CN102319323A - Eyedrop for reducing intraocular pressure and treating glaucoma and preparation method thereof - Google Patents
Eyedrop for reducing intraocular pressure and treating glaucoma and preparation method thereof Download PDFInfo
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- CN102319323A CN102319323A CN201110294829A CN201110294829A CN102319323A CN 102319323 A CN102319323 A CN 102319323A CN 201110294829 A CN201110294829 A CN 201110294829A CN 201110294829 A CN201110294829 A CN 201110294829A CN 102319323 A CN102319323 A CN 102319323A
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Abstract
The invention relates to an eyedrop, and particularly relates to an eyedrop for reducing intraocular pressure and treating glaucoma and a preparation method thereof. The eyedrop is prepared by the following raw material drugs by weight: 160-230 parts by weight of ginkgo leaves, 160-230 parts of cassia seeds, 160-230 parts of honeysuckle, 160-230 parts of chrysanthemum morifolium, 100-160 parts of butterflybush flowers, 100-160 parts of medlar, 100-160 parts of inula flowers, 40-60 parts of safflowers, 1-3 parts of musk, 0.5-1.5 parts of anisodamine, and 0.5-1.5 parts of borneol. The raw material drugs of the invention are prepared, are directly applied to eyes in a form of an eyedrop, and have fast effect, a good treatment course, no pain, a high cure rate, and no side effect.
Description
Technical field
The present invention relates to a kind of collyrium, be specifically related to a kind of reduction intraocular pressure and treat glaucomatous collyrium and preparation method thereof.
Background technology
Glaucoma; Be a kind ofly fall ill rapidly, hazardness causes the common difficult oculopathy of losing one's sight greatly, at any time; Characteristic is exactly the horizontal exceeding eyeball tolerant degree of institute that intraocular pressure is interrupted or persistence raises and bring infringement for eyeball each several part tissue and visual function; Cause optic atrophy, constriction of visual field, visual deterioration, the blind just time sooner or later, can be as blind as a bat at acute attack stage 24-48 hour.Glaucoma belongs to the eyes sexually transmitted disease (STD) and becomes, but eyes are fallen ill or a glance onset, secondary blindness simultaneously.Glaucoma is to cause blind second largest reason, and usually, the people's ratio more than 40 years old is easier to suffer from glaucoma, and female patient is common than the male patient again.Glaucomatous characteristic is that the inner intraocular pressure of eyeball increases; And eyeball surface sclerosis, this sick symptom comprise has the ring of light around eyes pain or uncomfortable (mainly betiding morning), blurred vision, the light source, pupil can't be in dark appropriate regulation amplify, the disappearance of Xu Guang (peripheral visual acuity) etc.
Glaucoma mainly is divided into by symptom: acute angle-closure, subacute angle-closure, chronic angle-closure and primary open-angle.
Glaucoma belongs to " five kinds of glaucoma " category in the traditional Chinese medical science, is owing to all kinds of reasons such as yin or yang excess, disorder of movement of QI, cause qi-blood disharmony, passages through which vital energy circulates is unfavorable, sweat pore obstruction in the order; Qi depression to blood stasis, refreshing water deposits and falls ill, and the general symptom oncoming force is violent, removes and eliminates the cause of disease; Control its at all outside, should also be noted that to shrink pupil refreshing, open Xuan Fu; The elimination stasis of blood stagnates, and improves symptom, with vision protection.But also has especially effectively Chinese medicine at present.
Summary of the invention
The purpose of this invention is to provide a kind of reduction intraocular pressure and treat glaucomatous collyrium and preparation method thereof.
The present invention adopts following technical scheme:
A kind of reduction intraocular pressure is treated glaucomatous collyrium, is processed by the crude drug of following parts by weight: Folium Ginkgo 160-230 part, Semen Cassiae 160-230 part, Flos Lonicerae 160-230 part, Flos Chrysanthemi 160-230 part, Flos Buddlejae 100-160 part, Fructus Lycii 100-160 part, Flos Inulae 100-160 part, Flos Carthami 40-60 part, Moschus 1-3 part, Anisodamine 0.5-1.5 part and Borneolum Syntheticum 0.5-1.5 part.
