JP2003342190A - Anti-helicobacter pylori composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an anti-Helicobacter pylori composition effective for disinfecting Helicobacter pylori, preventing gastric/duodenal ulcer, gastritis, gastric cancer, and gastric malignant lymphoma, and improving symptoms thereof. <P>SOLUTION: This anti-Helicobactor pylori composition contains at least one kind of a plant body selected from Acalypha australis, Acalypha indica, Acalypha siamensis, Agrimonia japonica, Aucuba japonica, Camellia japonica L., Camellia japonica L. var. hortensis Makino, Camellia sasanqua, Chaenomeles japonica, Chaenomeles sinensis, Chaenomeles spesiosa, Cornus baileyi, Cornus brachypoda, Cornus controversa, Cornus coreana, Cornus florida, Cornus kousa, Cornus officinalis, Cornus stolonifira, Crataegus cuneata, Crataegus laebigata, Croton argyratus, Croton cascarilloides, etc., a juice therefrom, a water extract therefrom, and an organic solvent extract therefrom. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to Helicobacter
The present invention relates to a composition having an antibacterial or bactericidal effect against Helicobacter pylori and having a preventive / symptom-improving effect on gastric / duodenal ulcer, gastritis, gastric cancer and gastric malignant lymphoma.

[0002]

Prior Art In 1983, by Warren and Marshall,
A bacterium called Helicobacter pylori (hereinafter referred to as H. pylori) was found in the stomach of a patient with chronic active gastritis. Subsequent human ingestion experiments confirmed that H. pylori was the cause of gastritis. Furthermore, research on H. pylori has progressed, and it has been suggested not only that it is involved in gastric and duodenal ulcers, but also that it is associated with gastric cancer. In 1994, the International Cancer Research Institute designated H. pylori as a reliable carcinogenic factor. A recent domestic survey also reported that 80% of gastric cancer patients were infected with H. pylori, and the relationship between H. pylori and disease has been gradually elucidated (for example, see Non-Patent Document 1).

Various studies have hitherto been made on the mechanism by which Helicobacter pylori damages gastric mucosal cells, and it is considered as follows. That is, H. pylori, like other E. coli, for example, enters the mouth and reaches the stomach, swims through the mucus layer to reach the gastric mucosal layer using its flagella, and adheres (adhesion) to gastric mucosal cells, It decomposes urea by its own urease to produce ammonia to neutralize gastric acid, establish a favorable living environment and start proliferation. When this Helicobacter pylori adheres to the gastric mucosal epithelial cells, interleukin 8 which is a chemotactic factor for neutrophils from the gastric mucosal cells
(IL-8) is released and neutrophils gather at the site of infection. Next, since H. pylori produces and releases the neutrophil activator, the activated neutrophils easily adhere to the endothelial cells of blood vessels. In addition to causing microcirculatory disturbance of the mucous membrane, this produces protease, free radical (active oxygen), leukotriene, etc. which are known as the causative agent of the microcirculatory disturbance. Further, ammonia produced by the action of urease produced by H. pylori reacts with the above free radicals to produce monochloramine, which is a poison that damages gastric mucosal cells and the like. In this way, inflammation is induced and progresses.

In addition to the above-mentioned inflammatory reaction, gastric mucosal injury caused by Helicobacter pylori includes, for example, attack of ammonia itself produced by the action of urease on gastric mucosa, and cytotoxin (vacuumization) produced by Helicobacter pylori itself. It is considered that one of the factors is vacuolar degeneration of mucosal cells due to (toxin) (see, for example, Patent Document 1).

Conventionally, H ₂ blockers and PPIs (proton pump inhibitors) that suppress the secretion of gastric acid have been known as pharmaceuticals for treating gastric and duodenal ulcers, and their effectiveness has been confirmed. However, these drugs are not able to exert the effect of suppressing the growth of H. pylori and the like.

From the viewpoint of suppressing the growth of H. pylori, various attempts have been made to use antibiotics as antibacterial agents. Currently, three types of aminopenicillin, tetracycline, macrolide and bismuth preparations are selected. Triple therapy, which is a combination of drugs, is considered to be the most effective means.

However, considering that the survival environment of Helicobacter pylori is quite deep between the gastric mucosa, and the division time is many times longer than that of normal bacteria, an effective antibacterial agent for this is It must be acid-stable, permeable between the gastric mucosa and have a strong antibacterial effect. However, until now, no single drug has been known to satisfy these conditions. Even with the above triple therapy, it is necessary to administer a relatively large amount of drug over a long period of time.
The side effects, in particular, bacterial symptomosis due to long-term administration of antibacterial agents are problems that cannot be ignored. Furthermore, in the use of the above-mentioned antibiotics accompanied by the destruction of H. pylori itself, along with the destruction of the bacteria, poisonous substances such as endotoxin possessed by H. pylori and substances causing inflammation may be discharged around the gastric mucosa. There is a large possibility that these may cause new inflammation and mucosal injury, and there is a problem that gastritis, gastric ulcer relapse and recurrence are sufficient.

Further, in recent years, licorice, rosemary, salvia, clove, thyme, ginger, sardine, ju, sikon, rooibos, mugwort, pears, tamarind, guava, yukinoshita, gnats, mukuroji, yucca,
Anti-Helicobacter pylori agents derived from natural products such as plants such as lemons (for example, refer to Patent Document 2), peppermint oil, spearmint oil, and various flavor components have been found and reported (for example, refer to Patent Document 3). ,
Contrary to the strength of the activity in the in vitro test, there is also a problem that it is not so effective under strong acidity in the stomach.

Further, lactoferrin (see, for example, Non-Patent Document 2) and propolis (see, for example, Non-Patent Document 3) have been reported to have an anti-Helicobacter pylori action and have been applied to foods. There is also a problem that the effect is not exhibited unless a large amount is ingested, such as 1 to 3 g.

[0010]

[Patent Document 1] Japanese Unexamined Patent Publication No. 8-119872 (second
page)

[Patent Document 2] Japanese Unexamined Patent Application Publication No. 8-119872 (eighth
-9, Table 4)

[Patent Document 3] Japanese Patent Application Laid-Open No. 11-1492 (Fifth Embodiment)
(Page, Table 1)

[Non-Patent Document 1] Hideyuki Kurihara, Chemistry and Biology, 2000,
Vol. 38, No. 10, p. 635-636

[Non-patent document 2] Yasuhiro Koga, Aseptic organisms, 1997, Vol. 27, No. 1, p44-45.

[Non-Patent Document 3] Toshio Sato, PRA QUARTERLY, 1999
Year, Volume 1, Issue 4, p. 6-10

[0011]

An object of the present invention is to replace all of the above-mentioned conventional chemotherapeutic agents and solve all of the various problems that they have, and there is no risk of side effects even after continuous use. And a highly safe agent against Helicobacter pylori and a food or a drug containing the same.

[0012]

Means for Solving the Problems As a result of intensive studies conducted for the above purpose, the present inventor has found that a plant of a particular species has a strong anti-Helicobacter pylori activity, and completed the present invention.

