CN104623291A - Traditional Chinese medicine for treating peptic ulcer - Google Patents
Traditional Chinese medicine for treating peptic ulcer Download PDFInfo
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- CN104623291A CN104623291A CN201510017393.1A CN201510017393A CN104623291A CN 104623291 A CN104623291 A CN 104623291A CN 201510017393 A CN201510017393 A CN 201510017393A CN 104623291 A CN104623291 A CN 104623291A
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Abstract
The invention relates to the field of traditional Chinese medicine application and particularly discloses a traditional Chinese medicine for treating peptic ulcer. The traditional Chinese medicine for treating peptic ulcer is prepared by mixing the following raw materials including Chinese clinopodium herbs, girald pteroxygonum roots, lotus rhizome nodes, radix melastomae, hairyvein agrimony, rhizoma bletillae, humus flava usta, folium loropetali, Chinese trumpet creeper, semen impatientis, phyllanthus reticulate, sargentgloryvine stems, caesalpinia minax hance, tamariskoid spikemoss herbs, albizia flowers and pearls according to a certain weight ratio. The traditional Chinese medicine is simple in preparation, good in absorption effect, long in medicinal effect lasting time, remarkable in curative effect, free of side effects, high in safety, low in production cost and beneficial to relief of symptoms of patients in time.
Description
(1) technical field
The present invention relates to application in TCM field, particularly a kind of Chinese medicine for the treatment of peptic ulcer.
(2) background technology
Peptic ulcer (peptic ulcer, PU) be a kind of commonly encountered diseases, frequently-occurring disease of digestive system, main finger betides the duodenal chronic ulcer of harmonization of the stomach, also lower esophageal can be betided, Meike that diverticulum around stomach intestinal anastomosis mouth and containing Ectopic Gastric Mucosa, the formation of these ulcer is relevant with pepsic Digestion with gastric acid, therefore claims peptic ulcer.Primary disease is with epigastrium pain repeatedly, and alimentary canal mucous membrane, muscle layer and placenta percreta suffer damage as feature, and Chinese medicine belongs to the category such as " stomachache ", " gastric abscess ", " noisy ", " acid regurgitation ".In recent years, along with the extensive use of proton pump inhibitor, bisfentidine, substantially increase the recent healing rate of ulcer, but ulcer easily recurs and is still clinical a great problem urgently to be resolved hurrily.
Modern medicine is clear and definite to peptic ulcer diagnosis, and short term efficacy is also good, mainly apply proton pump inhibitor, bisfentidine, three of combined with antibiotic, the treatment etc. of quadruple chemotherapy and eradicate helicobacter pylori.Simple Drug therapy all can improve the clinical symptoms of ulcers to some extent, but due to side effect large, patient is difficult to tolerance, and easily recurs after drug withdrawal, does not filter out generally acknowledged medicine safely and effectively so far yet.Therefore how to improve QOUH, prevention ulcer recurrence has become the focus studied the present age, although done a large amount of research work abroad, but often study from unification and point to start with, and it is relatively less for the research of compound effective ingredient, therefore develop new effective treatment peptic ulcer, the medicine improving Ulcer cicatrization quality has become the urgent technical problem solved.
(3) summary of the invention
The present invention, in order to make up the deficiencies in the prior art, provides and a kind ofly prepares a kind of Chinese medicine for the treatment of peptic ulcer simple, evident in efficacy.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine for peptic ulcer, be made up of the Chinese medicine of following parts by weight:
Herba Clinopodii 6-15 gram, Radix Polygoni Ciliinerve 5-16 gram, Nodus Nelumbinis Rhizomatis 5-15 gram, Herba Melastomatis dodecandri root 5-17 gram, Herba Agrimoniae 6-17 gram, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-15 gram, Terra Flava Usta 5-17 gram, Folium Loropetali 5-16 gram, Flos Campsis 5-17 gram, Semen Impatientis 6-15 gram, snapper eye 5-16 gram, Caulis Sargentodoxae 5-15 gram, Semen Caesalpiniae Minacis 4-16 gram, Herba Selaginellae 4-15 gram, Flos Albiziae 4-16 gram, Margarita 0.5-1.5 gram.