Reduce intraocular pressure and treat the method for preparing of glaucomatous collyrium; May further comprise the steps: (1) is got each raw material in proportion; Folium Ginkgo, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Flos Lonicerae, Flos Buddlejae, Flos Inulae, Flos Carthami are put on the double-edged fine-toothed comb of the marmite that water is housed, covered sealing with another marmite on this marmite then, 5-8h at a simmer; Cooling has one deck medicine frost on the marmite inwall above the back, the medicine frost is collected; (2) distillation of Moschus water is refined, get the brown distillation of pupil, sealing is preserved; (3) medicine of step (1) frost, Anisodamine and Borneolum Syntheticum are put into 1000 parts distilled water and dissolve, dissolve the brown distillation of pupil that the back adds step (2), the boric acid adjust pH is 6-7, filters, promptly gets after the sterilization.
The method for using of collyrium of the present invention is: every day three times, each two to six, can cure in general 4-7 days.
In the present invention, white chrysanthemums: hard Gan slightly cold, wind, detoxification, eyesight, their effectiveness is: for anger on the inflammation, blurred vision, dizziness, detoxification, red eyes and throat, boils boils blisters , heavy false fire; Wolfberry: of sweet, flat, owned by the liver, kidney essence, nourishing eyesight, blood and nerves, thirst, lungs cough, cure liver and kidney yin deficiency, weak knees, dizziness, blurred vision , head faint more tears, consumptive cough, diabetes, nocturnal emission; honeysuckle: detoxification, cool wind-heat, for carbuncles boils, pharyngitis, erysipelas, fever sera dysentery, their effectiveness as: clearing and detoxifying, through the meridians, broad-spectrum antimicrobial and antiviral effect, with "Chinese antibiotic", "green antibiotics known; Buddleia: slightly cold, sweet, Indications heat Liver, eyesight back shade, for the purpose red throat, more tears photophobia, look unfamiliar shade film, liver deficiency head dark, visual dim; Inula: sweet tiring, classified as lung, liver, stomach, dispel pathogenic cold leader of all the wind, only the sun, Yangming headache, OK Yangming milk barrier, cure Ruyan, mastitis, swelling and pain, red eyes of fire storm, eye disease pain, chills and eyesight, hidden astringent photophobia fear day, cold chills and fever cough, sputum, such as glue, go meridians, only surface cold abdominal pain, diuresis, cure single bloating, wind, fire, root swelling; safflower: spicy, warm, heart, liver, and its effectiveness is: with blood circulation, blood and analgesic effect, treating the blood stagnation amenorrhea, dysmenorrhea, pelvic mass, dystocia, bruises and blood stasis pain embolism; Ginkgo biloba: bitter and sweet flat, good heart convergence lung, dampness diarrhea, asthma, blood circulation, pain and other effects; Cassia: bitter, sweet and cool, with clear anger, rheumatism, kidney eyesight and other functions; musky, spicy and warm, owned by Heart, resuscitation refreshing, promoting blood circulation, relieve pain; anisodamine enable smooth apparent relaxation, and can relieve spasm, while analgesic effect; borneol, taste hard, cool, into cardiopulmonary classics, through various orifices, to shade eyesight, swelling and pain, treatment of stroke, lockjaw, fever coma, epilepsy sputum fans, gas closed deafness, pharyngitis, mouth sores, otitis media, carbuncles, hemorrhoids, head also shade film, enterobiasis.
All medicine reasonable compatibilities of the present invention complement each other, and have the effect of supplementing QI and nourishing YIN, activating blood and promoting diuresis, concern according to the dialectical the exterior and the interior of executing the traditional medical theory controlled and human five internal organs's six internal organs, belonging to through venation; The performance of the meridian distribution of property and flavor of medicine four natures and five flavors of drug is directly conducted in the efficacy of a drug drug effect eye and is treated glaucoma, eye blood vessels in the mediation body, and blood vessels are logical; Through ruton, sick painful from disappearing, disease is rehabilitated; Reach the purpose of treating both the principal and secondary aspects of a disease, can improve hemorheological property, improved vascular inner skin cell activity; Reduce elevated platelet activation, thereby improve the eye local blood circulation, improve the anoxia enduring of ocular tissue in retina, the optic nerve etc., anti-damage function etc.Crude drug of the present invention through preparation after, directly act on eye with the form of collyrium, instant effect, the course of treatment are good, no pain, cure rate are high, have no side effect; Work and life that method for using is simple, effective, do not influence the patient have positive effect than prior art.