That is, the present invention is: Acalypha australis, Acalypha indica, Acalypha siam
ensis), Agrimony japonica (Agrimonia japonica), Aoki (Aucuba japonica), Camellia japoni
ca L.), camellia (Camellia japonica L. var. hortens
is (Makino) Makino), Sasanqua (Camellia sasanqu)
a), chamomile (Chaenomeles japonica), karin (Cha
enomeles sinensis), bokeh (Chaenomeles specios)
a), Cornus baileyi, Anemone dogwood (Cornus brachypo
da), Cornus controversa, Cornus corana, Cornus fl
orida), Yamaboshi (Cornus kousa), Sanshuyu (C
ornus officinalis), Red horned dogwood (Cornus stolon)
ifera), hawthorn (Crataegus cuneata), hawthorn (Crataegus laebigata), giant clam (Cro)
ton argyratus), Gummido (Croton cascarilloide)
s), Croton hutchinsonianus, Croton longissimus, C
roton oblongifolius, Croton robustus, Croton subly
latus, shrimp (Croton tiglium), Euphorbia altissim
a, Holtflower (Euphorbia lathyris), Blue-bell (Euphorbia maculata), Red-breasted fish (Euphorbia)
pekinensis), Poinsettia (Euphorbia pulcherrim)
a), goldenrod (Euphorbia supina), Euphorbia t
erracina, Euphorbia trigona, striped shark (Excoecari
a agallocha), Ezo snake (Fragaria vesca), G
eranium fremontii, Geranium molle, red ginger (Geranium sanguineum), geranium geranium (Geranium
thunbergii), Geum canadense, Japanese radish (Geum j
aponicum), Red-spotted wrinkle (Mallotus japonicus), Kusunohagashiwa (Mallotus philippinensis), Mallotus
stewardii, evening primrose (Oenothera biennis), evening primrose (Oenothera erythrosepala), long-nosed primrose (Oenothera longiflora), evening primrose (Oenothera odorata), euglena (Oenothera ros)
ea), pearl mallow (Pelargonium zonale), Yucan (Phyllanthus emblica), Amber tree (Phyllanth)
us flexosus), Phyllanthus matsumu
rae), red citrus cane (Phyllanthus niruri), great citrus cane (Phyllanthus pulcher), sycamore (Phyllanthus reticulatus), red citrus (P
hyllanthus urinaria), Licorice cricket (Phyllan)
thus virgatus), Spodoptera litura (Potentill)
a anserina), Honey bee (Potentilla freynian)
a), Strawberry (Potentilla kleiniana), Prunus glandulosa, Prunus prunus
grayana), cherry tree (Prunus jamasakura), cherry tree (Prunus lannesiana), cherry tree (Prunus lann)
esiana Wils. f. albo-rosea Hara), plum (Prunus mu)
me), Genpeimomo (Prunus persica), Limbo (Pr
unus spinulosa), euglena (Prunus tomentosa),
Prunus verecunda, Psidium cattleianum, pomegranate (Psidium guajav)
a), Purple Rhododendron hort (Rhododendron hort
ense), Yamatsuji (Rhododendron kaempferi), Rhododendron keiskei, Rhod
odendron macrosepalum), Rhododend
ron metternichii), Rhododendr.
on reticulatum), Kerama azalea (Rhododendronscabru
m), Baika azalea (Rhododendron semibarbatum), damask rose (Rosa damascena), salamander (Rosa)
hirtula), Neubara (Rosa multiflora), Hermanus (Rosa rugosa), Maikai (Rosa rugosa Thunb. var.
plena Regel), rowan (Sorbus commixta), rowan rowan (Sorbus gracilis), white veil (Sorbus japonica), Terminalia alata, Terminalia
australis, oriental kamilobaran (Terminalia belliric
a), Honey Milobaran (Terminalia calamansanai), Momotamana (Terminalia catappa), Myrobalan (Termin
alia chebula), Terminalia glaucifolia, Terminalia
nigrovenulosa, Terminalia pierrii, Hishi (Trapa ja
ponica), Mebishi (Trapa japonica Flerov. var. rube
ola Ohwi), Machiko (Piper angustifolium Ruiz et Pa
v.) a plant selected from the group consisting of, or a composition for anti-Helicobacter pylori containing at least one of a juice or water extract or organic solvent extract obtained therefrom, according to 2.1. A plant, or a composition having an anti-gastric / duodenal ulcer action containing at least one of a juice or a water extract or an organic solvent extract obtained therefrom, the plant according to 3.1, or A composition having an anti-gastritis action containing at least one kind of the obtained juice or water extract or organic solvent extract, the plant according to 4.1, or the juice or water extract obtained from them. A composition having an anti-gastric cancer activity, which contains at least one kind of organic solvent extracts, the plant according to 5.1, or the juice or water extract obtained from them. Ku Among organic solvent extract, a composition having anti-gastric malignant lymphoma action which contains at least one, 6. 6. A composition for anti-Helicobacter pylori containing at least one kind of plants of Quercus cylindrica, Cryptococcus communis, Machiko, or juice or water extract or organic solvent extract obtained therefrom. 7. A composition having an anti-gastric / duodenal ulcer action, which contains at least one kind of Quercus japonicus, Citrus unshiu, Machiko plant, or juice or water extract or organic solvent extract obtained therefrom. 8. A composition having an anti-gastritis effect, which comprises at least one of the plants of Quercus cylindrica, Citrus unshiu, Machiko, or the juice or water extract or organic solvent extract obtained therefrom. 10. A composition having an anti-gastric cancer action, which comprises at least one kind of Quercus japonicus, Citrus unshiu, Machiko plant, or juice or water extract or organic solvent extract obtained therefrom. A composition having an anti-gastric malignant lymphoma activity, which comprises at least one kind of Quercus japonicus, Citrus unshiu, Machiko plant, or juice or water extract or organic solvent extract obtained therefrom, 11.1 to 10 1. A food containing the composition of any one of 1. to 10. A pharmaceutical containing the composition of any of 12.1 to 10.

[0014]

