CN102319323B - Eyedrop for reducing intraocular pressure and treating glaucoma and preparation method thereof - Google Patents
Eyedrop for reducing intraocular pressure and treating glaucoma and preparation method thereof Download PDFInfo
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- CN102319323B CN102319323B CN2011102948293A CN201110294829A CN102319323B CN 102319323 B CN102319323 B CN 102319323B CN 2011102948293 A CN2011102948293 A CN 2011102948293A CN 201110294829 A CN201110294829 A CN 201110294829A CN 102319323 B CN102319323 B CN 102319323B
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Abstract
The invention relates to an eyedrop, and particularly relates to an eyedrop for reducing intraocular pressure and treating glaucoma and a preparation method thereof. The eyedrop is prepared by the following raw material drugs by weight: 160-230 parts by weight of ginkgo leaves, 160-230 parts of cassia seeds, 160-230 parts of honeysuckle, 160-230 parts of chrysanthemum morifolium, 100-160 parts of butterflybush flowers, 100-160 parts of medlar, 100-160 parts of inula flowers, 40-60 parts of safflowers, 1-3 parts of musk, 0.5-1.5 parts of anisodamine, and 0.5-1.5 parts of borneol. The raw material drugs of the invention are prepared, are directly applied to eyes in a form of an eyedrop, and have fast effect, a good treatment course, no pain, a high cure rate, and no side effect.
Description
Technical field
The present invention relates to a kind of collyrium, be specifically related to a kind of reduction intraocular pressure and treat glaucomatous collyrium and preparation method thereof.
Background technology
Glaucoma, be a kind ofly fall ill rapidly, hazardness causes the common difficult oculopathy of losing one's sight greatly, at any time, feature is exactly the horizontal exceeding eyeball tolerant degree of institute that intraocular pressure is interrupted or persistence raises and bring infringement to eyeball each several part tissue and visual function, cause optic atrophy, constriction of visual field, visual deterioration, the blind just time sooner or later, can be as blind as a bat at acute attack stage 24-48 hour.Glaucoma belongs to the eyes sexually transmitted disease (STD) and becomes, but eyes are fallen ill or a glance onset, secondary blindness simultaneously.Glaucoma is to cause blind second largest reason, and usually, the people's ratio more than 40 years old is easier to suffer from glaucoma, and female patient is common than the male patient again.Glaucomatous feature is that the intraocular pressure of eyeball inside increases, and eyeball surface sclerosis, this sick symptom comprise the ring of light around eyes pain or uncomfortable (mainly betiding morning), blurred vision, the light source, pupil can't be in dark appropriate regulation amplify, the disappearance of Xu Guang (peripheral visual acuity) etc.
Glaucoma mainly is divided into by symptom: acute angle-closure, subacute angle-closure, chronic angle-closure and primary open-angle.
Glaucoma belongs to " five kinds of glaucoma " category in the traditional Chinese medical science, is owing to all kinds of reasons such as yin or yang excess, disorder of movement of QI, cause qi-blood disharmony, passages through which vital energy circulates is unfavorable; sweat pore obstruction in the order, qi depression to blood stasis, refreshing water deposits and falls ill; the general symptom oncoming force is violent; except eliminating the cause of disease, control its at all outside, should also be noted that to shrink pupil refreshing; opening pores; the elimination stasis of blood stagnates, and improves symptom, with vision protection.But also has at present especially effectively Chinese medicine.
Summary of the invention
The purpose of this invention is to provide a kind of reduction intraocular pressure and treat glaucomatous collyrium and preparation method thereof.
The present invention is by the following technical solutions:
A kind of reduction intraocular pressure is treated glaucomatous collyrium, is made by the crude drug of following parts by weight: Folium Ginkgo 160-230 part, Semen Cassiae 160-230 part, Flos Lonicerae 160-230 part, Flos Chrysanthemi 160-230 part, Flos Buddlejae 100-160 part, Fructus Lycii 100-160 part, Flos Inulae 100-160 part, Flos Carthami 40-60 part, Moschus 1-3 part, Anisodamine 0.5-1.5 part and Borneolum Syntheticum 0.5-1.5 part.
