CN104546700B - 用于多巴脱羧酶抑制剂连续施用的组合物 - Google Patents

用于多巴脱羧酶抑制剂连续施用的组合物 Download PDF

Info

Publication number
CN104546700B
CN104546700B CN201410800432.0A CN201410800432A CN104546700B CN 104546700 B CN104546700 B CN 104546700B CN 201410800432 A CN201410800432 A CN 201410800432A CN 104546700 B CN104546700 B CN 104546700B
Authority
CN
China
Prior art keywords
carbidopa
levodopa
composition
arginine
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201410800432.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN104546700A (zh
Inventor
奥龙·雅酷比-兹维
马拉·奈马斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuroderm Ltd
Original Assignee
Neuroderm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42320738&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN104546700(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neuroderm Ltd filed Critical Neuroderm Ltd
Publication of CN104546700A publication Critical patent/CN104546700A/zh
Application granted granted Critical
Publication of CN104546700B publication Critical patent/CN104546700B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10Hydrazines
    • C07C243/12Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
    • C07C243/16Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C243/18Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/15Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201410800432.0A 2009-05-19 2010-05-17 用于多巴脱羧酶抑制剂连续施用的组合物 Active CN104546700B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17951109P 2009-05-19 2009-05-19
US61/179,511 2009-05-19
CN201080022208.3A CN102438587B (zh) 2009-05-19 2010-05-17 用于多巴脱羧酶抑制剂连续施用的组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201080022208.3A Division CN102438587B (zh) 2009-05-19 2010-05-17 用于多巴脱羧酶抑制剂连续施用的组合物

Publications (2)

Publication Number Publication Date
CN104546700A CN104546700A (zh) 2015-04-29
CN104546700B true CN104546700B (zh) 2017-06-06

Family

ID=42320738

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201410800432.0A Active CN104546700B (zh) 2009-05-19 2010-05-17 用于多巴脱羧酶抑制剂连续施用的组合物
CN201080022208.3A Active CN102438587B (zh) 2009-05-19 2010-05-17 用于多巴脱羧酶抑制剂连续施用的组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201080022208.3A Active CN102438587B (zh) 2009-05-19 2010-05-17 用于多巴脱羧酶抑制剂连续施用的组合物

Country Status (26)

