alismatis: Poria: Cortex Moutan: Radix Rehmanniae: Semen Arecae=1: 40: 25: 50: 25: 25: 40: 15: 25: 40: 40: 25: 25: 50: 10: 25: 25: 25: 25: 10: 25: 25: 25: 25 weight ratio is got the raw materials ready, Cornu Saigae Tataricae is broken into coarse granule, add 10 times of water gagings, decoct secondary, each 7-10 hour, at any time replenish in the decoction process and steam the moisture content that loses, collecting decoction, filter, standby; Radix Ginseng is beaten powder and is become coarse powder, makes solvent with 30% ethanol, and hot reflux is extracted 2 times, merges hot reflux liquid, reclaims ethanol, and concentrated solution is standby, and medicinal residues also partly carry out decocting in water in decocting in water; 22 flavors such as all the other Fructus Tribulis, Herba Equiseti Hiemalis, Flos Chrysanthemi, Semen Plantaginis, Semen Cassiae, Fructus Corni, Herba Dendrobii, Fructus Lycii add the medicinal residues after the Radix Ginseng alcohol extraction, the decocting that adds 10 times of former medicine weight boils secondary, and each two hours, collecting decoction, filter, be evaporated to 1.5 times of former medicine weight; Extract of antelope's horn, panaxynol extract and medicinal liquid are merged, add an amount of antiseptic, correctives, stir evenly, adjust total amount 3.1 times to former medicine weight, packing, promptly.
Compare with tablet with the compound mixture that the present invention makes, improved bioavailability, absorb fast, good effect; Taking convenience, be suitable for children taking, also be beneficial to the treatment acute disease; Steady quality is easily preserved.Be mainly used in nourishing the liver and kidney, YIN nourishing and the production of body fluid promoting, liver heat removing and eyesight improving.To myopia, glaucoma, just, mid-term cataract and diseases such as the photophobia photophobia that causes of the hepatic and renal YIN deficiency, blurred vision better action is arranged.
Its method of inspection of compound mixture of the present invention is:
(1) gets this product 10ml, volatilize, add ethanol 10ml, left standstill after the jolting 2 hours, and filtered, filtrate is concentrated into 2ml, as need testing solution, other gets berberine hydrochloride and palmatine hydrochloride reference substance, adds methanol and makes the mixed liquor that contains 0.5mg among every 1ml, in contrast product solution, test according to thin layer chromatography (appendix VI B), drawing each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, is developing solvent with n-butyl alcohol-glacial acetic acid-water (7: 1: 2), launch, take out, dry, under ultra-violet lamp (365nm), inspect.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color.
(2) get this product 20ml, add strong ammonia solution 4ml, add chloroform 50ml, jolting is extracted, and chloroform liquid places separatory funnel, add dilute hydrochloric acid 5ml and water 20ml, jolting divides and gets the sour water layer, with chloroform 10ml washing once, discard chloroform liquid, add strong ammonia solution and regulate pH value about 9, extract 2 times with the chloroform jolting, each 10ml merges chloroform liquid, evaporate to dryness, residue add methanol 1ml makes dissolving, as need testing solution.Other gets the Semen Arecae control medicinal material, adds strong ammonia solution 4ml, adds chloroform 50ml, and supersound process 30 minutes filters, and residue with chloroform 10ml washing once merges chloroform liquid, places separatory funnel, shines medical material solution in pairs with legal system.Test according to thin layer chromatography (appendix VI B), drawing each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, is developing solvent with three chloromethanes-methanol (9.5: 0.5), put in the expansion cylinder of ammonia saturated with vapor, launch, take out airing, spray is with rare bismuth potassium iodide test solution, in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show identical Chinese red speckle.
(3) total solid check, precision is measured this product 25ml, puts in the evaporating dish that is dried to constant weight, behind evaporate to dryness in the water-bath, in 105 ℃ of dryings 3 hours, puts in the exsiccator cooling 30 minutes, accurately claims to decide weight.Leave over residue and must not be less than 5.0g (20%).