The weight proportion of its preferred each raw material is:
Herba Clinopodii 6 grams, Radix Polygoni Ciliinerve 5 grams, Nodus Nelumbinis Rhizomatis 5 grams, Herba Melastomatis dodecandri root 5 grams, Herba Agrimoniae 6 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 3 grams, Terra Flava Usta 5 grams, Folium Loropetali 5 grams, Flos Campsis 5 grams, Semen Impatientis 6 grams, snapper eye 5 grams, Caulis Sargentodoxae 5 grams, Semen Caesalpiniae Minacis 4 grams, Herba Selaginellae 4 grams, Flos Albiziae 4 grams, Margarita 0.5 gram.
Chinese medicine of the present invention is powder or pill, after being cleaned up by various raw material, plays powder mixing, makes powder or pill quantitative is taken.
Wherein the pharmaceutical characteristic of each raw material is:
Herba Clinopodii: astringing to arrest bleeding, belongs to the astringent hemostatic of hemorrhage subordinate classification;
Radix Polygoni Ciliinerve: hemostasis, invigorates blood circulation, nourishes blood, dysentery relieving, convergence pain relieving; Belong to the astringent hemostatic of hemorrhage subordinate classification; Tuber, containing condensed tannin, still contains phenols, saponin, protein, saccharide, phlegmatic temperament etc.; Pharmacological evaluation shows: 40% ethanol extract and the decocting liquid of Radix Polygoni Ciliinerve have antibacterial action; Significantly can shorten clotting time and the bleeding time of rabbit.
Nodus Nelumbinis Rhizomatis: astringing to arrest bleeding, blood stasis dispelling; Belong to the astringent hemostatic of hemorrhage subordinate classification; Using fresh herb energy clearing away heat and cooling blood, charcoal (calcined) repercussive stops blooding, and astriction is comparatively strong, can shorten the bleeding time.
Herba Melastomatis dodecandri root: promoting blood circulation to remove obstruction in the collateral, astringing to arrest bleeding; Belong to the astringent hemostatic under hemorrhage classification.
Herba Agrimoniae: astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances; Belong to the astringent hemostatic of hemorrhage subordinate classification, containing agrimonine, red crowned crane lactone, tannin, sterol, organic acid, phenolic constituent, saponin, flavonoid glycoside etc.; Herba Agrimoniae have hemostasis, adjustment heart rate, increases cell resistance power, reduces the effect such as blood glucose and antiinflammatory; Hibernaculum is containing phenolic substance crane bud phenol, and hibernaculum and root have stronger expelling tenia effect, all have inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus, shigella flexneri, Bacillus typhi.
Pseudobulbus Bletillae (Rhizoma Bletillae): astringing to arrest bleeding, detumescence and promoting granulation; Belong to the astringent hemostatic of hemorrhage subordinate classification; Containing Pseudobulbus Bletillae (Rhizoma Bletillae) colloid (being the glucomannan be made up of 4 parts of mannose and 1 part of glucose) starch, glucose, lymphatic temperament and anthraquinone analog compound physcione; Extract has good anastalsis to laboratory animal, may be relevant with contained gelling ingredient, and action principle may be physical property; 2% Pseudobulbus Bletillae (Rhizoma Bletillae) glucose injection does intraperitoneal injection test, has obvious inhibitory action to the rat liver cancer that DAB brings out.
Terra Flava Usta: astringing to arrest bleeding, warming middle-JIAO to arrest vomiting, antidiarrheal; Belong to the astringent hemostatic of hemorrhage subordinate classification; Main containing silicic acid, aluminium oxide and iron sesquioxide, also containing sodium oxide, potassium oxide, calcium oxide, magnesium oxide, calcium phosphate etc.; This product has preventing or arresting vomiting effect, and vomiting number of times can be made to reduce to pigeon vomiting caused by quiet note digitalis tincture, the incubation period of vomiting is without change; But the vomiting caused Apomorphinum is invalid.
Folium Loropetali: heat-clearing and toxic substances removing, convergence, hemostasis; Belong to the astringent hemostatic of hemorrhage subordinate classification; Leaf is containing tannin, gallic acid and flavones ingredient; It is reported again, from the flavones ingredient of leaf, isolate Quercetin; In addition, leaf is still containing reducing sugar, glycoside and phenolic substance; There is antibacterial and uterine contraction effect, have impact to cardiovascular; The tannic acid of this product and derivant thereof have coagulation sedimentation effect to protein or serum, can shrink blood capillary and promote blood coagulation.
