CN104547350A - 风湿性腰椎病疏风散寒膏剂及制备 - Google Patents
风湿性腰椎病疏风散寒膏剂及制备 Download PDFInfo
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Abstract
本发明公开了一种风湿性腰椎病疏风散寒膏剂，其特征在于，由下列原料药制备而成，均为重量份：淫羊藿10-20；杜仲9-16；老鹤草9-15；红孩儿9-12；木通根8-12；忍冬藤10-16；黄连7-10；火焰子6-9；乌骨麻8-12；朱唇6-9；乌骚风5-10；白附子9-18；补骨脂12-22。本发明的优良效果还表现在：本发明风湿性腰椎病疏风散寒膏剂，以住过中医药学理论为基础，结合多年临床实践配置而成，具有通经活血、舒筋止痛、疏风散寒的功效；本发明药物具有配方合理，疗效明显，无副作用等特点，宜于临床推广应用；本发明药物适用于各种时期不同类型的风湿性腰椎病患者，药源易得，药材成本低廉，能够减轻患者负担。
Description
技术领域
本发明涉及中医中药领域，特别是涉及一种风湿性腰椎病疏风散寒膏剂及制备。
背景技术
风湿性腰椎病主要是指风湿或类风湿性腰痛、风寒湿性腰痛、湿热性腰痛等由风寒湿热导致的、具有腰椎病常见症状的腰椎病。病因病机：外邪侵袭多由居处潮湿，或劳作汗出当风，衣裹冷湿，或冒雨着凉，或长夏之季，劳作于湿热交蒸之处，寒湿、湿热、暑热等六淫邪毒乘劳作之虚，侵袭腰府，造成腰部经脉受阻，气血不畅而发生腰椎病患。临床表现上，风湿性腰椎病患者具有腰痛、下肢放射痛、下肢麻木、马尾神经症状、腰椎间盘突出、腰椎骨质增生、腰椎管狭窄等症状。
中医学将本病归属为腰痛、痹症等范畴。中医辨证施治在临床上主要是分虚实以论治。实证多有寒湿、湿热所致。虚证主要由于肾虚。治疗上实证以驱邪为主，虚证以补肾为主。急性发作，患者疼痛剧烈。指标为主，缓解期其痹通绵绵，反复不愈，以治本为主，或随虚实标本兼顾。邓水苟等用自制抗风湿药酒按摩，具有活血散瘀、强筋壮骨、祛风通络的功效，通过药酒将药力渗入患处，达到调节神经，滑利关节，修复创伤，行血止痛的功效。
申请公布号 CN 103705751 A（申请号 201410016718.X）的中国专利文献公开了一种用于治疗风湿腰痛的中药组合物及其制备方法，由以下重量份数的原料药材组成：桂枝10-30 重量份、千灵丹15-25 重量份、羌活16-31重量份、独活16-31重量份、白芷11-21重量份、破骨风16-25重量份、狍茸16-25重量份、帕梯16-30重量份、木瓜16-30重量份、蚕沙12-25重量份、松节14-25重量份、青风藤16-24重量份、枫香脂16-31重量份、丹参16-25重量份、牡荆茎12-25重量份、千年艾12-3重量份、路路通12-20 重量份、牛膝10-21重量份、鸡血藤16-31重量份和穿山甲16-31重量份。申请公布号 CN 103550486 A（申请号 201310537882.0）的中国专利文献公开了一种治疗风湿性腰椎病的外用中药及其制备方法，由下述重量份的原料药组成：海风藤10-15、半夏1-3、蓖麻子0.1-0.2、细辛5-8、金银花3-6、天南星2-5、桂枝5-8、玄参6-9、大黄10-15、大枫子3-7、牛膝5-8、香附4-8、僵蚕3-6、知母5-10、枳壳10-15、黄柏1-3、威灵仙3-5、川乌6-9、草乌6-9、白术5-8。申请公布号 CN 103705682 A（申请号 201310695072.8）的中国专利文献公开了一种治疗风湿腰痛的药物，由以下重量份的药物组成：大黄6-10g，桃仁5-8g，当归15-25g，白芍25-35g，柴胡6-12g，黄连5-8g，厚朴8-15g，甘草6-12g，元胡8-12g，香附10-15g，补骨脂10-15g，牛膝15-25g，桑寄生25-35g，桂枝6-12g，羌活8-12g，独活8-12g，狗脊10-15g，川断10-15g，骨碎补10-15g，小茴香6-12g，白术20-30g，苍术10-15g，神曲15-25g，杜仲15-25g。
