CN104623355A - Traditional Chinese medicine for treating epidemic encephalitis B - Google Patents
Traditional Chinese medicine for treating epidemic encephalitis B Download PDFInfo
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- CN104623355A CN104623355A CN201510009463.9A CN201510009463A CN104623355A CN 104623355 A CN104623355 A CN 104623355A CN 201510009463 A CN201510009463 A CN 201510009463A CN 104623355 A CN104623355 A CN 104623355A
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Abstract
The invention provides a traditional Chinese medicine for treating epidemic encephalitis B. The traditional Chinese medicine is prepared from the following medicinal raw materials: radix scrophulariae, angelica sinensis, dendrobe, gorgon euryale seed, acorus calamus, lonicera japonica, cypress fruit, lawn pennywort herb, meadowrue root and rhizome, talinum crassifolium, liriope spicata, rabdosia rubescens, Chinese yam, rhizoma phragmitis, fructus xanthii, kadsura longepedunculata, bunge corydalis herb, kudzu vine root, scutellaria baicalensis, lactarius piperatus and subprostrate sophora. When the traditional Chinese medicine is adopted for treatment, the curative effect is good, use is safe, and operation is convenient, so that the traditional Chinese medicine is worthy of popularization and application in hospitals.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of Chinese medicine being used for the treatment of epidemic encephalitis type B.
Background technology
Epidemic encephalitis type B (abbreviation encephalitis b) is the acute central nervous system infectious disease caused by encephalitis b virus.It is a kind of serious arthropod borne viral disease based on central nervous system damage, and its case fatality rate is 25%, has neural commemorative sign person to account for 57% ~ 68% in the patient of survival.Previously mostly be western medical treatment, but curative effect is not good enough, has higher disability rate, case fatality rate.High heat, convulsions, disturbance of consciousness are the principal characters of primary disease, and respiratory failure is then the main cause that primary disease is lethal.
Epidemic encephalitis type B is that encephalitis b virus is when human body immune function weakens, central nervous system is entered and the acute infectious disease of breeding and causing by blood brain barrier, belong to the disease category of traditional Chinese medical science fever disease in summer, its pathogenic characteristic many with heat, expectorant, wind is closely related, pathogenic summer-heat poison intrinsic heat, pathogenic heat are refined Tianjin and are become expectorant, the hot priming liver-wind of expectorant, summer-heat is burnt bright simultaneously, consumption impairment of YIN Tianjin.Epidemic Febrile Disease theory is thought, primary disease system summer-heat epidemic disease poison invasion and attack human body, and pathogenic heat sense is in inner, and disturbing the mind upwards and going into a coma, by table as inner, enters nutrient blood from defending gas.Children's's timid and weak mind, QI and blood is not filled, and internal organs are not hard, and damp and hot three gas of tolerance to heat do not steam and compel, and cloudy liquid yang-energy is let out with antiperspirant, especially easily ill.Show as simultaneous occurrence of syndromes of both QI and WEI systems, disease involving of both qifen and yingfen, nutrient blood with sick, heat, expectorant, wind three are demonstrate,proved various, occur heating, coma, tic.Encephalitis b crisis, the turbid retardance of expectorant, clear key was covered, unconsciousness due to high fever, faints from fear and frequently does, often occur heart failure and respiratory failure due to evil malicious flourishing.For in encephalitis b etiology and pathogenesis, poison for cause a disease because of, main attacking the pathogen by pyretic toxicity in body treatment in, controlling that high heat worsens for blocking condition and develop is a step of key.Therefore, the present invention on the basis of theory of Chinese medical science with heat-clearing and toxic substances removing, YIN nourishing and the production of body fluid promoting, consciousness-restoring and orifice-opening, calming the mind and benefiting the brain is principle, provides a kind of Chinese medicine being used for the treatment of epidemic encephalitis type B, and adopt Chinese medicine treatment, curative effect is better, and use safety, easy to operate, be worth clinical application application.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine being used for the treatment of epidemic encephalitis type B, and adopt Chinese medicine treatment, curative effect is better, and use safety, easy to operate, be worth clinical application application.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine being used for the treatment of epidemic encephalitis type B, its crude drug comprises Radix Scrophulariae, Radix Angelicae Sinensis, Herba Dendrobii, Semen Euryales, Rhizoma Acori Calami, Flos Lonicerae, Strobilus Cupressi, Herba Hydrocotyles, Radix et Rhizoma Thalictri, Radix Talini Paniculati, Radix Liriopes, Rabdosia rubescens, Rhizoma Dioscoreae, Rhizoma Phragmitis, Fructus Xanthii, Fructus Schisandrae Sphenantherae, Herba Corydalis Bungeanae, Radix Puerariae, Radix Scutellariae, Virgin's milk mushroom and Radix Sophorae Tonkinensis.
Wherein, in described Chinese medicine, the weight portion of each crude drug is respectively Radix Scrophulariae 20 weight portion ~ 30 weight portion, Radix Angelicae Sinensis 35 weight portion ~ 45 weight portion, Herba Dendrobii 15 weight portion ~ 25 weight portion, Semen Euryales 30 weight portion ~ 40 weight portion, Rhizoma Acori Calami 15 weight portion ~ 25 weight portion, Flos Lonicerae 45 weight portion ~ 55 weight portion, Strobilus Cupressi 15 weight portion ~ 25 weight portion, Herba Hydrocotyles 20 weight portion ~ 30 weight portion, Radix et Rhizoma Thalictri 20 weight portion ~ 30 weight portion, Radix Talini Paniculati 30 weight portion ~ 40 weight portion, Radix Liriopes 25 weight portion ~ 35 weight portion, Rabdosia rubescens 20 weight portion ~ 30 weight portion, Rhizoma Dioscoreae 35 weight portion ~ 45 weight portion, Rhizoma Phragmitis 15 weight portion ~ 25 weight portion, Fructus Xanthii 20 weight portion ~ 30 weight portion, Fructus Schisandrae Sphenantherae 30 weight portion ~ 40 weight portion, Herba Corydalis Bungeanae 15 weight portion ~ 25 weight portion, Radix Puerariae 20 weight portion ~ 30 weight portion, Radix Scutellariae 40 weight portion ~ 50 weight portion, Virgin's milk mushroom 15 weight portion ~ 25 weight portion and Radix Sophorae Tonkinensis 20 weight portion ~ 30 weight portion.
