CN104547311B - Chinese medicine of cure scapulohumeral periarthritis and preparation method thereof - Google Patents
Chinese medicine of cure scapulohumeral periarthritis and preparation method thereof Download PDFInfo
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- CN104547311B CN104547311B CN201510035792.0A CN201510035792A CN104547311B CN 104547311 B CN104547311 B CN 104547311B CN 201510035792 A CN201510035792 A CN 201510035792A CN 104547311 B CN104547311 B CN 104547311B
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Abstract
The invention discloses a kind of Chinese medicines of cure scapulohumeral periarthritis and preparation method thereof.The Chinese medicine is made of the raw material of following weight parts by weight：100~250 parts of copper brill, 50~100 parts of treebine stem, 50~100 parts of lopseed, 25~75 parts of safflower, 10~30 parts of Chinese prickly ash, 0.1~0.5 part of muskone.The preparation method of the Chinese medicine is：Take the copper of formula ratio to bore, treebine stem, lopseed, safflower and Chinese prickly ash, crush, ethyl alcohol be added and extracts, the muskone of formula ratio is added in extracting solution, stirs evenly, a variety of different preparations is made by existing conventional method.Chinese medicine of the present invention only carries out scientific compatibilities by 6 kinds of raw materials, acts synergistically between each raw material, and Chinese medicine obtained by prescription is made to have specific antiinflammation well, and has the function of clearing heat and promoting diuresis, promoting blood circulation and removing obstruction in channels and rush revascularization；It is directly used in affected part after external preparation is made, is gone directly lesion, is had no toxic side effect, and therapeutic effect is good, thorough by Transdermal absorption.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine of cure scapulohumeral periarthritis and preparation method thereof.
Background technology
Scapulohumeral periarthritis is also known as the periarthritis of shoulderjoint, gradually generates pain with shoulder, night is very, gradually to aggravate, and shoulder joint is lived
It moves function limitation and increasingly aggravates, gradually alleviate after reaching to a certain degree, until being finally restored to the shoulder mainly showed completely
The chronic specific inflammatory of capsular ligament and its surrounding ligaments, tendon and synovial bursa.Scapulohumeral periarthritis is with shoulder arthralgia and inconvenient activity
Cardinal symptom is more common in physical labourer.Shoulder joint can have extensive tenderness, and be radiated to neck and ancon, it may also occur that different
The atrophy of the deltoid muscle of degree.Currently, be mainly expectant treatment to scapulohumeral periarthritis, including oral analgesics anti-inflammatory, physiotherapy, pain
The composite treatments such as point partial closure, massage are carried out at the same time function of joint practice.
There are many Chinese medicine of existing cure scapulohumeral periarthritis, such as the patent of invention that publication No. is CN103520385A, disclose one kind
The Chinese medicine preparation and preparation method thereof of chill wet type scapulohumeral periarthritis is treated, the raw medicinal material of Chinese medicine preparation includes：Spinyleaf pricklyash root, fermented soya bean
Ginger, fine stern wind, ternateleaf rabdosia herb, black breast mushroom, butterfly bush, rattan of drying, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae), radix heraclei hemaleyani, geranium wilfordii, false nettleleaf pepper herb, Bai Gui
The wooden root, Chinese alyxia herb and clematis armandi Francs.The invention Chinese medicine preparation expelling wind and clearing away cold, dampness removing dredging collateral, to chill wet type scapulohumeral periarthritis have compared with
Good curative effect, but its prescription is complicated.The for another example patent of invention of CN103656576A, CN104147578A etc., although equally having
Preferable good therapeutic effect, but their prescription is equally complex.
Invention content
A kind of the technical problem to be solved in the present invention is to provide prescriptions simple, the preferable cure scapulohumeral periarthritis of curative effect Chinese medicine and
Preparation method.
The Chinese medicine of cure scapulohumeral periarthritis of the present invention, by weight, it is made of the raw material of following weight parts：
100~250 parts of copper brill, 50~100 parts of treebine stem, 50~100 parts of lopseed, 25~75 parts of safflower, Chinese prickly ash 10~
30 parts, 0.1~0.5 part of muskone.
The parts by weight of above-mentioned each raw material are preferably：
100~200 parts of copper brill, 60~90 parts of treebine stem, 60~90 parts of lopseed, 30~70 parts of safflower, Chinese prickly ash 15~25
Part, 0.1~0.3 part of muskone.
