CN1579467A - Anti-virus medicine - Google Patents
Anti-virus medicine Download PDFInfo
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- CN1579467A CN1579467A CN 03153385 CN03153385A CN1579467A CN 1579467 A CN1579467 A CN 1579467A CN 03153385 CN03153385 CN 03153385 CN 03153385 A CN03153385 A CN 03153385A CN 1579467 A CN1579467 A CN 1579467A
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Abstract
The invention discloses an anti-virus medicine, which can be used to cure virus infecting diseases including SARS. Its ingredients include Chinese traditional medicine honeysuckle, banlangen, bupleurum root, and large-flowered skullcap root. The invention can use normal process to produce then into powder, tablet, pill, capsule or particles, and injection solution and so on. The preference is injection solution.
Description
Technical field
The present invention relates to be used for the treatment of the medicine of disease of viral infection, or claim antiviral drugs.It specifically is the Chinese patent medicine of feedstock production with Chinese herbal medicine.
Background technology
Modern medicine generally is to find out (or carrying out analytical judgment) infected microorganism of human body for infectious disease, selects suitable antibiotic drug to eliminate it.Virus is the class in the multiple pathogenic microorganism." viral infection " is main clinical manifestation with the heating, and patient's hemogram detects total white blood cells not to be increased, even reduce, lymphocyte is often higher.For viral infection, contemporary medical science also has two hang-ups: 1. aspect diagnosis, the viral species that causes people's morbidity is a lot, and in clinical treatment, it is difficult that each prescription on individual diagnosis patient is detected evaluation Causative virus species, unpractical in other words conj.or perhaps.And virus of the same race is developmental biology variation constantly also, has more increased the difficulty of viral detection and antiviral therapy; 2. suffering from does not have specific medicament.Helplessly, often impose to alleviate symptomatic treatment that patient's misery is a purpose and to be the supporting treatment of purpose with enhancing human body immunity power.
Spring in 2003, international scientific circle confirmation was that the mutation of coronavirus causes, is a kind of disease of viral infection in the popular severe acute respiratory syndromes of a plurality of provinces and cities of China (SARS).For the also not effective especially medicine of the coronavirus that causes severe acute respiratory syndrome.
The theoretical system and the modern medical theory of the traditional Chinese medical science differ widely, and to the heating being the disease of main performance clinically, under the situation that pathogen is failed to understand, by the theory of Chinese medical science determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, still can obtain good efficacy.For the disease of viral infection that comprises severe acute respiratory syndrome, according to its ubiquitous symptom, sign, undertaken dialectically by theory of Chinese medical science, be real valid approach by theory of Chinese medical science prescription, pharmacy, enforcement treatment.I constantly carry out the research and the laboratory observation of Chinese medicine viral infection resisting in traditional medical practice for many years, obtained the technological achievement that comprises the present invention.
Summary of the invention
The technical problem to be solved in the present invention is, a kind of antiviral function that has is provided, and to being the Chinese patent medicine that the disease of viral infection of main performance extensively is suitable for clinically with the heating, is specially adapted to treatment and prevention to severe acute respiratory syndrome.
Task of the present invention realizes by following technical scheme.
The component of medicine of the present invention comprises following Chinese herbal medicine crude drug kind, and the consumption proportion of each crude drug is expressed as follows with weight portion:
Flos Lonicerae 12～25 Radix Isatidis 8～15 Radix Bupleuri 8～15 Radix Scutellariaes 6～12
The preferable amount proportioning of each crude drug is expressed as follows with weight portion:
Flos Lonicerae 15～20 Radix Isatidis 10～12 Radix Bupleuri 10～12 Radix Scutellariaes 8～10
The optimum amount proportioning of each crude drug is expressed as follows with weight portion:
Flos Lonicerae 20 Radix Isatidis 10 Radix Bupleuri 10 Radix Scutellariaes 9
More than Pei Fang crude drug can adopt common process to make said multiple dosage form on the pharmaceutics, comprises dosage forms such as powder, tablet, the watered pill, capsule, granular pattern electuary, oral liquid, injection.Injection preferably.Medicament especially for preparation treatment and infection prevention atypical pneumonia.
More than various dosage forms each dosage of being grown up be equivalent to various crude drug gross weights 40～80 grams approximately, injection medication every day 1～2 time, peroral dosage form medication every day 2～3 times, general logotype 7～14 days was a course of treatment.