Flos Campsis: circulation of qi promoting blood stasis dispelling, cooling blood, expelling wind; Belong to the blood-activating and menstruation-regulating medicinal of drug for invigorating blood circulation and eliminating stasis subordinate classification; Containing flavonoid, organic acid, actinidine, Herba Boschniakiae Rossicae alkali etc.; Inhibitory action is had to shigella flexneri and Bacillus typhi.
Semen Impatientis: removing blood stasis softening the hard mass, removing food stagnancy; Belong to the medicinal for breaking blood stasis and eliminating mass of drug for invigorating blood circulation and eliminating stasis subordinate classification; Containing compositions such as balsaminasterol, saponin, flavone; Tincture, decoct and water logging agent have obvious excitation to unpregnancy rabbit isolated uterine and unpregnancy, pregnant each phase guinea pig in vitro uterus, and show as the rhythm and pace of moving things and shrink and speed, tensity increases even tetanic contraction; Anesthetized rabbit uterus in place test, vein or intramuscular injection water logging agent 0.05 ~ 0.3 gram/kilogram can make UT increase, and shrink and accelerate; To isolated rabbit intestinal, water logging agent or tincture are then inhibitory action; The oral decoct of female mice 10 days, has remarkable contraceptive efficacy, and can suppress to oestrus, and reduces the weight in ovary and uterus.
Snapper eye: expelling wind and activating blood circulation, dissipating blood stasis for subsidence of swelling; Belong to the blood-activating analgesic of drug for invigorating blood circulation and eliminating stasis subordinate classification.
Caulis Sargentodoxae: heat-clearing and toxic substances removing, promoting blood circulation by removing wind, pain relieving; Belong to the blood-activating analgesic of drug for invigorating blood circulation and eliminating stasis subordinate classification; Containing emodin, physcione, daucosterol, cupreol, stearic acid, salidroside, Liriodendrin; Zoopery shows, water extracting alcohol hypostasis can improve hypoxia-bearing capability, weakens heart contracting power, decreased heart rate, minimizing cardiac output, alleviate myocardial infarction and degree of myocardial ischemia, improve myocardial lactate metabolism disorder caused by myocardial infarction, the effect of the direct coronary artery dilator of tool, to gastrointestinal smooth muscle tool inhibitory action, also have blood pressure lowering, increase the effect of cAMP and cGMP content in blood.
Semen Caesalpiniae Minacis: dissipating blood stasis, pain relieving, heat clearing away, to dry; Belong to the blood-activating analgesic of drug for invigorating blood circulation and eliminating stasis subordinate classification.
Herba Selaginellae: blood circulation promoting and blood stasis dispelling, hemostasis; Belong to the blood-activating and menstruation-regulating medicinal of drug for invigorating blood circulation and eliminating stasis subordinate classification; Containing flavone, phenolic constituent and the polysaccharide such as aminoacid, trehalose, and a small amount of tannin; Flavone component has apigenin, amentoflavone, hinokiflavone and isocryptomerin.
Flos Albiziae: resolving stagnation for tranquilization; Belong to the medicine for nourishing the heart and tranquilizing the mind of sedative subordinate classification.
Margarita: arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation; Belong to the settling tranquilizer of sedative subordinate classification; Main containing calcium carbonate, and containing the inorganic elements such as more than 20 seed amino acids and sodium, magnesium, potassium, strontium; Experiment shows, Margarita hydrolyzed solution has delaying senility function, obviously can reduce old rats SOD active, reduces LPO and generates, reduce the content of lipofuscin; Its extract PFC has antioxidation, can suppress radical reaction.
In formula, Herba Clinopodii, Herba Agrimoniae, Terra Flava Usta are used for astringing to arrest bleeding, warming middle-JIAO to arrest vomiting; Add and join Radix Polygoni Ciliinerve, Herba Melastomatis dodecandri root, Folium Loropetali, Pseudobulbus Bletillae (Rhizoma Bletillae) for the blood coagulation detumescence and promoting granulation that stops blooding; Join again Semen Caesalpiniae Minacis, Herba Selaginellae, Semen Impatientis for dissipating blood stasis, pain relieving, heat clearing away, damp eliminating.