Above-mentioned each raw material it is preferable proportioning be：
150 parts of copper brill, 75 parts of treebine stem, 75 parts of lopseed, 50 parts of safflower, 20 parts of Chinese prickly ash, 0.2 part of muskone.
The dosage form of above-mentioned Chinese medicine can be tincture, gelling agent or emplastrum.
The preparation method of the Chinese medicine of above-mentioned cure scapulohumeral periarthritis is：Weigh copper brill, treebine stem, lopseed, the safflower of formula ratio
And Chinese prickly ash, it crushes, ethyl alcohol is added and extracts, the muskone of formula ratio is added into gained extracting solution, stirs evenly, by existing
A variety of different preparations are made in conventional method.
In above-mentioned preparation method, the mode of extraction can be existing conventional room temperature extraction or refluxing extraction, time of extraction
The addition of solvent is the same as those in the prior art when number, the time extracted every time and each extraction.
In the application, preferably prepared as follows：Weigh the copper brill of formula ratio, treebine stem, lopseed, safflower and
Chinese prickly ash crushes, and 40~60v/v% ethyl alcohol is added, and the muskone of formula ratio is added into gained extracting solution for slightly boiling refluxing extraction,
It stirs evenly, tincture is made or gelling agent or emplastrum is further made.In this method, after bulk pharmaceutical chemicals are typically ground into coarse powder
It extracts again；The slightly boiling refluxing extraction refers to that solvent keeps slight boiling condition during refluxing extraction；The number of extraction is logical
It it is often 1~3 time, the time extracted every time is 1~2h, and the addition of solvent is to participate in the bulk pharmaceutical chemicals gross weight of extraction when extraction every time
2~6 times of amount.
In preparation method of the present invention, in the muskone that formula ratio is added into gained extracting solution, after stirring evenly
Obtain tincture liquid.The specific method that tincture liquid is further made to gelling agent is：Tincture liquid is taken, under stirring
It is slowly added to appropriate thickener, is then 5~7 with the pH value of lye tune system, stirs to particle is visible by naked eyes, placed
Night to get.The selection of the thickener and its dosage are the same as those in the prior art, and usual thickener can be Acritamer 940, gather
Vinylpyrrolidone or cyclodextrin etc., dosage are usually the 1~2.5% of tincture liquid weight.The lye usually can be with
It is the common lye such as sodium hydrate aqueous solution or triethanolamine.
The specific method that tincture liquid is further made to emplastrum is：Emplastrum is manufactured in this way：Extracting solution is taken to be condensed into
The thick paste that relative density is 1.05~1.35 at 60 DEG C, it is spare；It is 1~3 by the weight ratio of thick paste and natural rubber：10 ratio
Natural rubber is weighed, is 1 by the weight ratio of gasoline and natural rubber：The swelling of gasoline soaked overnight is added in 0.5~2 ratio, then
Add equal petrols to stir evenly, is eventually adding the muskone of spare thick paste and formula ratio, stirs evenly, by gained rubber ointment
Be uniformly coated on base material, dry, cutting to get.
Compared with prior art, Chinese medicine of the present invention only carries out scientific compatibility by 6 kinds of raw materials, cooperates with and makees between each raw material
With making Chinese medicine obtained by prescription that there is specific antiinflammation well, and with clearing heat and promoting diuresis, promoting blood circulation and removing obstruction in channels and promote blood vessel again
Raw function；Manufactured external preparation is directly used in affected part, is gone directly lesion by Transdermal absorption, no liver first-pass effect, to liver,
The internal organs such as stomach, kidney do not damage, and have no toxic side effect, and therapeutic effect is good, thorough.
Specific implementation mode
With reference to specific embodiment, the present invention is described in further detail, to more fully understand present disclosure, but
The present invention is not limited to following embodiments.
Number described in following embodiment is parts by weight.
The concentration of the ethyl alcohol is concentration of volume percent.
Embodiment 1
Copper is taken to bore 150 parts, each 75 parts of treebine stem, lopseed, 50 parts of safflower, 20 parts of Chinese prickly ash crushes after mixing, be placed in extraction
In container, with 50% ethyl alcohol slightly boiling refluxing extraction 3 times.Every time when extraction the addition of 50% ethyl alcohol be respectively 1850 parts, 1480
Part and 1480 parts, the time extracted every time is respectively 2h, 1.5h and 1h.It is filtered after extraction every time, merges 3 filtrates, carried
Liquid is taken, 0.1 part of muskone is added into gained extracting solution, stirs 1 hour, is sealed the tincture to get cure scapulohumeral periarthritis.