Reduce intraocular pressure and treat the preparation method of glaucomatous collyrium, may further comprise the steps: (1) gets each raw material in proportion, Folium Ginkgo, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Flos Lonicerae, Flos Buddlejae, Flos Inulae, Flos Carthami are put on the double-edged fine-toothed comb of the marmite that water is housed, then cover sealing with another marmite on this marmite, 5-8h at a simmer, cooling has one deck medicine frost on the rear top marmite inwall, the medicine frost is collected; (2) distillation of Moschus water is refined, get the brown distillation of pupil, sealing is preserved; (3) medicine of step (1) frost, Anisodamine and Borneolum Syntheticum are put into 1000 parts distilled water and dissolved, dissolve the brown distillation of pupil of rear adding step (2), the boric acid adjust pH is 6-7, filters, after the sterilization and get final product.
The using method of collyrium of the present invention is: every day three times, each two to six, can cure in general 4-7 days.
Among the present invention, Flos Chrysanthemi: arduous sweet being slightly cold, wind and heat dispersing, detoxifcation makes eye bright, and its effect is: be used for flaming up of liver-fire, blurred vision, have a dizzy spell, heat-clearing and toxic substances removing, conjunctival congestion and swelling pain, furuncle bleb furuncle, heavy asthenic fire; Fructus Lycii: property is sweet, flat, returns the Liver and kidney warp, the kidney invigorating and essence nourishing, and nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough is controlled hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, dizzy, the many tears of blurred vision, cough due to consumptive disease, is quenched one's thirst, passes out semen; Flos Lonicerae: heat-clearing and toxic substances removing, wind-heat dissipating is used for the carbuncle furuncle, larynx Paralysis, erysipelas, toxic-heat and blood stasis, its effect is: have the effects such as heat-clearing and toxic substances removing, dredge the meridian passage, broad-spectrum antiseptic and antiviral, have " Chinese medicine antibiotic ", " title of antibacterial green element; Flos Buddlejae: cold nature, sweet in the mouth, function cures mainly heat clearing away nourishing the liver, improving acuity of vision and removing nebula, is used for conjunctival congestion and swelling pain, many tear photophobia, the nebula of looking unfamiliar film, hepatasthenia dim eyesight, blurring of vision; Flos Inulae: sweet in the mouth toil, be included into lung, liver, stomach warp, the head Zhu Fenghan that dispels is evil, end the sun, positive bright headache, the positive bright galactostasis of row, control that breast carcinoma, acute mastitis, congestion and swelling pain, sudden and violent red acute catarrhal conjunctivitis, order disease pain, dispelling pathogenic wind for improving eyesight, hidden puckery photophobia are afraid of day, the cough of cold cold and heat, old expectorant such as glue, walk meridians, end that the cold abdomen of face aches, diuresis, control tympanites, the wind-fire root of the tooth swells and ache; Flos Carthami: acrid in the mouth, warm in nature, GUIXIN, Liver Channel, its effect is: have the effect of promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving, can control the diseases such as amenorrhea due to stagnation of blood, dysmenorrhea, mass in the abdomen, difficult labour, traumatic injury and stasis of blood pain; Folium Ginkgo: nature and flavor sweetness and bitterness is puckery flat, and the useful heart is astringed the lung, removing dampness antidiarrheal, relievings asthma blood circulation promoting and blood stasis dispelling, the effects such as pain relieving; Semen Cassiae: bitter in the mouth, sweet and cool in nature has the functions such as clearing away liver-fire, wind-damp dispelling, tonifying kidney and improving eyesight; Moschus, acrid in the mouth is warm in nature, GUIXIN spleen channel, inducing resuscitation, promoting blood circulation to restore menstrual flow, pain relieving; Anisodamine can make smooth muscle obviously lax, and can remove vasospasm, and analgesic activity is arranged simultaneously; Borneolum Syntheticum, acrid in the mouth is bitter, and is cool in nature, enters the cardiopulmonary warp, logical all keys, removing nebula makes eye bright, and reducing swelling and alleviating pain is controlled apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order also nebula film, enterobiasis.
