CN102895547B - Uncaria, bamboo, radix angelicae pubescentis and semen lepidii soup for treatment of stroke sequelae - Google Patents

Abstract

The invention relates to the field of a pharmaceutical formula, in particular to uncaria, bamboo, radix angelicae pubescentis and semen lepidii soup for treatment of stroke sequelae. The uncaria, bamboo, radix angelicae pubescentis and semen lepidii soup is characterized by comprising the following raw materials by weight percentage: 5-9 percent of uncaria, 4-7 percent of bamboo shavings, 4-8 percent of radix angelicae pubescentis, 4-7 percent of semen lepidii, 4-8 percent of gastrodia elata, 5-8 percent of fructus ligustri lucidi, 6-9 percent of concha haliotidis, 6-9 percent of loranthus parasiticus, 7-9 percent of eucommia, 6-9 percent of radix achyranthis bidentatae, 2-5 percent of prepared liquorice, 6-9 percent of radix paeoniae alba, 2-5 percent of rhizoma acori graminei, 4-6 percent of radix ophiopogonis, 2-4 percent of scorpio, 4-6 percent of ligusticum wallichii and 2-4 percent of centipede. The 17 raw materials are soaked in water and decocted, and filtrate is obtained by removing residues. The uncaria, bamboo, radix angelicae pubescentis and semen lepidii soup has the advantages of low cost, high efficacy in treatment of stroke sequelae and no toxic or side effects, and also has the effects of tranquilizing the liver and yang, reinforcing qi, nourishing blood, dispersing blood stasis, dredging collaterals, dispelling wind, activating blood circulation and the like.

Description

Hook bamboo Li soup alive for apoplexy sequela

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of hook bamboo for apoplexy sequela Li soup alive.

Background technology

As everyone knows, cerebrovascular disease refers to the acute and chronic cerebrovascular disease being caused by a variety of causes.Wherein apoplexy (apoplexy) refers to due to the limitation due to acute brain circulatory disturbance or comprehensive brain function deficiency syndrome or claims acute cerebrovascular disease event.Apoplexy, as neural commonly encountered diseases and frequently-occurring disease, be one of three large principal diseases that cause at present mankind's death, and in survivor, 50%～70% patient has been left over handicap, brings white elephant to society and family.Apoplexy mind after rescuing is gradually waken up and enters convalescent period and sequela stage, and paralytic's sequela comprises hemiplegia, aphasia, facial hemiparalysis or dementia, and wherein 75% because of disability and the self care ability of disabling.The method of clinical treatment apoplexy sequela has thrombolytic, cytoprotective treatment etc. at present, and these methods are expensive and therapeutic effect is not good.

Summary of the invention

Object of the present invention is exactly in order to overcome above-mentioned existing technical deficiency, provide a kind of hook bamboo for apoplexy sequela Li soup alive, cost is low, and treatment effect for the treatment of sequela of apoplexy is high, have no side effect, there is the effects such as town liver YANG hyperactivity suppressing, benefiting QI and nourishing blood, disperse blood stasis and dredge collateral, expelling wind and activating blood circulation.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of hook bamboo for apoplexy sequela Li soup alive, it is characterized in that, raw material forms: Ramulus Uncariae Cum Uncis 5～9%, Caulis Bambusae In Taenia 4～7%, Radix Angelicae Pubescentis 4～8%, Semen Lepidii (Semen Descurainiae) 4～7%, Rhizoma Gastrodiae 4～8%, Fructus Ligustri Lucidi 5～8%, Concha Haliotidis 6～9%, Herba Taxilli 6～9%, the Cortex Eucommiae 7～9%, Radix Achyranthis Bidentatae 6～9%, Radix Glycyrrhizae Preparata 2～5%, the Radix Paeoniae Alba 6～9%, Rhizoma Acori Graminei 2～5%, Radix Ophiopogonis 4～6%, Scorpio 2～4%, Rhizoma Chuanxiong 4～6%, Scolopendra 2～4%, above-mentioned 17 kinds of crude drug are soaked in water, the filtrate of removing slag after decocting to obtain.

The invention has the beneficial effects as follows, cost is low, and treatment effect for the treatment of sequela of apoplexy is high, has no side effect, and has the effects such as town liver YANG hyperactivity suppressing, benefiting QI and nourishing blood, disperse blood stasis and dredge collateral, expelling wind and activating blood circulation.

The specific embodiment

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

Adopting Ramulus Uncariae Cum Uncis, Caulis Bambusae In Taenia, Radix Angelicae Pubescentis, Semen Lepidii (Semen Descurainiae), Rhizoma Gastrodiae, Fructus Ligustri Lucidi, Concha Haliotidis, Herba Taxilli, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Glycyrrhizae Preparata, the Radix Paeoniae Alba, Rhizoma Acori Graminei, Radix Ophiopogonis, Scorpio, Rhizoma Chuanxiong, Scolopendra is that raw material is prepared from.The every pair of its component (% by weight) is Ramulus Uncariae Cum Uncis 7.5, Caulis Bambusae In Taenia 6.1, Radix Angelicae Pubescentis 5.9, Semen Lepidii (Semen Descurainiae) 6.1, Rhizoma Gastrodiae 5.5, Fructus Ligustri Lucidi 7.1, Concha Haliotidis 7.8, Herba Taxilli 7.8, the Cortex Eucommiae 8.1, Radix Achyranthis Bidentatae 7.7, Radix Glycyrrhizae Preparata 3.2, the Radix Paeoniae Alba 7.7, Rhizoma Acori Graminei 2.9, Radix Ophiopogonis 5.5, Scorpio 3.5, Rhizoma Chuanxiong 4.7, Scolopendra 2.9.Get above-mentioned 17 taste raw materials, gross weight is 176 grams, and first by under after Ramulus Uncariae Cum Uncis list bag, Concha Haliotidis adds 100 milliliters of single bubbles of water, and 15 tastes of remaininging add 800～900 milliliters, water and at room temperature soak 5～6 hours.First Concha Haliotidis is decocted first 15 minutes, after 800～900 milliliters of Chinese herbal medicine immersion of again 15 tastes being soaked are poured a pot interior intense fire into and are boiled, slow fire decocted to 60～80 minutes, then poured the Ramulus Uncariae Cum Uncis of single bag into, boiled 10 minutes, the 150 milliliters of left and right of filtrate of removing slag to obtain, medicinal residues add water 200～300ml again, decoct 20～30 minutes, 50～70 milliliters of the filtrates removed slag to obtain, altogether the medicine juice of 200～220 milliliters of left and right, make " hook bamboo live Li soup ".Pack in aseptic vial, seal bottle cap is standby, and 1 dose minute every day 2 times is oral, sooner or later each once, 100～110 milliliters of each (medicine) being taken before meal.When taking above-mentioned decoction, then 20 of fit applications Semen Ricini, 0.3 gram of Borneolum Syntheticum, 6 grams of Rhizoma Typhoniis, grind and roll over into fine powder, when consumption is large, double successively, and the powder of getting it filled adds 75% ethanol furnishing pasty state, embrocates Ipsilateral, every day 1～2 time, each 20～30 minutes.This method of decoction and fit applications that takes is synchronizeed and is carried out, and 1 month 1 course for the treatment of, has a rest 3～5, then carries out lower 1 course for the treatment of, generally applies 3 courses for the treatment of.

The main Ramulus Uncariae Cum Uncis water decoction of the present invention has obvious sedation to mice, and outbreak that can preventing Guinea experimental epilepsy can suppress vasomotor center, causes peripheral vessels diastole, Peripheral resistance lowers and produce hypotensive effect.The hypotensive effect of Ramulus Uncariae Cum Uncis has obvious cholinergic character, and its abundant blood pressure lowering depends on vagal integrity, and has synergism with acetylcholine.Nature and flavor are sweet, cool, return liver, pericardium channel, have heat clearing away suppressing the hyperactive liver, endogenous wind stopping fixed interest effect,, dysphoric cold dizzy for having a headache, the tic of frightened pain, pre-eclampsia, hypertension.Caulis Bambusae In Taenia nature and flavor are sweet, be slightly cold, and attach to the lung and stomach meridians.Have removing heat-phlegm, the effect that relieves restlessness and prevents vomiting, holds expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm for phlegm-heat cough, gallbladder fire.Radix Angelicae Pubescentis nature and flavor are pungent, bitter, tepor, return kidney, urinary bladder channel.There is expelling wind and removing dampness, the effect of numbness relieving and pain relieving, for anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache.Semen Lepidii (Semen Descurainiae) nature and flavor are pungent, bitter, Great Cold, return lung, urinary bladder channel.There is the lung of letting out and relieving asthma, the swollen clearly effect of row water, for dyspnea and cough with excessive sputum, costa sternales distension, must not put down sleepingly, and ascites pleural fluid is swollen, dysuria etc.Rhizoma Gastrodiae nature and flavor are sweet flat, return Liver Channel, have suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion effect, dizzy for having a headache, numb limbs and tense tendons, infantile convulsion, epilepsy clonus, tetanus.Fructus Ligustri Lucidi nature and flavor sweet, bitter, cold.Return through liver, kidney channel.There is nourishing the liver and kidney, improving eyesight black hair effect, for vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.Concha Haliotidis nature and flavor are salty, cold.Return Liver Channel.Have suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving effect, for headache, dizzy, conjunctival congestion cataracta, blurring of vision, optic atrohic blindness nyctalopia.Herba Taxilli nature and flavor are bitter, sweet, flat, return liver, kidney channel.There is invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive effect,, metrorrhagia unable for rheumatism disadvantage, soreness of the waist and knees, muscles and bones is through many, blood leaking in gestation, frequent fetal movement, hypertension.Cortex Eucommiae nature and flavor are sweet, warm, return liver, kidney channel.There is invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect, for lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement, hypertension.Radix Achyranthis Bidentatae nature and flavor are bitter, acid, flat, return liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, and eliminating blood stasis and inducing menstruation, conducting blood to flow downwards effect, for soreness of the waist and knees, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.Radix Glycyrrhizae Preparata nature and flavor are sweet, flat, GUIXIN, lung, spleen, stomach warp.There is spleen reinforcing stomach function regulating, the multiple arteries and veins effect of lid gas, for weakness of the spleen and stomach, fatigue and weakness, severe palpitation, regularly intermittent pulse knot, the anxious pain of extremity contraction, cushion toxicity, strong.Radix Paeoniae Alba nature and flavor are bitter, acid, be slightly cold, and return liver spleen channel.There is suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating effect, dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.Rhizoma Acori Graminei nature and flavor acrid, bitter, warm, GUIXIN, stomach warp.There is removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment lid intelligence effect, not hungry for gastral cavity painful abdominal mass, mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Sweet, the micro-hardship of nature and flavor Radix Ophiopogonis, be slightly cold, GUIXIN, lung, stomach warp.There is YIN nourishing and the production of body fluid promoting, the lung moistening effect that clears away heart-fire, for dryness of the lung dry cough, chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Scorpio nature and flavor are pungent, flat, poisonous, return Liver Channel.There is endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain effect, for infantile convulsion, tic spasm, middle air port fish sticking its mouth out of the water, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache etc.Rhizoma Chuanxiong nature and flavor are pungent, warm, return liver, gallbladder pericardium channel, have blood-activating and qi-promoting, wind-expelling pain-stopping effect.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Scolopendra nature and flavor are pungent, warm, poisonous, return Liver Channel.There is endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain effect, for infantile convulsion, tic spasm, middle air port fish sticking its mouth out of the water, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.The ingenious combination of 17 taste Chinese herbal medicine, reasonable compatibility, increases principal agent and effect is identical or approximate curative effect of medication, makes its toxic and side effects alleviate or disappear, and plays altogether the specially good effect of apoplexy sequela.

The embodiment that each raw material of the present invention also can the listed ratio of according to the form below (percentage by weight) mixes realizes.Its processing technique is identical with embodiment 1.

The clinical preliminary test carrying out below in conjunction with Wendeng City, Wo Yuan，Ji In Shandong Weihai central hospital is done further, is described in detail the present invention:

1, case selection: the inpatient that selected case is Wendeng Central Hospital, Weihai City, all cases are all diagnosed as Patients with Apoplexy Sequela 63 examples through head CT inspection, man 39 years old, female 24 example age 57-76 year, the course of disease 2 months-6 months.

2, Therapeutic Method: 1 dose minute every day 2 times is oral, each (medicine) being taken before meal 100-110ml.When taking above-mentioned decoction, fit applications Semen Ricini, Borneolum Syntheticum, Rhizoma Typhonii grind the fine powder being ground into again, the powder of getting it filled adds 75% ethanol furnishing pasty state, embrocates Ipsilateral, every day 1-2 time, each 20-30 minute, this method of decoction and fit applications that takes is synchronizeed and is carried out, and within one month, is 1 course for the treatment of, rest 3-5 day, descended for 1 course for the treatment of again, apply 3 courses for the treatment of.

3, the standard of curative effect evaluation: effective: treat after 3 courses for the treatment of, affected limb is flexibly movable, and upper limb can be raised to head, and the symptom and signs such as limbs are cool, numb, distending pain, headache, dizziness disappear.Can enter lavatory, wear the clothes, the self-care ability such as diet, the functions such as cognition, language are obviously improved, hemorheology laboratory indexes normal.Effective: treat after 3 courses for the treatment of, affected limb can walking under other people assisting in, limbs can be movable, and upper limb can be lifted to shoulder.The symptom and signs such as limbs are cool, numb, distending pain, headache, dizziness obviously alleviate, and other people assist down to enter lavatory, wear the clothes, diet etc.The functions such as cognition, language make moderate progress, the light solidifying state of hemorheology chemical examination.Invalid: treat 3 courses for the treatment of, patient clinical symptom and sign and hemorheology index are without change.

4, therapeutic effect: use the present invention's 63 examples, carry out treatment effectiveness evaluation according to the standard of curative effect evaluation: effective 29 examples, effective 25 examples, no effect 9, total effective rate is 85.7%.

Claims (1)

1. for a hook bamboo Li soup alive for apoplexy sequela, it is characterized in that, raw material composition is by weight percentage: Ramulus Uncariae Cum Uncis 5～9%, Caulis Bambusae In Taenia 4～7%, Radix Angelicae Pubescentis 4～8%, Semen Lepidii (Semen Descurainiae) 4～7%, Rhizoma Gastrodiae 4～8%, Fructus Ligustri Lucidi 5～8%, Concha Haliotidis 6～9%, Herba Taxilli 6～9%, the Cortex Eucommiae 7～9%, Radix Achyranthis Bidentatae 6～9%, Radix Glycyrrhizae Preparata 2～5%, the Radix Paeoniae Alba 6～9%, Rhizoma Acori Graminei 2～5%, Radix Ophiopogonis 4～6%, Scorpio 2～4%, Rhizoma Chuanxiong 4～6%, Scolopendra 2～4%, above-mentioned 17 kinds of crude drug are soaked in water, the filtrate of removing slag to obtain after decocting.