Wherein, in described Chinese medicine, the weight portion of each crude drug is respectively Radix Scrophulariae 23 weight portion ~ 27 weight portion, Radix Angelicae Sinensis 38 weight portion ~ 42 weight portion, Herba Dendrobii 18 weight portion ~ 22 weight portion, Semen Euryales 33 weight portion ~ 37 weight portion, Rhizoma Acori Calami 18 weight portion ~ 22 weight portion, Flos Lonicerae 48 weight portion ~ 52 weight portion, Strobilus Cupressi 18 weight portion ~ 22 weight portion, Herba Hydrocotyles 23 weight portion ~ 27 weight portion, Radix et Rhizoma Thalictri 23 weight portion ~ 27 weight portion, Radix Talini Paniculati 33 weight portion ~ 37 weight portion, Radix Liriopes 28 weight portion ~ 32 weight portion, Rabdosia rubescens 23 weight portion ~ 27 weight portion, Rhizoma Dioscoreae 38 weight portion ~ 42 weight portion, Rhizoma Phragmitis 18 weight portion ~ 22 weight portion, Fructus Xanthii 23 weight portion ~ 27 weight portion, Fructus Schisandrae Sphenantherae 33 weight portion ~ 37 weight portion, Herba Corydalis Bungeanae 18 weight portion ~ 22 weight portion, Radix Puerariae 23 weight portion ~ 27 weight portion, Radix Scutellariae 43 weight portion ~ 47 weight portion, Virgin's milk mushroom 18 weight portion ~ 22 weight portion and Radix Sophorae Tonkinensis 23 weight portion ~ 27 weight portion.
Wherein, in described Chinese medicine, the weight portion of each crude drug is respectively Radix Scrophulariae 25 weight portion, Radix Angelicae Sinensis 40 weight portion, Herba Dendrobii 20 weight portion, Semen Euryales 35 weight portion, Rhizoma Acori Calami 20 weight portion, Flos Lonicerae 50 weight portion, Strobilus Cupressi 20 weight portion, Herba Hydrocotyles 25 weight portion, Radix et Rhizoma Thalictri 25 weight portion, Radix Talini Paniculati 35 weight portion, Radix Liriopes 30 weight portion, Rabdosia rubescens 25 weight portion, Rhizoma Dioscoreae 40 weight portion, Rhizoma Phragmitis 20 weight portion, Fructus Xanthii 25 weight portion, Fructus Schisandrae Sphenantherae 35 weight portion, Herba Corydalis Bungeanae 20 weight portion, Radix Puerariae 25 weight portion, Radix Scutellariae 45 weight portion, Virgin's milk mushroom 20 weight portion and Radix Sophorae Tonkinensis 25 weight portion.
Wherein, described Chinese medicine is prepared into injection.
Present invention also offers the preparation method of above-mentioned treatment epidemic encephalitis type B Chinese medicine, it comprises:
The first step, chooses Radix Scrophulariae, Radix Angelicae Sinensis, Herba Dendrobii, Semen Euryales, Radix Talini Paniculati, Radix Liriopes, Rhizoma Dioscoreae and Fructus Schisandrae Sphenantherae, is pulverized respectively by these crude drug compositions, loads in supercritical extraction tank, under 20 ~ 30MPa, 30 ~ 50 DEG C of conditions, uses supercritical CO
2extract 3 ~ 5h and carry out supercritical extraction, obtain extract for subsequent use;
Second step, pulverizes respectively by remaining crude drug composition, mixing, and with the alcohol reflux 3 times of the determining alcohol 50% ~ 70% of the mixture quality obtained relative to this step 6 ~ 8 times, each 2 hours, merge extractive liquid, filtered; Filtrate is adjusted to pH5.5 ~ 7 by NaOH solution, leaves standstill, filter, decompression filtrate recycling ethanol, to without alcohol taste, leaves standstill, centrifugalize, the supernatant after centrifugalize, and the heating relative density be concentrated at 50 DEG C ~ 60 DEG C is the mastic of 1.08 ~ 1.13;
3rd step, take a morsel water for injection, adds 3 ~ 8g tween 80 and 5 ~ 10g sodium chloride, stirring and dissolving, add the extract of first step acquisition and the mastic of second step acquisition again, stirring and dissolving, filters, injects water to 1000mL, adjust pH to 4.0 ~ 7.0, fine straining, embedding, sterilizing and get final product.
Beneficial effect of the present invention:
The invention provides Chinese medicine treatment epidemic encephalitis type B, curative effect is better, and use safety, easy to operate, be worth clinical application application.
Detailed description of the invention
The invention provides a kind of Chinese medicine being used for the treatment of epidemic encephalitis type B, its crude drug comprises Radix Scrophulariae, Radix Angelicae Sinensis, Herba Dendrobii, Semen Euryales, Rhizoma Acori Calami, Flos Lonicerae, Strobilus Cupressi, Herba Hydrocotyles, Radix et Rhizoma Thalictri, Radix Talini Paniculati, Radix Liriopes, Rabdosia rubescens, Rhizoma Dioscoreae, Rhizoma Phragmitis, Fructus Xanthii, Fructus Schisandrae Sphenantherae, Herba Corydalis Bungeanae, Radix Puerariae, Radix Scutellariae, Virgin's milk mushroom and Radix Sophorae Tonkinensis.