Pharmaceutical formulation of the present invention is not on the books in the classic of TCM.The inventor is undertaken dialectical by theory of Chinese medical science according to the ubiquitous symptom of disease of viral infection, sign,, by the types of drugs compatibility, constitute " monarch, minister, help, make " in conjunction with the understanding to the several kinds of Chinese medicinal materials property of medicine and organically combine, and makes Chinese patent medicine of the present invention.Wherein Flos Lonicerae is a principal agent, has the effect of heat-clearing and toxic substances removing, anti-inflammation; Radix Isatidis is auxilliary, and the effect of antiviral, heat-clearing and toxic substances removing is arranged; Radix Bupleuri clearing away heat and expelling pathogen in the exterior, soothing the liver reason lung strengthen Flos Lonicerae and the antiviral effect of Radix Isatidis; Radix Scutellariae rushes down the fire of three warmers, moves back innominate high fever.Four kinds of Chinese medicines can be removed heating, headache, pharyngalgia, cough that viral infection causes by the above-mentioned usage ratio preparation of the present invention patent medicine, are applicable to the treatment of parotitis, influenza, encephalitis B, severe acute respiratory syndrome.
Obtained confirmation in the EXPERIMENTAL EXAMPLE that the good result of medicine of the present invention on the treatment disease of viral infection put down in writing hereinafter.
The 65 routine curative effect checkings of EXPERIMENTAL EXAMPLE compound honeysuckle injection for treating viral pneumonia
The inventor uses preparation of the present invention---and the over one hundred example of compound honeysuckle injection for treating viral pneumonia obtains good result.For improving the science of checking, the inventor has also carried out contrast treatment viewing test.During this period, the prescription on individual diagnosis patient by 2: 1 randomized blocks, is entered compound honeysuckle injection for treating group (to call " treatment group " in the following text) and traditional method treatment group (to call " matched group " in the following text) respectively.The treatment group meets experimental design, includes case meter 65 examples of statistical analysis in; Matched group meets experimental design, includes case meter 24 examples of statistical analysis in.Two combination meter cases are totally 89 examples, and checking is the result be reported as follows.
(1) clinical data and case selection standard
1. sex, age and the course of disease distribute
In laboratory observation 89 examples, male's 46 examples, women's 43 examples; Age reckling 1 years old, the maximum 75 years old.The course of disease is the shortest 8 days, the longest 20 days before going to a doctor, average 14 days.Wherein most at 10～14 days.Its sex, age and the course of disease distribute and see Table 1.This group case course of disease is generally longer, is the important difference of viral pneumonia and bacterial pneumonia.Treatment group and matched group do not have marked difference on sex, age and the course of disease distribute, two groups have comparability widely.
Table 1 89 routine patients' sex, age and the course of disease distribute
| Group | Add up to | Sex | Age (year) | The course of disease (my god) | |||||
| The man | The woman | ??1～15 | ??16～45 | ??46～75 | ??8～10 | ?11～15 | ?16～20 | ||
| The treatment group | ??65 | ?34 | ?31 | ???18 | ????27 | ????20 | ???18 | ???26 | ???21 |
| Matched group | ??24 | ?12 | ?12 | ???8 | ????10 | ????6 | ???7 | ???11 | ???6 |
| Add up to | ??89 | ?46 | ?43 | ???26 | ????37 | ????26 | ???25 | ???37 | ???27 |
2. main clinical manifestation and case selection standard:
The cardinal symptom of this group case has heating, headache, pharyngalgia, cough, chest pain, asthma, and severe patient has dyspnea, even cyanosis.In fervescence, blood pressure is normal or on the low side, and pulse is slow relatively.
Press Chinese medical discrimination, all case diseases all belong to the hot category of the dryness of the lung.The dry cold of winter-spring season, " cold in an extreme giving rise to heat, heat in its extreme giving rise to cold ", morbidity easily.When resistance of human body was low, scorching heresy was taken advantage of a weak point, and The chill entered into the very flesh of the men, made the skin obturation, and pathogen can not foreign promotion, and in pathogenic heat was stranded in, scorching heresy is impairing the lung easily, then clear QI failing to ascend, and out of breath, the dyspnea of cough with asthma appears in turbid QI failing to descend.
The case selection standard: clinical manifestation when going to a doctor according to patient and check result meet following standard person and are diagnosed as viral pneumonia, classify the treatment object of observation as.Finish treatment plan, data is put down in writing complete person and is included the statistical analysis case in.