在现有的治疗风湿性腰椎病药物中，大多数中成药具有配方不合理，功能单一，治疗效果差等缺陷。西药价格高，副作用大，而且容易产生抗药性。
发明内容
针对现有技术的不足，本发明的目的是提供一种制备简单、服用方便、疗程短的一种风湿性腰椎病疏风散寒膏剂及制备方法。该膏剂疗效确切且无毒副作用。
本发明的技术方案是：
风湿性腰椎病疏风散寒膏剂，其特征在于，由下列原料药制备而成，均为重量份：淫羊藿10-20；杜仲9-16；老鹤草9-15；红孩儿9-12；木通根8-12；忍冬藤10-16；黄连7-10；火焰子6-9；乌骨麻8-12；朱唇6-9；乌骚风5-10；白附子9-18；补骨脂12-22。
优选的方案中，淫羊藿12-18；杜仲11-14；老鹤草11-13；红孩儿10-11；木通根9-11；忍冬藤12-14；黄连8-9；火焰子7-8；乌骨麻9-11；朱唇7-8；乌骚风6-9；白附子11-16；补骨脂14-20。
更加优选的，淫羊藿16；杜仲12.5；老鹤草12；红孩儿10.5；木通根10；忍冬藤13；黄连8.5；火焰子7.5；乌骨麻10；朱唇7.5；乌骚风7.5；白附子13.5；补骨脂17。
风湿性腰椎病疏风散寒膏剂的制备方法，步骤如下：
（1）杜仲洗净，置于热锅内，不断翻动，用武火炒至表面焦黑色，内面焦褐色，取出，喷洒清水少许，灭净火星，晒干，研成细粉；木通根洗净，置于米泔水中浸泡1-2小时，然后取出，置于热锅中，文火炒至表面焦黄色至黑褐色，断面灰棕色，质枯脆，具有焦香气，停止，放冷，研末备用；
（2）取补骨脂洗净，加黄酒浸泡20-30小时，过滤，置电炒锅内炒至微鼓起有噼啪声响，取出，充分晾干，粉碎备用；火焰子、白附子、忍冬藤和淫羊藿分别洗净，置于微波炉中，60%的微波热力炮制烘干，捣碎，研成细粉；
（3）将步骤（1）-（2）所得细粉混合均匀，过筛，置干燥器中备用；
（4）将老鹤草、红孩儿、黄连、乌骨麻、朱唇和乌骚风置于瓦罐中，加入6-10倍药材量的纯净水浸泡（优选加入8倍药材量的纯净水浸泡），武火煮沸，转文火煎煮60-80分钟（优选转文火煎煮70分钟），过滤，得滤液1；再次加入4-6倍药材量蒸馏水，煮沸15-35分钟，过滤，得滤液2；合并2次滤液，再用洁净无纺棉布过滤，滤液减压浓缩成稠膏，备用；
（5）向上述稠膏中加入步骤（3）所得混合细粉，然后加入冰片、樟脑和氮酮，搅拌均匀，将其均摊于布或膏药纸上，冷却，即得膏剂。
上述风湿性腰椎病疏风散寒膏剂的制备方法，优选的方案是，步骤（2）中加1.5-3.5倍药材量的黄酒浸泡（优选的加2-3倍药材量的黄酒浸泡，更加优选的加2.5倍药材量的黄酒浸泡）。
上述风湿性腰椎病疏风散寒膏剂的制备方法，优选的方案是，步骤（2）中用60%的微波热力炮制烘干50-70分钟（优选的用60%的微波热力炮制烘干55-65分钟，更加优选的用60%的微波热力炮制烘干60分钟）。
上述风湿性腰椎病疏风散寒膏剂的制备方法，优选的方案是，步骤（3）中过60-120目筛（优选过80-100目筛，更加优选的过90目筛）。
上述风湿性腰椎病疏风散寒膏剂的制备方法，优选的方案是，步骤（4）中纯净水浸泡时间为2-5小时（优选的纯净水浸泡时间为3-4小时，更加优选的纯净水浸泡时间为3.5小时）。
