CN1323595A - Composite medicine for glaucoma - Google Patents

Abstract

A medicinal composition used to treat glaucoma is disclosed in the invention. It includes active ingredients with following weight ratio: roast root of tuber fleecedlower 10-30 portions, root of herbaceous peony 10-30 portions, Chinese wolfberry fruit 10-30 portions, lilyturf root 10-30 portions, abalone shell 15-45 portions, uncaria 15-45 portions, magnet 15-45 portions, chrysanthemum 10-30 portions fetid cassia 15-45 portions plantain seed 10-30 portions, figwort 10-30 portions, semen celosiae 10-30 portions burrerfly bush flower 10-30 portions, bar faeces 10-30 portions, liquorice 5-25 portions etc.. The invented drug provides curative effect on glaucoma and can eliminate pathogenic factor of glucome radically.

Description

Be used for glaucomatous pharmaceutical composition

The present invention relates to a kind of pharmaceutical composition for the treatment of retinopathy, specifically be used for the treatment of glaucomatous pharmaceutical composition by what vegetable Chinese herbal medicine was prepared from.

Glaucoma is that the pathologic intraocular pressure raises with the oculopathy of the visual field, vision, optic nerve lesion.This disease mainly is that intraocular pressure continue to raise, and involves optic nerve and atrophy, constriction of visual field, visual deterioration take place gradually, often cause losing one's sight, and be one of oculopathy of big, the main blinding of hazardness.Said glaucoma of the traditional Chinese medical science and bluish glaucoma all are similar to glaucoma.Motherland's medical science thinks that its etiology and pathogenesis of bluish glaucoma is by melancholy angry, causes depression of liver-QI, and passages through which vital energy circulates is unfavorable, and pathogenic fire derived from stagnation of liver-QI is given birth to wind, and upward invading of wind-fire disturbing eye causes disharmony between QI and blood, and the interior mechanism of qi of order loses smooth, and refreshing water stagnates and is primary disease.The whenever unconscious or dizziness order of bluish glaucoma when morbidity patient expands slight, look forward or upwards looked of a specified duration, can have eyelid heavy, tired,

Senses such as pain, see around the lights like rainbow around.Initial vision is intact, and white of the eye, black eyeball, pupil god are as good as; Disease weight person, refreshing medium the loosing greatly of pupil, spirit is owed in companding, the little cyan that is of complexion in the pupil god, slightly hardened eyeball, poor vision day advances.Also visible mild ciliary congestion, epithelium hydrops on the cornea.The optical fundus can not have change in early days, and that continues looks the nipple central vessel slightly to nasal side displacement, and optic papilla sunken is deepened to enlarge, and causes to look the nipple blood vessel and move in looking the nipple edge, be the climbing shape of going down on one's knees, and it is pale to look the nipple complexion changed, and sees the Lycoperdon polymorphum Vitt point of sieve plate.The then many sudden onset of glaucoma, it is high violent also to can be " disease that bluish glaucoma becomes weight " (" Standards of Diagnosis and Treatment, seven apertures door ") patient's condition, an ophthalmagra, pearl is expanded and desires to split, and vision plunges.Its cause of disease mainly is often because of the strongly fragrant troubled thoughts of compassion, and the anger that is contrary to cruelly is depressed in liver, the mechanism of qi obturation, the catharsis dereliction of duty, the Yu Yun fire-transformation, to gallbladder, liver and gall heated, fire are contained and are given birth to wind by liver, bad temper master is diffusing, it is vehement to hold the wind benefit under the arm, the wind-fire liter is disturbed, on burn in order.Glaucoma outbreak after disgruntled or overstrain is often expanded frontal eminence hemialgia, dizziness discomfort, nasion pain from the beginning of conscious order pearl is little.Severe distending pain of the eyeball when serious, intense splitting headache, pain with distension involve orbit and nose volume temporo cheek etc. to be located, and vision is fast falls.Though it is different with the bluish glaucoma symptom, its morbidity is all unfavorable with the order key, and stagnation of aqueous humor is relevant.Doctor trained in Western medicine is when the treatment glaucoma, based on operative treatment,, then adopt eye drop 1%-2% pilocarpine eye liquid as because of the inoperable patient of other reason, to reduce intraocular pressure, relief of symptoms is because the patient is comparatively frightened to operated eye, so be not able to less than ten thousand, generally be reluctant the treatment that undergos surgery, and chemical drugss such as pilocarpine can not fundamentally be eliminated glaucomatous paathogenic factor, thereby, neither best medicament selection.In clinical treatment, the red mast XIAOYAO POWDER (seeing " internal medicine summary ") that the traditional Chinese medical science adopts Cortex Moutan, Fructus Gardeniae, Radix Glycyrrhizae, Radix Angelicae Sinensis, Poria, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Radix Bupleuri to make more, or treat by the Decoction of Gentiana for Purging the Liver-fire (seeing Golden Mirror of Medicine) that Radix Gentianae, the Radix Rehmanniae, Radix Angelicae Sinensis, Radix Bupleuri, Caulis Akebiae, Rhizoma Alismatis, Semen Plantaginis, Fructus Gardeniae, Radix Scutellariae, Radix Glycyrrhizae are formed, right effect is not very good.