BEST MODE FOR CARRYING OUT THE INVENTION The plants used in the present invention are: Acalypha australis,
ypha indica), Thai tea tree (Acalypha siamensi)
s), Agrimonia japonica, Aoki (A
ucuba japonica), Camellia japonica
L.), camellia (Camellia japonica L. var. Hortensis
(Makino) Makino), Sasanka (Camellia sasanqua),
Chestnut (Chaenomeles japonica), Karin (Chaenome)
les sinensis), bokeh (Chaenomeles speciosa), Corn
us baileyi, anemone dogwood (Cornus brachypoda), dogwood (Cornus controversa), Korean dogwood (Corn
us coreana), American Cornus (Cornus florid)
a), Yamaboshi (Cornus kousa), Sanshuyu (Cornu)
s officinalis), Red horned dogwood (Cornus stolonifer)
a), Hawthorn (Crataegus cuneata), Hawthorn (Crataegus laebigata), Great Hornbill (Croton)
argyratus), gummy beetle (Croton cascarilloides),
Croton hutchinsonianus, Croton longissimus, Croton
oblongifolius, Croton robustus, Croton sublylatu
s, Hus (Croton tiglium), Euphorbia altissima, Holthow (Euphorbia lathyris), Euphorbia (Eu)
phorbia maculata), euphorbia pekine
nsis), Poinsettia (Euphorbia pulcherrima), Cyprinidae (Euphorbia supina), Euphorbia terracin
a, Euphorbia trigona, Striped oyster (Excoecaria agall
ocha), lizard strawberry (Fragaria vesca), Geranium
fremontii, Geranium molle, Akabanafuro (Gerani
um sanguineum), Geranium thunberg
ii), Geum canadense, Japanese radish (Geum japonicu
m), Red-spotted wrinkle (Mallotus japonicus), Kusunohagashiwa (Mallotus philippinensis), Mallotus stewar
dii, evening primrose (Oenothera biennis), evening primrose (Oenothera erythrosepala), long-nosed primrose (Oenothera longiflora), evening primrose (Oeno)
thera odorata), Yugesha (Oenothera rosea),
Munting Mallow (Pelargonium zonale), Yucan (Phyllanthus emblica), Amber Tree (Phyllanthus f)
lexosus), Phyllanthus matsumura
e), Red bud (Phyllanthus niruri), Greater pine (Phyllanthus pulcher), Greater Amber (Phyllanthus reticulatus), Red citrus (Phy)
llanthus urinaria), Citrus chinensis (Phyllanth)
us virgatus), Potterilla (Potentilla)
anserina), Honeybill (Potentilla freynian)
a), Strawberry (Potentilla kleiniana), Prunus glandulosa, Prunus prunus
grayana), cherry tree (Prunus jamasakura), cherry tree (Prunus lannesiana), cherry tree (Prunus lann)
esiana Wils.f.albo-rosea Hara), plum (Prunus mum)
e), Genpeimomo (Prunus persica), Limbo (Pru)
nus spinulosa), euglena (Prunus tomentosa),
Prunus verecunda, Psidium cattleianum, pomegranate (Psidium guajav)
a), Purple Rhododendron hort (Rhododendron hort
ense), Yamatsuji (Rhododendron kaempferi), Rhododendron keiskei, Rhod
odendron macrosepalum), Rhododend
ron metternichii), Rhododendr.
on reticulatum), Kerama azalea (Rhododendron scabr
um), Baika azalea (Rhododendron semibarbatum),
Damask rose (Rosa damascena), salamander rose (Ro
sa hirtula), Neubara (Rosa multiflora), Hermanus (Rosa rugosa), Maikai (Rosa rugosa Thunb. va
r. plena Regel), rowan (Sorbus commixta),
Sorbus gracilis, Sorbus japonica, Terminalia alata, Terminali
a australis, Ceramiro balan (Terminalia bellir
ica), Honey Milobaran (Terminalia calamansanai),
Momotamana (Terminalia catappa), Myrobalan (Term
inalia chebula), Terminalia glaucifolia, Terminal
ia nigrovenulosa, Terminalia pierrii, Hishi (Trapa
japonica), Mebishi (Trapa japonica Flerov. var. ru.
beola Ohwi), Machiko (Piper angustifolium Ruiz et
Pav.) Can be used.

Acalypha australis is a dicotyledon plant of the family Euphorbiaceae, and in China, the whole plant is used for hemostasis, diuresis, bruises and the like. Acalypha indica is a dicotyledon of the Euphorbiaceae family and is widely distributed as a weed in the tropical region.
In Java, the young part is used as a vegetable for food, and in Malay it is used for medicinal purposes.

Thai cypress (Acalypha siamensis) is
It is a dicotyledon in the family Euphorbiaceae. Agrimony (Ag
rimonia japonica) is a dicotyledonous plant of the family Rosaceae, also known as dragon buds, dragonflies, and sacrum in China, and is used as a diuretic and tonic drug. Aoki (Aucuba japonica)
Is a dicotyledonous plant of the dogwood family, distributed in Honshu and Shikoku west of the Kanto region, and is used privately as a remedy for burns and cuts.

The camellia camellia (Camellia japonica L.) is
It is a dicotyledonous plant of the Camellia family, and is also called the Japanese camellia,
Corresponds to wild camellia species. Camellia japonic
a L. var. hortensis (Makino) Makino) is a dicotyledonous plant of the Camelliaaceae family, and in China it is also called mountain tea or sea stone garlic,
The oil obtained from seeds is camellia oil for hair, light,
Used as edible and machine oil.

Camellia sasanqua is a dicotyledonous plant of the Camellia family, also called tea plum in China, which grows naturally in the western end of Honshu (Yamaguchi Prefecture), southwestern Shikoku, Kyushu and the Okinawa Islands, and has long been a garden tree. The oil obtained from the seeds is used as an edible as a camellia oil as a hedge or a hedge. Chestnut (Chaenomeles japonica) is a dicotyledonous plant of the family Rosaceae, also known as grass melon in China, and is a deciduous shrub widely distributed in Japan. Karin (Chaenomeles sinensi
s) is a dicotyledonous plant of the family Rosaceae, also known as karanashi, bokeh, and melon in China, and is used as a folk remedy for sputum and diarrhea.

[0019] Bokeh (Chaenomeles speciosa) is a dicotyledonous plant of the family Rosaceae, also known as autumn melon and melon melon in China, which is used for muscular pain, contains tartaric acid and malic acid, and has a good fragrance. Therefore, it has also been used as a simmer or fruit liquor. Cornus baileyi is a dicotyledon in the Rosaceae family. Anemone dogfish (Cornus brachypod
a) is a dicotyledon of the dogwood family, also known as palm tree in China, and is used for fractures and pain relief of heartwood.

Cornus controversa is a dicotyledonous plant of the family Cornaceae, which is widely distributed throughout Japan, Korea, and mainland China to the Himalayas. It is sometimes used for food, but it has a problem in taste. Cornus coreana is a dicotyledonous plant of the dogwood family. Cornus florida is a dicotyledonous plant of the dogwood family, and is also called dogwood, or a multi-flowered goose tree in China.

[0021] Cornus kousa is a dicotyledonous plant of the dogwood family, which is also known as syringa in China, and is distributed in various parts of Japan except Hokkaido, Korea and China, but especially in Jeju. There are many islands (Korea), Unzen, and Hakone. Sanshuyu (Cornus officinalis), a dicotyledonous plant of the dogwood family, also called Harukoganebana, is used for decoction of dried fruit after removing the nucleus of the fruit, for low back pain, dizziness, tinnitus, frequent urination, tonic, etc. It has been used.

Red horned dogwood (Cornus stolonifera)
Is a dicotyledon of the dogwood family. Hawthorn (Crataeg
us cuneata) is a dicotyledonous plant of the family Rosaceae, and is said to be effective in digesting stomach and detoxifying Chinese herbs. It is also said to have the effect of dilating blood vessels to lower blood pressure. Hawthorn (Crataegus laebigata) is a dicotyledon of the Rosaceae family distributed from Europe to northern Africa, and its cultivation in Japan is not yet common. Crested oyster (Croton argyratus) is a dicotyledon in the Rosaceae family.

[0023] Gomidodoki (Croton cascarilloides) is a dicotyledonous plant of the family Rosaceae, which is also called a blue pinnacle in China, and is also edible as a fruit. Croton hutch
insonianus, Croton longissimus, Croton oblongifoli
us, Crotonrobustus, and Croton sublylatus are dicotyledons of the Rosaceae family.