上述风湿性腰椎病疏风散寒膏剂的制备方法，优选的方案是，步骤（5）中冰片占0.5%-1.5%、樟脑占0.5%-2.5%、氮酮占1%-2%。
上述风湿性腰椎病疏风散寒膏剂的制备方法，优选的方案是，步骤（5）中冰片占1.0%、樟脑占1.5%、氮酮占1.5%。
本发明组方科学，制备方法简单，所得产品使用方便、效果明显。除此之外，本发明的优良效果还表现在：
1、本发明风湿性腰椎病疏风散寒膏剂，以住过中医药学理论为基础，结合多年临床实践配置而成，具有通经活血、舒筋止痛、疏风散寒的功效。
2、本发明药物具有配方合理，疗效明显，无副作用等特点，宜于临床推广应用。
3、本发明药物适用于各种时期不同类型的风湿性腰椎病患者，药源易得，药材成本低廉，能够减轻患者负担。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案，但保护范围不限于此。
本发明所用主要中药原料的药理如下：
淫羊藿：基原：为小檗科植物淫羊藿、心叶淫羊藿或箭叶淫羊藿的茎叶。化学成份：淫羊藿茎、叶含淫羊藿甙，叶尚含挥发油、蜡醇、卅一烷、植物甾醇、鞣质、油脂。脂肪油中的脂肪酸有棕榈酸、硬脂酸、油酸、亚油酸。药理作用：①影响性机能；②对微生物有抑制作用；③镇咳、祛痰与平喘作用；④其他作用：淫羊藿提取液对家兔有降压作用，小量使尿分泌增加，大量则反而抑制之，对离体兔肠有抑制作用，离体子宫则先兴奋后抑制，口服能使高血糖大鼠血糖下降。性味：辛甘，温。归经：入肝、肾经。功能主治：补肾壮阳，祛风除湿。治阳痿不举，小便淋沥，筋骨挛急，半身不遂，腰膝无力，风湿痹痛，四肢不仁。
杜仲：基原：本品为杜仲科植物杜仲的干燥树皮。性状：本品呈板片状或两边稍向内卷，大小不一，厚3-7mm。外表面淡棕色或灰褐色，有明显的皱纹或纵裂槽纹，有的树皮较薄，未去粗皮，可见明显的皮孔。内表面暗紫色，光滑。质脆，易折断，断面有细密、银白色、富弹性的橡胶丝相连。气微，味稍苦。性味：甘，温。归经：归肝、肾经。功效：补肝肾，强筋骨。安胎。主治：用于肾虚腰痛．筋骨无力，妊娠漏血，胎动不安；高血压。
老鹤草：基原：为槐牛儿苗科植物牻牛儿苗或老鹳草、尼泊尔老鹳草、西伯利亚老鹤草及野老鹳草、块根者鹳草等带有果实的全草。化学成份：牻牛儿苗含挥发油，油中主要成分为牻牛儿醇。又含槲皮素及其他色素。药理作用：㈠抗菌作用：全草煎剂在试管内对卡他球菌、金黄色葡萄球菌、弗氏痢疾杆菌、β-链球菌、肺炎球菌等有较明显的抑制作用；其中所含鞣酸对其抑菌有一定影响。㈡抗病毒作用：全草煎剂对亚洲甲型流感病毒京科68-1株和副流感病毒I型仙台株有较明显的抑制作用。性味：苦辛，平。功能主治：祛风，活血，清热解毒。治风湿疼痛，拘挛麻木，痈疽，跌打，肠炎，痢疾。
红孩儿：基原：为秋海棠科植物裂叶秋海棠的全株。性味：《陆川本草》："甘，寒。" 功能主治：治感冒咳嗽，风湿骨痛，腰痛，消化不良，跌打肿痛，疔疮。
忍冬藤：基原：为忍冬科植物忍冬的茎叶。化学成份：叶含忍冬甙即木犀草素-7-鼠李糖葡萄糖甙、木犀草素等黄酮类。茎含鞣质、生物碱。药理作用：木犀草素对平滑肌（兔寓体小肠）有解痉作用，但不及罂粟碱；并有轻度利尿（增加氯化钠的排出）作用。性味：甘，寒。归经：入心、肺经。功能主治：清热，解毒，通络。治温病发热，热毒血痢，传染性肝炎，痈肿疮毒，筋骨疼痛。
黄连：基原：为毛茛科植物黄连、三角叶黄连、峨嵋野连或云南黄连的根茎。性味：苦，寒。归经：归心、脾、胃、肝、胆、大肠经。功能主治：清热燥湿，泻火解毒。用于湿热痞满，呕吐吞酸，泻痢，黄疸，高热神昏，心火亢盛，心烦不寐，血热吐衄，目赤，牙痛，消渴，痈肿疔疮；外治湿疹，湿疮，耳道流脓。酒黄连善清上焦火热。用于目赤，口疮。姜黄连清胃和胃止呕。用于寒热互结，湿热中阻，痞满呕吐。萸黄连舒肝和胃止呕。用于肝胃不和，呕吐吞酸。
乌骨麻：基原：为荨麻科植物庐山楼梯草的根茎及全草。性味：苦；辛；性温。功能主治：活血祛瘀；解毒消肿；止咳。主跌打扭伤；骨折；闭经；风湿痹痛；痄腮；带状疱疹；疮肿；毒蛇咬伤；咳嗽。
朱唇：基原：为唇形科鼠尾草属植物朱唇的全草。药理作用：耐缺氧作用。药性：辛、微苦、涩，凉。归经：肝，脾经。主治：血崩；高热；腹痛不适。
乌骚风：基原：为萝摩科植物青蛇藤的茎。性味：《四川中药志》：“味辛微苦，性热。”功能主治：①《分类草药性》："走表散寒，治腰痛，去风散血。"②《四川中药志》："治腰痛，风湿麻木，跌打损伤，蛇咬伤。"
白附子：基原：本品为天南星科植物独角莲的干燥块茎。性味：辛，温；有毒。归经： 归胃、肝经。功能主治：祛风痰，定惊搐，解毒散结止痛。用于中风痰壅，口眼歪斜，语言涩謇，痰厥头痛，偏正头痛，喉痹咽痛，破伤风；外治瘰疬痰核，毒蛇咬伤。
补骨脂：基原：为豆科植物补骨脂的果实。化学成份：果实含挥发油约20％、有机酸、一种甲基糖甙、碱溶性树脂、不挥发性萜类油、皂甙。种子含香豆精类补骨脂素和异补骨脂素共约1.1％、黄酮类补骨脂黄酮、甲基补骨脂黄酮、异补骨脂黄酮和查耳酮类补骨脂查耳酮、异补骨脂查耳酮、单萜烯酚衍生物补骨脂酚；尚含挥发油、树脂、脂肪油。花含脂肪油、挥发油、甾醇、生物碱等。本植物还含棉子糖。性味：辛，温。归经：入肾经。功能主治：补肾助阳。治肾虚冷泻，遗尿，滑精，小便频数，阳痿，腰膝冷痛，虚寒喘嗽。外用治白癜风。
木通根：基原：为木通科木通属植物木通的根。化学成分：木通根含有甾醇类：豆甾醇，胡萝卜苷。药性：味苦，性平。归膀胱、肝经。功用主治：祛风除湿，活血行气，利尿，解毒。主治风湿痹痛，跌打损伤，经闭，疝气，睾丸肿痛，脘腹胀闷，小便不利，带下，虫蛇咬伤。
火焰子：基原：为毛茛科乌头属植物松潘乌头的根。化学成分：塔拉胺，展花乌头宁，黄草乌碱甲。药理：抗炎、解热作用 药性：辛，苦，热，大毒功用主治：祛风胜湿，散寒止痛，散瘀消肿。主治风寒湿痹，肢节疼痛，牙痛，跌打损伤，痈肿毒疮，神经痛。
实施例1 风湿性腰椎病疏风散寒膏剂，由下列原料药制备而成，均为重量份（40g/份）：淫羊藿10份；杜仲9份；老鹤草9份；红孩儿9份；木通根8份；忍冬藤10份；黄连7份；火焰子6份；乌骨麻8份；朱唇6份；乌骚风5份；白附子9份；补骨脂12份。
上述风湿性腰椎病疏风散寒膏剂的制备方法是：
（1）杜仲洗净，置于热锅内，不断翻动，用武火炒至表面焦黑色，内面焦褐色，取出，喷洒清水少许，灭净火星，晒干，研成细粉；木通根洗净，置于米泔水中浸泡1小时，然后取出，置于热锅中，文火炒至表面焦黄色至黑褐色，断面灰棕色，质枯脆，具有焦香气，停止，放冷，研末备用；
（2）取补骨脂洗净，加1.5倍药材量的黄酒浸泡20小时，过滤，置电炒锅内炒至微鼓起有噼啪声响，取出，充分晾干，粉碎备用；火焰子、白附子、忍冬藤和淫羊藿分别洗净，置于微波炉中，60%的微波热力炮制烘干50分钟，捣碎，研成细粉；
（3）将步骤（1）-（2）所得细粉混合均匀，过60目筛，置干燥器中备用；
（4）将老鹤草、红孩儿、黄连、乌骨麻、朱唇和乌骚风置于瓦罐中，加入6倍药材量的纯净水浸泡2小时，武火煮沸，转文火煎煮60分钟，过滤，得滤液1；再次加入4倍药材量蒸馏水，煮沸15分钟，过滤，得滤液2；合并2次滤液，再用洁净无纺棉布过滤，滤液减压浓缩成稠膏，备用；
（5）向上述稠膏中加入步骤（3）所得混合细粉，然后加入冰片、樟脑和氮酮（冰片占0.5%、樟脑占0.5%、氮酮占1%），搅拌均匀，将其均摊于布或膏药纸上，冷却，即得膏剂。