The present invention is with astringing to arrest bleeding, detumescence and promoting granulation, heat-clearing and toxic substances removing for the rule for the treatment of, and multiple medical material combination is collaborative, and be mainly used in removing pathogenic heat from blood and toxic substance from the body, removing blood stasis softening the hard mass, blood circulation promoting and blood stasis dispelling, astringing to arrest bleeding, have significant therapeutic effect to peptic ulcer.
Clinical observation:
(1) clinical data
The present inventor in 2010 so far, carries out clinical observation treatment to 274 routine Peptic Ulcers, wherein, and male 205 example, women 69 example.
(2) Therapeutic Method
Oral, three times on the one, each 2 ~ 5g, one after each meal.Calculate treatment time according to conditions of patients weight, slight Peptic Ulcers takes healing in 10 ~ 15 days, and severe case serve on 20 ~ 60 and cures.
(3) curative effect determinate standard
Criterion of therapeutical effect is with reference to criterion of therapeutical effect relevant in " disease of tcm judgement criterion of therapeutical effect ".
Cure:
1. clinical symptom disappearance, appetite is normal, and gastric acid secretion is normal.
2. gastroscope finding ulcer healing and mucosal tissue change basic recovery normally.
Effective:
1. symptom substantially disappears or alleviates, and gastric acid secretion is close to normal.
2. gastroscope finding ulcer and mucosal tissue change alleviate, or ulcer range shorter reaches more than 50%.
Effective:
1. symptom alleviates, and reduces when gastric acid secretion is comparatively fallen ill.
2. gastroscope finding ulcer and mucosal tissue change alleviate, or ulcer range shorter.
Invalid:
1. symptom does not alleviate, and gastric acid secretion is still higher.
2. gastroscope finding ulcer and mucosal tissue unchanged, ulcer scope has no and reduces, and even expands.
(4) clinical effectiveness
Clinical cure 215 example (78.47%), effective 39 examples (14.23%), effective 17 examples (6.21%), invalid 3 examples (1.09%), total effective rate is 98.91%.
The present invention prepares simply, good absorbing effect, and duration of efficacy is long, evident in efficacy, has no side effect, and safety is high, and production cost is low, is conducive to sufferer and alleviates condition of illness in time.
(4) detailed description of the invention
Embodiment 1:
Get Herba Clinopodii 6 grams, Radix Polygoni Ciliinerve 5 grams, Nodus Nelumbinis Rhizomatis 5 grams, Herba Melastomatis dodecandri root 5 grams, Herba Agrimoniae 6 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 3 grams, Terra Flava Usta 5 grams, Folium Loropetali 5 grams, Flos Campsis 5 grams, Semen Impatientis 6 grams, snapper eye 5 grams, Caulis Sargentodoxae 5 grams, Semen Caesalpiniae Minacis 4 grams, Herba Selaginellae 4 grams, Flos Albiziae 4 grams, Margarita 0.5 gram, above-mentioned raw materials is cleaned up, plays powder mixing, make powder or pill.
Usage and dosage: oral, three times on the one, each 2 ~ 5g, one after each meal.
Embodiment 2:
Get Herba Clinopodii 15 grams, Radix Polygoni Ciliinerve 16 grams, Nodus Nelumbinis Rhizomatis 15 grams, Herba Melastomatis dodecandri root 17 grams, Herba Agrimoniae 17 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 15 grams, Terra Flava Usta 17 grams, Folium Loropetali 16 grams, Flos Campsis 17 grams, Semen Impatientis 15 grams, snapper eye 16 grams, Caulis Sargentodoxae 15 grams, Semen Caesalpiniae Minacis 16 grams, Herba Selaginellae 15 grams, Flos Albiziae 16 grams, Margarita 1.5 grams, above-mentioned raw materials is cleaned up, plays powder mixing, make powder or pill.
Usage and dosage: oral, three times on the one, each 2 ~ 5g, one after each meal.