Country Link
US (9) US8193243B2 (cg-RX-API-DMAC7.html)
EP (3) EP2432454B1 (cg-RX-API-DMAC7.html)
JP (3) JP5643297B2 (cg-RX-API-DMAC7.html)
KR (2) KR101709904B1 (cg-RX-API-DMAC7.html)
CN (2) CN104546700B (cg-RX-API-DMAC7.html)
AR (3) AR078413A1 (cg-RX-API-DMAC7.html)
AU (1) AU2010250766B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI1011031B8 (cg-RX-API-DMAC7.html)
CA (1) CA2761624C (cg-RX-API-DMAC7.html)
CL (1) CL2011002895A1 (cg-RX-API-DMAC7.html)
CY (1) CY1119495T1 (cg-RX-API-DMAC7.html)
DK (2) DK3192500T3 (cg-RX-API-DMAC7.html)
ES (2) ES2840748T3 (cg-RX-API-DMAC7.html)
HR (2) HRP20170805T1 (cg-RX-API-DMAC7.html)
HU (2) HUE052685T2 (cg-RX-API-DMAC7.html)
IL (1) IL216383A (cg-RX-API-DMAC7.html)
LT (1) LT2432454T (cg-RX-API-DMAC7.html)
MX (2) MX364974B (cg-RX-API-DMAC7.html)
NZ (1) NZ596963A (cg-RX-API-DMAC7.html)
PL (2) PL2432454T3 (cg-RX-API-DMAC7.html)
PT (2) PT2432454T (cg-RX-API-DMAC7.html)
RU (3) RU2678839C2 (cg-RX-API-DMAC7.html)
SG (3) SG176159A1 (cg-RX-API-DMAC7.html)
SI (1) SI2432454T1 (cg-RX-API-DMAC7.html)
WO (1) WO2010134074A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201109037B (cg-RX-API-DMAC7.html)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN192600B (cg-RX-API-DMAC7.html) * 1996-10-18 2004-05-08 Hoechst Celanese Corp
PT2432454T (pt) 2009-05-19 2017-06-12 Neuroderm Ltd Composições para administração contínua de inibidores de dopa decarboxilase
HUE047841T2 (hu) 2010-11-15 2020-05-28 Neuroderm Ltd L-dopa, dopa dekarboxiláz inhibitorok, katekol-o-metil transzferáz inhibitorok folyamatos adagolására szolgáló készítmények
PL2854764T3 (pl) 2012-06-05 2019-07-31 Neuroderm Ltd Kompozycje zawierające apomorfinę i kwasy organiczne oraz ich zastosowania
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
CN103845318A (zh) * 2012-12-07 2014-06-11 天津市汉康医药生物技术有限公司 恩他卡朋分散片
CN105209029A (zh) * 2013-03-13 2015-12-30 纽罗德姆有限公司 帕金森病的治疗方法
CN113384373B (zh) * 2013-11-05 2022-10-21 辛纳吉勒公司 经由口腔进行连续药物递送的装置和方法
US10258585B2 (en) 2014-03-13 2019-04-16 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
JP6591995B2 (ja) 2014-03-13 2019-10-16 ニューロダーム リミテッドNeuroderm Ltd ドーパデカルボキシラーゼ阻害剤組成物
EP4356907A1 (en) 2014-09-04 2024-04-24 LobSor Pharmaceuticals Aktiebolag Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a comtinhibitor and method of administration thereof
AU2015335941B2 (en) 2014-10-21 2021-04-01 Abbvie Inc. Carbidopa and L-dopa prodrugs and their use to treat Parkinson's disease
MA41377A (fr) 2015-01-20 2017-11-28 Abbvie Inc Gel intestinal de lévodopa et de carbidona et procédés d'utilisation
CN107847722B (zh) 2015-05-06 2021-05-18 辛纳吉勒公司 包含药物粒子的药用悬浮液、用于其配给的装置、以及其使用方法
WO2017039525A1 (en) 2015-09-04 2017-03-09 Lobsor Pharmaceuticals Aktiebolag Method of treating a dopamine related disorder in a subject by administering levodopa, in combination with a dopamine decarboxylase inhibitor and a catechol-o-methyltransferase inhibitor
JP2018535230A (ja) 2015-11-24 2018-11-29 ニューロダーム リミテッドNeuroderm Ltd レボドパアミドを含む医薬組成物およびその使用
US10874629B2 (en) 2016-04-11 2020-12-29 University Of Canberra Ophthalmic compositions comprising levodopa, an antioxidant and an aqueous carrier
US10064834B2 (en) 2016-05-09 2018-09-04 Texas Tech University System Carbidopa for the treatment of cancer
AU2018280745B2 (en) * 2017-06-05 2023-03-09 Dizlin Pharmaceuticals Ab Levodopa infusion solution
US20230123806A1 (en) * 2017-07-07 2023-04-20 Neuroderm, Ltd. Device for subcutaneous delivery of fluid medicament
JP2021517128A (ja) * 2018-03-29 2021-07-15 アヴィオン ファーマシューティカルズ、リミティッド ライアビリティ カンパニー レボドパ分割用量組成物および使用
MX2021005776A (es) 2018-11-15 2021-07-02 Abbvie Inc Formulaciones farmaceuticas para administracion subcutanea.
WO2020252257A1 (en) * 2019-06-12 2020-12-17 President And Fellows Of Harvard College Methods and compositions for modulation of an interspecies gut bacterial pathway for levodopa metabolism
WO2022047298A1 (en) * 2020-08-31 2022-03-03 Purdue Pharma L.P. Compositions and methods for levodopa delivery
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11986449B2 (en) 2020-12-22 2024-05-21 Amneal Pharmaceuticals Llc Levodopa dosing regimen
KR20230124622A (ko) 2020-12-22 2023-08-25 암닐 파마슈티컬스 엘엘씨 레보도파 투여 요법
AU2022428092A1 (en) * 2022-01-03 2024-07-25 Neuroderm, Ltd. Methods and compositions for treating parkinson's disease
US12161612B2 (en) 2023-04-14 2024-12-10 Neuroderm, Ltd. Methods and compositions for reducing symptoms of Parkinson's disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409233A (en) * 1978-07-04 1983-10-11 Sankyo Company, Limited Highly concentrated preparations of dopa compounds
CN101022784A (zh) * 2004-07-12 2007-08-22 迪兹林医疗设计公司 左旋多巴输液和注射液

