CN104623469A - Emulsion with effects of promoting qi circulation and helping digestion for treating gastric and duodenal ulcer and preparation method thereof - Google Patents
Emulsion with effects of promoting qi circulation and helping digestion for treating gastric and duodenal ulcer and preparation method thereof Download PDFInfo
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Abstract
The invention discloses emulsion with effects of promoting qi circulation and helping digestion for treating gastric and duodenal ulcer. The emulsion is prepared from the following raw materials in parts by mass: 520-650 parts of badger fat, 20-30 parts of Rhizoma polygoni paleacei, 10-20 parts of resurrection lily rhizome, 25-40 parts of calamus, 20-30 parts of Erigeron annuus, 40-60 parts of panax pseudoginseng, 70-90 parts of rhizoma bletillae, 62-110 parts of stearic acid, 4-10 parts of Tween-80, 3-8 parts of sodium benzoate, 2-4 parts of butoben, 1.5-1.8 parts of concentrated vanilla and 6-10 parts of mint oil essence. The emulsion disclosed by the invention has the excellent effects that the emulsion is scientific in ratio and has the effects of promoting qi circulation and helping digestion, reducing swelling and helping digestion, relieving swelling and pain and invigorating qi and blood; and moreover, the emulsion disclosed by the invention is developed by combining the latest scientific research achievements on the basis of the traditional syndrome differentiation and treatment of the traditional Chinese medicine, the medicines are combined with one another, and the emulsion has the characteristics of obvious curative effect, safety, convenience and low price.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion and preparation method.
Background technology
Gastric and duodenal ulcers refers to coat of the stomach, pylorus or duodenum generation ulcer pathological changes.Ulcer mostly is single, and sick sending out is called gastric ulcer when stomach, appears at duodenum and then claims duodenal ulcer.Clinical characters is chronic, periodic Upper abdominal pain, and the pain of gastric ulcer mostly occurs on the feed half an hour to one hour, and gastric acid increases or normally; The pain of duodenal ulcer then more comes across food latter three to four hours, and gastric acid is generally remarkable to be increased.Slight person has the symptoms such as regurgitation, vomiting, pain, and severe patient can be bled profusely because of digestive tract (hematemesis or have blood in stool) causes shock.
The traditional Chinese medical science thinks that gastric and duodenal ulcers belongs to the category such as " gastric abscess ", " stomachache ", " pained ".The formation of Peptic Ulcers, relevant more than feelings will diet.Worry impairing spleen, or the institute of feelings is strongly fragrant, and stagnation of liver-QI violates stomach, causes gastrointestinal dysfunction, legion, forms ulcer gradually.Also due to eating and drinking without temperance, irregular diet, the pungent equivalent damage taste of diet raw food, cause ulcer occur or increase the weight of.Excessive sorrow, continues strong psychic trauma, has substantial connection with the generation of peptic ulcer and aggravation.Primary disease etiology and pathogenesis is complicated, and state of an illness intermittence, in the chronic course of disease, easily causes multiple complications, and treatment can cause serious adverse consequences not in time.
Application publication number CN 102764403 A(application number 201210259541.7) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of chronic gastritis, gastroduodenal ulcer, be made up of the material medicine of following weight: Cortex Magnoliae Officinalis 12g, Pericarpium Citri Reticulatae 12g, Radix Angelicae Sinensis 12g, Radix Paeoniae Alba 12g, Radix Aucklandiae 10g, Radix Bupleuri 10g, Endoconcha Sepiae 30g, Rhizoma Pinelliae 10g, Fructus Evodiae 10g, Rhizoma Coptidis 6g, Fructus Amomi 6g, Poria 12g, Rhizoma Atractylodis 10g, Herba Taraxaci 20g, Fructus Aurantii 10g, Radix Glycyrrhizae Preparata 10g, Hemerocallis citrina Baroni 20g.Application publication number CN 104189702 A(application number 201410367388.9) Chinese invention patent document disclose a kind of Chinese medicine for oral administration ball for the treatment of gastric and duodenal ulcers, its raw medicinal material respectively: Radix Bupleuri 9 parts, Rhizoma Cyperi 6 parts, Rhizoma Chuanxiong 9 parts, Fructus Amomi 5 parts, Radix Codonopsis 9 parts, the Radix Astragali 10 parts, Pollen Typhae 9 parts, Oletum Trogopterori 12 parts, Rhizoma Corydalis 10 parts.Application publication number CN 103961632 A(application number 201410233301.9) Chinese invention patent document disclose a kind of Chinese medicine composition for the treatment of gastric and duodenal ulcers, it is characterized in that being made up of the raw material of Chinese medicine of following weight proportion: Fructus Tribuli 10-20 part, Rhizoma Cyperi 5-15 part, Rhizoma Atractylodis (parched) 5-15 part, Rhizoma Chuanxiong 5-10 part, Bulbus Fritillariae Thunbergii 15-30 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part, Os Sepiae 5-15 part, Radix Codonopsis 10-25 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Poria 20-40 part, Fructus Evodiae 15-30 part, Flos Inulae 5-15 part, Fructus Amomi 5-15 part, Radix Glycyrrhizae 10-20 part.