The specific embodiment
Embodiment 1
Reduce intraocular pressure and treat glaucomatous collyrium, process: 0.5 part of 160 parts of Folium Ginkgos, 160 parts of Semen Cassiaes, 160 parts of Flos Loniceraes, 160 parts of Flos Chrysanthemis, 100 parts of Flos Buddlejaes, 100 parts of Fructus Lycii, 100 parts of Flos Inulae, 40 parts on Flos Carthami, 1 part in Moschus, 0.5 part of Anisodamine and Borneolum Syntheticum by following crude drug.
May further comprise the steps during preparation: each raw material is got in (1); In marmite, add entry, place a double-edged fine-toothed comb on the marmite, then Folium Ginkgo, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Flos Lonicerae, Flos Buddlejae, Flos Inulae, Flos Carthami are put on the double-edged fine-toothed comb; Another marmite covers sealing with the marmite that is filled with water; 6h at a simmer cools and is attached with one deck medicine frost on the marmite inwall above the back, and the medicine frost is collected; (2) distillation of Moschus water is refined, get the brown distillation of pupil (Main Ingredients and Appearance is muscone, fatty resin), sealing is preserved; (3) medicine of step (1) frost, Anisodamine and Borneolum Syntheticum are put into 1000 parts distilled water and dissolve, dissolve the brown distillation of pupil that the back adds step (2), the boric acid adjust pH is 6.75, filters the back through the anion exchanger and bottles, and promptly gets behind the high pressure steam sterilization.
Embodiment 2
Reduce intraocular pressure and treat glaucomatous collyrium, process: 1.5 parts of 230 parts of Folium Ginkgos, 230 parts of Semen Cassiaes, 230 parts of Flos Loniceraes, 230 parts of Flos Chrysanthemis, 160 parts of Flos Buddlejaes, 160 parts of Fructus Lycii, 160 parts of Flos Inulae, 60 parts on Flos Carthami, 3 parts in Moschus, 1.5 parts of Anisodamine and Borneolum Syntheticums by following crude drug.
May further comprise the steps during preparation: each raw material is got in (1); In marmite, add entry, place a double-edged fine-toothed comb on the marmite, then Folium Ginkgo, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Flos Lonicerae, Flos Buddlejae, Flos Inulae, Flos Carthami are put on the double-edged fine-toothed comb; Another marmite covers sealing with the marmite that is filled with water; 5h at a simmer cools and is attached with one deck medicine frost on the marmite inwall above the back, and the medicine frost is collected; (2) distillation of Moschus water is refined, get the brown distillation of pupil (Main Ingredients and Appearance is muscone, fatty resin), sealing is preserved; (3) medicine of step (1) frost, Anisodamine and Borneolum Syntheticum are put into 1000 parts distilled water and dissolve, dissolve the brown distillation of pupil that the back adds step (2), the boric acid adjust pH is 6, filters, promptly gets after the sterilization.
Embodiment 3
Reduce intraocular pressure and treat glaucomatous collyrium, process: 1 part of 200 parts of Folium Ginkgos, 200 parts of Semen Cassiaes, 200 parts of Flos Loniceraes, 200 parts of Flos Chrysanthemis, 130 parts of Flos Buddlejaes, 130 parts of Fructus Lycii, 130 parts of Flos Inulae, 50 parts on Flos Carthami, 2 parts in Moschus, 1 part of Anisodamine and Borneolum Syntheticum by following crude drug.
May further comprise the steps during preparation: each raw material is got in (1); In marmite, add entry, place a double-edged fine-toothed comb on the marmite, then Folium Ginkgo, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Flos Lonicerae, Flos Buddlejae, Flos Inulae, Flos Carthami are put on the double-edged fine-toothed comb; Another marmite covers sealing with the marmite that is filled with water; 8h at a simmer cools and is attached with one deck medicine frost on the marmite inwall above the back, and the medicine frost is collected; (2) distillation of Moschus water is refined, get the brown distillation of pupil (Main Ingredients and Appearance is muscone, fatty resin), sealing is preserved; (3) medicine of step (1) frost, Anisodamine and Borneolum Syntheticum are put into 1000 parts distilled water and dissolve, dissolve the brown distillation of pupil that the back adds step (2), the boric acid adjust pH is 7, filters the back through the anion exchanger and bottles, and promptly gets behind the high pressure steam sterilization.
Embodiment 4
Reduce intraocular pressure and treat glaucomatous collyrium, process: 0.5 part of 160 parts of Folium Ginkgos, 230 parts of Semen Cassiaes, 160 parts of Flos Loniceraes, 230 parts of Flos Chrysanthemis, 100 parts of Flos Buddlejaes, 160 parts of Fructus Lycii, 100 parts of Flos Inulae, 60 parts on Flos Carthami, 1 part in Moschus, 1.5 parts of Anisodamine and Borneolum Syntheticum by following crude drug.
May further comprise the steps during preparation: each raw material is got in (1); In marmite, add entry, place a double-edged fine-toothed comb on the marmite, then Folium Ginkgo, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Flos Lonicerae, Flos Buddlejae, Flos Inulae, Flos Carthami are put on the double-edged fine-toothed comb; Another marmite covers sealing with the marmite that is filled with water; 7h at a simmer cools and is attached with one deck medicine frost on the marmite inwall above the back, and the medicine frost is collected; (2) distillation of Moschus water is refined, get the brown distillation of pupil (Main Ingredients and Appearance is muscone, fatty resin), sealing is preserved; (3) medicine of step (1) frost, Anisodamine and Borneolum Syntheticum are put into 1000 parts distilled water and dissolve, dissolve the brown distillation of pupil that the back adds step (2), the boric acid adjust pH is 6.5, filters, promptly gets after the sterilization.
Embodiment 5
Reduce intraocular pressure and treat glaucomatous collyrium, process: 1.5 parts of 230 parts of Folium Ginkgos, 160 parts of Semen Cassiaes, 230 parts of Flos Loniceraes, 160 parts of Flos Chrysanthemis, 160 parts of Flos Buddlejaes, 100 parts of Fructus Lycii, 160 parts of Flos Inulae, 40 parts on Flos Carthami, 3 parts in Moschus, 0.5 part of Anisodamine and Borneolum Syntheticums by following crude drug.
May further comprise the steps during preparation: each raw material is got in (1); In marmite, add entry, place a double-edged fine-toothed comb on the marmite, then Folium Ginkgo, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Flos Lonicerae, Flos Buddlejae, Flos Inulae, Flos Carthami are put on the double-edged fine-toothed comb; Another marmite covers sealing with the marmite that is filled with water; 6h at a simmer cools and is attached with one deck medicine frost on the marmite inwall above the back, and the medicine frost is collected; (2) distillation of Moschus water is refined, get the brown distillation of pupil (Main Ingredients and Appearance is muscone, fatty resin), sealing is preserved; (3) medicine of step (1) frost, Anisodamine and Borneolum Syntheticum are put into 1000 parts distilled water and dissolve, dissolve the brown distillation of pupil that the back adds step (2), the boric acid adjust pH is 6.75, filters the back through the anion exchanger and bottles, and promptly gets behind the high pressure steam sterilization.
Model case one:
Lee, woman, 65 years old, Yongcheng City Jiang Kou township Jiang Hekoucun; Primary open angle glaucoma was seen the doctor for treatment everywhere, imitates not goodly, came this diagnosis and treatment on March 30th, 2010; Through the collyrium drop that makes with the embodiment of the invention 1 and cooperate hospitalization after 4 days, intraocular pressure reduces, and pain disappears, and cures.
Model case two:
The Wang, woman, 52 years old, Huaibei City phase mountain secondary school teachers; Suffered from the chronic angle closure glaucoma 4 years, and, spent seven, 80,000 yuan and fail to cure in April, 2010 through curing in many ways; Come this diagnosis and treatment,, cure through 6 days transference cures of collyrium that every day, the drop embodiment of the invention 2 made.
Model case three:
Week so-and-so, the man, 53 years old, the Xiayi County, Henan is the bridge village people recklessly, suffered from the subacute angle-closure glaucoma, prepared to have an operation, and came diagnosis and treatment on June 3rd, 2010, reduce internal heat medicine 6 days of the collyrium that the drop embodiment of the invention 3 makes 6 days and cooperating is complete.
Model case four:
High so-and-so, 64 years old, the woman, Yongcheng City Chen Ji township horse alleyway people from village suffers from the acute angle closure glaucoma; Behind the operative treatment, ophthalmalgia is painful not to disappear, and came diagnosis and treatment on JIUYUE 30th, 2010, the collyrium that makes through the drop embodiment of the invention 4; And the cooperation anti-inflammation drugs, intraocular pressure is normal after 7 days, and pain disappears entirely, cures.
Through following up a case by regular visits to above-mentioned 4 cases, cure so far all not recurrences certainly.