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769424A (en) * 1970-10-01 1973-10-30 Merck & Co Inc Composition and method of treating dopamine deficiency in brain tissue
AU6889274A (en) * 1973-05-17 1975-11-20 Astra Laekemedel Ab Treatment of neurological disorders
US3936495A (en) * 1973-11-27 1976-02-03 Merck & Co., Inc. Purification process
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4241082A (en) * 1977-09-02 1980-12-23 Sankyo Company Limited Agents for promoting reproductive ability of domestic animals
JPS5450700A (en) 1977-09-28 1979-04-20 Sankyo Co Glazing agent of animal leather
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US4642316A (en) * 1985-05-20 1987-02-10 Warner-Lambert Company Parenteral phenytoin preparations
DE3779500T2 (de) * 1986-06-10 1993-01-21 Chiesi Farma Spa Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen.
US4684666A (en) * 1986-08-19 1987-08-04 Haas Pharmaceuticals, Inc. Stabilized liquid analgesic compositions
US4963568A (en) 1989-05-31 1990-10-16 Abbott Laboratories Dopamine agonists
CA2058975C (en) * 1990-10-30 2000-06-06 Shuichi Kasai Antiinflammatory gel preparation
US5877176A (en) 1991-12-26 1999-03-02 Cornell Research Foundation, Inc. Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
CA2143070C (en) * 1994-02-22 2001-12-18 Pankaj Modi Oral controlled release liquid suspension pharmaceutical formulation
GB9523833D0 (en) 1995-11-22 1996-01-24 Boots Co Plc Medical treatment
US5861423A (en) * 1997-02-21 1999-01-19 Caldwell; William Scott Pharmaceutical compositions incorporating aryl substituted olefinic amine compounds
AU1917899A (en) * 1998-03-20 1999-10-18 Warner-Lambert Company Crystalline sodium phenytoin monohydrate
US7201923B1 (en) * 1998-03-23 2007-04-10 General Mills, Inc. Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles
NZ508015A (en) 1998-05-15 2003-11-28 Warner Lambert Co Stabilized pharmaceutical preparations of gamma- aminobutyric acid derivatives and process for preparing the same
US6274168B1 (en) * 1999-02-23 2001-08-14 Mylan Pharmaceuticals Inc. Phenytoin sodium pharmaceutical compositions
US6716452B1 (en) * 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
WO2000054773A1 (en) 1999-03-12 2000-09-21 Nitromed, Inc. Dopamine agonists in combination with nitric oxide donors, compositions and methods of use
FI109453B (fi) * 1999-06-30 2002-08-15 Orion Yhtymae Oyj Farmaseuttinen koostumus
US7479498B2 (en) * 1999-08-23 2009-01-20 Phoenix Biosciences, Inc. Treatments for viral infections
US6348965B1 (en) * 1999-09-24 2002-02-19 Henry Palladino Solid state fluorescence and absorption spectroscopy
SE0001151D0 (sv) 2000-03-31 2000-03-31 Amarin Dev Ab Method for producing a controlled-release composition
US20020028799A1 (en) 2000-07-06 2002-03-07 Naylor Alasdair Mark Treatment of male sexual dysfunction
GB0017387D0 (en) * 2000-07-14 2000-08-30 Pfizer Ltd Novel enzyme
US20020099013A1 (en) 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
US20030119714A1 (en) 2000-12-15 2003-06-26 Naylor Alasdair Mark Treatment of male sexual dysfunction
AU2002357137A1 (en) 2001-12-10 2003-06-23 Bristol-Myers Squibb Company (1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial f1f0 atp hydrolase
AU2003214551A1 (en) * 2002-04-11 2003-10-20 Ranbaxy Laboratories Limited Controlled release pharmaceutical compositions of carbidopa and levodopa
US7985422B2 (en) 2002-08-05 2011-07-26 Torrent Pharmaceuticals Limited Dosage form
ATE463494T1 (de) 2002-10-10 2010-04-15 Morphochem Ag Komb Chemie Neue verbindungen mit antibakterieller aktivität