[0024] A lotus (Croton tiglium) is a dicotyledonous plant of the Euphorbiaceae family, and is also called Tomoe bean in China. The lotus oil obtained from seeds is used for industrial purposes, but lauric acid, palmitic acid, stearic acid, olein are used. Acids, linoleic acid, etc. are included. The leaves are also used as insecticides or remedies for eczema.

Euphorbia altissima is a dicotyledon of the Euphorbiaceae family. Horthosaw (Euphorbia lathyri
s) is a dicotyledonous plant of Euphorbiaceae, which is used for detoxification, laxation, diuretics, and menopause in Kampo. Euphorbia maculata is a dicotyledon in the Euphorbiaceae family and is also known as Jinjisa in China. The whole plant has good bacterial diarrhea, enteritis, hemoptysis, vomiting, traumatic bleeding and milk production. Used when not in use.

[Tokatodai] (Euphorbia pekinensis)
Is a dicotyledonous plant of the Euphorbiaceae family, and in China, the dried roots are called daiso and is used as a diuretic. Poinsettia (Euphorbia pulcherrima) is
It is a dicotyledon in the Euphorbiaceae family, also called Drosophila, which is widely used at the end of the year as pots and cut flowers. Euphorbia supin
a) is a dicotyledonous plant of the Euphorbiaceae family, which is also called Mochi Nishiki in China, and the whole plant is used for various types of hemostasis and lack of milk.

Euphorbia terracina, Euphorbia trigona
Is a dicotyledon of the Euphorbiaceae family. Shimashiraki (Excoecaria agallocha) is a dicotyledon in the Euphorbiaceae family, whose seeds are roasted and edible to obtain oil.
In China, root bark is used as a diuretic. Fragaria vesca is a dicotyledon in the Euphorbiaceae family.

Geranium fremontii, Akabanafuro (Ge
ranium sanguineum) and Geranium molle are dicotyledons of the Euphorbiaceae family. Geranium t
hunbergii) is a dicotyledonous plant of the family Furoaceae, a perennial plant commonly found on roadsides in the mountains, and has long been used as a medicinal herb to prevent diarrhea. Geum canadense is a dicotyledon of the Rosaceae family. Japanese radish (Geum japonic
um) is a dicotyledonous plant of the family Rosaceae, also known as water syrup in China, and the whole plant is used as a folk medicine for diuresis, bacterial diarrhea, toothache, and eczema.

Red wrinkles (Mallotus japonicus) are
It is a dicotyledon of the Euphorbiaceae family and is also called Nogiri in China.Since ancient times, the bark has been used for cholelithiasis, and the decoction of leaves has been externally applied to hemorrhoids. It has been used for stopping. Malachus philippinensis is a dicotyledonous plant of the Euphorbiaceae family, also known as rough bran in China, and used in the Nansei Islands for menstrual irregularities and skin diseases. Mallotus stewardii is a dicotyledon in the Euphorbiaceae family.

Evening primrose (Oenothera biennis)
Is a dicotyledonous plant of the family Acadana, and is also called evening primrose in China. Oenothera erythr
osepala) is a dicotyledonous plant of the family Acadana, and is called red cabbage evening primrose. Oenothera
longiflora) is a dicotyledon in the family Acadanaceae. Evening primrose (Oenothera odorata), Oenothera (Oenot)
hera rosea) is a dicotyledon in the family Acadanaceae.

[0031] Monte sage mallow (Pelargonium zonal
e) is a dicotyledonous plant of the family Frostaceae and is native to South Africa. Yukan (Phyllanthus emblica)
Is a dicotyledonous plant of the Euphorbiaceae family, also called Ammalok, which is distributed from India to Malaysia (Timor) and southern China, and its roots, leaves, bark, galls, etc. are also used medicinally. is there. Amber tree (Phyllanthus flexosus) is a dicotyledonous plant of the Euphorbiaceae family, and is a deciduous shrub that grows naturally from the mountainous regions of Shikoku and Kyushu to the west of the Kinki region of Honshu.

Phyllanthus matsumura
e) is a dicotyledon of the Euphorbiaceae family. Phyllanthus niruri is a dicotyledon of the Euphorbiaceae family, and is used as a diuretic for Indonesia, such as antidiarrheal, analgesia and gonorrhea. Cranium citrus (Phyllanthus pulcher) and sycamore (Phyllanthusreticulatus) are dicotyledonous plants of the Euphorbiaceae family. Phyllanthus urinaria
Is a dicotyledonous plant of the Euphorbiaceae family, which is also known as the interfoliar beetle in China.The whole plant is called Rinzhu-grass and is used as an antidote for enteritis, various infectious diseases, urinary tract infections, etc. Is.

[0033] Phyllanthus virgat
us) is a dicotyledon of the Euphorbiaceae family. Potterilla anserina is a dicotyledon in the Rosaceae family. Honey beetle (Potentilla freyn
iana) is a dicotyledonous plant of the family Rosaceae, also known as trifoliate plant in China, which is used for medicinal purposes such as detoxification, tuberculosis, bruises, and wound bleeding. The snake strawberry (Potentilla kleiniana) is a dicotyledon in the Rosaceae family.

Prunus glandulosa is also known as Niwaume, which is also called Iku-Li in China, and is used as a diuretic in the Chinese medicine called Iku-Li Jin. Prunus grayana is a dicotyledonous plant of the family Rosaceae, a deciduous small tree, and a cherry tree distributed in the mountains from southwest Hokkaido to Kyushu. Prunus jamasakura is a dicotyledonous plant of the family Rosaceae, also known as Fukushima cherry tree in China. It grows west of Miyagi prefecture in Honshu, in the mountains of Shikoku and Kyushu, and is also distributed in Jeju island of Korea.

Prunus lannesiana is a dicotyledonous plant of the family Rosaceae, which is a general term for cherry blossoms that begin to bloom later in the mid to late April than Yamazaki and Yoshino cherry. Prunus lannesiana
Wils. F. Albo-rosea Hara) is a dicotyledonous plant of the Rosaceae family and is a closely related species of Satozakura. Prunus
mume) is a dicotyledonous plant of the family Rosaceae, and is used for pickled fruits, boiled plums, candied sugar and plum wine. Karasu is smoked from immature fruits and dried in the sun. It is used as a herbal medicine for anthelmintic insects, coughs, diarrhea, bloody stools, and hematuria. Plum extract is also a folk medicine.

[0036] Genpei peach (Prunus persica) is a dicotyledonous plant of the family Rosaceae and is generally eaten with fruits as peaches. Limboku (Prunus spinulosa) is a dicotyledonous plant of the family Rosaceae, an evergreen tree that is distributed in warm regions, and has spike-shaped flowers in autumn. Prunus tomentosa is a dicotyledonous plant of the family Rosaceae, which is called mountain peach in China, and is used as a bonsai tree, garden tree, or small garden fruit tree. Kasumizakura (Prunus verecunda) is a dicotyledonous plant of the family Rosaceae, also known as zelkova, which grows in the mountains of Hokkaido to Kyushu and is distributed from the Korean Peninsula to northeastern China.