All medicine reasonable compatibilities of the present invention, complement each other, has supplementing QI and nourishing YIN, the effect of activating blood and promoting diuresis, according to dialectical traditional medical theory and the human five internal organs's six internal organs of controlling of executing, the exterior and the interior that belongs to through venation concerns, the performance of the meridian distribution of property and flavor of medicine four natures and five flavors of drug is directly conducted in the efficacy of a drug drug effect eye and is treated glaucoma, eye blood vessels in the dredging body, Xuemaitong, through ruton, sick painful from disappearing, disease is rehabilitated, reached the purpose for the treatment of both the principal and secondary aspects of a disease, can improve hemorheological property, improve vascular inner skin cell activity, reduce elevated platelet activation, thereby improve the eye local blood circulation, improve retina, the anoxia enduring of ocular tissue in the optic nerve etc., anti-damage function etc.Crude drug of the present invention by preparation after, directly act on eye with the form of collyrium, instant effect, the course for the treatment of are good, no pain, cure rate are high, have no side effect; Work and life that using method is simple, effective, do not affect the patient have positive effect than prior art.
The specific embodiment
Embodiment 1
Reduce intraocular pressure and treat glaucomatous collyrium, made by following crude drug: 0.5 part of 160 parts of Folium Ginkgos, 160 parts of Semen Cassiaes, 160 parts of Flos Loniceraes, 160 parts of Flos Chrysanthemis, 100 parts of Flos Buddlejaes, 100 parts of Fructus Lycii, 100 parts of Flos Inulae, 40 parts on Flos Carthami, 1 part in Moschus, 0.5 part of Anisodamine and Borneolum Syntheticum.
May further comprise the steps during preparation: (1) gets each raw material, in marmite, add entry, place a double-edged fine-toothed comb on the marmite, then Folium Ginkgo, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Flos Lonicerae, Flos Buddlejae, Flos Inulae, Flos Carthami are put on the double-edged fine-toothed comb, another marmite covers sealing with the marmite that is filled with water, 6h at a simmer cools and is attached with one deck medicine frost on the rear top marmite inwall, and the medicine frost is collected; (2) distillation of Moschus water is refined, get the brown distillation of pupil (Main Ingredients and Appearance is muscone, fatty resin), sealing is preserved; (3) medicine of step (1) frost, Anisodamine and Borneolum Syntheticum are put into 1000 parts distilled water and dissolved, dissolve the brown distillation of pupil of rear adding step (2), the boric acid adjust pH is 6.75, and bottling after the anion exchanger filters is behind the high pressure steam sterilization and get final product.
Embodiment 2
Reduce intraocular pressure and treat glaucomatous collyrium, made by following crude drug: 1.5 parts of 230 parts of Folium Ginkgos, 230 parts of Semen Cassiaes, 230 parts of Flos Loniceraes, 230 parts of Flos Chrysanthemis, 160 parts of Flos Buddlejaes, 160 parts of Fructus Lycii, 160 parts of Flos Inulae, 60 parts on Flos Carthami, 3 parts in Moschus, 1.5 parts of Anisodamine and Borneolum Syntheticums.
May further comprise the steps during preparation: (1) gets each raw material, in marmite, add entry, place a double-edged fine-toothed comb on the marmite, then Folium Ginkgo, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Flos Lonicerae, Flos Buddlejae, Flos Inulae, Flos Carthami are put on the double-edged fine-toothed comb, another marmite covers sealing with the marmite that is filled with water, 5h at a simmer cools and is attached with one deck medicine frost on the rear top marmite inwall, and the medicine frost is collected; (2) distillation of Moschus water is refined, get the brown distillation of pupil (Main Ingredients and Appearance is muscone, fatty resin), sealing is preserved; (3) medicine of step (1) frost, Anisodamine and Borneolum Syntheticum are put into 1000 parts distilled water and dissolved, dissolve the brown distillation of pupil of rear adding step (2), the boric acid adjust pH is 6, filters, after the sterilization and get final product.
Embodiment 3
Reduce intraocular pressure and treat glaucomatous collyrium, made by following crude drug: 1 part of 200 parts of Folium Ginkgos, 200 parts of Semen Cassiaes, 200 parts of Flos Loniceraes, 200 parts of Flos Chrysanthemis, 130 parts of Flos Buddlejaes, 130 parts of Fructus Lycii, 130 parts of Flos Inulae, 50 parts on Flos Carthami, 2 parts in Moschus, 1 part of Anisodamine and Borneolum Syntheticum.