The current treatment for gastric and duodenal ulcers is main mainly with oral western medicine, and Western medicine side effect is large, and easy impairing the liver, easily recurs.Tcm syndrome differentiation and treatment gastric and duodenal ulcers, can eliminate the cause of disease, relief of symptoms effectively, and healing ulcer, prevents and treats complication, few side effects.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide that one is prepared simply, taking convenience, safely and effectively a kind of gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion and preparation method.Emulsion of the present invention is evident in efficacy and without any side effects, is convenient to clinical practice.
Technical scheme of the present invention is:
Gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, is prepared from by the raw material of following mass parts: Adeps melis 520-650; Rhizoma Polygoni Paleachi 20-30, Rhizoma Kaempferiae 10-20; Rhizoma Acori Graminei 25-40; Herba Erigerontis Annui 20-30; Radix Notoginseng 40-60; Pseudobulbus Bletillae (Rhizoma Bletillae) 70-90; Stearic acid 62-110; Tween 80 4-10; Sodium benzoate 3-8; Butoben 2-4; Vanilla 1.5-1.8; Peppermint oil essence 6-10.
In preferred scheme, Adeps melis 570-600; Rhizoma Polygoni Paleachi 22-28; Rhizoma Kaempferiae 13-17; Rhizoma Acori Graminei 30-35; Herba Erigerontis Annui 23-27; Radix Notoginseng 45-55; Pseudobulbus Bletillae (Rhizoma Bletillae) 75-85; Stearic acid 80-92; Tween 80 5-9; Sodium benzoate 4-7; Butoben 2.5-3.5; Vanilla 1.6-1.7; Peppermint oil essence 7-9.
Be more preferably, Adeps melis 585; Rhizoma Polygoni Paleachi 25; Rhizoma Kaempferiae 15; Rhizoma Acori Graminei 32.5; Herba Erigerontis Annui 25; Radix Notoginseng 50; Pseudobulbus Bletillae (Rhizoma Bletillae) 80; Stearic acid 86; Tween 80 7; Sodium benzoate 5.5; Butoben 3; Vanilla 1.65; Peppermint oil essence 8.
The preparation method of gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, step is as follows:
(1) Adeps melis is placed in medicine pot, moderate heat heating boils 20-50 minute, with remove portion stink, then in medicine pot, adds stearic acid and butoben, stirs fusing fully, is cooled to 30-50 DEG C, for subsequent use;
(2) Rhizoma Polygoni Paleachi, Rhizoma Kaempferiae, Rhizoma Acori Graminei, Herba Erigerontis Annui, Radix Notoginseng and Pseudobulbus Bletillae (Rhizoma Bletillae) are placed in Chinese medicine thermal dryer, freeze-day with constant temperature 2-5 hour, take out, be ground into fine powder; Gained fine powder is placed in Chinese medicinal pot, adds the distilled water of 4-7 times of raw material dose, slow fire boiling 18-40 minute (preferred slow fire boiling 29 minutes), filter with three layers of non-woven fabrics, filtrate continuation is evaporated to 3/4 of original liquid volume, obtains Chinese medicine rubber cement; In gained Chinese medicine rubber cement, add sodium benzoate fine powder, stir and make it fully dissolve, be cooled to 40 DEG C, for subsequent use;
(3) step (2) gained rubber cement and tween 80 are together joined in emulsion tank, electric blender high-speed stirred, step (1) gained medicinal liquid is added while stirring toward emulsion tank center, be stirred to liquid color to turn white, retrogradation and till exquisiteness, then add vanilla and peppermint oil essence, continue high-speed stirred, obtain Emulsion;
(4) step (3) gained Emulsion is distributed into bottle according to the metering (preferably according to the metering of 300g/ bottle) of 200-400g/ bottle, adds a cover, add wax sealing, to obtain final product.
The preparation method of above-mentioned gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, preferred scheme is, in step (1), moderate heat heating boils 30-40 minute (preferred moderate heat heating boils 35 minutes).
The preparation method of above-mentioned gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, preferred scheme is, is cooled to 35-45 DEG C (being preferably cooled to 40 DEG C) in step (1).
The preparation method of above-mentioned gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, preferred scheme is, in step (2), the temperature of freeze-day with constant temperature is 55-75 DEG C (temperature of preferred freeze-day with constant temperature is 60-70 DEG C, and the temperature of the freeze-day with constant temperature be more preferably is 65 DEG C).
The preparation method of above-mentioned gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, preferred scheme is, in step (2) freeze-day with constant temperature 3-4 hour (preferred freeze-day with constant temperature 3.5 hours).
The preparation method of above-mentioned gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, preferred scheme is, adds the distilled water (preferably adding the distilled water of 5.5 times amount raw material doses) of 5-6 times of raw material dose in step (2).
The preparation method of above-mentioned gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, preferred scheme is, continues high-speed stirred 5-15 minute (preferred continuation high-speed stirred 7-13 minute, the continuation high-speed stirred be more preferably 10 minutes) in step (3).