Liquid directly painting is dipped when use to put on the skin in affected part.
Experimental example 1
1, Lee, man, 61 years old, long campaigns manual labor, scapulohumeral periarthritis medical history 14 years took C14H10Cl2NNaO2 control disease usually
Shape.Since nearly 2 years, symptom obviously aggravates, and breaking-out is frequent, almost monthly acute attack, and right side omoplate position severe pain, holds when morbidity
The continuous time is more than 9 days, takes C14H10Cl2NNaO2 effect unobvious.In October, 2013 uses tincture soak made from embodiment 1
At night, swelling and pain are substantially reduced, and two days later, symptom disappears for continuous use.Without allergic phenomena and other adverse reactions during use.
2, Mr. Wang, female, in 48 years old this year, because of long campaigns heavy physical labour, scapulohumeral periarthritis has had 5 years medical histories, seriously affects
To work and life, using tincture soak made from embodiment 1 when in October, 2013 breaks out, disappeared using symptom two days later, then
Continuous use three weeks, yet there are no recurrence in three months so far.Without allergic phenomena and other adverse reactions during use.
Embodiment 2
Copper is taken to bore 100 parts, 90 parts of treebine stem, 60 parts of lopseed, 75 parts of safflower, 30 parts of Chinese prickly ash crushes after mixing, be placed in and carry
In extracting container, 50% ethyl alcohol, 3965 parts of room temperature extractions are added, filtering, filtrate is extracting solution, and gram muskone is added thereto
It 0.15 part, stirs 1 hour, is sealed the tincture to get cure scapulohumeral periarthritis.
Liquid directly painting is dipped when use to put on the skin in affected part.
Experimental example 2
1, Jiang, female, 41 years old, in June, 2013, scapulohumeral periarthritis first attack, continued 2 wheat harvesting periods, with massage, oral anti-inflammatory
The measures such as pain are invalid, and tincture soak made from embodiment 2 is begun to use in November, 2013 to stay overnight, and after three times, swell and ache symptom
It disappears.Without allergic phenomena and other adverse reactions during use.
2, Hu, man, 57 years old, left shoulder pain was unbearable since in October, 2014, and eating analgesic codeine piece does not all have
Effect.In November, 2014 using tincture soak made from embodiment 2, is disappeared using symptom after three days.Without allergy during use
Phenomenon and other adverse reactions.
Embodiment 3
Liquid 500m1 prepared by Example 1 is slowly added to 5g Acritamer 940s (making thickener) under stirring,
And it is 6 that triethanolamine tune pH value, which is added, stirs to particle is visible by naked eyes, stands overnight the gelling agent to get cure scapulohumeral periarthritis.
Liquid is coated on affected part when use.
Experimental example 3
1, patient Wu, man, 56 years old, scapulohumeral periarthritis medical history 5 years, in September, 2014 was coated outside the gelling agent made from embodiment 3
Night, swelling in second day disappear.Without allergic phenomena and other adverse reactions during use.
2, Huang, 52 years old, the acute scapulohumeral periarthritis arthritis of female, induction of straining started to break out at the beginning of 6 months 2014, two months
Pain repeatedly.Fenbid is taken without positive effect.In September, 2014 is disappeared using gelling agent made from embodiment 3, two days later symptom
It loses.Without allergic phenomena and other adverse reactions during use.
Embodiment 4
Copper is taken to bore 250 parts, each 50 parts of treebine stem, lopseed, 25 parts of safflower, 10 parts of Chinese prickly ash crushes after mixing, be placed in extraction
In container, with 50% ethyl alcohol slightly boiling refluxing extraction 3 times.Every time when extraction the addition of 50% ethyl alcohol be respectively 1925 parts, 1540
Part and 1540 parts, the time extracted every time is respectively 2h, 1h and 1h.It is filtered after extraction every time, merges 3 filtrates, extracted
Liquid, it is 1.1 that extracting solution, which is condensed into relative density at 60 DEG C, obtains thick paste.200 parts of natural rubbers are taken, were impregnated with 200 parts of gasoline
Night is swollen, then 200 parts of gasoline is added to stir half an hour, and 0.5 part of 50 parts of thick paste obtained above and muskone is added, stirs 1 hour,
It is uniformly coated in non-woven fabrics matrix, dries, cut the emplastrum to get cure scapulohumeral periarthritis.
Ointment is affixed on affected part when use.
Experimental example 4
1, certain is revived, man 56 years old, has the scapulohumeral periarthritis medical history of recurrent exerbation, after scapulohumeral periarthritis breaking-out, right shoulder pain obtains terribly.