The specific embodiment: with 24 flavor Chinese medicines such as Cornu Saigae Tataricae 0.5g, Fructus Tribuli 20g, Herba Equiseti Hiemalis 12.5g, Flos Chrysanthemi 25g, Semen Plantaginis 12.5g, Spica Prunellae 12.5g, Semen Cassiae 20g, Radix Ginseng 7.5g, Fructus Corni (system) 12.5g, Herba Dendrobii 20g, Fructus Lycii 20g, Semen Cuscutae 12.5g, Fructus Ligustri Lucidi 12.5g, Concha Haliotidis 25g, Rhizoma Coptidis 5g, Flos Eriocauli 12.5g, Caulis Akebiae 12.5g, Radix Rehmanniae Preparata 12.5g, Rhizoma Dioscoreae 12.5g, Rhizoma Alismatis 5g, Poria 12.5g, Cortex Moutan 12.5g, Radix Rehmanniae 12.5g, Semen Arecae 12.5g.Cornu Saigae Tataricae is broken into coarse granule, add 10 times of water gagings, decoct secondary, each 7-10 hour, replenish at any time in the decoction process and steam the moisture content that loses, collecting decoction filters, and is standby; Radix Ginseng, powder becomes coarse powder, makes solvent with 30% ethanol, and hot reflux is extracted 2 times, merges hot reflux liquid, reclaims ethanol, and concentrated solution is standby, and medicinal residues also partly carry out decocting in water in decocting in water; 22 flavors such as all the other Fructus Tribulis, Herba Equiseti Hiemalis, Flos Chrysanthemi, Semen Plantaginis, Semen Cassiae, Fructus Corni, Herba Dendrobii, Fructus Lycii decoct with water secondary, and each two hours, collecting decoction filtered, and is evaporated to 500ml; Extract of antelope's horn, panaxynol extract and medicinal liquid are merged, add an amount of antiseptic, correctives, stir evenly, adjust total amount to 1000ml, packing, promptly.
Claims (3)
1, a kind of preparation method of compound mixture, it is characterized in that by Cornu Saigae Tataricae: Fructus Tribuli: Herba Equiseti Hiemalis: Flos Chrysanthemi: Semen Plantaginis: Spica Prunellae: Semen Cassiae: Radix Ginseng: Fructus Corni (system): Herba Dendrobii: Fructus Lycii: Semen Cuscutae: Fructus Ligustri Lucidi: Concha Haliotidis: Rhizoma Coptidis: Flos Eriocauli: Caulis Akebiae: Radix Rehmanniae Preparata: Rhizoma Dioscoreae: Rhizoma Alismatis: Poria: Cortex Moutan: Radix Rehmanniae: Semen Arecae=1: 40: 25: 50: 25: 25: 40: 15: 25: 40: 40: 25: 25: 50: 10: 25: 25: 25: 25: 10: 25: 25: 25: 25 weight ratio is got the raw materials ready, Cornu Saigae Tataricae is broken into coarse granule, add 10 times of water gagings, decoct secondary, each 7-10 hour, at any time replenish in the decoction process and steam the moisture content that loses, collecting decoction, filter, standby; Radix Ginseng breaks into coarse powder, makes solvent with 30% ethanol, and hot reflux is extracted 2 times, merges hot reflux liquid, reclaims ethanol, and concentrated solution is standby, and medicinal residues also partly carry out decocting in water in decocting in water;
The medicinal residues that 22 flavors such as all the other Fructus Tribulis, Herba Equiseti Hiemalis, Flos Chrysanthemi, Semen Plantaginis, Semen Cassiae, Fructus Corni, Herba Dendrobii, Fructus Lycii add after the Radix Ginseng alcohol extraction become former medicine, the decocting that adds 10 times of former medicine weight boils secondary, and each two hours, collecting decoction, filter, be evaporated to the medicinal liquid of 1.5 times of former medicine weight; Extract of antelope's horn, panaxynol extract and medicinal liquid are merged, add an amount of antiseptic, correctives, stir evenly, adjust total amount 3.1 times to former medicine weight, packing, promptly.