Scientific formula of the present invention, preparation method is simple, easy to use, Be very effective.In addition, excellent results of the present invention also shows:
1,the present invention uses theory of Chinese medical science to analyze prescription composition, and according to each physicochemical property of flavour of a drug ingredient and the result of study of pharmacological action, research obtains the preparation method of reasonable, stable active component;
2,proportioning science of the present invention, has circulation of qi promoting food stagnation removing, relieving distension relieving dyspepsia, the effect such as reducing swelling and alleviating pain, benefiting vital QI and blood;
3,the present invention develops in conjunction with latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment, and all medicines share, and has evident in efficacy, safe ready, cheap feature.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, is prepared from (55g/ part) by the raw material of following mass parts: Adeps melis 520 parts; Rhizoma Polygoni Paleachi 20 parts; Rhizoma Kaempferiae 10 parts; Rhizoma Acori Graminei 25 parts; Herba Erigerontis Annui 20 parts; Radix Notoginseng 40 parts; Pseudobulbus Bletillae (Rhizoma Bletillae) 70 parts; Stearic acid 62 parts; Tween 80 4 parts; Sodium benzoate 3 parts; Butoben 2 parts; Vanilla 1.5 parts; Peppermint oil essence 6 parts.
The preparation method of above-mentioned gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion is:
(1) Adeps melis is placed in medicine pot, moderate heat heating boils 20 minutes, with remove portion stink, then in medicine pot, adds stearic acid and butoben, stirs fusing fully, is cooled to 30 DEG C, for subsequent use;
(2) Rhizoma Polygoni Paleachi, Rhizoma Kaempferiae, Rhizoma Acori Graminei, Herba Erigerontis Annui, Radix Notoginseng and Pseudobulbus Bletillae (Rhizoma Bletillae) are placed in Chinese medicine thermal dryer, 55 DEG C of freeze-day with constant temperature 2 hours, take out, be ground into fine powder; Gained fine powder is placed in Chinese medicinal pot, adds the distilled water of 4 times of raw material doses, slow fire boiling 18 minutes, filter with three layers of non-woven fabrics, filtrate continuation is evaporated to 3/4 of original liquid volume, obtains Chinese medicine rubber cement; In gained Chinese medicine rubber cement, add sodium benzoate fine powder, stir and make it fully dissolve, be cooled to 40 DEG C, for subsequent use;
(3) step (2) gained rubber cement and tween 80 are together joined in emulsion tank, electric blender high-speed stirred, step (1) gained medicinal liquid is added while stirring toward emulsion tank center, be stirred to liquid color to turn white, retrogradation and till exquisiteness, then add vanilla and peppermint oil essence, continue high-speed stirred 5 minutes, obtain Emulsion;
(4) step (3) gained Emulsion is entered bottle according to the metering, distributing, packaging of 200/ bottle, add a cover, add wax sealing, to obtain final product.
The instructions of taking of Emulsion of the present invention is: twice daily, and each 150-200mL(is oral), 7 days courses for the treatment of.
embodiment 2gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, is prepared from (35g/ part) by the raw material of following mass parts: Adeps melis 650 parts; Rhizoma Polygoni Paleachi 30 parts; Rhizoma Kaempferiae 20 parts; Rhizoma Acori Graminei 40 parts; Herba Erigerontis Annui 30 parts; Radix Notoginseng 60 parts; Pseudobulbus Bletillae (Rhizoma Bletillae) 90 parts; Stearic acid 110 parts; Tween 80 10 parts; Sodium benzoate 8 parts; Butoben 4 parts; Vanilla 1.8 parts; Peppermint oil essence 10 parts.
The preparation method of above-mentioned gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion is:
(1) Adeps melis is placed in medicine pot, moderate heat heating boils 50 minutes, with remove portion stink, then in medicine pot, adds stearic acid and butoben, stirs fusing fully, is cooled to 50 DEG C, for subsequent use;
(2) Rhizoma Polygoni Paleachi, Rhizoma Kaempferiae, Rhizoma Acori Graminei, Herba Erigerontis Annui, Radix Notoginseng and Pseudobulbus Bletillae (Rhizoma Bletillae) are placed in Chinese medicine thermal dryer, 75 DEG C of freeze-day with constant temperature 2 hours, take out, be ground into fine powder; Gained fine powder is placed in Chinese medicinal pot, adds the distilled water of 7 times of raw material doses, slow fire boiling 40 minutes, filter with three layers of non-woven fabrics, filtrate continuation is evaporated to 3/4 of original liquid volume, obtains Chinese medicine rubber cement; In gained Chinese medicine rubber cement, add sodium benzoate fine powder, stir and make it fully dissolve, be cooled to 40 DEG C, for subsequent use;
(3) step (2) gained rubber cement and tween 80 are together joined in emulsion tank, electric blender high-speed stirred, step (1) gained medicinal liquid is added while stirring toward emulsion tank center, be stirred to liquid color to turn white, retrogradation and till exquisiteness, then add vanilla and peppermint oil essence, continue high-speed stirred 15 minutes, obtain Emulsion;
(4) step (3) gained Emulsion is entered bottle according to the metering, distributing, packaging of 400g/ bottle, add a cover, add wax sealing, to obtain final product.