Described Chinese medicine is preferably only made up of above-mentioned raw materials medicine.
In described Chinese medicine, the weight portion of each crude drug is respectively Radix Scrophulariae 20 weight portion ~ 30 weight portion, Radix Angelicae Sinensis 35 weight portion ~ 45 weight portion, Herba Dendrobii 15 weight portion ~ 25 weight portion, Semen Euryales 30 weight portion ~ 40 weight portion, Rhizoma Acori Calami 15 weight portion ~ 25 weight portion, Flos Lonicerae 45 weight portion ~ 55 weight portion, Strobilus Cupressi 15 weight portion ~ 25 weight portion, Herba Hydrocotyles 20 weight portion ~ 30 weight portion, Radix et Rhizoma Thalictri 20 weight portion ~ 30 weight portion, Radix Talini Paniculati 30 weight portion ~ 40 weight portion, Radix Liriopes 25 weight portion ~ 35 weight portion, Rabdosia rubescens 20 weight portion ~ 30 weight portion, Rhizoma Dioscoreae 35 weight portion ~ 45 weight portion, Rhizoma Phragmitis 15 weight portion ~ 25 weight portion, Fructus Xanthii 20 weight portion ~ 30 weight portion, Fructus Schisandrae Sphenantherae 30 weight portion ~ 40 weight portion, Herba Corydalis Bungeanae 15 weight portion ~ 25 weight portion, Radix Puerariae 20 weight portion ~ 30 weight portion, Radix Scutellariae 40 weight portion ~ 50 weight portion, Virgin's milk mushroom 15 weight portion ~ 25 weight portion and Radix Sophorae Tonkinensis 20 weight portion ~ 30 weight portion.
Further preferably, in described Chinese medicine, the weight portion of each crude drug is respectively Radix Scrophulariae 23 weight portion ~ 27 weight portion, Radix Angelicae Sinensis 38 weight portion ~ 42 weight portion, Herba Dendrobii 18 weight portion ~ 22 weight portion, Semen Euryales 33 weight portion ~ 37 weight portion, Rhizoma Acori Calami 18 weight portion ~ 22 weight portion, Flos Lonicerae 48 weight portion ~ 52 weight portion, Strobilus Cupressi 18 weight portion ~ 22 weight portion, Herba Hydrocotyles 23 weight portion ~ 27 weight portion, Radix et Rhizoma Thalictri 23 weight portion ~ 27 weight portion, Radix Talini Paniculati 33 weight portion ~ 37 weight portion, Radix Liriopes 28 weight portion ~ 32 weight portion, Rabdosia rubescens 23 weight portion ~ 27 weight portion, Rhizoma Dioscoreae 38 weight portion ~ 42 weight portion, Rhizoma Phragmitis 18 weight portion ~ 22 weight portion, Fructus Xanthii 23 weight portion ~ 27 weight portion, Fructus Schisandrae Sphenantherae 33 weight portion ~ 37 weight portion, Herba Corydalis Bungeanae 18 weight portion ~ 22 weight portion, Radix Puerariae 23 weight portion ~ 27 weight portion, Radix Scutellariae 43 weight portion ~ 47 weight portion, Virgin's milk mushroom 18 weight portion ~ 22 weight portion and Radix Sophorae Tonkinensis 23 weight portion ~ 27 weight portion.
Most preferably, in described Chinese medicine, the weight portion of each crude drug is respectively Radix Scrophulariae 25 weight portion, Radix Angelicae Sinensis 40 weight portion, Herba Dendrobii 20 weight portion, Semen Euryales 35 weight portion, Rhizoma Acori Calami 20 weight portion, Flos Lonicerae 50 weight portion, Strobilus Cupressi 20 weight portion, Herba Hydrocotyles 25 weight portion, Radix et Rhizoma Thalictri 25 weight portion, Radix Talini Paniculati 35 weight portion, Radix Liriopes 30 weight portion, Rabdosia rubescens 25 weight portion, Rhizoma Dioscoreae 40 weight portion, Rhizoma Phragmitis 20 weight portion, Fructus Xanthii 25 weight portion, Fructus Schisandrae Sphenantherae 35 weight portion, Herba Corydalis Bungeanae 20 weight portion, Radix Puerariae 25 weight portion, Radix Scutellariae 45 weight portion, Virgin's milk mushroom 20 weight portion and Radix Sophorae Tonkinensis 25 weight portion.
Radix Scrophulariae: bitter in the mouth, sweet, salty, cold nature, enters lung, stomach, kidney channel, has the effect of clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, detoxicating and resolving stagnation of pathogens, for warm febrile disease join the army blood, intense heat in both QI and blood systems, send out speckle dermexanthesis; Consumption of YIN caused by febrile disease, Tianjin hinder constipation, hectic fever due to YIN-deficiency chronic cough; Conjunctival congestion is red and swollen, have sore throat, the cards such as too fat to move sore.
Radix Angelicae Sinensis: latin name angelicae sinensis radix, sweet in the mouth, pungent, bitter, warm in nature, enter liver, the heart, spleen channel, enrich blood and invigorate blood circulation, regulating menstruation relieves the pain, the effect of loosening bowel to relieve constipation.The head being mainly used in treating deficiency of heart-blood is giddy, fatigue and weakness, shortness of breath and palpitation, and other syndrome of deficiency of blood.
Herba Dendrobii: latin name Dendrobii Caulis, cold nature, sweet in the mouth, enters stomach, kidney channel, has reinforcing stomach reg fluid, and effect of nourishing YIN and clearing away heat, cures mainly consumption of body fluid by heat, low grade fever excessive thirst, the few tongue of red tongue; Deficiency of stomach-Yin, thirsty and dry pharynx, vomiting is eaten less, vague epigastralgia, the few tongue of tongue light; Deficiency of kidney yin, the cards such as blurring of vision.