[0037] Peridium cattleianu
m) is a dicotyledon of the Rosaceae, native to Brazil,
The fruits are small and are considered garden trees. Pomegranate (Psidium
guajava) is a dicotyledonous plant of the pomegranate family, also known as stone garlic in China, and is used for the production of fruit wine and soft drinks. Moreover, the peel is also used as an antidiarrheal. Rhododendron horte
nse) is a dicotyledonous plant of the azalea family, also known as Shirahana-no-Mori in China, which is used for flowers, foliage, and roots of hemorrhagic diseases.

Yamatsuji (Rhododendron kaempferi)
Is a dicotyledonous plant of the azalea family and is a kind of azalea distributed in Japan (Hokkaido to Kyushu). Leek Azalea (Rh
ododendron keiskei) is a dicotyledonous plant of the azalea family, which is distributed west of the Kanto region of Honshu, Shikoku, and Kyushu in Japan, and is often cultivated for appreciation. Mochi azalea (Rhododendron macrosepalum) is a dicotyledonous plant of the azalea family, distributed from west of Shizuoka prefecture to Shikoku, and a small number of horticultural varieties are differentiated.

[0039] Rhododendron metternic
hii) is a dicotyledonous plant of the azalea family, in northern Shikoku,
It is distributed from the Chugoku region to the Chubu region. Rhododendron reticulatum is a dicotyledonous plant of the azalea family, whose flowers are light magenta and west to west of the Chubu region.
It is distributed in the low mountains of Shikoku and Kyushu. Kerama Azalea (Rh
ododendron scabrum) is a dicotyledonous plant of the azalea family, the flowers and leaves are large, the flowers are purple-red, distributed from Amami Oshima to the main island of Okinawa. It does not have much cold resistance,
It is also cultivated in the warm regions of southwestern Japan.

Rhododendron semibarbatu
m) is a dicotyledonous plant of the azalea family, in which the flower bud has one flower and the fruit is a kind of globular azalea. Damask rose (Rosa damascena) is a dicotyledonous plant of the family Rosaceae, with many flowers in clusters and many petals. Flower colors are red, pink, white, and aperture. It has a very strong fragrance, is rich in perfume oil, and is a raw material for perfumes. Salamander (Rosa hirtul
a) is a dicotyledon in the family Rosaceae, which, as the name suggests, resembles a salamander and opens a pink flower. The distribution range is narrow for wild roses, and it occurs in Kanagawa, Yamanashi, and Shizuoka prefectures.
It is often noticeable around Hakone.

[0041] Neubara (Rosa multiflora) is a dicotyledonous plant of the family Rosaceae, also called multi-flowered rose in China, and is a deciduous deciduous shrub found in fields from Hokkaido to Kyushu, such as river fields and mountain skirts. Is used as a cathartic drug in Japan. Hermanus (Rosa rugosa)
Is a dicotyledon of the Rosaceae family, a deciduous shrub with beautiful flowers that grows on coastal sand. The dried petals are
It is used for stomach pain, diarrhea, and menorrhagia. In addition, the fruit contains a large amount of vitamin C and is also used for food.

Maikai (Rosa rugosa Thunb. Var. Plen
a Regel) is a dicotyledon of the Rosaceae family. Rowan (Sorbus commixta) is a dicotyledon of the family Rosaceae,
A deciduous Kotakagi that is widely distributed from Hokkaido to Kyushu, grows in the mountains, and is known for its beautiful autumn colors. Since the material is yellowish brown and hard, it is used as wood for work. Sorbus gracilis is a dicotyledonous plant of the family Rosaceae, a small deciduous shrub that is distributed west of central Honshu. Besides being used for cut flowers, fruits can be eaten.

Virginia cypress (Sorbus japonica) is a dicotyledonous plant of the family Rosaceae, a deciduous tree that grows in the mountains.
It is distributed in Honshu, Shikoku, and Kyushu, and because it has beautiful young shoots, it is used for flower arrangements. Terminalia alata, Terminal
ia australis, St. Kamilo balun (Terminaliabellir
ica), Honey Milobaran (Terminalia calamansanai)
Is a dicotyledonous plant of the family Corsifolia. Momota Mana (Term
inalia catappa) is a dicotyledonous plant of the family Asteridae,
It is widely distributed from Asia to the tropical and subtropical coasts of Polynesia and reaches the Okinawa Islands and Ogasawara Islands. The fruits are
It contains tannin and is used as a black dye, and it is used in the Malaysian region to dye teeth like black tooth.

[0044] Myrobalan (Terminalia chebula) is a deciduous tree, which is also known as licorice in China, and is famous as a raw material for tannins. In China, as a medicinal product, a hoarse voice,
It is used for the treatment of diarrhea, bloody stools, etc.

Terminalia glaucifolia, Terminalia nig
rovenulosa and Terminalia pierrii are dicotyledonous plants of the family Compositae. Trapa (Trapa japonica) is a dicotyledonous plant of the family Asteraceae, also known as Nobishi in China, distributed in the temperate to subtropical regions of East Asia and India, Hokkaido,
Found in Honshu, Shikoku, Kyushu, Korea, Taiwan and China. The seeds are boiled or baked and edible. Mebishi (Tr
apa japonica Flerov. var. rubeola Ohwi) is a dicotyledonous plant of the family Asteraceae, and has smaller fruits and plants than the abalone. It is distributed in Honshu, Shikoku and Kyushu. The fruit is small,
It is said to be edible. Machiko (Piper angustifolium Ruiz
et Pav.) is a dicotyledonous plant of the pepper family and is mainly distributed in Central and South America. The leaves are used for the treatment of bleeding, insect biting, skin inflammation and the like.

In the present invention, plants are leaves, stems, buds,
All parts such as flowers, woody parts, above-ground parts such as bark (bark) and roots, underground parts such as tubers, seeds, fruits and resins can be used. Further, dried products obtained by drying plants themselves, crushed products thereof, squeezed juice obtained by squeezing and extracting themselves, crude extract with water or a solvent such as ethyl alcohol, methyl alcohol, diethyl ether, acetone, and crude It is also possible to use an extract fraction obtained by purifying the extract stepwise by various chromatography such as partition or column chromatography. The obtained extract fraction may be concentrated, spray-dried or freeze-dried by an appropriate method. These may be used alone or in combination of two or more.

[0048] For example, a chamomile (Chaenomeles japonic)
The extract obtained by adding 3 L of 99.5% ethanol to 1 kg of dried plant a) and immersing it overnight at room temperature is used as it is for the prevention of anti-Helicobacter pylori, gastric / duodenal ulcer, gastritis, gastric cancer and gastric malignant lymphoma. -It may be used for the purpose of symptom improvement, or may be purified by combining various chromatographies.

It has not been known at all from the fact that these dried or extracts of specific plants according to the present invention have anti-Helicobacter pylori activity, which is a new finding obtained by the present invention. The plant according to the present invention has an anti-Helicobacter pylori activity, and can be used as a food or medicine having a preventive / symptom-improving action on gastric / duodenal ulcer, gastritis, gastric cancer and gastric malignant lymphoma.