Purpose of the present invention is exactly the pharmaceutical composition that a kind of good effect will be provided and fundamentally eliminate its paathogenic factor.

The object of the present invention is achieved like this, to glaucoma (being glaucoma, bluish glaucoma) pathogeny and Therapeutic Principle, glaucoma patient adopted clearing away heat-fire, soothing the liver endogenous wind stopping, lowering fire and expelling phlegm, excessive cloudy pathogenic fire reducing based on motherland's medical science.By weight, select baked polygonum capitatum 10-30 part for use, Radix Paeoniae Alba 10-30 part, Radix Ophiopogonis 10-30 part, Fructus Lycii 10-30 part, Semen Cassiae 15-45 part, Semen Plantaginis 10-30 part, Radix Scrophulariae 10-30 part, QINGXIANGZI 10-30 part, Flos Buddlejae 10-30 part, Faeces Vespertilionis 10-30 part, Radix Glycyrrhizae 5-25 part, Ramulus Uncariae Cum Uncis 15-45 part, Concha Haliotidis 15-45 part, Magnetitum 15-45 part, Flos Chrysanthemi 10-30 part.

Preferred weight proportioning of the present invention is:

Baked polygonum capitatum 15-20 part, Radix Paeoniae Alba 15-20 part, Radix Ophiopogonis 20-30 part, Fructus Lycii 20-30 part, Concha Haliotidis 25-30 part, Ramulus Uncariae Cum Uncis 15-20 part, Magnetitum 15-20 part, Flos Chrysanthemi 20-30 part, Semen Cassiae 30-45 part, Semen Plantaginis 10-20 part, Radix Scrophulariae 20-30 part, QINGXIANGZI 15-20 part, Flos Buddlejae 20-30 part, Faeces Vespertilionis 20-30 part, Radix Glycyrrhizae 20-25 part.

Medicine of the present invention can be prepared into various oral formulations such as tablet, capsule, oral liquid, electuary.

Medication preparation of the present invention becomes the method for capsule to be:

1, takes by weighing each component by the proportioning in the prescription of the present invention, soaked 2-4 hour, decocted 1-2 hour, filter, twice filtrate merges, and the filtrate vacuum and low temperature is concentrated into the thick paste shape, and oven dry is ground into fine powder, cross 80 orders-100 mesh sieve, the capsule of packing into is divided in the back, and every capsules includes 0.3 gram medicated powder.

The usage and dosage of the capsule that medication preparation of the present invention becomes when the treatment glaucoma is: each four, every day three times, taking for 3 weeks continuously is a course of treatment.

Important innovations point of the present invention is to screen the drug component of combination, has good synergism.Choice of drug Ramulus Uncariae Cum Uncis of the present invention, Semen Cassiae, Flos Chrysanthemi, suppressing the hyperactive liver fresh breeze, simultaneously 5 usefulness Concha Haliotidis, Semen Plantaginis, Faeces Vespertilionis, Radix Glycyrrhizae are all goes into the meridian of Foot-JUE YIN medicine with the heat clearing away promoting the circulation of blood, assistant with Radix Scrophulariae, QINGXIANGZI, Flos Buddlejae, Fructus Lycii, Radix Ophiopogonis, Magnetitum with nourishing YIN and moistening the lung, and the selecting for use of baked polygonum capitatum, the Radix Paeoniae Alba, make its medicine have interior QI and blood regulating simultaneously, the effect that the tonifying liver the liver benefiting nourishes blood.All medicines are worked in coordination with heat clearing away, suppressing the hyperactive liver, eliminating pathogenic fire to subdue liverwind, and so to bluish glaucoma, glaucoma has the effect of removing burning wood away under the boiler.