Semen Euryales: sweet in the mouth, puckery, property is put down.Return spleen, kidney channel.Have supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the function of damp eliminating leukorrhagia stopping, cures mainly emission, diarrhea due to hypofunction of the spleen, and insufficiency of the spleen nebulousurine is with inferior card.
Rhizoma Acori Calami: latin name Acori Calami Rhizoma, bitter in the mouth, pungent, warm in nature, have stomach warming, effect of anti-inflammatory analgetic, for mending stomach sun, dyspepsia, food stagnates, diphtheria, the cards such as anthrax.
Flos Lonicerae: latin name lonicerae japonicae flos, sweet in the mouth, cold in nature, enter the heart, lung, stomach, large intestine channel, have the effect of heat-clearing and toxic substances removing, holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity is comparatively contained, or when epidemic febrile disease is still not descending at the part of the body cavity above the diaphragm housing the heart and lungs from the beginning of pathogenic heat; Pyretic toxicity dysentery, stool hematochezia; Fever disease in summer is demonstrate,proved.
Strobilus Cupressi: be the cone of Cupressaceae cypress Cupressus funebris Endl., bitter in the mouth, sweet, property is put down, and has and dispels the wind, and in, calm the nerves, effect of hemostasis, cures mainly cold, fever, gastralgic vomitting, irritated, insomnia, the cards such as over-strained hemoptysis.
Herba Hydrocotyles: acrid in the mouth, micro-hardship, cool in nature, have clearing away heat-damp and promoting diuresis, effect of removing toxic substances and promoting subsidence of swelling, cures mainly jaundice, dysentery, edema, stranguria, and larynx swells, herpes zoster, the cards such as traumatic injury.
Radix et Rhizoma Thalictri: be the root and rhizome of Ranunculaceae thalictrum spp spun gold Radix et Rhizoma Thalictri, Zhaotong Thalictrum aquilegifolium L. var. sibiricum Regel, plateau Thalictrum aquilegifolium L. var. sibiricum Regel, leafy Thalictrum aquilegifolium L. var. sibiricum Regel, bitter in the mouth, cold in nature, GUIXIN, liver, large intestine channel, there is heat clearing and damp drying, effect of eliminating fire and detoxication, cures mainly diarrhea due to damp-heat, dysentery, jaundice, cold, fever, measles, the cards such as conjunctival congestion and swelling pain.
Radix Talini Paniculati: latin name Pedicularis muscicola Maxim, sweet in the mouth, micro-hardship, tool heat-clearing toxin-expelling functions, weak to the deficiency of vital energy, diarrhea due to hypofunction of the spleen, xeropulmonary cough, neurasthenia etc. have certain curative effect, strongly invigorating primordial QI, promoting the production of body fluid and inducing sedation of the mind, heart tonifying.Control QI and blood deficient, asthenia hyperhidrosis, collapse exhaustion, blood pressure reduces.
Radix Liriopes: latin name liriopes radix, sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp, have YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, and for dryness of the lung dry cough, cough due to consumptive disease, Tianjin wound is thirsty, vexed insomnia, the cards such as dryness of the intestine constipation.
Rabdosia rubescens: bitter in the mouth, sweet, cold nature, returns lung, stomach, Liver Channel, has heat-clearing and toxic substances removing, effect of promoting blood circulation and stopping pain, cures mainly the cards such as laryngopharynx swelling and pain, tonsillitis, headache due to common cold, tracheitis, chronic hepatitis, articular rheumatic pain, snake bite and insect sting.
Rhizoma Dioscoreae: latin name dioscoreae rhizoma, sweet in the mouth, property are flat, and enter lung, spleen, stomach warp, have spleen reinforcing nourishing the stomach, lung benefiting reinforces the kidney, and the effect of YIN nourishing and the production of body fluid promoting, cures mainly weakness of the spleen and stomach, the lack of appetite poor appetite of dysfunction of the spleen in transportation, the cards such as the vexed diarrhoea of gastral cavity.
Rhizoma Phragmitis: sweet in the mouth, cold in nature, attach to the lung and stomach meridians, there is lung heat clearing gastric heat, diuresis, dissipating depression of QI clearing away phlegm, effect of YIN nourishing and the production of body fluid promoting, cure mainly the dysphoria with smothery sensation that epidemic febrile disease joins the army point thirsty, dryness of the tongue Tianjin is few, and the rash of measles goes out not saturating, and pathogenic heat violates the cough and expectoration of lung, the cough vomiting pus of lung abscess, the damp and hot card such as vomiting singultus blocked in stomach.
Fructus Xanthii: latin name Xanthii Fructus, acrid in the mouth, hardship, warm in nature, return lung meridian, there is the function of the dehumidifying of loose wind, understand things pain-stopping, cure mainly nasal sinusitis; Headche due to wind-cold; Rheumatic arthralgia; Rubella; Eczema; The cards such as scabies.
Fructus Schisandrae Sphenantherae: latin name Schisandrae Sphenantherae Fructus, sour in the mouth, sweet, warm in nature, return lung, the heart, kidney channel, have skillfully astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, effect of kidney calming, cures mainly chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous sweating, Tianjin wound is thirsty, the cards such as interior-heat is quenched one's thirst, palpitation and insomnia.
Herba Corydalis Bungeanae: latin name Corydalis Bungeanae Herba, bitter in the mouth, cold in nature, GUIXIN, liver, large intestine channel, have effect of heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, cures mainly epidemic disease flu, laryngopharynx swelling and pain, carbuncle carbuncle on the back, treats skin ulcer and the card such as to swell and ache.
