CN103893105A - Traditional Chinese medicine compound whitening and freckle-removing cream - Google Patents
Traditional Chinese medicine compound whitening and freckle-removing cream Download PDFInfo
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- CN103893105A CN103893105A CN201410165851.1A CN201410165851A CN103893105A CN 103893105 A CN103893105 A CN 103893105A CN 201410165851 A CN201410165851 A CN 201410165851A CN 103893105 A CN103893105 A CN 103893105A
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Abstract
The invention relates to traditional Chinese medicine compound whitening and freckle-removing cream which is prepared from a traditional Chinese medicine formula and a matrix. The traditional Chinese medicine formula comprises the following components in percentage by weight: 15-25% of radix angelicae, 15-25% of rhizoma bletillae, 10-20% of rhizoma typhonii, 15-25% of divaricate saposhnikovia roots, 15-25% of kaempferiae and 15-25% of poria cocos. The matrix comprises the following components in percentage by weight: 0.3-0.4% of xanthan gum, 2-4% of cetostearyl alcohol, 2-4% of glycerol monostearate, 5-7% of squalane, 4-6% of iso-octyl palmitate, 4-6% of white oil, 1-2% of simethicone, 4-6% of stearic acid, 7-9% of glycerinum, 1-2% of polytetrafluoroethylene, 0.05% of sodium benzoate, 1.5-2.5% of a traditional Chinese medicine solution and the balance of deionized water. According to the invention, animal experiments verify that the traditional Chinese medicine compound whitening and freckle-removing cream is safe, effective and free of toxic and side effects, and animal experiment data provides a ground for clinical medicinal development, as well as research and development of freckle-removing cosmetics.
Description
Technical field
The present invention relates to cosmetics, particularly relate to a kind of Chinese medicine compound whitening and spot eliminating cream.
Background technology
External whitening and speckle dispelling product variety is various in the market, pattern is numerous and diverse, but very different, really can reach the also few of the desired ideal effect of user, mainly there is following problem in it: 1. have potential safety hazard, after a lot of products use, cause skin allergy; 2. invalid; 3. although effectively but side effect is obvious.As everyone knows, the feature that Chinese medicine is effective and side effect is little has been widely used in a lot of fields, the research of herbal mixture external preparation is main mainly with clinical observation on the therapeutic effect, what its mechanism was studied is less, therefore, establish a kind of Chinese medicine compound whitening and spot eliminating cream product problem of research and development, its mechanism is inquired into, further meet people and make the different demands that apply some make up.
Summary of the invention
The object of the invention is to research and develop a kind of Chinese medicine compound whitening and spot eliminating cream, by the animal experimental data to herbal mixture whitening and spot eliminating cream, its mechanism is inquired into, as inquired into the curative effect mechanism of " clearing heat in the pericardium case " " macerating son side " (Radix Angelicae Dahuricae, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Typhonii, Radix Saposhnikoviae, Rhizoma Kaempferiae, Poria) treatment chloasma.Expecting provides the compound external-use that a kind of curative effect is clear and definite, side effect is little preparation for people, and can be clinical medicine exploitation and cosmetics and research and develop foundation is provided.
The technical scheme that the present invention takes is: a kind of Chinese medicine compound whitening and spot eliminating cream, is characterized in that: add substrate preparation by Chinese medicine formula and form; Described Chinese medicine formula is according to following weight ratio: Radix Angelicae Dahuricae 15-25%, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-25%, Rhizoma Typhonii 10-20%, Radix Saposhnikoviae 15-25%, Rhizoma Kaempferiae 15-25%, Poria 15-25% extract Chinese medicine compound powder, are mixed with the By Chinese Medicines that concentration is 20-40%; Described substrate comprises four groups of components, is respectively A phase, B phase, C phase and D phase; The weight ratio of the shared Chinese medicine compound whitening and spot eliminating cream of each group component is as follows: A phase: HANSHENGJIAO 0.3-0.4%; B phase: cetearyl alcohol 2-4%, glycerol monostearate 2-4%, angle Trionyx sinensis Wiegmann alkane 5-7%, the different monooctyl ester 4-6% of brown eleostearic acid, white oil 4-6%, dimethicone 1-2%, stearic acid 4-6%; C phase: glycerol 7-9%; D phase: politef 1-2%, sodium benzoate 0.05%; The weight ratio of the shared Chinese medicine compound whitening and spot eliminating cream of described By Chinese Medicines is 1.5-2.5%; All the other are deionized water.