The consumption proportion scope of each component of medicine of the present invention is determined through prolonged and repeated experiment screening.It has guaranteed that medicine of the present invention has the curative effect height, acts on persistent characteristics.

The optimum ratio scope of each component of the present invention makes each component have better synergism.

The beneficial effect of pharmaceutical composition of the present invention has obtained checking by system's clinical observation of 132 routine patients.

The verification method of curative effect of medication of the present invention is:

Selection meets patient 132 people (diagnostic criteria sees that the People's Medical Officer Press publishes, and " clinical disease diagnosis is according to curing the improvement standard " compiled by The General Logistics Department of PLA) of clinical diagnosis of glaucoma standard

Criterion of therapeutical effect:

Cure: the anterior chamber recovers, transference cure, and intraocular pressure is reduced to normally.

Take a turn for the better: the more preceding decline of intraocular pressure.

Invalid: clinical symptoms is not improved.

Experimental result sees the following form:

Case	Average medication natural law	Cure	Take a turn for the better	Invalid
					132 examples	????21	????103	????22	????7

Below be specific embodiments of the invention.

Embodiment 1:

Take by weighing baked polygonum capitatum 30kg, Radix Paeoniae Alba 10kg, Radix Ophiopogonis 20kg, Fructus Lycii 20kg, Concha Haliotidis 45kg, Ramulus Uncariae Cum Uncis 15kg, Magnetitum 20kg, Flos Chrysanthemi 20kg, Semen Cassiae 15kg, Semen Plantaginis 20kg, Radix Scrophulariae 30kg, QINGXIANGZI 15kg, Flos Buddlejae 20kg, Faeces Vespertilionis 15kg, Radix Glycyrrhizae 20kg, all medicines are mixed, soaked 2 hours, decocted 1 hour, filter, medicinal liquid is standby, and medicinal residues add water and decocted 1 hour again, merge filtrate twice, be concentrated into the thick paste shape, oven dry is ground into fine powder, cross 80 mesh sieves, adorn 0.3 gram extract powder by every capsules and carry out packing.

Following examples 2-6, its preparation method are all with embodiment 1, and just the proportional quantity of each component is different, but all can reach purpose of the present invention and effect.

Embodiment 2-6:

Claims (2)

1, a kind ofly is used for glaucomatous pharmaceutical composition, it is characterized in that it includes the active ingredient of following weight proportioning raw material: baked polygonum capitatum 10-30 part, Radix Paeoniae Alba 10-30 part, Fructus Lycii 10-30 part, Radix Ophiopogonis 10-30 part, Concha Haliotidis 15-45 part, Ramulus Uncariae Cum Uncis 15-45 part, Magnetitum 15-45 part, Flos Chrysanthemi 10-30 part, Semen Cassiae 15-45 part, Semen Plantaginis 10-30 part, Radix Scrophulariae 10-30 part, QINGXIANGZI 10-30 part, Flos Buddlejae 10-30 part, Faeces Vespertilionis 10-30 part, Radix Glycyrrhizae 5-25 part.

2, pharmaceutical composition according to claim 1 is characterized in that it includes the active ingredient of following weight proportioning raw material: baked polygonum capitatum 15-20 part, Radix Paeoniae Alba 15-20 part, Fructus Lycii 20-30 part, Radix Ophiopogonis 20-30 part, Concha Haliotidis 25-30 part, Ramulus Uncariae Cum Uncis 15-20 part, Magnetitum 15-30 part, Flos Chrysanthemi 20-30 part, Semen Cassiae 30-45 part, Semen Plantaginis 10-20 part, Radix Scrophulariae 20-30 part, QINGXIANGZI 15-20 part, Flos Buddlejae 20-30 part, Faeces Vespertilionis 20-30 part, Radix Glycyrrhizae 20-25 part.