Radix Puerariae: latin name Puerariae Lobatae Radix, sweet in the mouth, pungent, cool in nature, enter spleen, stomach warp, have inspiration gastric qi, clearing away heat and promoting production of body fluid, expelling pathogenic factors from muscles is delivered, and raw sun, oozes the effect of rash, be mainly used in fever caused by exogenous pathogens, headache, stiff nape and back, and calentura is thirsty, quenches one's thirst; Diarrhea due to hypofunction of the spleen, the cards such as clear YANG failing to ascend.
Radix Scutellariae: bitter in the mouth, cold in nature, enter the heart, lung, stomach, gallbladder, large intestine channel, there is heat clearing and damp drying, eliminating fire and detoxication, antiabortive, the effect of hemostasis, be mainly used in hygropyrexia heat-damp in summer, damp and hot painful abdominal mass is vexed, jaundice dysentery, lung-heat cough with asthma, calentura excessive thirst, the haematemesis caused by bleeding due to blood-heat, have blood in stool, metrorrhagia, pathopyretic ulcer, laryngopharynx swelling and pain, excessive fetal movement due to heat in pregnancy, the card of vexed vomiting and nausea, the effect that Radix Scutellariae has Developing restraint to multiple coccus, bacillus and fungus and kills, baicalin in Radix Scutellariae, baicalin have antiinflammatory action, and Radix Scutellariae also has obvious antitumor action.
Virgin's milk mushroom: be the sporophore of the peppery newborn mushroom of Russula Fungi In The Genus Lactarius On Pinus, bitter in the mouth, pungent, warm in nature, have expelling wind and cold, effect of relaxing muscles and tendons and activating QI and blood in the collateral, cures mainly lumbago and skelalgia, numb hand and foot, the cards such as muscles and bones is not relaxed, tic of the limbs.
Radix Sophorae Tonkinensis: bitter in the mouth, cold in nature, have and relieve inflammation or internal heat, removing toxic substances, detumescence, the effect of pain relieving, cures mainly: control retropharyngeal abscess, acute throat trouble, sore throat, gingival swelling and pain, dyspnea with fullness of the chest heat syndrome cough, jaundice, dysentery, haemorrhoids, and heat is swollen, tinea alba, scabies, Serpentis, worm, lyssodexis.
The Chinese medicine for the treatment of epidemic encephalitis type B provided by the invention is prepared into injection.
Present invention also offers the preparation method of the Chinese medicine of above-mentioned treatment epidemic encephalitis type B, it comprises:
The first step, chooses Radix Scrophulariae, Radix Angelicae Sinensis, Herba Dendrobii, Semen Euryales, Radix Talini Paniculati, Radix Liriopes, Rhizoma Dioscoreae and Fructus Schisandrae Sphenantherae, is pulverized respectively by these crude drug compositions, loads in supercritical extraction tank, under 20 ~ 30MPa, 30 ~ 50 DEG C of conditions, uses supercritical CO
2extract 3 ~ 5h and carry out supercritical extraction, obtain extract for subsequent use;
Second step, pulverizes respectively by remaining crude drug composition, mixing, and with the alcohol reflux 3 times of the determining alcohol 50% ~ 70% of the mixture quality obtained relative to this step 6 ~ 8 times, each 2 hours, merge extractive liquid, filtered; Filtrate is adjusted to pH5.5 ~ 7 by NaOH solution, leaves standstill, filter, decompression filtrate recycling ethanol, to without alcohol taste, leaves standstill, centrifugalize, the supernatant after centrifugalize, and the heating relative density be concentrated at 50 DEG C ~ 60 DEG C is the mastic of 1.08 ~ 1.13;
3rd step, take a morsel water for injection, adds 3 ~ 8g tween 80 and 5 ~ 10g sodium chloride, stirring and dissolving, add the extract of first step acquisition and the mastic of second step acquisition again, stirring and dissolving, filters, injects water to 1000mL, adjust pH to 4.0 ~ 7.0, fine straining, embedding, sterilizing and get final product.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 injection 1
Choose Radix Scrophulariae 25g, Radix Angelicae Sinensis 40g, Herba Dendrobii 20g, Semen Euryales 35g, Radix Talini Paniculati 35g, Radix Liriopes 30g, Rhizoma Dioscoreae 40g and Fructus Schisandrae Sphenantherae 35g, these crude drug compositions are pulverized respectively, load in supercritical extraction tank, under 30MPa, 50 DEG C of conditions, use supercritical CO
2extract 5h and carry out supercritical extraction, obtain extract for subsequent use, Rhizoma Acori Calami 20g, Flos Lonicerae 50g, Strobilus Cupressi 20g, Herba Hydrocotyles 25g, Radix et Rhizoma Thalictri 25g, Rabdosia rubescens 25g, Rhizoma Phragmitis 20g, Fructus Xanthii 25g, Herba Corydalis Bungeanae 20g, Radix Puerariae 25g, Radix Scutellariae 45g, Virgin's milk mushroom 20g and Radix Sophorae Tonkinensis 25g are pulverized respectively, mixing, with the alcohol reflux 3 times of the determining alcohol 60% of 2.5kg, each 2 hours, merge extractive liquid, filtered; Filtrate NaOH solution being adjusted to pH is 7, leaves standstill, and filters, and decompression filtrate recycling ethanol is extremely without alcohol taste, leave standstill, centrifugalize, the supernatant after centrifugalize, the heating relative density be concentrated at 60 DEG C is the mastic of 1.10, and take a morsel water for injection, adds 5g tween 80 and 10g sodium chloride, stirring and dissolving, then add the extract and mastic that obtain above, stirring and dissolving, filter, inject water to 1000mL, adjust pH to 4.0 ~ 7.0, fine straining, embedding, namely sterilizing obtains injection 1.