The plant of the present invention can be produced as a composition having a preventive / symptom-improving effect on gastric / duodenal ulcer, gastritis, gastric cancer and gastric malignant lymphoma, and foods and pharmaceuticals containing these. The anti-Helicobacter pylori agent, gastric / duodenal ulcer, gastritis, composition having a preventive / symptom-improving effect on gastric cancer and gastric malignant lymphoma of the present invention, and a medicament containing them are either orally or parenterally administered. be able to. Upon administration, the active ingredient should be mixed with a solid or liquid nontoxic pharmaceutical carrier suitable for administration methods such as oral administration, transdermal administration, rectal administration, and injection, and then administered in the form of a conventional pharmaceutical preparation. You can Examples of such preparations include solid preparations such as tablets, granules, powders and capsules, liquid preparations such as solutions, suspensions and emulsions, and freeze-dried preparations. It can be prepared by conventional means. Examples of the nontoxic carrier for pharmaceutical use include glucose, lactose, sucrose, starch, mannitol, dextrin, fatty acid glyceride,
Polyethylene glycol, hydroxyethyl starch,
Ethylene glycol, polyoxyethylene sorbitan fatty acid ester, amino acid, gelatin, albumin, water,
Examples include physiological saline. Further, if necessary, conventional additives such as a stabilizer, a wetting agent, an emulsifier, a binder and an isotonicity agent can be appropriately added.

As foods, as they are, or by adding various nutritional components or by including them in foods and drinks, eradication of Helicobacter pylori, stomach / duodenal ulcer, gastritis,
It is eaten as a health food or a food material useful for prevention of gastric cancer and malignant lymphoma of the stomach and improvement of symptoms. For example, after adding the appropriate auxiliaries mentioned above, using a conventional means, an edible form, such as granules, granules, tablets, capsules,
It may be formed into a paste or the like and used for edible foods, and also various foods, for example, processed meat products such as ham and sausage, processed fish products such as kamaboko and chikuwa, bread, confectionery, butter, milk powder, and fermented dairy products. Or use it by adding
You may add and use it to drinks, such as water, fruit juice, milk, a soft drink, and tea.

In the present invention, the effective dose of the plant as a solvent extract depends on the patient's age, body weight, symptom, patient's degree, administration route, administration schedule, formulation form, strength of inhibitory activity of the material, etc. It is selected and decided appropriately. For example, when administered orally, it is generally 0.001-1000 mg / day.
It may be administered in several divided doses at about / kg body weight.

The plant of the present invention has low toxicity, for example, 1000 mg of a hot water extract of radish (Geum japonicum) daily.
Even after oral administration to rats for a long time of 100 kg / kg for 100 days, no death was observed and no change in body weight was observed.

[0053]

EXAMPLES The present invention will be specifically described below with reference to examples, but the invention is not limited thereto.

Production Example [Extraction of plant] To 20 g of whole grass of Acalypha australis, 100 mL of 99.5% ethanol was added, extracted at room temperature for 30 minutes, concentrated under reduced pressure to remove ethanol, and extract 1400
mg was obtained.

Whole plant of Acalypha indica, branches and leaves of Acalypha siamensis, whole plant of Agrimonia japonica, Aucu
Camellia japonica)
L.) seed, camellia (Camellia japonica L. var. Hor
tensis (Makino) Makino) flowers, Sasanca (Camellia sas)
anqua), branches of chamomile (Chaenomeles japonica), fruits of karin (Chaenomeles sinensis), leaves of boke (Chaenomeles speciosa), branches of Cornus baileyi, leaves of Cornus brachypoda, leaves of Cornus controversa. The branches and leaves of Cornus coreana, Cornus
foliage of us florida, foliage of Cornus kousa, foliage containing fruits of cornus officinalis, foliage of Cornus stolonifera, foliage of hawthorn (Crataegus cuneata), foliage of hawthorn (Crataegus laebigata), Brown crab (C
roton argyratus)
above ground, branches of Croton hutchinsonianus, Cr
oton longissimus leaf, Croton oblongifolius aerial part, Croton robustus aerial part, Croton sublylatus branch, Hus (Croton tiglium) whole plant, Euphorbia altiss
ima aboveground, whole grass of Euphorbia lathyris, whole grass of Euphorbia maculata, aboveground of Euphorbia pekinensis, branches and leaves of Euphorbia pulcherrima, whole grass of Euphorbia supina Euphorbia terracina
Whole grass, Euphorbia trigona lumber, Striped oyster (Excoeca
ria agallocha) leaves, lizard strawberry (Fragaria vesc)
a) Whole leaf, above-ground part of Geranium fremontii, Geranium mo
All plants of lle, above ground of Geranium sanguineum, above ground of Geranium thunbergii, all of Geum canadense, Geum jap
onicum), the red wrinkle (Mallotus japonicus)
Bark, camphoraceae (Mallotus philippinensis)
Foliage, whole plant of Mallottus stewardii, whole plant of evening primrose (Oenothera biennis), evening primrose (Oen)
othera erythrosepala), whole grass of Oenothera longiflora, evening primrose (Oeno)
whole plant of thera odorata, Oenothera ros
ea) whole plant, pearl mallow (Pelargonium zonal)
e) above-ground part, branches and leaves containing fruits of Yukan (Phyllanthus emblica), leaves of Amber tree (Phyllanthus flexosus),
The whole plant of Phyllanthus matsumurae, the whole plant of Phyllanthus niruri, the branches and leaves of Phyllanthus pulcher, the branches of Phyllanthus reticulatus, the whole plant of Phyllanthus reticulatus. Whole plant of Phyllanthus virgatus, aboveground part of Potterilla anserina, whole plant of Honey beetle (Potentilla freyniana), whole plant of Strawberry (Potentilla kleiniana), Prunus
glandulosa) leaves and leaves, Prunus grayan
a) branches and leaves, Prunus jamasakura branches and leaves,
Branches and leaves of Prunus lannesiana, wood of Prunus lannesiana Wils. F. Albo-rosea Hara, branches and leaves of Prunus mume, Prunu
s persica), limbs (Prunus spinulosa), foliage (Prunus tomentosa), moss cherry (Prunus verecunda), Psidium cattleianum (Psidium cattleianum), and pomegranate (P
Branches and leaves of sidium guajava), branches and leaves of Rhododendron hortense, and Japanese azalea (R
Hododendron kaempferi), leaves and leaves, Rhodo
dendron keiskei), leaves and leaves, Rhododendron
Macrosepalum) leaves and leaves, Rhododendron
The leaves and leaves of the metternichii), Rhodode
ndron reticulatum) branches and leaves, Rhododend
Rhododendron se, leaves and leaves of ron scabrum
mibarbatum) branches and leaves, Damask rose (Rosa damascena)
Branches and leaves, salamander (Rosa hirtula) branches, Neubara (Rosa multiflora) branches and leaves, Hermanus (Rosa rugo)
sa) above ground, Maikai (Rosa rugosa Thunb. var. pl.
ena Regel) above ground, rowan (Sorbus commixta)
Foliage, foliage of Sorbus gracilis, foliage containing fruits of Sorbus japonica, bark of Terminalia alata, foliage of Terminalia australis, foliage containing fruits of Ceita milobalan, Terminalia bellirica, Terminalia calaman
sanai) bark, Momotamana (Terminaliacatappa) branches and leaves, Myrobalan (Terminalia chebula) fruit, Termin
alia glaucifolia branches, Terminalia nigrovenulosa branches and leaves, Terminalia pierrii bark, Trapa (Trapa japonic
a) whole plant, Mebishi (Trapa japonica Flerov. var. rub
Mackerel (Piper angustifolium Rui)
z et Pay) leaves were also extracted with ethanol under the same conditions and then concentrated under reduced pressure to remove the solvent, and the extracts were respectively extracted in the order of 1860, 1330, 1580, 990, 1040, 2514, 2
320, 4950, 3210, 2354, 782, 1423, 2653, 4521, 256
2, 3265, 1473, 1023, 2105, 2538, 4521, 2486, 125
6, 4789, 5896, 2563, 1287, 1453, 4523, 1056, 423
1, 2231, 1735, 4231, 2215, 2658, 1179, 1986, 215
6, 3265, 5632, 4236, 5563, 2234, 2769, 3365, 312
0, 4123, 2278, 2146, 2536, 3218, 2354, 1532, 178
9, 2196, 2493, 1145, 1028, 1546, 2163, 3356, 289
6, 2437, 2236, 6987, 2364, 5479, 4234, 2289, 452
3,2378,5564,4236,1179,2345,1256,4623,332
5, 2198, 2465, 3365, 3870, 4203, 2036, 3526, 248
6, 4126, 4158, 3570, 5423, 4126, 2573, 1982, 390
1, 4100, 2097, 2569, 3129, 4109, 1489, 2873, 426
3,1520 mg was obtained.