The instructions of taking of Emulsion of the present invention is: twice daily, and each 150-200mL(is oral), 7 days courses for the treatment of.
Model case: Lee XX, man, 57 years old, Yuegongqiao people.Patient is to our hospital on October 13rd, 2012.There is paroxysmal upper abdomen distending pain without obvious inducement before ten days in patient, after feed, distending pain increases the weight of, and without radiating pain, is interrupted melena, in local clinic with treating gastritis, has no improvement.Went to my institute's treatment afterwards.Check: patient separates situations such as occurring dizzy, nervous, Nausea and vomiting after melena, patients diet since idiopathy, sleep are poor, and urine is without exception.Gastroscopy has a large amount of content, is diagnosed as duodenal ulcer through gastrointestinal tract x-ray barium meal examination.
Take the present embodiment gained gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, instructions of taking is: twice daily, and each 150-200mL(is oral), 7 days courses for the treatment of.After the course for the treatment of of medication, patient suffers from abdominal pain disappearance, and patient mental's state is clearly better, and partial symptoms and sign disappear, and continue two courses for the treatment of of medication, patient fully recovers.Pay a return visit after three months, without recurrence.
embodiment 3gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, is prepared from (50g/ part) by the raw material of following mass parts: Adeps melis 570 parts; Rhizoma Polygoni Paleachi 22 parts; Rhizoma Kaempferiae 13 parts; Rhizoma Acori Graminei 30 parts; Herba Erigerontis Annui 23 parts; Radix Notoginseng 45 parts; Pseudobulbus Bletillae (Rhizoma Bletillae) 75 parts; Stearic acid 80 parts; Tween 80 5 parts; Sodium benzoate 4 parts; Butoben 2.5 parts; Vanilla 1.6 parts; Peppermint oil essence 7 parts.
The preparation method of above-mentioned gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion is:
(1) Adeps melis is placed in medicine pot, moderate heat heating boils 30 minutes, with remove portion stink, then in medicine pot, adds stearic acid and butoben, stirs fusing fully, is cooled to 35 DEG C, for subsequent use;
(2) Rhizoma Polygoni Paleachi, Rhizoma Kaempferiae, Rhizoma Acori Graminei, Herba Erigerontis Annui, Radix Notoginseng and Pseudobulbus Bletillae (Rhizoma Bletillae) are placed in Chinese medicine thermal dryer, 60 DEG C of freeze-day with constant temperature 3 hours, take out, be ground into fine powder; Gained fine powder is placed in Chinese medicinal pot, adds the distilled water of 5 times of raw material doses, slow fire boiling 22 minutes, filter with three layers of non-woven fabrics, filtrate continuation is evaporated to 3/4 of original liquid volume, obtains Chinese medicine rubber cement; In gained Chinese medicine rubber cement, add sodium benzoate fine powder, stir and make it fully dissolve, be cooled to 40 DEG C, for subsequent use;
(3) step (2) gained rubber cement and tween 80 are together joined in emulsion tank, electric blender high-speed stirred, step (1) gained medicinal liquid is added while stirring toward emulsion tank center, be stirred to liquid color to turn white, retrogradation and till exquisiteness, then add vanilla and peppermint oil essence, continue high-speed stirred 7 minutes, obtain Emulsion;
(4) step (3) gained Emulsion is entered bottle according to the metering, distributing, packaging of 250g/ bottle, add a cover, add wax sealing, to obtain final product.
The instructions of taking of Emulsion of the present invention is: twice daily, and each 150-200mL(is oral), 7 days courses for the treatment of.
embodiment 4gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, is prepared from (40g/ part) by the raw material of following mass parts: Adeps melis 600 parts; Rhizoma Polygoni Paleachi 28 parts; Rhizoma Kaempferiae 17 parts; Rhizoma Acori Graminei 35 parts; Herba Erigerontis Annui 27 parts; Radix Notoginseng 55 parts; Pseudobulbus Bletillae (Rhizoma Bletillae) 85 parts; Stearic acid 92 parts; Tween 80 9 parts; Sodium benzoate 7 parts; Butoben 3.5 parts; Vanilla 1.7 parts; Peppermint oil essence 9 parts.
The preparation method of above-mentioned gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion is:
(1) Adeps melis is placed in medicine pot, moderate heat heating boils 40 minutes, with remove portion stink, then in medicine pot, adds stearic acid and butoben, stirs fusing fully, is cooled to 45 DEG C, for subsequent use;
(2) Rhizoma Polygoni Paleachi, Rhizoma Kaempferiae, Rhizoma Acori Graminei, Herba Erigerontis Annui, Radix Notoginseng and Pseudobulbus Bletillae (Rhizoma Bletillae) are placed in Chinese medicine thermal dryer, 70 DEG C of freeze-day with constant temperature 4 hours, take out, be ground into fine powder; Gained fine powder is placed in Chinese medicinal pot, adds the distilled water of 6 times of raw material doses, slow fire boiling 36 minutes, filter with three layers of non-woven fabrics, filtrate continuation is evaporated to 3/4 of original liquid volume, obtains Chinese medicine rubber cement; In gained Chinese medicine rubber cement, add sodium benzoate fine powder, stir and make it fully dissolve, be cooled to 40 DEG C, for subsequent use;
(3) step (2) gained rubber cement and tween 80 are together joined in emulsion tank, electric blender high-speed stirred, step (1) gained medicinal liquid is added while stirring toward emulsion tank center, be stirred to liquid color to turn white, retrogradation and till exquisiteness, then add vanilla and peppermint oil essence, continue high-speed stirred 13 minutes, obtain Emulsion;
(4) step (3) gained Emulsion is entered bottle according to the metering, distributing, packaging of 350g/ bottle, add a cover, add wax sealing, to obtain final product.