Embodiment 2 injection 2
Choose Radix Scrophulariae 23g, Radix Angelicae Sinensis 38g, Herba Dendrobii 18g, Semen Euryales 33g, Radix Talini Paniculati 33g, Radix Liriopes 28g, Rhizoma Dioscoreae 38g and Fructus Schisandrae Sphenantherae 33g, these crude drug compositions are pulverized respectively, load in supercritical extraction tank, under 30MPa, 50 DEG C of conditions, use supercritical CO
2extract 5h and carry out supercritical extraction, obtain extract for subsequent use, Rhizoma Acori Calami 18g, Flos Lonicerae 48g, Strobilus Cupressi 18g, Herba Hydrocotyles 23g, Radix et Rhizoma Thalictri 23g, Rabdosia rubescens 23g, Rhizoma Phragmitis 18g, Fructus Xanthii 23g, Herba Corydalis Bungeanae 18g, Radix Puerariae 23g, Radix Scutellariae 43g, Virgin's milk mushroom 18g and Radix Sophorae Tonkinensis 23g are pulverized respectively, mixing, with the alcohol reflux 3 times of the determining alcohol 60% of 2.5kg, each 2 hours, merge extractive liquid, filtered; Filtrate NaOH solution being adjusted to pH is 7, leaves standstill, and filters, and decompression filtrate recycling ethanol is extremely without alcohol taste, leave standstill, centrifugalize, the supernatant after centrifugalize, the heating relative density be concentrated at 60 DEG C is the mastic of 1.10, and take a morsel water for injection, adds 5g tween 80 and 10g sodium chloride, stirring and dissolving, then add the extract and mastic that obtain above, stirring and dissolving, filter, inject water to 1000mL, adjust pH to 4.0 ~ 7.0, fine straining, embedding, namely sterilizing obtains injection 2.
Embodiment 3 injection 3
Choose Radix Scrophulariae 27g, Radix Angelicae Sinensis 42g, Herba Dendrobii 22g, Semen Euryales 37g, Radix Talini Paniculati 37g, Radix Liriopes 32g, Rhizoma Dioscoreae 42g and Fructus Schisandrae Sphenantherae 37g, these crude drug compositions are pulverized respectively, load in supercritical extraction tank, under 30MPa, 50 DEG C of conditions, use supercritical CO
2extract 5h and carry out supercritical extraction, obtain extract for subsequent use, Rhizoma Acori Calami 22g, Flos Lonicerae 52g, Strobilus Cupressi 22g, Herba Hydrocotyles 27g, Radix et Rhizoma Thalictri 27g, Rabdosia rubescens 27g, Rhizoma Phragmitis 22g, Fructus Xanthii 27g, Herba Corydalis Bungeanae 22g, Radix Puerariae 27g, Radix Scutellariae 47g, Virgin's milk mushroom 22g and Radix Sophorae Tonkinensis 27g are pulverized respectively, mixing, with the alcohol reflux 3 times of the determining alcohol 60% of 2.5kg, each 2 hours, merge extractive liquid, filtered; Filtrate NaOH solution being adjusted to pH is 7, leaves standstill, and filters, and decompression filtrate recycling ethanol is extremely without alcohol taste, leave standstill, centrifugalize, the supernatant after centrifugalize, the heating relative density be concentrated at 60 DEG C is the mastic of 1.10, and take a morsel water for injection, adds 5g tween 80 and 10g sodium chloride, stirring and dissolving, then add the extract and mastic that obtain above, stirring and dissolving, filter, inject water to 1000mL, adjust pH to 4.0 ~ 7.0, fine straining, embedding, namely sterilizing obtains injection 3.
Embodiment 4 toxicology test
1, general pharmacology test
Adopt experimental dog and livid purple blue rabbit under anesthesia, first Normal Dogs before administration, the blood pressure of rabbit, breathing, heart rate and EKG is measured, then intravenous injection injection of the present invention 160,240,1000mg/kg and 10,50,500mg/kg tri-dosage groups, the change of above-mentioned indices after observation administration, result domesticated dog and family exempt from dosage and all have no significant effect blood pressure, heart rate, breathing, electrocardiogram up to during 1000mg/kg and 500mg/kg respectively, through statistical procedures there was no significant difference; To sobering animal K.M kind injected in mice 1000mg/kg injection 1 of the present invention, observe 7 days, result voluntary activity is normal, Neurotoxicity is without obvious excited or suppression phenomenon, hair is smooth, diet, feces no abnormality seen, illustrate that injection 1 injection of the present invention all has no side effect to nervous system, cardiovascular system respiratory system of unifying.
2, acute toxicity test
Because injection 1 injection toxicity of the present invention is low, LD cannot be obtained
50therefore maximum tolerance determination is adopted, with Cmax 5g/ml, dose tail vein injection (suitable crude drug 250g/kg) of maximum volume 50ml/mg observes 7 days, 20 mice all none only death, have no obvious malicious accessory symptom, diet, activity are normally, be 2g/70kg according to clinical adult's effective dose every day, according to the weight, be equivalent to 8750 times of adult's effective dose every day, press thing coefficient calculations, be equivalent to 950 times of effective dose of being grown up, without Acute Toxicity when injection 1 injection intravenous administration of the present invention is described.
3, long term toxicity test
Domesticated dog continuous intravenous injection injection 1200mg/kg and 1000mg/kg90 days of the present invention, experimental session, each treated animal has no poisoning symptom, activity, behavior, diet, feces no abnormality seen, and body weight increases with matched group close; Within 10 days, measure electrocardiogram, hematology, blood biochemical, urinalysis 25 test items respectively after 45 days and 90 days and drug withdrawal before administration, after administration, result medication two groups is basically identical with matched group; Medication after 90 days and after drug withdrawal 10 days, to heavy dose of 8, middle dosage 6, matched group 6, carries out 12 organ coefficients and 25 histology's microscopies, except a heavy dose of example find slight hepatic cell focal turbid dense except, all the other are showed no exception; Animal behavior no abnormality seen after drug withdrawal, illustrates that injection 1 injection of the present invention is without savings intoxication.