本发明膏剂的使用方法是：将患处清洗干净，取大小适宜的本膏剂，加温软化，贴在患处，一天更换一次，7天为一个疗程。
实施例2 风湿性腰椎病疏风散寒膏剂，由下列原料药制备而成，均为重量份（20g/份）：淫羊藿20份；杜仲16份；老鹤草15份；红孩儿12份；木通根12份；忍冬藤16份；黄连10份；火焰子9份；乌骨麻12份；朱唇9份；乌骚风10份；白附子18份；补骨脂22份。
上述风湿性腰椎病疏风散寒膏剂的制备方法是：
（1）杜仲洗净，置于热锅内，不断翻动，用武火炒至表面焦黑色，内面焦褐色，取出，喷洒清水少许，灭净火星，晒干，研成细粉；木通根洗净，置于米泔水中浸泡2小时，然后取出，置于热锅中，文火炒至表面焦黄色至黑褐色，断面灰棕色，质枯脆，具有焦香气，停止，放冷，研末备用；
（2）取补骨脂洗净，加3.5倍药材量的黄酒浸泡30小时，过滤，置电炒锅内炒至微鼓起有噼啪声响，取出，充分晾干，粉碎备用；火焰子、白附子、忍冬藤和淫羊藿分别洗净，置于微波炉中，60%的微波热力炮制烘干70分钟，捣碎，研成细粉；
（3）将步骤（1）-（2）所得细粉混合均匀，过120目筛，置干燥器中备用；
（4）将老鹤草、红孩儿、黄连、乌骨麻、朱唇和乌骚风置于瓦罐中，加入10倍药材量的纯净水浸泡5小时，武火煮沸，转文火煎煮80分钟，过滤，得滤液1；再次加入6倍药材量蒸馏水，煮沸35分钟，过滤，得滤液2；合并2次滤液，再用洁净无纺棉布过滤，滤液减压浓缩成稠膏，备用；
（5）向上述稠膏中加入步骤（3）所得混合细粉，然后加入冰片、樟脑和氮酮（冰片占1.5%、樟脑占2.5%、氮酮占2%），搅拌均匀，将其均摊于布或膏药纸上，冷却，即得膏剂。
本发明膏剂的使用方法是：将患处清洗干净，取大小适宜的本膏剂，加温软化，贴在患处，一天更换一次，7天为一个疗程。
典型病例：李XX，男，52岁，2011年10月20日来我处就诊。患者自述：反复腰、腿痛3年有余，伴左下肢酸痛半年。患者于1年期前，在劳作中不慎扭伤腰部，疼痛难忍，CT检查显示：腰椎间盘突出，曾去当地医院住院治疗，当好转时间不长，反复发作，效果欠佳，四处求医问药，疗效总是不能持久，无法重体力劳动。6天前，腰痛再次发作，下短困难，行走不便，也不能寐，舌淡，脉沉细。检查：CT片显示：L4-5椎间盘突出。诊断为风湿入侵，经络痹阻，筋骨失养所致。
使用本实施例所得风湿性腰椎病疏风散寒膏剂，使用方法：将患处清洗干净，取大小适宜的本膏剂，加温软化，贴在患处，一天更换一次，7天为一个疗程。治疗5天后，患者腰、腿痛感明显减轻，用药2个疗程后，患者症状基本疼痛症状基本消失，继续治疗1个疗程，患者康复，至今无复发。
实施例3 风湿性腰椎病疏风散寒膏剂，由下列原料药制备而成，均为重量份（35g/份）：淫羊藿12份；杜仲11份；老鹤草11份；红孩儿10份；木通根9份；忍冬藤12份；黄连8份；火焰子7份；乌骨麻9份；朱唇7份；乌骚风6份；白附子11份；补骨脂14份。
上述风湿性腰椎病疏风散寒膏剂的制备方法是：
（1）杜仲洗净，置于热锅内，不断翻动，用武火炒至表面焦黑色，内面焦褐色，取出，喷洒清水少许，灭净火星，晒干，研成细粉；木通根洗净，置于米泔水中浸泡1.3小时，然后取出，置于热锅中，文火炒至表面焦黄色至黑褐色，断面灰棕色，质枯脆，具有焦香气，停止，放冷，研末备用；
（2）取补骨脂洗净，加2倍药材量的黄酒浸泡23小时，过滤，置电炒锅内炒至微鼓起有噼啪声响，取出，充分晾干，粉碎备用；火焰子、白附子、忍冬藤和淫羊藿分别洗净，置于微波炉中，60%的微波热力炮制烘干55分钟，捣碎，研成细粉；
（3）将步骤（1）-（2）所得细粉混合均匀，过80目筛，置干燥器中备用；
（4）将老鹤草、红孩儿、黄连、乌骨麻、朱唇和乌骚风置于瓦罐中，加入7倍药材量的纯净水浸泡3小时，武火煮沸，转文火煎煮65分钟，过滤，得滤液1；再次加入4.5倍药材量蒸馏水，煮沸20分钟，过滤，得滤液2；合并2次滤液，再用洁净无纺棉布过滤，滤液减压浓缩成稠膏，备用；
（5）向上述稠膏中加入步骤（3）所得混合细粉，然后加入冰片、樟脑和氮酮（冰片占0.8%、樟脑占1.0%、氮酮占1.2%），搅拌均匀，将其均摊于布或膏药纸上，冷却，即得膏剂。
本发明膏剂的使用方法是：将患处清洗干净，取大小适宜的本膏剂，加温软化，贴在患处，一天更换一次，7天为一个疗程。
实施例4 风湿性腰椎病疏风散寒膏剂，由下列原料药制备而成，均为重量份（25g/份）：淫羊藿18份；杜仲14份；老鹤草13份；红孩儿11份；木通根11份；忍冬藤14份；黄连9份；火焰子8份；乌骨麻11份；朱唇8份；乌骚风9份；白附子16份；补骨脂20份。
上述风湿性腰椎病疏风散寒膏剂的制备方法是：
（1）杜仲洗净，置于热锅内，不断翻动，用武火炒至表面焦黑色，内面焦褐色，取出，喷洒清水少许，灭净火星，晒干，研成细粉；木通根洗净，置于米泔水中浸泡1.7小时，然后取出，置于热锅中，文火炒至表面焦黄色至黑褐色，断面灰棕色，质枯脆，具有焦香气，停止，放冷，研末备用；
（2）取补骨脂洗净，加3倍药材量的黄酒浸泡27小时，过滤，置电炒锅内炒至微鼓起有噼啪声响，取出，充分晾干，粉碎备用；火焰子、白附子、忍冬藤和淫羊藿分别洗净，置于微波炉中，60%的微波热力炮制烘干65分钟，捣碎，研成细粉；
（3）将步骤（1）-（2）所得细粉混合均匀，过100目筛，置干燥器中备用；
（4）将老鹤草、红孩儿、黄连、乌骨麻、朱唇和乌骚风置于瓦罐中，加入9倍药材量的纯净水浸泡4小时，武火煮沸，转文火煎煮75分钟，过滤，得滤液1；再次加入5.5倍药材量蒸馏水，煮沸30分钟，过滤，得滤液2；合并2次滤液，再用洁净无纺棉布过滤，滤液减压浓缩成稠膏，备用；
（5）向上述稠膏中加入步骤（3）所得混合细粉，然后加入冰片、樟脑和氮酮（冰片占1.2%、樟脑占2.0%、氮酮占1.8%），搅拌均匀，将其均摊于布或膏药纸上，冷却，即得膏剂。
本发明膏剂的使用方法是：将患处清洗干净，取大小适宜的本膏剂，加温软化，贴在患处，一天更换一次，7天为一个疗程。
典型病例：范XX，女，57岁，章丘人。2010年12月7日来我院治疗。患者多年从事田间劳作，时常感觉腰酸腿痛，近两年疼痛加剧，经常痛得直不起腰。有时候还有间断性抽痛，在劳作后或天气变化前时常反复发作，一直自行在患处贴膏药来缓解痛苦。后来因为疼痛难忍，由家人送往我院就诊。经过询问和检查，诊断为风湿性腰痛。
使用本实施例所得风湿性腰椎病疏风散寒膏剂，使用方法：将患处清洗干净，取大小适宜的本膏剂，加温软化，贴在患处，一天更换一次，7天为一个疗程。治疗一个疗程后，患者疼痛减轻，可以干些轻松的活，第二个疗程后，患者精神好转，疼痛基本消失，自述感觉轻松，随访半年后，患者病情未复发，精神大为好转。
实施例5 风湿性腰椎病疏风散寒膏剂，由下列原料药制备而成，均为重量份（30g/份）：淫羊藿16份；杜仲12.5份；老鹤草12份；红孩儿10.5份；木通根10份；忍冬藤13份；黄连8.5份；火焰子7.5份；乌骨麻10份；朱唇7.5份；乌骚风7.5份；白附子13.5份；补骨脂17份。
上述风湿性腰椎病疏风散寒膏剂的制备方法是：
（1）杜仲洗净，置于热锅内，不断翻动，用武火炒至表面焦黑色，内面焦褐色，取出，喷洒清水少许，灭净火星，晒干，研成细粉；木通根洗净，置于米泔水中浸泡1.5小时，然后取出，置于热锅中，文火炒至表面焦黄色至黑褐色，断面灰棕色，质枯脆，具有焦香气，停止，放冷，研末备用；