KR101137785B1 (ko) * 2003-07-18 2012-04-25 백스터 인터내셔널 인코포레이티드 제어된 상 분리에 의해 제조된 작은 구형 입자의 제조방법, 이용 방법 및 조성물
US8173840B2 (en) 2003-07-29 2012-05-08 Signature R&D Holdings, Llc Compounds with high therapeutic index
US7589233B2 (en) * 2003-07-29 2009-09-15 Signature R&D Holdings, Llc L-Threonine derivatives of high therapeutic index
GB0319935D0 (en) 2003-08-26 2003-09-24 Cipla Ltd Polymorphs
WO2005023185A2 (en) * 2003-08-29 2005-03-17 Transform Pharmaceuticals, Inc. Pharmaceutical compositions and method of using levodopa and carbidopa
US20050053669A1 (en) 2003-09-05 2005-03-10 Boehringer Ingelheim International Gmbh Administration form for the oral application of poorly soluble acidic and amphorteric drugs
CN1968680A (zh) * 2003-10-31 2007-05-23 阿尔扎公司 促进加巴喷丁和普加巴林的吸收的组合物和剂型
KR20060108692A (ko) * 2003-10-31 2006-10-18 알자 코포레이션 메트포르민의 개선된 흡수를 위한 조성물 및 제형
WO2005099678A1 (en) 2004-04-06 2005-10-27 Transform Pharmaceuticals, Inc. Pharmaceutical compositions and method of using levodopa and carbidopa
US7560100B2 (en) * 2004-09-09 2009-07-14 Yeda Research And Development Co., Ltd. Mixtures of polypeptides, compositions containing and processes for preparing same, for treating neurodegenerative diseases
WO2006037061A2 (en) * 2004-09-28 2006-04-06 Farouk Karoum Compositions and methods of using d-dopa to treat parkinson's disease
WO2006043532A1 (ja) * 2004-10-19 2006-04-27 Ono Pharmaceutical Co., Ltd. パーキンソン病治療剤
DE102006021872B4 (de) 2006-05-11 2008-04-17 Sanofi-Aventis 4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA2653683A1 (en) 2006-05-31 2007-12-06 Solvay Pharmaceuticals Gmbh Long term 24-hour intestinal administration of levodopa/carbidopa
US8058243B2 (en) 2006-10-13 2011-11-15 Hsc Research And Development Limited Partnership Method for treating a brain cancer with ifenprodil
JP5631734B2 (ja) * 2007-04-06 2014-11-26 トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド 流体薬物を供給するためのシステム及び方法
CN101669925B (zh) 2008-09-10 2011-08-10 天津药物研究院 干粉吸入剂、其制备方法和用途
US20130253056A1 (en) 2009-05-19 2013-09-26 Neuroderm, Ltd. Continuous Administration of Levodopa and/or Dopa Decarboxylase Inhibitors and Compositions for Same
PT2432454T (pt) 2009-05-19 2017-06-12 Neuroderm Ltd Composições para administração contínua de inibidores de dopa decarboxilase
CN101987081B (zh) 2010-07-16 2012-08-08 钟术光 一种控释制剂
KR101187064B1 (ko) 2010-07-18 2012-09-28 주식회사 바이오폴리메드 양이온성 지질, 이의 제조 방법 및 이를 포함하는 세포내 이행성을 갖는 전달체
US10150792B2 (en) 2010-11-08 2018-12-11 Synthonics, Inc. Bismuth-containing compounds, coordination polymers, methods for modulating pharmacokinetic properties of biologically active agents, and methods for treating patients
US9415108B2 (en) 2010-11-15 2016-08-16 Neuroderm, Ltd. Compositions for transdermal delivery of active agents
HUE047841T2 (hu) 2010-11-15 2020-05-28 Neuroderm Ltd L-dopa, dopa dekarboxiláz inhibitorok, katekol-o-metil transzferáz inhibitorok folyamatos adagolására szolgáló készítmények
SG191090A1 (en) 2010-12-10 2013-07-31 Synagile Corp Subcutaneously infusible levodopa prodrug compositions and methods of infusion
WO2013061161A2 (en) 2011-10-28 2013-05-02 Green Bcn Consulting Services Sl New combination therapies for treating neurological disorders
CN105209029A (zh) 2013-03-13 2015-12-30 纽罗德姆有限公司 帕金森病的治疗方法
JP6591995B2 (ja) 2014-03-13 2019-10-16 ニューロダーム リミテッドNeuroderm Ltd ドーパデカルボキシラーゼ阻害剤組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409233A (en) * 1978-07-04 1983-10-11 Sankyo Company, Limited Highly concentrated preparations of dopa compounds
CN101022784A (zh) * 2004-07-12 2007-08-22 迪兹林医疗设计公司 左旋多巴输液和注射液