The instructions of taking of Emulsion of the present invention is: twice daily, and each 150-200mL(is oral), 7 days courses for the treatment of.
Model case: Yao XX, female, 36 years old, people from Jining.Patient is to our hospital on April 19th, 2013.Patient started interruption without obvious inducement before 2 years and occurs epigastrium dull pain, with feed without obvious relation, occasionally had acid regurgitation, belch, without nauseating, melena, weight loss.Once in certain hospitalize local, row upper digestive tract radiography prompting " gastric ulcer ", gave the medicine such as cimetidine, bismuth potassium citrate, remission after treatment.Symptom is interrupted appearance afterwards, all takes a turn for the better after thing of taking medicine, non-rule diagnosis and treatment.Before one week, patient again upper abdominal pain increases the weight of, and is sent to my institute checks treatment by household.Check: patient's Upper abdominal pain is obvious, with acid regurgitation, belch, burning sensation, feeling of repletion, the symptoms such as Nausea and vomiting; Pale tongue or light red, white and thin fur, thready and stringy pulse.Gastric ulcer is made a definite diagnosis errorless through gastroscopy.
Take the present embodiment gained gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, instructions of taking: twice daily, each 150-200mL(is oral), 7 days courses for the treatment of.After the course for the treatment of of medication, patient's Upper abdominal pain obviously alleviates, and other symptoms and sign alleviate or disappear, and continue two courses for the treatment of of medication, patient's ulcer healing, patient fully recovers.Pay a return visit after three months, without recurrence.
embodiment 5gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, is prepared from (45g/ part) by the raw material of following mass parts: Adeps melis 585 parts; Rhizoma Polygoni Paleachi 25 parts; Rhizoma Kaempferiae 15 parts; Rhizoma Acori Graminei 32.5 parts; Herba Erigerontis Annui 25 parts; Radix Notoginseng 50 parts; Pseudobulbus Bletillae (Rhizoma Bletillae) 80 parts; Stearic acid 86 parts; Tween 80 7 parts; Sodium benzoate 5.5 parts; Butoben 3 parts; Vanilla 1.65 parts; Peppermint oil essence 8 parts.
The preparation method of above-mentioned gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion is:
(1) Adeps melis is placed in medicine pot, moderate heat heating boils 35 minutes, with remove portion stink, then in medicine pot, adds stearic acid and butoben, stirs fusing fully, is cooled to 40 DEG C, for subsequent use;
(2) Rhizoma Polygoni Paleachi, Rhizoma Kaempferiae, Rhizoma Acori Graminei, Herba Erigerontis Annui, Radix Notoginseng and Pseudobulbus Bletillae (Rhizoma Bletillae) are placed in Chinese medicine thermal dryer, 65 DEG C of freeze-day with constant temperature 3.5 hours, take out, be ground into fine powder; Gained fine powder is placed in Chinese medicinal pot, adds the distilled water of 5.5 times of raw material doses, slow fire boiling 29 minutes, filter with three layers of non-woven fabrics, filtrate continuation is evaporated to 3/4 of original liquid volume, obtains Chinese medicine rubber cement; In gained Chinese medicine rubber cement, add sodium benzoate fine powder, stir and make it fully dissolve, be cooled to 40 DEG C, for subsequent use;
(3) step (2) gained rubber cement and tween 80 are together joined in emulsion tank, electric blender high-speed stirred, step (1) gained medicinal liquid is added while stirring toward emulsion tank center, be stirred to liquid color to turn white, retrogradation and till exquisiteness, then add vanilla and peppermint oil essence, continue high-speed stirred 10 minutes, obtain Emulsion;
(4) step (3) gained Emulsion is entered bottle according to the metering, distributing, packaging of 300g/ bottle, add a cover, add wax sealing, to obtain final product.
The instructions of taking of Emulsion of the present invention is: twice daily, and each 150-200mL(is oral), 7 days courses for the treatment of.
The effect of the present invention's primary raw material used is as follows:
Adeps melis: base is former: be the fatty oil of mustelid badger.Function cures mainly: control deficiency of QI in middle-JIAO, uterine prolapse, hemoptysis, hemorrhoid, chancre, scabies, bald in vain, scalds, chilblain.
Rhizoma Polygoni Paleachi: base is former: be the rhizome of Polygonaceae arsesmart Rhizoma Polygoni Paleachi.Composition: Rhizoma Polygoni Paleachi rhizome is containing Combination tannin.The property of medicine: bitter, acrid, cold.Function cures mainly: dissipating blood stasis stops blooding, therapeutic method to keep the adverse QI flowing downwards removing food stagnancy, removing toxic substances, dampness removing.Zhu Zhi WEIJIA is gathered, traumatic injury, traumatic hemorrhage, spits blood, spitting of blood, epistaxis, amenorrhea, metrorrhagia, chronic gastritis, taste-blindness rate, and food stagnation is stagnated, dysentery, enteritis, edema, sore, venom, burn and scald.
Rhizoma Kaempferiae: base is former: be the rhizome of zingiberaceous plant Rhizoma Kaempferiae.Nature and flavor: pungent, temperature.Gui Jing: enter stomach warp.Function cures mainly: warming middle-JIAO, helps digestion, pain relieving.Control trusted subordinate's cold type of pain, stop dyspepsia, traumatic injury, toothache.For septum pectorale distension, coldness and pain in the epigastrium.Diet does not disappear.
Rhizoma Acori Graminei: nature and flavor: pungent, bitter, warm in nature.Gui Jing: GUIXIN, stomach warp.Chemical analysis: containing α-, beta-Asarone, cis-Methylisoeugenol, methyleugenol, Rhizoma Acori Graminei enediol, Rhizoma Acori Graminei helicene ketone, acolamone, acorone, the large bull ketone of Rhizoma Acori Graminei, acorone, isoacrone etc.Energy inducing resuscitation and resolving phlegm, wards off dirty parasite killing.Dirtyly to have one's ideas straightened out for warding off, a surname's gas by expectorant, removing toxic substances, parasite killing.Control demented, infantile convulsion, coma due to phlegm syncope, anemofrigid-damp arthralgia, a mouthful fulminant dysentery of keeping silent, external application carbuncle scabies.Have one's ideas straightened out, reduce phlegm, stomach invigorating., chronic bronchitis vexed for epilepsy, expectorant febrile convulsion, breast abdominal distention.Cure mainly: sputum heap soil or fertilizer over and around the roots is closed, unconsciousness, chronic tracheitis; Dysentery, enteritis, abdominal distention stomachache, inappetence, anemofrigid-damp arthralgia, skin ulcer scabies is applied in external.
Herba Erigerontis Annui: base is former: be herb and the root of chrysanthemum kind of plant Herba Erigerontis Annui.Nature and flavor: " Zhejiang conventional medical herbs among the people ": " property is put down, lightly seasoned." function cures mainly: heat-clearing and toxic substances removing, aid digestion.Control dyspepsia, enteritis, diarrhea, infectious hepatitis, lymphadenitis, hematuria.Pharmacological action: stem, leaf, with the water extract after petroleum ether, ether, chloroform, have hypoglycemic activity.
Radix Notoginseng: base is former: this product is the dry root and rhizome of panax araliaceae plant.Nature and flavor: sweet, micro-hardship, temperature.Gui Jing: return liver, stomach warp.Effect: dissipating blood stasis stops blooding, subduing swelling and relieving pain.Cure mainly: for spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.
Pseudobulbus Bletillae (Rhizoma Bletillae): base is former: be the tuber of orchid Pseudobulbus Bletillae (Rhizoma Bletillae).Chemical analysis: fresh tuber moisture content 14.6%, starch 30.48%, glucose 1.5%.Again containing volatile oil, phlegmatic temperament.Root contains bletilla mannan, the glucomannan be made up of 4 parts of mannose and 1 part of glucose.Nature and flavor: bitter sweet, cool.Gui Jing: enter lung meridian.Function cures mainly: tonifying the lung, hemostasis, detumescence, granulation promoting, sore.Control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, canker sores, and soup fire is burnt, rhagadia manus et pedis.
Stearic acid: 1, sterling is the soft small pieces of the glossiness white of band.2, be slightly soluble in cold water, be dissolved in ethanol, acetone, be soluble in benzene, chloroform, ether, carbon tetrachloride, Carbon bisulfide, amyl acetate and toluene etc.Nontoxic.3, be present in cured tobacco leaf, burley tobaccos Nicotiana tabacum L., Turkish tobaccos Nicotiana tabacum L., flue gas.4, be the fatty acid forming stearin.Effect and purposes: be widely used in inhibition and generation cosmetic, plastics cold resistant plasticizer, releasing agent, stabilizing agent, surfactant, thiofide, waterproofing agent, polishing agent, metallic soap, metalliferous mineral flotation agent, softening agent, pharmaceuticals and other organic chemicals.Stearic acid is main in medicine is used as excipient.
Tween 80: character: soluble in water, is dissolved in ethanol, vegetable oil, ethyl acetate, methanol, toluene, is insoluble to mineral oil.Agglutination during low temperature, restores after being heated.There is special smell, mildly bitter flavor.Function effect: (1) tween 80 is oleate, has emulsification.(2) tween 80 in tablets can as disintegrating agent: because tween 80 can increase the wettability of medicine, accelerate the input of moisture, thus accelerate disintegration rate.(3) in suppository base, add tween 80, the hydrophilic of medicine can be increased, accelerate the release of medicine, thus improve the absorbance of medicine.