Pharmacological test (1) [Measurement of anti-Helicobacter pylori activity] The antibacterial activity of the plant extract against Helicobacter pylori was measured by NC.
It was performed according to CLS (American Laboratory Standards Board) guideline M100-S9. ATCC43504 was used as the test bacterium. DMSO (dimethyl sulfoxide) of the plant extract obtained in the production example
The solution was prepared to have a concentration of 30 mg / ml, and 50 μl of these sample solutions were adsorbed on a paper disk, then added to an agar plate medium, and a microaerobic culture device was used at 35 ° C. and 72 ° C.
After culturing for a period of time, the diameter of the inhibition circle whose growth was suppressed was measured on an agar plate medium.

As a comparative example, anti-Helicobacter
Choji (Sy
zygiumaromaticum MERR.) flower buds, licorice (Glyeyrrh)
izaglabra L.) rhizome (root), mugwort (Artemisia prin)
ceps PAMPAN.) stems and leaves, and propolis (Propolis), an ethanol extract was prepared under the same conditions as in the production example, and tested in the same manner. Similarly, a commercially available lactoferrin (Lactoferrin) having anti-Helicobacter pylori activity (trade name: "Morinaga lactoferrin MLF-1") was also tested. The test results are shown in Tables 1 to 4.

[0058]

[Table 1]

[0059]

[Table 2]

[0060]

[Table 3]

[0061]

[Table 4]

As shown in Tables 1 to 4, the plants of the present invention, Acalypha australis, Acalypha indica, and Acalypha si
amensis), Aoki (Aucuba japonica), Camellia japonica L., Camellia japonic
a L. var.hortensis (Makino) Makino), Sasanqua (Cam
ellia sasanqua), chamomile (Chaenomeles japonic)
a), Karin (Chaenomelessinensis), Bokeh (Chaenome)
les speciosa), Cornus baileyi, anemone dogfish (Corn
us brachypoda), dogwood (Cornus controversa), Korean dogwood (Cornus coreana), American porcupine (Cornus florida), porcupine (Cornuskousa),
Hawthorn (Cornus officinalis), Red horned dogwood (Cornus stolonifera), Hawthorn (Crataegus cuneat)
a), hawthorn (Crataegus laebigata), giant crab (Croton argyratus), crested crab (Croton)
cascarilloides), Croton hutchinsonianus, Croton
longissimus, Croton oblongifolius, Croton robustu
s, Croton sublylatus, Huz (Croton tiglium), Euph
orbia altissima, Euphorbia lathyri
s), Hypericum perforatum (Euphorbiamaculata), Red sea bream (Euphorbia pekinensis), Poinsettia (Euphor)
bia pulcherrima), goldenrod (Euphorbia supin)
a), Euphorbia terracina, Euphorbia trigona, Striped oyster (Excoecaria agallocha), Ezo snake strawberry (Fr
agaria vesca), Geranium fremontii, Geranium moll
e, Akabanafuro (Geranium sanguineum), Geranium thunbergii, Geum canadense, Japanese radish (Geum japonicum), Akamegasiwa (Mallot)
us japonicus), Kusunohagashiwa (Mallotus philippin)
ensis), Mallotus stewardii, evening primrose (Oenot)
hera biennis), evening primrose (Oenothera erythr)
osepala), gypsophila (Oenothera longiflor)
a), Evening primrose (Oenothera odorata), Yugesho (Oenothera rosea), Munting water mallow (Pelargo)
nium zonale), Yukan (Phyllanthus emblica), Amber tree (Phyllanthus flexosus), Scutellaria baicalensis (Ph)
yllanthus matsumurae), Yellow citrus plant (Phyllant
hus niruri), Amberjack (Phyllanthus reti)
culatus), Red Clover (Phyllanthus urinaria),
Ivan Cicada (Phyllanthus virgatus), Scutellaria vulgare (Potentilla anserina), Honey honey (Potentilla freyniana), Strawberry (Pote)
ntilla kleiniana), Japanese cherry (Prunus glandulos)
a), Uwamizu-zakura (Prunus grayana), Yama-zakura (Prunus jamasakura), Sato-zakura (Prunus lannesia)
na), Yaezakura (Prunus lannesiana Wils. f. albo-
rosea Hara), plum (Prunus mume), genpeimomo (P
runus persica), limb (Prunus spinulosa), euglena (Prunus tomentosa), moss cherry (Prunus)
verecunda), terriha bunjirou (Psidium cattleianu)
m), Pomegranate (Psidium guajava), Purple Ryukyu Azalea (Rhododendron hortense), Yamatsuji (Rho)
dodendron kaempferi), Rhododendron
keiskei), Mochi Azalea (Rhododendron macrosepalu
m), Rhododendron metternichii,
Rhododendron reticulatum, Rhododendron scabrum, Rhododendron semibarbatum, Damask rose (Rosa)
damascena), salamander (Rosa hirtula), Neubara (Rosa multiflora), Hermanus (Rosa rugosa),
Mai Kai (Rosa rugosa Thunb. Var. Plena Regel),
Rowan (Sorbus commixta), Rowan rowan (Sorbus gracilis), White veil (Sorbus japonic)
a), Terminalia alata, Terminalia australis, Seita Kamirobaran (Terminalia bellirica), Honey Milobaran (Terminalia calamansanai), Momotamana (Termi)
nalia catappa), Myrobalan (Terminalia chebul)
a) 、 Terminalia glaucifolia 、 Terminalia nigrovenul
osa, Terminalia pierrii, Hishi (Trapa japonica),
Mebishi (Trapa japonica Flerov. Var. Rubeola Ohwi)
It can be seen that shows a stronger anti-Helicobacter pylori activity than the plants and food materials of the comparative examples reported hitherto.