Embodiment 5 clinical data
Patients with Japanese B Encephalitis 127 example selecting in July, 2011 ~ 2013 year JIUYUE to be in hospital in the court, wherein man 63 example, female 64 example, the oldest 36 years old, minimum 3 years old, 12.9 years old mean age, be divided into treatment group 67 example at random, matched group 60 example, two groups of cases there was no significant difference in sex, age, cerebrospinal fluid detection, Clinical typing etc.
Diagnostic criteria: " lemology " that meet Wang Jiwu chief editor.
Therapeutic Method: matched group as cooling, convulsion, reduction intracranial pressure, oxygen uptake and protect from infection, applies virazole or interferon anti-reflecting virus treatment based on symptomatic treatment simultaneously.Treatment group, on the basis of above-mentioned Comprehensive Treatment, adds the injection 1 prepared by embodiment 1, often props up 2ml, 5mgkg
- 1d
-1to add in 10% glucose solution 250ml quiet, the course for the treatment of 10 ~ 15d.
Observation index
The heating natural law of two groups, convulsive seizure number of times, the disturbance of consciousness persistent period, crisis the course of disease and the incidence rate of the complication such as respiratory failure, pneumonia, digestive tract hemorrhage and sequela example (disorder of limb ' s activity, swallow exception, aphasis).
Criterion of therapeutical effect
Cure: Clinical symptom and sign disappears, and does not leave over any sequela; Take a turn for the better: Clinical symptom and sign takes a turn for the better, consciousness is clear, and some patients leaves the sequela such as slight limbs disturbance; Invalid: the state of an illness worsens without improvement, continuation, has serious sequela or death.
The observation of untoward reaction
The observation of nausea and vomiting, erythra etc.
Statistical procedures
Adopt SPSS13.0 statistical software, enumeration data adopt chi-square criterion, measurement data with
represent, adopt t inspection, with P < 0.05 for difference has statistical significance.
Result
Two groups of cardinal symptoms, sign time and courses of disease compare, and the results are shown in Table 1.
Table 1 liang group cardinal symptom, sign time and the course of disease (my god)
| Grouping | Heating continuing time | Tic dwell time | The disturbance of consciousness time | Crisis the course of disease |
| Treatment group | 4.93±0.62 | 1.17±0.33 | 3.87±0.53 | 5.08±0.41 |
| Matched group | 9.79±1.35 | 3.99±0.72 | 8.66±1.07 | 9.98±0.81 |
As can be seen from Table 1, compared with matched group, treatment group heating continuing time, tic dwell time, the disturbance of consciousness time and crisis the course of disease all have shortening, significant difference, have statistical significance.
Two groups of complication and sequela situation compare, and the results are shown in Table 2.
A situation arises for table 2 liang group complication and sequela
| Grouping | Respiratory failure | Sequela | Pneumonia | Digestive tract hemorrhage | Total incidence rate |
| Treatment group | 3 | 5 | 2 | 2 | 17.9％ |
| Matched group | 8 | 17 | 5 | 6 | 60％ |
Two groups of comparitive study, the results are shown in Table 3.
Table 3 liang group comparitive study
| Group | Cure | Take a turn for the better | Invalid | Total effective rate |
| Treatment group | 51 | 10 | 6 | 91.0％ |
| Matched group | 22 | 17 | 21 | 65.0％ |
As can be seen from Table 3, injection provided by the invention is adopted to coordinate western medicine, Be very effective in treatment epidemic encephalitis type B.
Untoward reaction: two groups are showed no obvious adverse reaction at viewing duration and occur.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. be used for the treatment of a Chinese medicine for epidemic encephalitis type B, it is characterized in that: crude drug comprises Radix Scrophulariae, Radix Angelicae Sinensis, Herba Dendrobii, Semen Euryales, Rhizoma Acori Calami, Flos Lonicerae, Strobilus Cupressi, Herba Hydrocotyles, Radix et Rhizoma Thalictri, Radix Talini Paniculati, Radix Liriopes, Rabdosia rubescens, Rhizoma Dioscoreae, Rhizoma Phragmitis, Fructus Xanthii, Fructus Schisandrae Sphenantherae, Herba Corydalis Bungeanae, Radix Puerariae, Radix Scutellariae, Virgin's milk mushroom and Radix Sophorae Tonkinensis.