From in February, 2010-2011 year June, clinical treatment observation 168 routine patients, male 78 examples, women 90 examples; Wherein acute angle-closure 15 examples, subacute angle-closure 33 examples, chronic angle-closure's 69 examples, primary open-angle 51 examples; Cure 166 examples altogether, cure rate reaches 98.8%, and all the other 2 examples take a turn for the better effective percentage 100%.
The glaucoma efficacy assessment standard:
Cure: transference cure, intraocular pressure recover normal;
Take a turn for the better: symptom partly disappears, and intraocular pressure descends to some extent;
Do not heal: intraocular pressure does not fall, and all diseases of eye and General Symptoms do not have improvement.
Claims (2)
1. a reduction intraocular pressure is treated glaucomatous collyrium, it is characterized in that being processed by the crude drug of following parts by weight: Folium Ginkgo 160-230 part, Semen Cassiae 160-230 part, Flos Lonicerae 160-230 part, Flos Chrysanthemi 160-230 part, Flos Buddlejae 100-160 part, Fructus Lycii 100-160 part, Flos Inulae 100-160 part, Flos Carthami 40-60 part, Moschus 1-3 part, Anisodamine 0.5-1.5 part and Borneolum Syntheticum 0.5-1.5 part.
2. prepare the described reduction intraocular pressure of claim 1 and treat the method for glaucomatous collyrium; It is characterized in that may further comprise the steps: (1) is got each raw material in proportion; Folium Ginkgo, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Flos Lonicerae, Flos Buddlejae, Flos Inulae, Flos Carthami are put on the double-edged fine-toothed comb of the marmite that water is housed, covered sealing with another marmite on this marmite then, 5-8h at a simmer; Cooling has one deck medicine frost on the marmite inwall above the back, the medicine frost is collected; (2) distillation of Moschus water is refined, get the brown distillation of pupil, sealing is preserved; (3) medicine of step (1) frost, Anisodamine and Borneolum Syntheticum are put into 1000 parts distilled water and dissolve, dissolve the brown distillation of pupil that the back adds step (2), the boric acid adjust pH is 6-7, filters, promptly gets after the sterilization.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102948293A CN102319323B (en) | 2011-10-08 | 2011-10-08 | Eyedrop for reducing intraocular pressure and treating glaucoma and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102948293A CN102319323B (en) | 2011-10-08 | 2011-10-08 | Eyedrop for reducing intraocular pressure and treating glaucoma and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102319323A true CN102319323A (en) | 2012-01-18 |
| CN102319323B CN102319323B (en) | 2013-02-27 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102715308A (en) * | 2012-05-18 | 2012-10-10 | 李晓林 | Tea preparation method |
| CN104644941A (en) * | 2014-06-10 | 2015-05-27 | 陈莉芬 | Eye drop |
| CN105998336A (en) * | 2016-05-27 | 2016-10-12 | 王金国 | Eyedrops applied to glaucoma of mid-aged people and aged people and preparation method |
| CN106421747A (en) * | 2016-11-25 | 2017-02-22 | 江苏爱西施科技服务咨询股份有限公司 | Fibroin moisturizing eye drop and preparation method thereof |
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| CN1650998A (en) * | 2002-06-03 | 2005-08-10 | 宋志民 | Preparation method of Chinese medicinal eye drops for treating myopia |
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2011
- 2011-10-08 CN CN2011102948293A patent/CN102319323B/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1650998A (en) * | 2002-06-03 | 2005-08-10 | 宋志民 | Preparation method of Chinese medicinal eye drops for treating myopia |
Non-Patent Citations (2)
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| 游剑等: "中西医结合治疗青光眼的临床研究进展", 《江西中医学院学报》 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102715308A (en) * | 2012-05-18 | 2012-10-10 | 李晓林 | Tea preparation method |
| CN104644941A (en) * | 2014-06-10 | 2015-05-27 | 陈莉芬 | Eye drop |
| CN105998336A (en) * | 2016-05-27 | 2016-10-12 | 王金国 | Eyedrops applied to glaucoma of mid-aged people and aged people and preparation method |
| CN106421747A (en) * | 2016-11-25 | 2017-02-22 | 江苏爱西施科技服务咨询股份有限公司 | Fibroin moisturizing eye drop and preparation method thereof |
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| Publication number | Publication date |
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| CN102319323B (en) | 2013-02-27 |
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