Embodiment 3:
Get Herba Clinopodii 10 grams, Radix Polygoni Ciliinerve 11 grams, Nodus Nelumbinis Rhizomatis 12 grams, Herba Melastomatis dodecandri root 9 grams, Herba Agrimoniae 9 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 11 grams, Terra Flava Usta 9 grams, Folium Loropetali 10 grams, Flos Campsis 11 grams, Semen Impatientis 10 grams, snapper eye 7 grams, Caulis Sargentodoxae 9 grams, Semen Caesalpiniae Minacis 12 grams, Herba Selaginellae 10 grams, Flos Albiziae 12 grams, Margarita 0.8 gram, above-mentioned raw materials is cleaned up, plays powder mixing, make powder or pill.
Usage and dosage: oral, three times on the one, each 2 ~ 5g, one after each meal.
Claims (3)
1. treat a Chinese medicine for peptic ulcer, it is characterized by, be made up of the Chinese medicine of following parts by weight: Herba Clinopodii 6-15 gram, Radix Polygoni Ciliinerve 5-16 gram, Nodus Nelumbinis Rhizomatis 5-15 gram, Herba Melastomatis dodecandri root 5-17 gram, Herba Agrimoniae 6-17 gram, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-15 gram, Terra Flava Usta 5-17 gram, Folium Loropetali 5-16 gram, Flos Campsis 5-17 gram, Semen Impatientis 6-15 gram, snapper eye 5-16 gram, Caulis Sargentodoxae 5-15 gram, Semen Caesalpiniae Minacis 4-16 gram, Herba Selaginellae 4-15 gram, Flos Albiziae 4-16 gram, Margarita 0.5-1.5 gram.
2. a kind of Chinese medicine for the treatment of peptic ulcer according to claim 1, is characterized by, be made up of the Chinese medicine of following parts by weight: Herba Clinopodii 6 grams, Radix Polygoni Ciliinerve 5 grams, Nodus Nelumbinis Rhizomatis 5 grams, Herba Melastomatis dodecandri root 5 grams, Herba Agrimoniae 6 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 3 grams, Terra Flava Usta 5 grams, Folium Loropetali 5 grams, Flos Campsis 5 grams, Semen Impatientis 6 grams, snapper eye 5 grams, Caulis Sargentodoxae 5 grams, Semen Caesalpiniae Minacis 4 grams, Herba Selaginellae 4 grams, Flos Albiziae 4 grams, Margarita 0.5 gram.
3. a kind of Chinese medicine for the treatment of peptic ulcer according to claim 1 and 2, is characterized in that: described Chinese medicine is powder or pill.
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| CN201510017393.1A CN104623291A (en) | 2015-01-14 | 2015-01-14 | Traditional Chinese medicine for treating peptic ulcer |
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| CN201510017393.1A CN104623291A (en) | 2015-01-14 | 2015-01-14 | Traditional Chinese medicine for treating peptic ulcer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497924A (en) * | 2016-02-18 | 2016-04-20 | 卢立征 | Development assistance traditional Chinese medicine used for B ultrasonography |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1197670A (en) * | 1998-05-20 | 1998-11-04 | 靳家富 | Medicine for ulcer |
| JP2003342190A (en) * | 2002-03-19 | 2003-12-03 | Fancl Corp | Anti-helicobacter pylori composition |
| CN102284008A (en) * | 2011-07-21 | 2011-12-21 | 刘湘秋 | Chinese medicinal granules for treating gastric ulcer and duodenal ulcer |
-
2015
- 2015-01-14 CN CN201510017393.1A patent/CN104623291A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1197670A (en) * | 1998-05-20 | 1998-11-04 | 靳家富 | Medicine for ulcer |
| JP2003342190A (en) * | 2002-03-19 | 2003-12-03 | Fancl Corp | Anti-helicobacter pylori composition |
| CN102284008A (en) * | 2011-07-21 | 2011-12-21 | 刘湘秋 | Chinese medicinal granules for treating gastric ulcer and duodenal ulcer |
Non-Patent Citations (4)
| Title |
|---|
| 吴大真等: "《中西医结合治疗难治病的良方妙法》", 30 April 1998 * |
| 戴霞: "活血化瘀治法防治消化性溃疡复发浅议", 《山东中医药大学学报》 * |
| 江宁熙等: "《饮食调补与中老年保健》", 31 August 2008 * |
| 胡小勤等: "《中药学》", 31 January 2014 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497924A (en) * | 2016-02-18 | 2016-04-20 | 卢立征 | Development assistance traditional Chinese medicine used for B ultrasonography |
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Application publication date: 20150520 |