2, a kind of preparation method of compound mixture, it is characterized in that using Cornu Saigae Tataricae 0.5g, Fructus Tribuli 20g, Herba Equiseti Hiemalis 12.5g, Flos Chrysanthemi 25g, Semen Plantaginis 12.5g, Spica Prunellae 12.5g, Semen Cassiae 20g, Radix Ginseng 7.5g, Fructus Corni (system) 12.5g, Herba Dendrobii 20g, Fructus Lycii 20g, Semen Cuscutae 12.5g, Fructus Ligustri Lucidi 12.5g, Concha Haliotidis 25g, Rhizoma Coptidis 5g, Flos Eriocauli 12.5g, Caulis Akebiae 12.5g, Radix Rehmanniae Preparata 12.5g, Rhizoma Dioscoreae 12.5g, Rhizoma Alismatis 5g, Poria 12.5g, Cortex Moutan 12.5g, Radix Rehmanniae 12.5g, Semen Arecae 12.5g, Cornu Saigae Tataricae is broken into coarse granule, add 10 times of water gagings, decoct secondary, each 7-10 hour, at any time replenish in the decoction process and steam the moisture content that loses, collecting decoction, filter, standby; Radix Ginseng, powder becomes coarse powder, makes solvent with 30% ethanol, and hot reflux is extracted 2 times, merges hot reflux liquid, reclaims ethanol, and concentrated solution is standby, and medicinal residues also partly carry out decocting in water in decocting in water; All the other Fructus Tribulis, Herba Equiseti Hiemalis, Flos Chrysanthemi, Semen Plantaginis, Semen Cassiae, Fructus Corni, Herba Dendrobii, Fructus Lycii 22 flavors decoct with water secondary, and each two hours, collecting decoction filtered, and is evaporated to 500ml; Extract of antelope's horn, panaxynol extract and medicinal liquid are merged, add an amount of antiseptic, correctives, stir evenly, adjust total amount to 1000ml, packing, promptly.
3, a kind of method of inspection of compound mixture is characterized in that step is as follows:
(1) gets this product 10ml, volatilize, add ethanol 10ml, left standstill after the jolting 2 hours, filter, filtrate is concentrated into 2ml, as need testing solution, other gets berberine hydrochloride and palmatine hydrochloride reference substance, add methanol and make the mixed liquor that contains 0.5mg among every 1ml, product solution is tested according to thin layer chromatography in contrast, draw each 10 μ l of above-mentioned two kinds of solution, putting respectively on same silica gel g thin-layer plate, is that developing solvent launches with n-butyl alcohol-glacial acetic acid-water=(7: 1: 2), takes out, dry, under the 365nm ultra-violet lamp, inspect; In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color;
(2) get this product 20ml, add strong ammonia solution 4ml, add chloroform 50ml, jolting is extracted, and chloroform liquid places separatory funnel, add dilute hydrochloric acid 5ml and water 20ml, jolting divides and gets the sour water layer, with chloroform 10ml washing once, discard chloroform liquid, add strong ammonia solution and regulate pH value about 9, extract 2 times with the chloroform jolting, each 10ml merges chloroform liquid, evaporate to dryness, residue add methanol 1ml makes dissolving, as need testing solution; Other gets the Semen Arecae control medicinal material, adds strong ammonia solution 4ml, adds chloroform 50ml, and supersound process 30 minutes filters, and residue with chloroform 10ml washing once merges chloroform liquid, places separatory funnel, shines medical material solution in pairs with legal system; Test according to thin layer chromatography, drawing each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, is developing solvent with three chloromethanes-methanol=(9.5: 0.5), put in the expansion cylinder of ammonia saturated with vapor, launch, take out airing, spray is with rare bismuth potassium iodide test solution, in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show identical Chinese red speckle;