The invention has the beneficial effects as follows: prove that by zoopery Chinese medicine compound whitening and spot eliminating cream is safe and effective, have no side effect, and animal experimental data is researched and developed foundation is provided for clinical medicine exploitation and cosmetics.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described:
Mechanism of TCM:
The Radix Angelicae Dahuricae: expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidifying are sensible, detumescence and apocenosis.Can improve microcirculation in human body, promote skin metabolism, eliminate pigment and excessively pile up in tissue, remove facial colour spot cicatrix etc.
Pseudobulbus Bletillae (Rhizoma Bletillae): astringing to arrest bleeding, the merit of detumescence and promoting granulation, for all cards of interior external haemorrhage and carbuncle, scald, rhagadia manus et pedis etc.
Rhizoma Typhonii: expelling wind and cold, promoting the flow of QI in the collateral by warming the meridian, dispelling wind whitening.
Radix Saposhnikoviae: expelling pathogenic wind from the body surface, antalgesic-antipruritic.
Rhizoma Kaempferiae: promoting the circulation of QI to relieve pain, dispelling wind whitening.
Poria: spleen invigorating, removing dampness, whitening.
Above 6 taste medicine compatibilities have the effect of dispelling wind to relieve the exterior syndrome, dredging collateral whitening.
The substrate mechanism of action: HANSHENGJIAO, politef are forming agent.Cetearyl alcohol, glycerol monostearate, angle Trionyx sinensis Wiegmann alkane, the different monooctyl ester of brown eleostearic acid, white oil, dimethicone, stearic acid are oil phase raw material, have the effect of moisturizing skin.Glycerol is water raw material, has moisture-keeping function.Sodium benzoate is antiseptic.
Embodiment 1: Chinese medicine is weighed: Radix Angelicae Dahuricae 18g, Pseudobulbus Bletillae (Rhizoma Bletillae) 18g, Rhizoma Typhonii 14g, Radix Saposhnikoviae 16g, Rhizoma Kaempferiae 16g, Poria 18g.Substrate weight ratio: A phase: HANSHENGJIAO 0.35%; B phase: cetearyl alcohol 3%, glyceryl monostearate 3%, angle Trionyx sinensis Wiegmann alkane 6%, the different monooctyl ester 5% of brown eleostearic acid, white oil 5%, dimethicone 1.5%, stearic acid 5%; C phase: glycerol 8%, D phase: politef 1.5%, sodium benzoate 0.05%; By Chinese Medicines 2%; All the other are deionized water.
Embodiment 2: Chinese medicine is weighed: Radix Angelicae Dahuricae 18g, Pseudobulbus Bletillae (Rhizoma Bletillae) 18g, Rhizoma Typhonii 14g, Radix Saposhnikoviae 16g, Rhizoma Kaempferiae 16g, Poria 18g.Substrate weight ratio: A phase: HANSHENGJIAO 0.4%; B phase: cetearyl alcohol 4%, glyceryl monostearate 4%, angle Trionyx sinensis Wiegmann alkane 7%, the different monooctyl ester 6% of brown eleostearic acid, white oil 6%, dimethicone 2%, stearic acid 6%; C phase: glycerol 9%; D phase: politef 2%, sodium benzoate 0.05%; By Chinese Medicines 2.5%; All the other are deionized water.
Embodiment 3: Chinese medicine is weighed: Radix Angelicae Dahuricae 18g, Pseudobulbus Bletillae (Rhizoma Bletillae) 18g, Rhizoma Typhonii 14g, Radix Saposhnikoviae 16g, Rhizoma Kaempferiae 16g, Poria 18g.Substrate weight ratio: A phase: HANSHENGJIAO 0.3%; B phase: cetearyl alcohol 2%, glyceryl monostearate 2%, angle Trionyx sinensis Wiegmann alkane 5%, the different monooctyl ester 4% of brown eleostearic acid, white oil 4%, dimethicone 1%, stearic acid 4%; C phase: glycerol 7%; D phase: politef 1%, sodium benzoate 0.05%; By Chinese Medicines 1.5%; All the other are deionized water.
Above embodiment preparation process is as follows:
The first step: Chinese medicine compound extracts active ingredients
1. weigh and pulverize with pulverizing machine according to Chinese medicine proportioning, cross 100 mesh sieves, obtain Chinese medicine compound powder.
2. to be soaked in concentration be, in 95% ethanol, after alcohol extraction is static, gets supernatant and continue to be condensed into extractum to Chinese medicine compound powder.
3. extractum is put in and in drying baker, is dried to Chinese medicine compound powder.