Pass through massage therapy in one month, pain detumescence completely not yet in June, 2014.In July, 2013 patch obtained by embodiment 4
Cream, daily patch symptom disappearance after 8 hours, three days.Without allergic phenomena and other adverse reactions during use.
2, section, man, 62 years old, because scapulohumeral periarthritis occurs for long-term heavy physical labour, in November, 2013 patch obtained of embodiment 4
Cream pastes 8 hours, symptom disappearance two days later daily.Without allergic phenomena and other adverse reactions during use.
Embodiment 5
Copper is taken to bore 200 parts, each 100 parts of treebine stem, lopseed, 40 parts of safflower, 15 parts of Chinese prickly ash crushes after mixing, be placed in and carry
In extracting container, with 50% ethyl alcohol slightly boiling refluxing extraction 3 times.Every time when extraction the addition of 50% ethyl alcohol be respectively 1850 parts,
1480 parts and 1480 parts, the time extracted every time is respectively 1h, 1h and 1h.It is filtered after extraction every time, merges 3 filtrates, obtain
0.3 part of muskone is added into gained extracting solution for extracting solution, stirs 1 hour, is sealed the tincture to get cure scapulohumeral periarthritis.
Claims (6)
1. the Chinese medicine of cure scapulohumeral periarthritis, it is characterised in that：By weight, it is made of the raw material of following weight parts：
150 parts of copper brill, 75 parts of treebine stem, 75 parts of lopseed, 50 parts of safflower, 20 parts of Chinese prickly ash, 0.2 part of muskone.
2. the Chinese medicine of cure scapulohumeral periarthritis according to claim 1, it is characterised in that：The dosage form of the Chinese medicine is ointment, patch
Agent or gelling agent.
3. the preparation method of the Chinese medicine of cure scapulohumeral periarthritis described in claim 1, it is characterised in that：Weigh formula ratio copper bore,
Treebine stem, lopseed, safflower and Chinese prickly ash crush, and ethyl alcohol is added and extracts, the Moschus of formula ratio is added into gained extracting solution
Ketone stirs evenly, and a variety of different preparations are made by existing conventional method.
4. the preparation method of the Chinese medicine of cure scapulohumeral periarthritis according to claim 3, it is characterised in that：Weigh the copper of formula ratio
Brill, treebine stem, lopseed, safflower and Chinese prickly ash crush, and 40~60v/v% ethyl alcohol is added, and slightly boiling refluxing extraction is extracted to gained
The muskone of formula ratio is added in liquid, stirs evenly, tincture is made or gelling agent or emplastrum is further made.
5. the preparation method of the Chinese medicine of cure scapulohumeral periarthritis according to claim 4, it is characterised in that：Gelling agent is to make in this way
At：Tincture liquid is taken, appropriate thickener is slowly added under stirring, is then 5~7 with the pH value of lye tune system,
Stirring to particle is visible by naked eyes, stand overnight to get.
6. the preparation method of the Chinese medicine of cure scapulohumeral periarthritis according to claim 4, it is characterised in that：Emplastrum is to be made in this way
's：Extracting solution is taken to be condensed into the thick paste that relative density is 1.05~1.35 at 60 DEG C, it is spare；By the weight of thick paste and natural rubber
Than being 1~3：10 ratio weighs natural rubber, is 1 by the weight ratio of gasoline and natural rubber：Vapour is added in 0.5~2 ratio
Oily soaked overnight swelling, then add and petrols is waited to stir evenly, it is eventually adding the muskone of spare thick paste and formula ratio, stirring is equal
It is even, gained rubber ointment is uniformly coated on base material, dry, cutting to get.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510035792.0A CN104547311B (en) | 2015-01-23 | 2015-01-23 | Chinese medicine of cure scapulohumeral periarthritis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510035792.0A CN104547311B (en) | 2015-01-23 | 2015-01-23 | Chinese medicine of cure scapulohumeral periarthritis and preparation method thereof |
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| CN104547311A CN104547311A (en) | 2015-04-29 |
| CN104547311B true CN104547311B (en) | 2018-10-02 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102210778A (en) * | 2011-05-26 | 2011-10-12 | 张兆俊 | Medicine for treating scapulohumeral periarthritis and preparation method thereof |
| CN103432551B (en) * | 2013-09-02 | 2015-05-13 | 张文举 | Externally applied medicine for treating scapulohumeral periarthritis, radiohumeral bursitis and inexplicable ostalgia |
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