It is better that sodium benzoate belongs to acid antiseptic antiseptic effect under sour environment, is the food, the pharmaceutical preservative with no toxicity that are in daily use, has and prevent the rotten effect of turning sour, extending the shelf life.
Butoben: chemical name: butyl p-hydroxybenzoate.Character: white crystals, micro-have special odor, is dissolved in alcohol, ether and chloroform, is insoluble in water, have numb feeling in the tongue when mouth is tasted.Purposes: this product is mainly used as organic synthesis, the sterilization antiseptic of food, medicine, cosmetics, is also used as feed anticorrosion agent.
Vanilla: vanillon is a kind of edible essence refined from Rhizoma et radix valerianae, is usually used in cake class and removes egg fishy smell or make vanilla oral dessert.
Peppermint oil essence: this product is that the fresh stem of labiate Herba Menthae and Ye Jing vapor distillation obtain oily, and general yield is 0.3%-0.6%.Character: this product is colourless or flaxen supernatant liquid.Have special refrigerant fragrance, taste is just pungent, rear cool.Purposes: be mainly used in chewing gum. confection. beverage. wait in food.Increase or modify its fragrance fragrance.Pharmacological effect: 1, for anemopyretic cold, epidemic febrile disease from the beginning of: this product is pungent to disperse, cool to heat clearing away, clear light cool loose, is the product that dispelling wind and heat pathogens is conventional.2, for conjunctival congestion of having a headache, laryngopharynx swelling and pain: this product lightly floats and rises floating, awakening consciousness, merit is kind evacuates part of the body cavity above the diaphragm housing the heart and lungs wind heat, refresh oneself, throat.Attack with controlling in wind heat, headache conjunctival congestion.3, for stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.This product double enter Liver Channel, can dispersing the stagnated live-QI to relieve the stagnation of QI.
test example 1the clinical practice of gained gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion (embodiment 5) of the present invention:
1 data and method
1.1 physical data
In April, 2010, in JIUYUE ,-2013, screened 318 routine patients in the outpatient service of 4 divisions of gastroenterology of hospital, wherein male 182 example, and women 136 example, the oldest 61 years old, at minimum 20 years old of age, the course of disease was at three months-2 years.All patients all make a definite diagnosis through electronic gastroscope or x-ray barium meal examination.
1.2 diagnostic criteria
Western medicine diagnose standard: gastroscope or x-ray barium meal inspection Inspection Certificate have gastric ulcer or duodenal ulcer person;
Tcm diagnosis standard: clinical all based on different journey gastric abscess, partly has acid regurgitation, belch, burning sensation, feeling of repletion, the symptoms such as n or V.Most patients pale tongue or light red, white and thin fur, thready and stringy pulse.
1.3 Therapeutic Method
All patients are divided into treatment group and matched group at random, and two groups of patients, in sex, the state of an illness, the course of disease etc., through statistical procedures no significant difference (P > 0.05), have comparability.Wherein treatment group takes gained medicine of the present invention, observes three courses for the treatment of of treatment altogether.Matched group takes other drug (as conventional medicines such as bismuth potassium citrate, lansoprazole, omeprazoles).
1.4 curative effect determinate standard
" disease of tcm Standardization of diagnosis and curative effect " with reference to State Administration of Traditional Chinese Medicine promulgates:
Cure: after treatment, the ulcer symptoms of patient, around inflammatory symptoms and clinical symptoms all disappear; Effective: after treatment, clinical symptoms and the ulcer symptoms of patient disappear substantially, still have inflammation around to exist; Effective: after treatment, the ulcer area of patient reduces over half, and clinical symptoms obviously alleviates; Invalid: after treatment, clinical symptoms is unchanged even to be increased the weight of.Total effective rate=cure rate+obvious effective rate+effective percentage
1.5 therapeutic outcome
Table 1: take embodiment 5 product treatment group and matched group patient treatment outcome
Therapeutic effect: cure 132 examples (66%), effective 41 examples (20.5%), effective 23 examples (11.5%), invalid 4 examples (2%), total effective rate 98%.Treatment group successful is better than matched group.
The present invention select Adeps melis, Rhizoma Polygoni Paleachi, Rhizoma Kaempferiae, Rhizoma Acori Graminei, Herba Erigerontis Annui, Radix Notoginseng and Pseudobulbus Bletillae (Rhizoma Bletillae) etc. totally 13 taste raw materials be prepared from.Fang Zhong, Rhizoma Polygoni Paleachi has dissipating blood stasis hemostasis, and effect of therapeutic method to keep the adverse QI flowing downwards removing food stagnancy, cures mainly chronic gastritis, gastric and duodenal ulcers; Rhizoma Kaempferiae enters stomach warp, controls trusted subordinate's cold type of pain, stops dyspepsia; Rhizoma Acori Graminei cures mainly enteritis, abdominal distention stomachache, inappetence etc., and effect is remarkable; Herba Erigerontis Annui heat-clearing and toxic substances removing is aid digestion; Radix Notoginseng dissipating blood stasis stops blooding, subduing swelling and relieving pain; Pseudobulbus Bletillae (Rhizoma Bletillae) tonifying the lung, hemostasis, detumescence, granulation promoting; After taking three courses for the treatment of, treatment group effective percentage is 98%, and matched group is only 77.1%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion, is characterized in that, is prepared from by the raw material of following mass parts: Adeps melis 520-650; Rhizoma Polygoni Paleachi 20-30; Rhizoma Kaempferiae 10-20; Rhizoma Acori Graminei 25-40; Herba Erigerontis Annui 20-30; Radix Notoginseng 40-60; Pseudobulbus Bletillae (Rhizoma Bletillae) 70-90; Stearic acid 62-110; Tween 80 4-10; Sodium benzoate 3-8; Butoben 2-4; Vanilla 1.5-1.8; Peppermint oil essence 6-10.
2. gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion as claimed in claim 1; It is characterized in that; Be prepared from by the raw material of following mass parts: Adeps melis 570-600; Rhizoma Polygoni Paleachi 22-28; Rhizoma Kaempferiae 13-17; Rhizoma Acori Graminei 30-35; Herba Erigerontis Annui 23-27; Radix Notoginseng 45-55; Pseudobulbus Bletillae (Rhizoma Bletillae) 75-85; Stearic acid 80-92; Tween 80 5-9; Sodium benzoate 4-7; Butoben 2.5-3.5; Vanilla 1.6-1.7; Peppermint oil essence 7-9.
3. gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion as claimed in claim 1; It is characterized in that; Be prepared from by the raw material of following mass parts: Adeps melis 585; Rhizoma Polygoni Paleachi 25; Rhizoma Kaempferiae 15; Rhizoma Acori Graminei 32.5; Herba Erigerontis Annui 25; Radix Notoginseng 50; Pseudobulbus Bletillae (Rhizoma Bletillae) 80; Stearic acid 86; Tween 80 7; Sodium benzoate 5.5; Butoben 3; Vanilla 1.65; Peppermint oil essence 8.
4. the preparation method of the gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion according to claim 1-3, it is characterized in that, step is as follows:
(1) Adeps melis is placed in medicine pot, moderate heat heating boils 20-50 minute, with remove portion stink, then in medicine pot, adds stearic acid and butoben, stirs fusing fully, is cooled to 30-50 DEG C, for subsequent use;
(2) Rhizoma Polygoni Paleachi, Rhizoma Kaempferiae, Rhizoma Acori Graminei, Herba Erigerontis Annui, Radix Notoginseng and Pseudobulbus Bletillae (Rhizoma Bletillae) are placed in Chinese medicine thermal dryer, freeze-day with constant temperature 2-5 hour, take out, be ground into fine powder; Gained fine powder is placed in Chinese medicinal pot, adds the distilled water of 4-7 times of raw material dose, slow fire boiling 18-40 minute (preferred slow fire boiling 29 minutes), filter with three layers of non-woven fabrics, filtrate continuation is evaporated to 3/4 of original liquid volume, obtains Chinese medicine rubber cement; In gained Chinese medicine rubber cement, add sodium benzoate fine powder, stir and make it fully dissolve, be cooled to 40 DEG C, for subsequent use;
(3) step (2) gained rubber cement and tween 80 are together joined in emulsion tank, electric blender high-speed stirred, step (1) gained medicinal liquid is added while stirring toward emulsion tank center, be stirred to liquid color to turn white, retrogradation and till exquisiteness, then add vanilla and peppermint oil essence, continue high-speed stirred, obtain Emulsion;
(4) step (3) gained Emulsion is distributed into bottle according to the metering (preferably according to the metering of 300g/ bottle) of 200-400g/ bottle, adds a cover, add wax sealing, to obtain final product.
5. the preparation method of gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion according to claim 4, is characterized in that, in step (1), moderate heat heating boils 30-40 minute (preferred moderate heat heating boils 35 minutes).
6. the preparation method of gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion according to claim 5, is characterized in that, is cooled to 35-45 DEG C (being preferably cooled to 40 DEG C) in step (1).
7. the preparation method of gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion according to claim 4, it is characterized in that, in step (2), the temperature of freeze-day with constant temperature is 55-75 DEG C (temperature of preferred freeze-day with constant temperature is 60-70 DEG C, and the temperature of the freeze-day with constant temperature be more preferably is 65 DEG C).
8. the preparation method of gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion according to claim 4, is characterized in that, in step (2) freeze-day with constant temperature 3-4 hour (preferred freeze-day with constant temperature 3.5 hours).
9. the preparation method of gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion according to claim 4, is characterized in that, adds the distilled water (preferably adding the distilled water of 5.5 times amount raw material doses) of 5-6 times of raw material dose in step (2).
10. the preparation method of gastric and duodenal ulcers circulation of qi promoting food stagnation removing Emulsion according to claim 4, it is characterized in that, continue in step (3) high-speed stirred 5-15 minute (preferred continuation high-speed stirred 7-13 minute, the continuation high-speed stirred be more preferably 10 minutes).
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| US5730986A (en) * | 1995-06-14 | 1998-03-24 | Council Of Scientific & Industrial Research | Process for the isolation of an active principle from azadirachta indica useful for controlling gastric hyperacidity and gastric ulceration |
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