(1) cough, chest pain, asthma symptom are arranged;
(2) body temperature 〉=38 ℃;
(3) the blood test total white blood cells is normal or on the low side, and lymphocyte raises;
(4) the X ray examination bronchus both sides and two lobes of the lung have large stretch of consolidation shade, can be with hydrothorax.
(2) Therapeutic Method
1. treatment group Therapeutic Method: use by 20 milliliters of the compound honeysuckle injection of the embodiment of the invention 1 method preparation, join in 500 milliliters of 5% glucoses intravenous drip, every day 1～2 time; The simultaneously oral compound honeysuckle capsule of pressing the preparation of embodiment 2 methods, each 2～3,3 times on the 1st.More than be general adult's consumption, for child's dosage that then cuts down according to the circumstance.
Continuous use 7 days was a course of treatment.One course of treatment end did not reach recovery from illness standard person and continued for second course of treatment.Result with second course of treatment end carries out statistical analysis.
2. treatment of control group method: by traditional bring down a fever, antibiotic, antiinflammatory handles.
(1) cooling: oral antipyretic or Physical temperature-lowering.
(2) antibiotic, antiinflammatory: the intramuscular injection of penicillin injection liquid, each 800,000 units, every day 3 times; Or intravenous drip penicillin 4,800,000 units～8,000,000 units, every day 1～2 time.While oral antibiotic class medicine is as oxytetracycline, spiramycin, penicillin sheet etc.
(3) hormone medicine: the case higher to body temperature, that symptom is heavier takes the circumstances into consideration to use 100 milligrams of hydrocortisones, or 10～15 milligrams of dexamethasone, intravenous drip.
Above Therapeutic Method was a course of treatment in continuous 7 days.One course of treatment end did not reach recovery from illness standard person and continued for second course of treatment.Result with second course of treatment end carries out statistical analysis.
(3) curative effect determinate standard
All cases of including statistical analysis in by following standard, are divided into recovery from illness, effective, invalid Three Estate.
1. recovery from illness: meet following condition person simultaneously and be judged to recovery from illness.
1. body temperature is above for three days on end in normal range;
2. clinical symptoms complete obiteration or basic disappearance;
3. blood test and X ray examination are normal substantially.
2. effective: as to have one of following condition person and be judged to effectively.
1. body temperature reduces, but abnormal fully;
2. clinical symptoms totally alleviates, and can have partial symptoms to disappear;
3. blood test and X ray examination index take a turn for the better.
3. invalid: heating is not moved back, and clinical symptoms and blood test, X ray examination have no significant change.
(4) interpretation of result
Treatment group case is sx after medication 1 course of treatment generally, stable disease.2 course cure rates reach 82.7%, and total effective rate reaches 96.9%, and cure rate and total effective rate all are significantly higher than matched group, see Table 2.
Table 2 curative effect statistical analysis
| Group | Add up to | Total effective rate | Recovery from illness | Effectively | Invalid | ||||
| Example | ???％ | Example | ???％ | Example | ??％ | Example | ???％ | ||
| The treatment group | ??65 | ??63 | ??96.9 | ??57 | ??82.7 | ?6 | ??9.2 | ??2 | ???3.1 |
| Matched group | ??24 | ??10 | ??41.6 | ??6 | ??25.0 | ?4 | ??16.6 | ??14 | ???58.3 |
Most of case in the invalid case of the last listed matched group of table is used compound honeysuckle injection for treating of the present invention again instead and is obtained good result behind laboratory observation, this paper does not remake discussion.
The specific embodiment
The invention will be further described by the following examples.
Embodiment 1 preparation compound honeysuckle injection
Take by weighing Flos Lonicerae 2000 grams, carry secondary with decocting in water, concentrating under reduced pressure, accent PH is a strong basicity, the leaching precipitation, under agitation add ethanol, make its suspendible, it is acid transferring PH, stirs, filters, and it is neutral transferring PH, filter, reclaim ethanol, concentrate, get about 1000 milliliters of Flos Lonicerae extractive solution, cold preservation is standby;
Take by weighing Radix Isatidis 1000 grams, carry secondary, filter extracting solution, merging filtrate with decocting in water, add dense ethanol, cold preservation, sucking filtration, decompression recycling ethanol, cold preservation is filtered, and must clarify concentrated solution, under agitation dropping ammonia, making PH is 8.5～9.0, the airtight placement of cold preservation, sucking filtration, the filtrate heating is stirred to the ammonia flavor and disappears, and making PH is 5.5～6.0, get about 500 milliliters of isatis root extract, cold preservation is placed, and is standby.