4. the Chinese medicine compound powder ultrasound wave distilled water after extracting being dissolved into concentration is that 30% By Chinese Medicines is stand-by.
Second step: Chinese medicine compound whitening and spot eliminating cream preparation
(1) pretreatment
Take by weight A phase materials HANSHENGJIAO, carry out sterilizing in HANSHENGJIAO and deionized water 1:20 ratio, in the deionized water below 50 ℃, be dissolved as HANSHENGJIAO solution for later use completely.
(2) feed intake
By weight accurately taking B phase materials, C phase materials and By Chinese Medicines, B phase materials is packed in beaker, HANSHENGJIAO solution, C phase materials and By Chinese Medicines are mixed and packed in another beaker, two beakers are put into water-bath and be heated to 75 ℃-85 ℃, until solid material fully dissolves.
(3) emulsifying
Material in two beakers is injected respectively to emulsifying pot, start stirring paddle, oar velocity modulation, to 40-50rpm, is started homogenizer homogenizing 5-IOmin, adds D phase materials politef according to weight ratio simultaneously, emulsifying kettle temperature is about 85 ℃ insulations, continue to stir half an hour, in the time that material temperature is down to below 50 ℃, regulate PH=5-6 with NaOH, then add D phase materials sodium benzoate to stir according to weight ratio, be prepared into Chinese medicine compound whitening and spot eliminating cream.
Above three embodiment are prepared into respectively after Chinese medicine compound whitening and spot eliminating cream, checking after using: because embodiment 1 adopts preferred substrate composition, and its best results.
Zoopery quick-reading flow sheets and experimental data are as follows:
1. modelling: adopt chloasma experimental animal model clone method, get 60 of Healthy female mices, every mice is pressed 0.02g/kg dosage, and hindlimb muscle is injected the progesterone injection of 0.4% concentration, the alternately injection of each both legs, 6 times weekly, continuous 5 weeks.
2. animal grouping and administration: 60 mices of above modeling are divided into six groups at random, 10 every group.Be respectively concentration group, Chinese medicine compound whitening and spot eliminating cream high concentration group and hydroquinone positive controls in blank group, blank white group, Chinese medicine compound whitening and spot eliminating cream low concentration group, Chinese medicine compound whitening and spot eliminating cream.Three concentration groups of Chinese medicine compound whitening and spot eliminating cream (being respectively 15%, 30%, 60% By Chinese Medicines containing concentration) are respectively at the medication of mice modeling local skin on the same day, every day 2 times, continuous use 35 days.Blank group mice gives distilled water partial smearing in the corresponding time; Blank white group gives the not blank frost containing Chinese medicine ingredients (only containing substrate part) partial smearing in the corresponding time; Hydrochinone Cream positive controls started local application's (concentration is 3%) in modeling the same day, and the time is identical with the basic, normal, high concentration group of Chinese medicine compound whitening and spot eliminating cream with the course for the treatment of.
3. observation index and detection
After medication 35 days, mouse orbit is got blood, and mice is put to death in cervical vertebra dislocation, and back unhairing is got rapidly one of 1cm × 2cm skin histology at coating position.Wherein, eye socket obtain blood after static 3 hours centrifuging and taking serum for subsequent use; Obtain ice-cold normal saline flushing for skin, remove blood, filter paper blots, and puts into the beaker of the pre-cold saline of 2.0ml, shreds tissue, then pours in test tube, with high speed disperser 10r/min homogenate twice, and each 10 seconds; With 3500r/min rotating speed centrifugal 15 minutes again, get supernatant.Adopt xanthine oxidase, detect description method by test kit and measure superoxide dismutase (SOD); Adopt thiobarbituricacidα-method, detect description method by test kit and measure malonaldehyde (MDA) value.
Statistical method: adopt SPSS17.0 statistical software to analyze, between group, relatively adopt independent sample t check, indices result employing mean ± standard deviation (
) represent.Statistical result is in table 1, table 2.
The impact of table 1. Chinese medicine compound whitening and spot eliminating cream on SOD in Mice content (
)
As can be seen from Table 1: with relatively * P<0.05 of blank group, * * P<0.01; Compare with the positive group of hydroquinone
△p<0.05.
The impact of table 2. Chinese medicine compound whitening and spot eliminating cream on mice MDA content (
)
As can be seen from Table 2: with relatively * P<0.05 of blank group, * * P<0.01; Compare with the positive group of hydroquinone
△p<0.05.