Pharmacological test (2) [Measurement of anti-Helicobacter pylori activity] The anti-Helicobacter pylori activity was measured by the same method as in the pharmacological test (1). The adsorption amount of the plant extract and the Propolis extract as a comparative example on the paper disk was 200 to 300 μg. The test results are shown in Table 5.

[0064]

[Table 5]

As shown in Table 5, the present invention, Agrimonia japonica, and Cryptaceae (Phyl)
lanthus pulcher), Machiko (Piper angustifolium Rui
z etPav.) is a previously reported propolis (Pr.
It is shown that it exhibits anti-Helicobacter pylori activity equivalent to or higher than that of opolis).

Formulation Example 1 [Production of tablets] Karin (Chaenomeles) obtained in Production Example
sinensis) ethanol extract according to a conventional method,
A tablet having the following composition is obtained. (Composition: wt%) Karin ethanol extract 24 Lactose 63 Corn starch 12 Guar gum 1

Formulation Example 2 [Manufacture of juice] The sasanqua (Camell) obtained in the manufacture example
ia sasanqua) ethanol extract is obtained according to a conventional method to obtain a juice having the following composition. (Composition:% by weight) Frozen Concentrated Satsuma Mandarin Juice 5.0 Fructose Glucose Liquid Sugar 11.0 Citric acid 0.2 L-Ascorbic acid 0.02 Fragrance 0.2 Pigment 0.1 Southern Saca ethanol extract 0.2 Water 83.28

[0068]

EFFECTS OF THE INVENTION Since the plant of the present invention has a strong anti-Helicobacter pylori activity, it eradicates Helicobacter pylori and is effective in preventing stomach / duodenal ulcer, gastritis, gastric cancer, gastric malignant lymphoma, and improving symptoms. Is.

Continued front page    (72) Inventor Kazuma Yoshizumi             Kanagawa Prefecture Toyama City Totsuka Ward Shinano 12-13 shares             FANCL Central Research Institute (72) Inventor Takashi Naito             Kanagawa Prefecture Toyama City Totsuka Ward Shinano 12-13 shares             FANCL Central Research Institute (72) Inventor Toyoyuki Nishi             14 Kyoshoin Nishinoshomonguchi-cho, Minami-ku, Kyoto-shi, Kyoto Prefecture             Local Nippon Shinyaku Co., Ltd. (72) Inventor Takeshi Nishino             5-chome Santanagacho, Matsugasaki, Sakyo Ward, Kyoto City, Kyoto Prefecture             No. 1 F-term (reference) 4B018 MD48 ME08 ME11 MF01                 4C088 AB12 AB44 AB45 AB46 AB51                       AB52 AB53 AB55 AC01 BA07                       BA09 BA10 BA37 CA03 CA11                       CA14 MA07 MA17 MA22 MA23                       MA31 MA35 MA37 MA41 MA43                       MA44 MA52 MA60 MA66 ZA68                       ZB26 ZB35

Claims (12)

[Claims] Claims: 1. Enokigusa, Yellow-tailed squirrel, Yellow-chested cypress, Astragalus membranaceus, Aoki, Camellia japonica, Camellia, Sasanqua, Kusaboke, Karin, Bokeh, Cornus baileyi, Anemone sycamore, Cornus sycamore, Acacia nigra, Cornus sycamore, Cornus sylvestris, Yamaboshi, Yamaboshi, Yamasaki. , Hawthorn, Hawthorn, Hawthorn, Gummi, Crotonhutchinsonianus, Croton longissimus, Croton oblongifolius, Croton oblongifolius, Croton robustus, Croton robust
ton sublylatus), Haz, Euphorbia altissima, Holtose, Steller's wort, hawk-toed daisies, poinsettia, konishiki, Euphorbia terracina, Euphorbia trigona, Euphorbia trigona, Euphorbia trigona, Euphorbia trigona. (Geranium fremontii), Geranium Mole (Gerani
um molle), Akabanafuro, Genshosho, Geum canadense, Japanese radish, Akamegashiwa, Kusunohagashiwa, Mallotus stewardii, Evening squirrel, Aspergillus serrata, Asparagus japonicus, Aspergillus serrata, Prunus vulgaris, Prunus vulgaris, Prickly pear Amber tree, citrus cane, citrus cane, citrus cane, sycamore, citrus cane, citrus cane,
Prickly pearl syrup, Honey beetle, Strawberry strawberry, Japanese cherry, Uwamizuzakura, Yamazakura, Satozakura, Yaezakura, Ume, Genpeimomo, Limbok, Yusuume, Kasumizakura, Terihabanjirou, Pomegranate,
Purple Ryukyu Azalea, Yamatsuji, Rhizoma Azalea, Mochi Azalea, Hong rhododendron, Kobano honey azalea, Keramatsu azalea, Baika azalea, Damask rose, Sanshobara, Noibara, Hamanasu, Maikai, Nanakamado, Nankinna Nakamado, Urana, Teruma, Urana Terminalia australis, Seita Kamiro Balan, Honey Milo Balan, Momotamana, Milo Balan, Terminalia glaucifoli
a), Terminalia Nigrovenuroza (Terminalia)
nigrovenulosa), Terminali pielie (Terminali
a pierrii), a plant selected from the group consisting of Hishi, Mebishi, and Machiko, or a squeezed or water extract or an organic solvent extract obtained therefrom, for use as an anti-Helicobacter pylori composition. object. 2. A composition having an anti-gastric ulcer action or an anti-duodenal ulcer action, which comprises at least one of the plant according to claim 1, or the juice or water extract or organic solvent extract obtained therefrom. object. 3. A composition having an anti-gastritis activity, which comprises at least one of the plant according to claim 1, or the juice, water extract or organic solvent extract obtained from them. 4. A composition having an anti-gastric cancer activity, which comprises at least one of the plant according to claim 1, or the juice, water extract or organic solvent extract obtained therefrom. 5. A composition having an anti-gastric malignant lymphoma activity, which contains at least one of the plant according to claim 1, and the juice, water extract or organic solvent extract obtained from them. 6. A composition for anti-Helicobacter pylori, which comprises at least one kind of plants of Quercus cypress, Cercis chinensis, Machiko, or squeezed or water extracts or organic solvent extracts obtained therefrom. 7. An anti-gastric ulcer action or an anti-duodenal ulcer action, which contains at least one of plants of Quercus japonicus, Cercis chinensis, Machiko, or squeezed or water extract or organic solvent extract obtained from them. Composition. 8. A composition having an anti-gastritis activity, which comprises at least one of plants of Quercus cylindrica, Cryptococcus communis, plants of Machiko, or juice or water extract or organic solvent extract obtained from them. 9. A composition having an anti-gastric cancer activity, which comprises at least one of plants of Quercus cylindrica, C. lanceolata, Machiko, or squeezed or water extracts or organic solvent extracts obtained from them. 10. A composition having an anti-gastric malignant lymphoma action, which comprises at least one of plants of Quercus cylindrica, Cryptococcus communis, Machiko plant, or juice or water extract or organic solvent extract obtained from them. 11. A food containing the composition according to claim 1. 12. A medicine containing the composition according to any one of claims 1 to 10.