（2）取补骨脂洗净，加2.5倍药材量的黄酒浸泡25小时，过滤，置电炒锅内炒至微鼓起有噼啪声响，取出，充分晾干，粉碎备用；火焰子、白附子、忍冬藤和淫羊藿分别洗净，置于微波炉中，60%的微波热力炮制烘干60分钟，捣碎，研成细粉；
（3）将步骤（1）-（2）所得细粉混合均匀，过90目筛，置干燥器中备用；
（4）将老鹤草、红孩儿、黄连、乌骨麻、朱唇和乌骚风置于瓦罐中，加入8倍药材量的纯净水浸泡3.5小时，武火煮沸，转文火煎煮70分钟，过滤，得滤液1；再次加入5倍药材量蒸馏水，煮沸25分钟，过滤，得滤液2；合并2次滤液，再用洁净无纺棉布过滤，滤液减压浓缩成稠膏，备用；
（5）向上述稠膏中加入步骤（3）所得混合细粉，然后加入冰片、樟脑和氮酮（冰片占1.0%、樟脑占1.5%、氮酮占1.5%），搅拌均匀，将其均摊于布或膏药纸上，冷却，即得膏剂。
本发明膏剂的使用方法是：将患处清洗干净，取大小适宜的本膏剂，加温软化，贴在患处，一天更换一次，7天为一个疗程。
试验例1 本发明所得风湿性腰椎病疏风散寒膏剂（实施例5）的临床应用：
1、资料和方法
1.1 一般资料
2009年10月-2013年9月，选取来我院治疗的315例诊断为风寒感冒患者。其中男性患者155例，女性患者160例；年龄最大的74岁，年龄最小的36岁。病程至少2个月。
1.2 诊断标准
诊断标准：
中医诊断标准参照《中医病症诊断疗效标准》中风湿或类风湿性腰痛、风寒湿性腰痛、湿热性腰痛等由风寒湿热导致的、具有腰椎病常见症状的相关诊断标准：临床表现为具有腰痛、下肢放射痛、下肢麻木、马尾神经症状、腰椎间盘突出、腰椎骨质增生、腰椎管狭窄；舌质暗紫，或有瘀斑，或舌淡、苔白、脉细等症状。
1.3 治疗方法
所有患者随机分为两组，实验组和对照组，实验组使用本发明所得产品，使用方法为：将患处清洗干净，取大小适宜的本膏剂，加温软化，贴在患处，一天更换一次，7天为一个疗程。对照组服用其它药品（如布洛芬、腰痹通胶囊、腰痛宁胶囊等常规药品）。共观察治疗两个疗程。
1.4 疗效评定标准
治愈：治疗后临床症状消失，体质恢复正常，观察半年无复发者；
好转：临床症状明显改善，体质逐步恢复；
无效：临床部分症状消失或无改变，达不到好转标准者。
1.5 治疗结果
治疗结果如表1所示：
表1：服用本发明产品36-74岁风湿性腰椎病患者治疗结果
治疗效果：治愈140例（70%），好转57例（28.5%）；无效3例（1.5%），总有效率98.5%。效果明显优于对照组。
治疗前后实验组和对照组患者症状消失情况，如表2所示：
表2：治疗前后实验组和对照组患者症状消失情况
本发明选择淫羊藿、杜仲、老鹤草、红孩儿、木通根、忍冬藤、黄连、火焰子、乌骨麻、朱唇、乌骚风、白附子和补骨脂共13味中草药进行配伍，使得这些药物组合后产生协同作用，能够更有效地治疗风湿性腰椎病。方中，淫羊藿具有补肾壮阳，祛风除湿的功效；杜仲用于肾虚腰痛．筋骨无力；老鹤草主治风湿疼痛，拘挛麻木；红孩儿主治感冒咳嗽，风湿骨痛，腰痛，消化不良，跌打肿痛；忍冬藤具有清热，解毒，通络的功效；黄连用于寒热互结，湿热中阻，痞满呕吐；补骨脂主治腰膝冷痛，虚寒喘嗽。全方配伍，共奏疏风散寒、行气止痛之功。治疗两个疗程，有效率可达98.5%。
应当指出的是，具体实施方式只是本发明比较有代表性的例子，显然本发明的技术方案不限于上述实施例，还可以有很多变形。本领域的普通技术人员，以本发明所明确公开的或根据文件的书面描述毫无异议的得到的，均应认为是本专利所要保护的范围。
Claims (10)