Take by weighing Radix Bupleuri 1000 grams, carry secondary, filter extracting solution with decocting in water, merging filtrate, concentrating under reduced pressure, the cooling back adds dense ethanol, cold preservation, leaching filtrate, precipitation, use washing with alcohol, merge washing liquid and filtrate, reclaim ethanol, cold preservation, the leaching clear liquor gets about 500 milliliters of Radix Bupleuri extracting solution, cold preservation is placed, and is standby.
Take by weighing Radix Scutellariae 900 grams, carry secondary, filter extracting solution with decocting in water, merging filtrate, concentrating under reduced pressure, the cooling back adds dense ethanol, cold preservation, leaching filtrate, precipitation, use washing with alcohol, merge washing liquid and filtrate, reclaim ethanol, cold preservation, the leaching clear liquor gets about 500 milliliters of Radix Scutellariae extracting solution, cold preservation is placed, and is standby.
Merge above four kinds of Chinese medicine extraction liquid, mix homogeneously is bottled behind fine straining, and 20 milliliters every, evacuation seals.Take the wet heating sterilization, be about to bottle and place 100 ℃ of boiled water sterilizations 30 minutes.
The Flos Lonicerae injection made from said method is an aqueous solution injection, and per 20 milliliters of medicinal liquids are equivalent to about 40.0 grams of crude drug in whole.Intravenous drip is first-selected administrated method, also can do intramuscular injection.The suitable consumption of intravenous drip is each 20～40 milliliters, medication every day 1～2 time.
Embodiment 2 preparation compound honeysuckle capsules
Take by weighing Flos Lonicerae 2000 grams, Radix Isatidis 1200 grams, Radix Bupleuri 1100 grams, Radix Scutellariae 800 grams.Each medicine soaked after 2 hours decoct each 1 hour 2 times.Merge each each time of medicine filtrate, be concentrated into relative density 1.05～1.10 (50 ℃ of mensuration), remove water extract impurity, decompression recycling ethanol with the method for 70% ethanol precipitation.Vacuum drying becomes dry extract, pulverizes, and sieves dry (below 60 ℃), encapsulated about 200.Each oral 2～3 of general adult, 3 times on the 1st.
Embodiment 3 preparation compound honeysuckle tablets
Take by weighing Flos Lonicerae 2400 grams, Radix Isatidis 900 grams, Radix Bupleuri 1200 grams, Radix Scutellariae 1000 grams.Each medicine merged to soak decoct each 1 hour 2 times after 3 hours.Merging filtrate, being concentrated into relative density is 1.05～1.10 (50 ℃ of mensuration), removes water extract impurity, decompression recycling ethanol with the method for 70% ethanol precipitation.Vacuum drying becomes dry extract, pulverizes, and sieves dry (below 60 ℃), about 200 of tabletting.Each oral 3 of general adult, 3 times on the 1st.
Embodiment 4 preparation compound infusion of honeysuckle flowers
Take by weighing Flos Lonicerae 1500 grams, Radix Isatidis 1200 grams, Radix Bupleuri 1200 grams, Radix Scutellariae 1000 grams.Each medicine merges and adds water saturates, decocts 3 times, and each 1 hour, get decoction liquor and filter merging, heating is condensed into clear paste, and drying and crushing gets drug powder and excipient mixing, is that wetting agent is granulated with 95% ethanol, oven dry, about 100 bags of packing.Each oral 1 bag of general adult, 2 times on the 1st.
Claims (9)
1. a medicine that is used for the treatment of disease of viral infection is characterized in that, it is the medicament of being made by the crude drug that comprises following weight proportioning (weight portion):
Flos Lonicerae 12～25 Radix Isatidis 8～15 Radix Bupleuri 8～15 Radix Scutellariaes 6～12
2. the weight proportion (weight portion) of described each crude drug of medicine of claim 1 is,
Flos Lonicerae 15～20 Radix Isatidis 10～12 Radix Bupleuri 10～12 Radix Scutellariaes 8～10
3. the weight proportion (weight portion) of described each crude drug of medicine of claim 1 is,
Flos Lonicerae 20 Radix Isatidis 10 Radix Bupleuri 10 Radix Scutellariaes 9
4. according to the medicine of claim 1,2 or 3 described treatment diseases of viral infection, it is characterized in that said medicament is a said dosage form on any pharmaceutics.