(3) total solid check, precision is measured this product 25ml, puts in the evaporating dish that is dried to constant weight, behind evaporate to dryness in the water-bath, in 105 ℃ of dryings 3 hours, puts in the exsiccator cooling 30 minutes, and accurate the title, decided weight, leaves over residue and must not be less than 5.0g or 20%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100109508A CN100522225C (en) | 2006-06-12 | 2006-06-12 | Preparation of compound mixture and its inspection |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100109508A CN100522225C (en) | 2006-06-12 | 2006-06-12 | Preparation of compound mixture and its inspection |
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| CN1895552A true CN1895552A (en) | 2007-01-17 |
| CN100522225C CN100522225C (en) | 2009-08-05 |
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| CNB2006100109508A Expired - Fee Related CN100522225C (en) | 2006-06-12 | 2006-06-12 | Preparation of compound mixture and its inspection |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579488B (en) * | 2009-06-16 | 2011-01-26 | 唐凯 | Chinese medicament for treating cataract and glaucoma |
| CN102240366A (en) * | 2009-11-13 | 2011-11-16 | 西安碑林药业股份有限公司 | Quality detection method for preparation for vision rehabilitation |
| CN104644941A (en) * | 2014-06-10 | 2015-05-27 | 陈莉芬 | Eye drop |
| CN104689107A (en) * | 2015-02-10 | 2015-06-10 | 潘雄峰 | Traditional Chinese medicine for treating nearsightedness and preparation method thereof |
| CN104800490A (en) * | 2015-04-18 | 2015-07-29 | 青岛辰达生物科技有限公司 | Traditional Chinese medicine composition for treating open-angle glaucoma |
| CN106370749A (en) * | 2016-08-29 | 2017-02-01 | 鲁南厚普制药有限公司 | Quality detection method of ginseng basis-consolidating oral solution |
-
2006
- 2006-06-12 CN CNB2006100109508A patent/CN100522225C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579488B (en) * | 2009-06-16 | 2011-01-26 | 唐凯 | Chinese medicament for treating cataract and glaucoma |
| CN102240366A (en) * | 2009-11-13 | 2011-11-16 | 西安碑林药业股份有限公司 | Quality detection method for preparation for vision rehabilitation |
| CN104644941A (en) * | 2014-06-10 | 2015-05-27 | 陈莉芬 | Eye drop |
| CN104689107A (en) * | 2015-02-10 | 2015-06-10 | 潘雄峰 | Traditional Chinese medicine for treating nearsightedness and preparation method thereof |
| CN104689107B (en) * | 2015-02-10 | 2017-12-26 | 潘雄峰 | It is a kind of to be used to treat Chinese medicine composition of myopia and preparation method thereof |
| CN104800490A (en) * | 2015-04-18 | 2015-07-29 | 青岛辰达生物科技有限公司 | Traditional Chinese medicine composition for treating open-angle glaucoma |
| CN106370749A (en) * | 2016-08-29 | 2017-02-01 | 鲁南厚普制药有限公司 | Quality detection method of ginseng basis-consolidating oral solution |
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| Publication number | Publication date |
|---|---|
| CN100522225C (en) | 2009-08-05 |
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Owner name: DALI BAI AUTONOMOUS PREFECTURE TCM PHARMACEUTICAL Free format text: FORMER NAME: DALI BAI-NATIONALITY AUTONOMOUS PREFECTURE CHINESE MEDICINE PHARMACY CO., LTD. |
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Address after: 672400 No. 66 East Road, Nanzhao Town, Weishan County, Yunnan Patentee after: Dali Bai Autonomous Prefecture Traditional Chinese Medicine Pharmaceutical Co., Ltd. Address before: 672400 No. 66 East Road, Nanzhao Town, Weishan County, Yunnan Patentee before: Dali Bai-Nationality Autonomous Prefecture Chinese Medicine Pharmacy Co., Ltd. |
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Granted publication date: 20090805 Termination date: 20120612 |