1.风湿性腰椎病疏风散寒膏剂，其特征在于，由下列原料药制备而成，均为重量份：淫羊藿10-20；杜仲9-16；老鹤草9-15；红孩儿9-12；木通根8-12；忍冬藤10-16；黄连7-10；火焰子6-9；乌骨麻8-12；朱唇6-9；乌骚风5-10；白附子9-18；补骨脂12-22。
2.如权利要求1所述的风湿性腰椎病疏风散寒膏剂，其特征在于，由下列原料药制备而成，均为重量份：淫羊藿12-18；杜仲11-14；老鹤草11-13；红孩儿10-11；木通根9-11；忍冬藤12-14；黄连8-9；火焰子7-8；乌骨麻9-11；朱唇7-8；乌骚风6-9；白附子11-16；补骨脂14-20。
3.如权利要求1所述的风湿性腰椎病疏风散寒膏剂，其特征在于，由下列原料药制备而成，均为重量份：淫羊藿16；杜仲12.5；老鹤草12；红孩儿10.5；木通根10；忍冬藤13；黄连8.5；火焰子7.5；乌骨麻10；朱唇7.5；乌骚风7.5；白附子13.5；补骨脂17。
4.如权利要求1-3任一所述的风湿性腰椎病疏风散寒膏剂的制备方法，其特征是，步骤如下：
（1）杜仲洗净，置于热锅内，不断翻动，用武火炒至表面焦黑色，内面焦褐色，取出，喷洒清水少许，灭净火星，晒干，研成细粉；木通根洗净，置于米泔水中浸泡1-2小时，然后取出，置于热锅中，文火炒至表面焦黄色至黑褐色，断面灰棕色，质枯脆，具有焦香气，停止，放冷，研末备用；
（2）取补骨脂洗净，加黄酒浸泡20-30小时，过滤，置电炒锅内炒至微鼓起有噼啪声响，取出，充分晾干，粉碎备用；火焰子、白附子、忍冬藤和淫羊藿分别洗净，置于微波炉中，60%的微波热力炮制烘干，捣碎，研成细粉；
（3）将步骤（1）-（2）所得细粉混合均匀，过筛，置干燥器中备用；
（4）将老鹤草、红孩儿、黄连、乌骨麻、朱唇和乌骚风置于瓦罐中，加入6-10倍药材量的纯净水浸泡（优选加入8倍药材量的纯净水浸泡），武火煮沸，转文火煎煮60-80分钟（优选转文火煎煮70分钟），过滤，得滤液1；再次加入4-6倍药材量蒸馏水，煮沸15-35分钟，过滤，得滤液2；合并2次滤液，再用洁净无纺棉布过滤，滤液减压浓缩成稠膏，备用；
（5）向上述稠膏中加入步骤（3）所得混合细粉，然后加入冰片、樟脑和氮酮，搅拌均匀，将其均摊于布或膏药纸上，冷却，即得膏剂。
5.如权利要求4所述的风湿性腰椎病疏风散寒膏剂的制备方法，其特征在于，步骤（2）中加1.5-3.5倍药材量的黄酒浸泡（优选的加2-3倍药材量的黄酒浸泡，更加优选的加2.5倍药材量的黄酒浸泡）。
6.如权利要求4所述的风湿性腰椎病疏风散寒膏剂的制备方法，其特征在于，步骤（2）中用60%的微波热力炮制烘干50-70分钟（优选的用60%的微波热力炮制烘干55-65分钟，更加优选的用60%的微波热力炮制烘干60分钟）。
7.如权利要求4所述的风湿性腰椎病疏风散寒膏剂的制备方法，其特征在于，步骤（3）中过60-120目筛（优选过80-100目筛，更加优选的过90目筛）。
8.如权利要求4所述的风湿性腰椎病疏风散寒膏剂的制备方法，其特征在于，步骤（4）中纯净水浸泡时间为2-5小时（优选的纯净水浸泡时间为3-4小时，更加优选的纯净水浸泡时间为3.5小时）。
9.如权利要求4所述的风湿性腰椎病疏风散寒膏剂的制备方法，其特征在于，步骤（5）中冰片占0.5%-1.5%、樟脑占0.5%-2.5%、氮酮占1%-2%。
10.如权利要求9所述的风湿性腰椎病疏风散寒膏剂的制备方法，其特征在于，步骤（5）中冰片占1.0%、樟脑占1.5%、氮酮占1.5%。
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