5. the medicine of treatment disease of viral infection according to claim 4 is characterized in that, said medicament is an injection.
6. the medicine of treatment disease of viral infection according to claim 4 is characterized in that, said medicament is a capsule.
7. the medicine of treatment disease of viral infection according to claim 4 is characterized in that, said medicament is a tablet.
8. the medicine of treatment disease of viral infection according to claim 4 is characterized in that, said medicament is the granular pattern electuary.
9. claim 1, the application of 2 or 3 described medicines in the medicament of preparation treatment and infection prevention atypical pneumonia.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03153385 CN1259929C (en) | 2003-08-12 | 2003-08-12 | Anti-virus medicine |
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| CN 03153385 CN1259929C (en) | 2003-08-12 | 2003-08-12 | Anti-virus medicine |
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| CN1259929C CN1259929C (en) | 2006-06-21 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095721B (en) * | 2007-07-12 | 2011-10-05 | 辽宁省海洋水产科学研究院 | Sea cucumber Chinese medicinal herb preparations for preventing diseases and increasing the weight |
| CN101327250B (en) * | 2007-06-22 | 2011-11-09 | 深圳市北科联药业科技有限公司 | Suppositorium for treating fever in children and preparation method thereof |
| CN101698005B (en) * | 2009-11-25 | 2011-12-14 | 河南太龙药业股份有限公司 | Gold granules used for treating cold and influenza and preparation method thereof |
| CN102379920A (en) * | 2010-09-06 | 2012-03-21 | 北京大北农动物保健科技有限责任公司 | Veterinary antiviral and antifebrile drug composition |
| CN104352743A (en) * | 2014-11-18 | 2015-02-18 | 郝建友 | Injection for treating epidemic parotitis and preparation method of injection |
| CN104623355A (en) * | 2015-01-07 | 2015-05-20 | 青岛市第三人民医院 | Traditional Chinese medicine for treating epidemic encephalitis B |
| CN111228366A (en) * | 2020-03-18 | 2020-06-05 | 上海馨和文化发展有限公司 | Traditional Chinese medicine composition for treating viral pneumonia |
| CN111298049A (en) * | 2020-04-22 | 2020-06-19 | 南昌大学第一附属医院 | Traditional Chinese medicine composition for treating novel coronavirus pneumonia and application thereof |
-
2003
- 2003-08-12 CN CN 03153385 patent/CN1259929C/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101327250B (en) * | 2007-06-22 | 2011-11-09 | 深圳市北科联药业科技有限公司 | Suppositorium for treating fever in children and preparation method thereof |
| CN101095721B (en) * | 2007-07-12 | 2011-10-05 | 辽宁省海洋水产科学研究院 | Sea cucumber Chinese medicinal herb preparations for preventing diseases and increasing the weight |
| CN101698005B (en) * | 2009-11-25 | 2011-12-14 | 河南太龙药业股份有限公司 | Gold granules used for treating cold and influenza and preparation method thereof |
| CN102379920A (en) * | 2010-09-06 | 2012-03-21 | 北京大北农动物保健科技有限责任公司 | Veterinary antiviral and antifebrile drug composition |
| CN104352743A (en) * | 2014-11-18 | 2015-02-18 | 郝建友 | Injection for treating epidemic parotitis and preparation method of injection |
| CN104623355A (en) * | 2015-01-07 | 2015-05-20 | 青岛市第三人民医院 | Traditional Chinese medicine for treating epidemic encephalitis B |
| CN111228366A (en) * | 2020-03-18 | 2020-06-05 | 上海馨和文化发展有限公司 | Traditional Chinese medicine composition for treating viral pneumonia |
| CN111228366B (en) * | 2020-03-18 | 2021-08-31 | 上海馨和文化发展有限公司 | Traditional Chinese medicine composition for treating viral pneumonia |
| CN111298049A (en) * | 2020-04-22 | 2020-06-19 | 南昌大学第一附属医院 | Traditional Chinese medicine composition for treating novel coronavirus pneumonia and application thereof |
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| CN1259929C (en) | 2006-06-21 |
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