May further comprise the steps during preparation: (1) gets each raw material, in marmite, add entry, place a double-edged fine-toothed comb on the marmite, then Folium Ginkgo, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Flos Lonicerae, Flos Buddlejae, Flos Inulae, Flos Carthami are put on the double-edged fine-toothed comb, another marmite covers sealing with the marmite that is filled with water, 8h at a simmer cools and is attached with one deck medicine frost on the rear top marmite inwall, and the medicine frost is collected; (2) distillation of Moschus water is refined, get the brown distillation of pupil (Main Ingredients and Appearance is muscone, fatty resin), sealing is preserved; (3) medicine of step (1) frost, Anisodamine and Borneolum Syntheticum are put into 1000 parts distilled water and dissolved, dissolve the brown distillation of pupil of rear adding step (2), the boric acid adjust pH is 7, and bottling after the anion exchanger filters is behind the high pressure steam sterilization and get final product.
Embodiment 4
Reduce intraocular pressure and treat glaucomatous collyrium, made by following crude drug: 0.5 part of 160 parts of Folium Ginkgos, 230 parts of Semen Cassiaes, 160 parts of Flos Loniceraes, 230 parts of Flos Chrysanthemis, 100 parts of Flos Buddlejaes, 160 parts of Fructus Lycii, 100 parts of Flos Inulae, 60 parts on Flos Carthami, 1 part in Moschus, 1.5 parts of Anisodamine and Borneolum Syntheticum.
May further comprise the steps during preparation: (1) gets each raw material, in marmite, add entry, place a double-edged fine-toothed comb on the marmite, then Folium Ginkgo, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Flos Lonicerae, Flos Buddlejae, Flos Inulae, Flos Carthami are put on the double-edged fine-toothed comb, another marmite covers sealing with the marmite that is filled with water, 7h at a simmer cools and is attached with one deck medicine frost on the rear top marmite inwall, and the medicine frost is collected; (2) distillation of Moschus water is refined, get the brown distillation of pupil (Main Ingredients and Appearance is muscone, fatty resin), sealing is preserved; (3) medicine of step (1) frost, Anisodamine and Borneolum Syntheticum are put into 1000 parts distilled water and dissolved, dissolve the brown distillation of pupil of rear adding step (2), the boric acid adjust pH is 6.5, filters, after the sterilization and get final product.
Embodiment 5
Reduce intraocular pressure and treat glaucomatous collyrium, made by following crude drug: 1.5 parts of 230 parts of Folium Ginkgos, 160 parts of Semen Cassiaes, 230 parts of Flos Loniceraes, 160 parts of Flos Chrysanthemis, 160 parts of Flos Buddlejaes, 100 parts of Fructus Lycii, 160 parts of Flos Inulae, 40 parts on Flos Carthami, 3 parts in Moschus, 0.5 part of Anisodamine and Borneolum Syntheticums.
May further comprise the steps during preparation: (1) gets each raw material, in marmite, add entry, place a double-edged fine-toothed comb on the marmite, then Folium Ginkgo, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Flos Lonicerae, Flos Buddlejae, Flos Inulae, Flos Carthami are put on the double-edged fine-toothed comb, another marmite covers sealing with the marmite that is filled with water, 6h at a simmer cools and is attached with one deck medicine frost on the rear top marmite inwall, and the medicine frost is collected; (2) distillation of Moschus water is refined, get the brown distillation of pupil (Main Ingredients and Appearance is muscone, fatty resin), sealing is preserved; (3) medicine of step (1) frost, Anisodamine and Borneolum Syntheticum are put into 1000 parts distilled water and dissolved, dissolve the brown distillation of pupil of rear adding step (2), the boric acid adjust pH is 6.75, and bottling after the anion exchanger filters is behind the high pressure steam sterilization and get final product.
Model case one:
Lee, woman, 65 years old, Yongcheng City Jiang Kou township Jiang Hekoucun, primary open angle glaucoma was seen the doctor for treatment everywhere, imitates not goodly, came this diagnosis and treatment on March 30th, 2010, collyrium drop through making with the embodiment of the invention 1 also cooperates hospitalization after 4 days, and intraocular pressure reduces, and pain disappears, and cures.
Model case two:
The Wang, woman, 52 years old, Huaibei City phase mountain secondary school teachers, suffered from the chronic angle closure glaucoma 4 years, and through in many ways curing, spent seven, 80,000 yuan and fail to cure in April, 2010, come this diagnosis and treatment, by 6 days transference cures of collyrium that every day, the drop embodiment of the invention 2 made, cure.