Also Published As

Publication number Publication date
EP2432454A1 (en) 2012-03-28
KR20160091424A (ko) 2016-08-02
PT3192500T (pt) 2021-01-05
CL2011002895A1 (es) 2012-10-12
KR20120027371A (ko) 2012-03-21
WO2010134074A1 (en) 2010-11-25
MX2011012315A (es) 2011-12-16
AU2010250766A1 (en) 2012-01-12
CN102438587A (zh) 2012-05-02
US20230321019A1 (en) 2023-10-12
BRPI1011031A2 (pt) 2016-08-16
ES2627655T3 (es) 2017-07-31
US7863336B2 (en) 2011-01-04
JP5643297B2 (ja) 2014-12-17
KR101709904B1 (ko) 2017-02-23
CY1119495T1 (el) 2018-03-07
HUE033388T2 (en) 2017-12-28
KR101641401B1 (ko) 2016-07-20
JP6157678B2 (ja) 2017-07-05
PL2432454T3 (pl) 2017-10-31
AR117412A2 (es) 2021-08-04
US20100298429A1 (en) 2010-11-25
AR117502A2 (es) 2021-08-11
BRPI1011031B8 (pt) 2021-05-25
JP2016121199A (ja) 2016-07-07
US20110269833A1 (en) 2011-11-03
RU2559083C2 (ru) 2015-08-10
HRP20170805T1 (hr) 2017-08-25
IL216383A (en) 2016-02-29
NZ596963A (en) 2014-01-31
US20140249231A1 (en) 2014-09-04
JP2015017144A (ja) 2015-01-29
MX364974B (es) 2019-05-16
DK2432454T3 (en) 2017-06-19
SG10201709016RA (en) 2017-11-29
CN104546700A (zh) 2015-04-29
US20100298428A1 (en) 2010-11-25
US20160151317A1 (en) 2016-06-02
AR078413A1 (es) 2011-11-09
PT2432454T (pt) 2017-06-12
RU2011149976A (ru) 2013-06-27
US9993451B2 (en) 2018-06-12
SG176159A1 (en) 2011-12-29
CA2761624A1 (en) 2010-11-25
US9040589B2 (en) 2015-05-26
EP2432454B1 (en) 2017-03-01
US20210077442A1 (en) 2021-03-18
BRPI1011031B1 (pt) 2020-06-23
LT2432454T (lt) 2017-07-10
DK3192500T3 (da) 2020-12-21
HUE052685T2 (hu) 2021-05-28
RU2019101159A (ru) 2020-07-16
HRP20202038T1 (hr) 2021-03-05
US9101663B2 (en) 2015-08-11
US9040590B2 (en) 2015-05-26
US20190125708A1 (en) 2019-05-02
IL216383A0 (en) 2012-01-31
SI2432454T1 (sl) 2017-09-29
ZA201109037B (en) 2013-02-27
US8193243B2 (en) 2012-06-05
RU2678839C2 (ru) 2019-02-04
CN102438587B (zh) 2015-08-19
JP2012527447A (ja) 2012-11-08
RU2559083C9 (ru) 2016-01-20
PL3192500T3 (pl) 2021-04-06
CA2761624C (en) 2016-10-18
EP3192500B1 (en) 2020-12-02
EP3192500A1 (en) 2017-07-19
ES2840748T3 (es) 2021-07-07
JP5921002B2 (ja) 2016-05-24
AU2010250766B2 (en) 2015-04-09
RU2015115064A (ru) 2015-11-20
SG10201505101VA (en) 2015-07-30
US20140249230A1 (en) 2014-09-04
EP3777839A1 (en) 2021-02-17

Similar Documents

Publication Publication Date Title
CN104546700B (zh) 用于多巴脱羧酶抑制剂连续施用的组合物
JP6231145B2 (ja) L−ドーパ、ドーパデカルボキシラーゼ阻害剤、カテコール−o−メチルトランスフェラーゼ阻害剤、およびそれらのための組成物の継続的投与
HK40046868A (en) Compositions for continuous administration of dopa decarboxylase inhibitors
HK1168557B (en) Compositions for continuous administration of dopa decarboxylase inhibitors
HK1168557A (en) Compositions for continuous administration of dopa decarboxylase inhibitors

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant