CN103623112B - The Chinese medicine composition for the treatment of skin pruritus and preparation method - Google Patents
The Chinese medicine composition for the treatment of skin pruritus and preparation method Download PDFInfo
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- CN103623112B CN103623112B CN201310683441.1A CN201310683441A CN103623112B CN 103623112 B CN103623112 B CN 103623112B CN 201310683441 A CN201310683441 A CN 201310683441A CN 103623112 B CN103623112 B CN 103623112B
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Abstract
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of skin pruritus, also relate to the preparation method of this Chinese medicine composition.The middle compositions for the treatment of skin pruritus of the present invention, comprises the component of following portions by weight: Herba Houttuyniae 5-12, Radix Sophorae Flavescentis 5-15, Cortex Magnoliae Officinalis 5-15, Cortex Phellodendri 5-15, Herba Leonuri 2-8, Fructus Schisandrae Chinensis 3-10, Radix Saposhnikoviae 2-10, Radix Paeoniae Alba 2-8, Radix Scutellariae 1-7, Herba Menthae 2-8, Rhizoma Chuanxiong 1-10, Fructus Atriplicis Sibiricae 1-6, Radix Cynanchi Paniculati 1-6, Radix Angelicae Dahuricae 1-8, Fructus Kochiae 5-10, Ramulus Mori 2-8.Adopt above-mentioned formula and method to prepare the medicine of obtained treatment skin pruritus, compound method is easy, the wide material sources of crude drug, and cost is comparatively low.Follow the prescriptions principle of the traditional Chinese medical science, adopt and to be decocted in water for oral dose use, through clinical difficulty, it is evident in efficacy, reliable effect, mild in medicine property and, have no side effect, effective percentage reaches more than 95%, and cure rate reaches 75%.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of skin pruritus, also relate to the preparation method of this Chinese medicine composition.
Background technology
General pruritus is often the occurring together or onset symptoms of many general diseases, as uremia, biliary cirrhosis, hyperthyroidism or go down, diabetes, malignant tumor and neuropsychiatric pruritus etc.The exopathogenic factor of general pruritus and environmental factors (comprising the biological or chemical material incentive in humidity, season, working environment), external used medicine, to cause xerosis cutis etc. with the sebaceous gland of the strong soap of alkalescence and patient skin and sweat gland secretion hypofunction relevant.
The cause of disease of local pruritus is sometimes identical with general pruritus, as diabetes.Pruritus ani is how relevant with enterobiasis, blood stasis, anal fistula etc.Vulval pruritus is how relevant with leucorrhea, trichomonal vaginitis, vaginal thrush, gonorrhea and cervical cancer.Scrotal pruritus normal with locally Pi Wengao, hyperhidrosis, friction, fungal infection be relevant.The generation of pruritus mainly by chemical mediator caused by the release of histamine, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, kassinin kinin and protease etc.
Be more common in adult, pruritus Chang Congyi place starts, and expands to whole body gradually.Normal be paroxysmal, and especially to attach most importance to night, severe patient be that persistence pruritus companion paroxysmal is aggravated, and drinks, coffee, tea, emotion changes, the stimulation of pungent diet, mechanicalness are scratched, warm bedding, even certain hint can impel the outbreak of pruritus and increase the weight of., even there is the change of eczema sample, lichenification, pyoderma and lymphangitis and lymphadenitis in Chang Jifa scratch, blood crusts, pigmentation.
Skin pruritus is clinical comparatively common a kind of chronic dermatosis without former skin lesion, especially higher at winter-spring season sickness rate, skin pruritus patient skin is without any pimple, the colour of skin is normal, and when can fall ill, but pruritus unbearably, can show as locality or general, in paroxysmal, can last for hours, especially being night that very patient suffers untold misery at every turn.At present, the Western medicine for the treatment of skin pruritus, generally all adopt and apply medicinal lotion or ointment or oral medicine containing the outer of artificial hormone, although drug effect is rapidly effective, alleviate pruritis to a certain extent, be easier to tolerance, relapse rate is high, and normal with certain side effect.Particularly easily there is the phenomenons such as pigementation, telangiectasis and keratodermatitis thicken in outer agents area of wiping, and clinical efficacy is still difficult satisfactory.The Chinese medicine for oral administration of some treatment skin pruritus, although determined curative effect after taking, relapse rate are low, it is slowly effective, concerning skin pruritus critical patient, is difficult to resolve " matter of great urgency ".
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of instant effect and the Chinese medicine composition for the treatment of skin pruritus to human non-toxic's side effect;
Present invention also offers the preparation method of above-mentioned Chinese medicine composition.
Chinese medicine composition of the present invention comprises the component of following portions by weight:
A kind of compositions for the treatment of skin pruritus of the present invention, said composition comprises the component of following portions by weight:
Preferably, a kind of compositions for the treatment of skin pruritus of the present invention, said composition comprises the component of following portions by weight:
Preferred, a kind of compositions for the treatment of skin pruritus of the present invention, said composition comprises the component of following portions by weight:
Preferred, a kind of compositions for the treatment of skin pruritus of the present invention, said composition comprises the component of following portions by weight:
The preparation method of the compositions for the treatment of skin pruritus of the present invention, comprises following step:
Get Herba Houttuyniae, Radix Sophorae Flavescentis, Cortex Magnoliae Officinalis, Cortex Phellodendri, Herba Leonuri, Fructus Schisandrae Chinensis, Radix Saposhnikoviae, the Radix Paeoniae Alba, Radix Scutellariae, Herba Menthae, Rhizoma Chuanxiong, Fructus Atriplicis Sibiricae, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, the Fructus Kochiae, Ramulus Mori, add water, decoct, adopt military soak by water at a simmer, after boiling, adopt slow fire boiling 20-40 minute; Filter, retain filtrate, in filtering residue, add water, intense fire boils, then adds water, and decocts 10-30 minute after water boils, and merges the filtrate of twice.
In the preparation of the Chinese medicine composition for the treatment of skin pruritus, twice amount of water be the 3-4 of raw material dose doubly.
Preferably, the preparation method of the compositions for the treatment of skin pruritus, comprises following step:
Get Herba Houttuyniae, Radix Sophorae Flavescentis, Cortex Magnoliae Officinalis, Cortex Phellodendri, Herba Leonuri, Fructus Schisandrae Chinensis, Radix Saposhnikoviae, the Radix Paeoniae Alba, Radix Scutellariae, Herba Menthae, Rhizoma Chuanxiong, Fructus Atriplicis Sibiricae, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, the Fructus Kochiae, Ramulus Mori, add water, decoct, adopt military soak by water at a simmer, after boiling, adopt slow fire boiling 25-35 minute; Filter, retain filtrate, in filtering residue, add water, intense fire boils, then adds water, and decocts 15-25 minute after water boils, and merges the filtrate of twice.
Preferred, the preparation method of the compositions for the treatment of skin pruritus, comprises following step:
Get Herba Houttuyniae, Radix Sophorae Flavescentis, Cortex Magnoliae Officinalis, Cortex Phellodendri, Herba Leonuri, Fructus Schisandrae Chinensis, Radix Saposhnikoviae, the Radix Paeoniae Alba, Radix Scutellariae, Herba Menthae, Rhizoma Chuanxiong, Fructus Atriplicis Sibiricae, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, the Fructus Kochiae, Ramulus Mori, add water, decoct, adopt military soak by water at a simmer, adopt slow fire boiling after boiling 30 minutes; Filter, retain filtrate, in filtering residue, add water, intense fire boils, then adds water, and decocts 20 minutes, merge the filtrate of twice after water boils.
Herba Houttuyniae cold nature, bitter in the mouth, has heat-clearing and toxic substances removing, the effects such as inducing diuresis to remove edema.Cure mainly pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.
Cortex Phellodendri is the dry bark of rutaceae wampee or Cortex Phellodendri.The former practises title " Cortex Phellodendri ", and the latter practises title " Cortex Phellodendri ".Can be used as medicine, nature and flavor bitter cold, has heat clearing and damp drying, and pathogenic fire purging removes steams, effect of detoxification sore treatment.Cortex Phellodendri is distributed in the area such as Northeast China and North China each province, and happiness is grown among mountain area, assorted woods, and strong adaptability, is applicable to the cultivation of sun-drenched place, also can anti-severe cold.Cortex Phellodendri is conventional Chinese medicine, and its cold in nature, bitter in the mouth, the effects such as tool heat clearing and damp drying, eliminating fire and detoxication, are usually used in damp-heat dysentery, jaundice, leucorrhea and the disease such as pyretic arthralgia, pyretic stranguria.Modern study shows, Cortex Phellodendri containing the main component such as berberine, obacunone, have antibacterial, convergence, antiinflammatory etc. effect.
Herba Leonuri is the herb of labiate Herba Leonuri.1 year or biennial herb, summer-flowering.Be born in hill wasteland, ridge, meadow etc.Whole nation most area all has distribution.Pluck when the non-standard-sized sheet of riotous growth flower in summer.Edible effect: acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria.
Radix Scutellariae another name Radix Scutellariae, tsuchikane tea root.Radix Scutellariae is a kind of plant of Labiatae Scutellaria, belongs to semi-wild half kind kind, herbaceos perennial.The root of Radix Scutellariae is a kind of medical herbs, bitter in the mouth, cold in nature, can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, and be used in fungal culture miscellaneous bacteria and infect special severe, fine by Radix Scutellariae extracting solution effect, it is that agricultural disease prevents and treats optimal a herb.
Rhizoma Chuanxiong is perennial herb, high 40-60 centimetre, and rhizome is flourishing, forms irregular nodositas fist shape agglomerate, tool enhanced aroma.The florescence 7-8 month, the young fruit period 9-10 month.Rhizoma Chuanxiong is a kind of Chinese medicinal plant, is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, and the pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.The pungent temperature rise of this product is fallen apart, and all hyperactivity of YANG due to deficiency of YIN and excessive rising of liver-YANG person should not apply; Menorrhagia, anemia of pregnant woman also avoid use.
Radix Cynanchi Paniculati is pungent, temperature.Return Liver Channel, stomach warp.Function is removing dampness of dispeling the wind, antalgesic-antipruritic.Cure mainly for rheumatic arthralgia, stomachache distension, toothache, lumbago, injury from falling down, urticaria, eczema.
Pharmacology analysis: the Herba Houttuyniae in side's medicine of the present invention has effect of heat-clearing and toxic substances removing, Fructus Schisandrae Chinensis has effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming, the Radix Paeoniae Alba have clear and coherent blood vessels, nourishing blood to suppress the hyperactive liver, slow in hold back effect of juice; Radix Saposhnikoviae has effect that Eradicates wind only induces sweat, removing dampness to relieve pain, relieving convulsion are jerked surely; Herba Menthae has effect of dispelling wind and heat pathogens, clear profit removing toxic substances, dispersing the stagnated live-QI to relieve the stagnation of QI, and above all medical instruments have that heat-clearing and toxic substances removing, clear and coherent blood vessels, Eradicates wind are antipruritic, effect of nourishing the liver and kidney.
Beneficial effect of the present invention is, adopt above-mentioned formula and method to prepare the medicine of obtained treatment skin pruritus, compound method is easy, the wide material sources of crude drug, and cost is comparatively low.Follow the prescriptions principle of the traditional Chinese medical science, adopt and to be decocted in water for oral dose use, through clinical difficulty, it is evident in efficacy, reliable effect, mild in medicine property and, have no side effect, effective percentage reaches more than 95%, and cure rate reaches 75%.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Herba Houttuyniae, Radix Sophorae Flavescentis, Cortex Magnoliae Officinalis, Cortex Phellodendri, Herba Leonuri, Fructus Schisandrae Chinensis, Radix Saposhnikoviae, the Radix Paeoniae Alba, Radix Scutellariae, Herba Menthae, Rhizoma Chuanxiong, Fructus Atriplicis Sibiricae, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, the Fructus Kochiae, Ramulus Mori is got by above-mentioned parts by weight, add water, decoct, adopt military soak by water at a simmer, adopt slow fire boiling after boiling 30 minutes; Filter, retain filtrate, in filtering residue, add water, intense fire boils, then adds water, and decocts 20 minutes, merge the filtrate of twice after water boils.
The clinical observation for the treatment of by Chinese herbs skin pruritus of the present invention.
Physical data
Clinical observation case totally 100 example, wherein man 50 example, female 50 example, age 20-40 year 30 example, 40-50 year 30 example,
50-60 year 30 examples, more than 60 years old 10 is routine.
Diagnostic criteria
General skin pruritus: whole body skin is itched without determining place or general property skin pruritus, and night attaches most importance to, xerosis cutis, and scratch is obvious.Limitation skin pruritus: gargalesthesia is confined to a certain position of health more, as places such as anus, cysthus, scrotum, affected part by
See in long-term pruritus and infiltrate plumpness, lichen sample becomes and eczematization.Deficiency of YIN wind contains disease diagnosis: primary symptom: 1, skin pruritus, becoming severe at night and/or rise one after another; 2, red tongue or partially red, Artemusia lactiflora Wall. or flower stripping; 3, skin is scorching hot and/or dry.Secondary disease: 1, scratch becomes again and again or in lichen sample; 2, dysphoria with smothery sensation; 3, dry throat and mouth; 4, difficulty in defecation; 5, stringy and thready pulse or stringy and thready pulse number.
Method
Every day 1 dose, once, each scouring ten minutes, directly clean skin after above-mentioned medicine can being heated, cleaning skin after also above-mentioned medicine can being converted hot water, 15 days was 1 course for the treatment of, 2-3 the course for the treatment of in each scouring sooner or later.
Efficacy assessment standard
Clinical recovery: pruritus disappears completely, other clinical pathological changes transference cures.
Effective: pruritis disappears substantially, secondary skin obviously improves.Effective: pruritus alleviates, meeting inducement by chance has endurable gargalesthesia, and diseased region reduces, and skin is light red or red; Secondary skin lesion makes moderate progress.Invalid: pruritus and secondary skin lesion improve not obvious.
Efficacy result 75 examples of fully recovering account for 75%, and effective 95 examples account for 95%, and total effective rate reaches 95%.
Embodiment 2
Herba Houttuyniae, Radix Sophorae Flavescentis, Cortex Magnoliae Officinalis, Cortex Phellodendri, Herba Leonuri, Fructus Schisandrae Chinensis, Radix Saposhnikoviae, the Radix Paeoniae Alba, Radix Scutellariae, Herba Menthae, Rhizoma Chuanxiong, Fructus Atriplicis Sibiricae, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, the Fructus Kochiae, Ramulus Mori is got by above-mentioned parts by weight, add water, decoct, adopt military soak by water at a simmer, adopt slow fire boiling after boiling 30 minutes; Filter, retain filtrate, in filtering residue, add water, intense fire boils, then adds water, and decocts 20 minutes, merge the filtrate of twice after water boils.
Embodiment 3
Herba Houttuyniae, Radix Sophorae Flavescentis, Cortex Magnoliae Officinalis, Cortex Phellodendri, Herba Leonuri, Fructus Schisandrae Chinensis, Radix Saposhnikoviae, the Radix Paeoniae Alba, Radix Scutellariae, Herba Menthae, Rhizoma Chuanxiong, Fructus Atriplicis Sibiricae, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, the Fructus Kochiae, Ramulus Mori is got by above-mentioned parts by weight, add water, decoct, adopt military soak by water at a simmer, adopt slow fire boiling after boiling 20 minutes; Filter, retain filtrate, in filtering residue, add water, intense fire boils, then adds water, and decocts 10 minutes, merge the filtrate of twice after water boils.
Embodiment 4
Herba Houttuyniae, Radix Sophorae Flavescentis, Cortex Magnoliae Officinalis, Cortex Phellodendri, Herba Leonuri, Fructus Schisandrae Chinensis, Radix Saposhnikoviae, the Radix Paeoniae Alba, Radix Scutellariae, Herba Menthae, Rhizoma Chuanxiong, Fructus Atriplicis Sibiricae, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, the Fructus Kochiae, Ramulus Mori is got by above-mentioned parts by weight, add water, decoct, adopt military soak by water at a simmer, adopt slow fire boiling after boiling 40 minutes; Filter, retain filtrate, in filtering residue, add water, intense fire boils, then adds water, and decocts 30 minutes, merge the filtrate of twice after water boils.
Claims (1)
1. treat a preparation method for the Chinese medicine composition of skin pruritus, comprise following step:
Get Herba Houttuyniae, Radix Sophorae Flavescentis, Cortex Magnoliae Officinalis, Cortex Phellodendri, Herba Leonuri, Fructus Schisandrae Chinensis, Radix Saposhnikoviae, the Radix Paeoniae Alba, Radix Scutellariae, Herba Menthae, Rhizoma Chuanxiong, Fructus Atriplicis Sibiricae, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, the Fructus Kochiae, Ramulus Mori, add water, decoct, adopt intense fire to decoct at a simmer, adopt slow fire boiling after boiling 30 minutes; Filter, retain filtrate, in filtering residue, add water, intense fire boils, then adds water, and decocts 20 minutes, merge the filtrate of twice after water boils;
The parts by weight of above-mentioned each raw material are: Herba Houttuyniae 9, Radix Sophorae Flavescentis 10, Cortex Magnoliae Officinalis 10, Cortex Phellodendri 10, Herba Leonuri 5, Fructus Schisandrae Chinensis 7, Radix Saposhnikoviae 6, the Radix Paeoniae Alba 5, Radix Scutellariae 5, Herba Menthae 5, Rhizoma Chuanxiong 7, Fructus Atriplicis Sibiricae 3, Radix Cynanchi Paniculati 3, the Radix Angelicae Dahuricae 5, the Fructus Kochiae 7, Ramulus Mori 5.
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| CN1214261A (en) * | 1998-10-21 | 1999-04-21 | 余际康 | Oral medicine for curing dermatosis |
| CN1238973A (en) * | 1998-06-12 | 1999-12-22 | 许世平 | 'Pikang' No.2 for treating dermatosis |
| CN101380417A (en) * | 2008-10-20 | 2009-03-11 | 吴伶 | Preparation for quickly treating urticaria |
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| KR20110058753A (en) * | 2011-04-15 | 2011-06-01 | (주)아모레퍼시픽 | Composition for improving condition of hair and scalp containing plant extracts |
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| CN1097138A (en) * | 1993-12-03 | 1995-01-11 | 陈保清 | Dermopathic Chinese medicine preparation of a kind of treatment and production method thereof |
| CN1238973A (en) * | 1998-06-12 | 1999-12-22 | 许世平 | 'Pikang' No.2 for treating dermatosis |
| CN1214261A (en) * | 1998-10-21 | 1999-04-21 | 余际康 | Oral medicine for curing dermatosis |
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Effective date of registration: 20151109 Address after: 257300 Shandong Street Office of city of Dongying province Guangrao County Guandi Temple Street No. 6, building 9, unit 3, Room 201 Patentee after: Jia Hongbin Address before: 250062, No. ten, No. 16369, Lixia District, Ji'nan City, Shandong Province Patentee before: SHANDONG ZHONGDA PHARMACEUTICAL CO., LTD. |
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