Model case three:
Week so-and-so, the man, 53 years old, the Xiayi County, Henan is the bridge village people recklessly, suffered from the subacute angle-closure glaucoma, prepared to have an operation, and came diagnosis and treatment on June 3rd, 2010, reduce internal heat medicine 6 days of the collyrium that the drop embodiment of the invention 3 makes 6 days and cooperating is complete.
Model case four:
High so-and-so, 64 years old, the woman, Yongcheng City Chen Ji township horse alleyway people from village suffers from the acute angle closure glaucoma, behind the operative treatment, ophthalmalgia is painful not to disappear, and comes diagnosis and treatment on the 30th in JIUYUE in 2010, the collyrium that makes by the drop embodiment of the invention 4, and the cooperation anti-inflammation drugs, intraocular pressure is normal after 7 days, and pain disappears entirely, cures.
Through following up a case by regular visits to above-mentioned 4 cases, certainly cure so far all not recurrences.
From in February, 2010-2011 year June, clinical treatment observation 168 routine patients, male 78 examples, women 90 examples, acute angle-closure 15 examples wherein, subacute angle-closure 33 examples, chronic angle-closure's 69 examples, primary open-angle 51 examples, cure altogether 166 examples, cure rate reaches 98.8%, and all the other 2 examples take a turn for the better effective percentage 100%.
The glaucoma efficacy assessment standard:
Cure: transference cure, intraocular pressure recover normal;
Take a turn for the better: symptom partly disappears, and intraocular pressure descends to some extent;
Do not heal: intraocular pressure does not fall, and all diseases of eye and General Symptoms are without improvement.
Claims (2)
1. one kind is reduced intraocular pressure and treats glaucomatous collyrium, it is characterized in that being made by the crude drug of following parts by weight: 1000 parts of Folium Ginkgo 160-230 part, Semen Cassiae 160-230 part, Flos Lonicerae 160-230 part, Flos Chrysanthemi 160-230 part, Flos Buddlejae 100-160 part, Fructus Lycii 100-160 part, Flos Inulae 100-160 part, Flos Carthami 40-60 part, Moschus 1-3 part, Anisodamine 0.5-1.5 part, Borneolum Syntheticum 0.5-1.5 part and distilled water.
2. prepare reduction intraocular pressure claimed in claim 1 and treat the method for glaucomatous collyrium, it is characterized in that may further comprise the steps: (1) gets each raw material in proportion, Folium Ginkgo, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Flos Lonicerae, Flos Buddlejae, Flos Inulae, Flos Carthami are put on the double-edged fine-toothed comb of the marmite that water is housed, then cover sealing with another marmite on this marmite, 5-8h at a simmer, cooling has one deck medicine frost on the rear top marmite inwall, the medicine frost is collected; (2) distillation of Moschus water is refined, get the brown distillation of pupil, sealing is preserved; (3) medicine of step (1) frost, Anisodamine and Borneolum Syntheticum are put into 1000 parts distilled water and dissolved, dissolve the brown distillation of pupil of rear adding step (2), the boric acid adjust pH is 6-7, filters, after the sterilization and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102948293A CN102319323B (en) | 2011-10-08 | 2011-10-08 | Eyedrop for reducing intraocular pressure and treating glaucoma and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102948293A CN102319323B (en) | 2011-10-08 | 2011-10-08 | Eyedrop for reducing intraocular pressure and treating glaucoma and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102319323A CN102319323A (en) | 2012-01-18 |
| CN102319323B true CN102319323B (en) | 2013-02-27 |
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| CN102715308A (en) * | 2012-05-18 | 2012-10-10 | 李晓林 | Tea preparation method |
| CN104644941A (en) * | 2014-06-10 | 2015-05-27 | 陈莉芬 | Eye drop |
| CN105998336A (en) * | 2016-05-27 | 2016-10-12 | 王金国 | Eyedrops applied to glaucoma of mid-aged people and aged people and preparation method |
| CN106421747A (en) * | 2016-11-25 | 2017-02-22 | 江苏爱西施科技服务咨询股份有限公司 | Fibroin moisturizing eye drop and preparation method thereof |
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| CN1274324C (en) * | 2002-06-03 | 2006-09-13 | 宋志民 | Preparation method of Chinese medicinal eye drops for treating myopia |
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