2. Chinese medicine as claimed in claim 1, it is characterized in that: the weight portion of each crude drug is respectively Radix Scrophulariae 20 weight portion ~ 30 weight portion, Radix Angelicae Sinensis 35 weight portion ~ 45 weight portion, Herba Dendrobii 15 weight portion ~ 25 weight portion, Semen Euryales 30 weight portion ~ 40 weight portion, Rhizoma Acori Calami 15 weight portion ~ 25 weight portion, Flos Lonicerae 45 weight portion ~ 55 weight portion, Strobilus Cupressi 15 weight portion ~ 25 weight portion, Herba Hydrocotyles 20 weight portion ~ 30 weight portion, Radix et Rhizoma Thalictri 20 weight portion ~ 30 weight portion, Radix Talini Paniculati 30 weight portion ~ 40 weight portion, Radix Liriopes 25 weight portion ~ 35 weight portion, Rabdosia rubescens 20 weight portion ~ 30 weight portion, Rhizoma Dioscoreae 35 weight portion ~ 45 weight portion, Rhizoma Phragmitis 15 weight portion ~ 25 weight portion, Fructus Xanthii 20 weight portion ~ 30 weight portion, Fructus Schisandrae Sphenantherae 30 weight portion ~ 40 weight portion, Herba Corydalis Bungeanae 15 weight portion ~ 25 weight portion, Radix Puerariae 20 weight portion ~ 30 weight portion, Radix Scutellariae 40 weight portion ~ 50 weight portion, Virgin's milk mushroom 15 weight portion ~ 25 weight portion and Radix Sophorae Tonkinensis 20 weight portion ~ 30 weight portion.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that: the weight portion of each crude drug is respectively Radix Scrophulariae 23 weight portion ~ 27 weight portion, Radix Angelicae Sinensis 38 weight portion ~ 42 weight portion, Herba Dendrobii 18 weight portion ~ 22 weight portion, Semen Euryales 33 weight portion ~ 37 weight portion, Rhizoma Acori Calami 18 weight portion ~ 22 weight portion, Flos Lonicerae 48 weight portion ~ 52 weight portion, Strobilus Cupressi 18 weight portion ~ 22 weight portion, Herba Hydrocotyles 23 weight portion ~ 27 weight portion, Radix et Rhizoma Thalictri 23 weight portion ~ 27 weight portion, Radix Talini Paniculati 33 weight portion ~ 37 weight portion, Radix Liriopes 28 weight portion ~ 32 weight portion, Rabdosia rubescens 23 weight portion ~ 27 weight portion, Rhizoma Dioscoreae 38 weight portion ~ 42 weight portion, Rhizoma Phragmitis 18 weight portion ~ 22 weight portion, Fructus Xanthii 23 weight portion ~ 27 weight portion, Fructus Schisandrae Sphenantherae 33 weight portion ~ 37 weight portion, Herba Corydalis Bungeanae 18 weight portion ~ 22 weight portion, Radix Puerariae 23 weight portion ~ 27 weight portion, Radix Scutellariae 43 weight portion ~ 47 weight portion, Virgin's milk mushroom 18 weight portion ~ 22 weight portion and Radix Sophorae Tonkinensis 23 weight portion ~ 27 weight portion.
4. the Chinese medicine as described in claims 1 to 3, it is characterized in that: the weight portion of each crude drug is respectively Radix Scrophulariae 25 weight portion, Radix Angelicae Sinensis 40 weight portion, Herba Dendrobii 20 weight portion, Semen Euryales 35 weight portion, Rhizoma Acori Calami 20 weight portion, Flos Lonicerae 50 weight portion, Strobilus Cupressi 20 weight portion, Herba Hydrocotyles 25 weight portion, Radix et Rhizoma Thalictri 25 weight portion, Radix Talini Paniculati 35 weight portion, Radix Liriopes 30 weight portion, Rabdosia rubescens 25 weight portion, Rhizoma Dioscoreae 40 weight portion, Rhizoma Phragmitis 20 weight portion, Fructus Xanthii 25 weight portion, Fructus Schisandrae Sphenantherae 35 weight portion, Herba Corydalis Bungeanae 20 weight portion, Radix Puerariae 25 weight portion, Radix Scutellariae 45 weight portion, Virgin's milk mushroom 20 weight portion and Radix Sophorae Tonkinensis 25 weight portion.
5. the Chinese medicine as described in Claims 1-4, is characterized in that: described Chinese medicine is prepared into injection.
6. the preparation method of Chinese medicine described in claim 1 to 5, is characterized in that, comprising:
The first step, chooses Radix Scrophulariae, Radix Angelicae Sinensis, Herba Dendrobii, Semen Euryales, Radix Talini Paniculati, Radix Liriopes, Rhizoma Dioscoreae and Fructus Schisandrae Sphenantherae, is pulverized respectively by these crude drug compositions, loads in supercritical extraction tank, under 20 ~ 30MPa, 30 ~ 50 DEG C of conditions, uses supercritical CO
2extract 3 ~ 5h and carry out supercritical extraction, obtain extract for subsequent use;
Second step, pulverizes respectively by remaining crude drug composition, mixing, and with the alcohol reflux 3 times of the determining alcohol 50% ~ 70% of the mixture quality obtained relative to this step 6 ~ 8 times, each 2 hours, merge extractive liquid, filtered; Filtrate is adjusted to pH5.5 ~ 7 by NaOH solution, leaves standstill, filter, decompression filtrate recycling ethanol, to without alcohol taste, leaves standstill, centrifugalize, the supernatant after centrifugalize, and the heating relative density be concentrated at 50 DEG C ~ 60 DEG C is the mastic of 1.08 ~ 1.13;
3rd step, take a morsel water for injection, adds 3 ~ 8g tween 80 and 5 ~ 10g sodium chloride, stirring and dissolving, add the extract of first step acquisition and the mastic of second step acquisition again, stirring and dissolving, filters, injects water to 1000mL, adjust pH to 4.0 ~ 7.0, fine straining, embedding, sterilizing and get final product.
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| CN1579467A (en) * | 2003-08-12 | 2005-02-16 | 杨荣 | Anti-virus medicine |
| CN102846753A (en) * | 2011-06-30 | 2013-01-02 | 苏州知微堂生物科技有限公司 | Preparation process of integration-type novel formulation of Radix Puerariae, Rhizoma Coptidis and Scutellaria baicalensis decoction and production method thereof |
| CN104225497A (en) * | 2014-10-08 | 2014-12-24 | 张文艳 | Traditional Chinese medicinal pill for treating epidemic encephalitis B |
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2015
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|---|---|---|---|---|
| CN1579467A (en) * | 2003-08-12 | 2005-02-16 | 杨荣 | Anti-virus medicine |
| CN102846753A (en) * | 2011-06-30 | 2013-01-02 | 苏州知微堂生物科技有限公司 | Preparation process of integration-type novel formulation of Radix Puerariae, Rhizoma Coptidis and Scutellaria baicalensis decoction and production method thereof |
| CN104225497A (en) * | 2014-10-08 | 2014-12-24 | 张文艳 | Traditional Chinese medicinal pill for treating epidemic encephalitis B |
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