Conclusion: this result of study shows that after Chinese medicine compound whitening and spot eliminating cream treatment chloasma mouse model, MDA content decreases, and SOD content increases.With the comparison of blank group, significant difference (P<0.05, P<0.01); Wherein, significantly (P<0.05) of concentration group and hydroquinone positive controls comparing difference in Chinese medicine compound whitening and spot eliminating cream.Draw thus: Chinese medicine compound whitening and spot eliminating cream can be removed oxygen-derived free radicals and reduce free-radical generating, has freckle removing and whitening effect.Wherein middle concentration Chinese medicine compound whitening and spot eliminating cream effect is better, and effect significantly.
Claims (1)
1. a Chinese medicine compound whitening and spot eliminating cream, is characterized in that: add substrate preparation by Chinese medicine formula and form; Described Chinese medicine formula is according to following weight ratio: Radix Angelicae Dahuricae 15-25%, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-25%, Rhizoma Typhonii 10-20%, Radix Saposhnikoviae 15-25%, Rhizoma Kaempferiae 15-25%, Poria 15-25% extract Chinese medicine compound powder, are mixed with the By Chinese Medicines that concentration is 20-40%;
Described substrate comprises four groups of components, is respectively A phase, B phase, C phase and D phase; The weight ratio of the shared Chinese medicine compound whitening and spot eliminating cream of each group component is as follows:
A phase: HANSHENGJIAO 0.3-0.4%;
B phase: cetearyl alcohol 2-4%, glycerol monostearate 2-4%, angle Trionyx sinensis Wiegmann alkane 5-7%, the different monooctyl ester 4-6% of brown eleostearic acid, white oil 4-6%, dimethicone 1-2%, stearic acid 4-6%;
C phase: glycerol 7-9%;
D phase: politef 1-2%, sodium benzoate 0.05%;
The weight ratio of the shared Chinese medicine compound whitening and spot eliminating cream of described By Chinese Medicines is 1.5-2.5%;
All the other are deionized water.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410165851.1A CN103893105A (en) | 2014-04-24 | 2014-04-24 | Traditional Chinese medicine compound whitening and freckle-removing cream |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410165851.1A CN103893105A (en) | 2014-04-24 | 2014-04-24 | Traditional Chinese medicine compound whitening and freckle-removing cream |
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| CN103893105A true CN103893105A (en) | 2014-07-02 |
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| CN201410165851.1A Pending CN103893105A (en) | 2014-04-24 | 2014-04-24 | Traditional Chinese medicine compound whitening and freckle-removing cream |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688664A (en) * | 2015-03-05 | 2015-06-10 | 苏州经贸职业技术学院 | Effective traditional Chinese medicine whitening and skin-smoothing cream |
| CN105343729A (en) * | 2015-11-30 | 2016-02-24 | 王浩 | Health-care skin-beautifying bath decoction |
| CN108348562A (en) * | 2015-10-30 | 2018-07-31 | 安卡有限责任公司 | Treatment or the method for reducing skin disorder severity |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1183958A (en) * | 1997-12-09 | 1998-06-10 | 周自强 | Freckle dispelling powder |
| JP2004323468A (en) * | 2003-04-28 | 2004-11-18 | Noevir Co Ltd | Skin care preparation for external use |
| CN102068391A (en) * | 2010-12-30 | 2011-05-25 | 广州赛莱拉化妆品科技有限公司 | Application of human steam cell growth factors in cosmetics |
-
2014
- 2014-04-24 CN CN201410165851.1A patent/CN103893105A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1183958A (en) * | 1997-12-09 | 1998-06-10 | 周自强 | Freckle dispelling powder |
| JP2004323468A (en) * | 2003-04-28 | 2004-11-18 | Noevir Co Ltd | Skin care preparation for external use |
| CN102068391A (en) * | 2010-12-30 | 2011-05-25 | 广州赛莱拉化妆品科技有限公司 | Application of human steam cell growth factors in cosmetics |
Non-Patent Citations (2)
| Title |
|---|
| 刘昭纯等: "《滋补养生实用方》", 31 July 1999, article "6味药", pages: 332 * |
| 裘炳毅: "《化妆品化学与工艺技术大全》", 30 April 2011, article "辅料", pages: 931-933 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688664A (en) * | 2015-03-05 | 2015-06-10 | 苏州经贸职业技术学院 | Effective traditional Chinese medicine whitening and skin-smoothing cream |
| CN108348562A (en) * | 2015-10-30 | 2018-07-31 | 安卡有限责任公司 | Treatment or the method for reducing skin disorder severity |
| CN105343729A (en) * | 2015-11-30 | 2016-02-24 | 王浩 | Health-care skin-beautifying bath decoction |
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Application publication date: 20140702 |