CN104542604B - A kind of bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide - Google Patents
A kind of bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide Download PDFInfo
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- CN104542604B CN104542604B CN201410776702.9A CN201410776702A CN104542604B CN 104542604 B CN104542604 B CN 104542604B CN 201410776702 A CN201410776702 A CN 201410776702A CN 104542604 B CN104542604 B CN 104542604B
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- flurocytosine
- fluorine ether
- ether bacterium
- bacterium amide
- bactericidal composition
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of agriculture chemical compounding, be specifically related to the Fungicidal composition of Synergistic, the fluorine ether bacterium amide of its 5-fluorine cytosine containing effective fungicidal amount and antifungal, antibacterial effective dose.Compositions activity exceedes and is used alone, and there occurs synergistic function.
Description
Technical field
The invention belongs to the technical field of agriculture chemical compounding, be specifically related to the Fungicidal composition of Synergistic, the fluorine ether bacterium amide of its 5-fluorine cytosine containing effective fungicidal amount and antifungal, antibacterial effective dose.
Background technology
Some crops effectively can not grow when not having antifungal, uses antifungal can increase product to agricultural production, improve quality, thus additional income.
Any antifungal is not had can still to keep original efficient sterilizing effect after repeated, drug resistance will necessarily be produced, therefore, for my house journal's product fluorine ether bacterium amide (ZL201010274196.5), for delaying its Drug resistance, reduce use cost, reduce and make consumption, the special research and development better Fungicidal composition of performance.
Fluorine ether bacterium amide is N-(3-chloro-5-trifluoromethylpyridin-2-ylmethyl)-2,3,5,6-tetra-fluoro-4-methoxy-b enzamide, structural formula:
5-fluorine cytosine is 4-amino-5-fluorine-2 (1H)-pyrimidone, structural formula:
Have no the composite report of fluorine ether bacterium amide and 5-fluorine cytosine at present.
Summary of the invention
It is an object of the invention to provide the Synergistic compositions of the compound comprising antifungal, said composition can prevent and treat the disease that fungus brings to crop, and said composition includes 5-fluorine cytosine and the fluorine ether bacterium amide of effective dose.
The technical scheme is that
A kind of bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide, effective ingredient is 5-fluorine cytosine and fluorine ether bacterium amide.
Wherein, as preferably, the weight ratio of 5-fluorine cytosine and fluorine ether bacterium amide is, 5-fluorine cytosine: fluorine ether bacterium amide=1:2-20:1.
As it is preferred that, the weight ratio of 5-fluorine cytosine and fluorine ether bacterium amide is, 5-fluorine cytosine: fluorine ether bacterium amide=1:1-5:1.
As it is preferred that, the weight ratio of 5-fluorine cytosine and fluorine ether bacterium amide is, 5-fluorine cytosine: fluorine ether bacterium amide=3:1.
Wherein, as preferably, the weight percentage that the effective ingredient of 5-fluorine cytosine and fluorine ether bacterium amide is total is 9%-63%.
Wherein, as preferably, the weight percentage that the effective ingredient of 5-fluorine cytosine and fluorine ether bacterium amide is total is 30%-50%.
As it is preferred that, the weight percentage that the effective ingredient of 5-fluorine cytosine and fluorine ether bacterium amide is total is 40%.
The dosage form that the compositions of the present invention is made includes cream, aqueous emulsion, microemulsion, suspending agent, microcapsule suspending agent, water preparation, soluble concentrate, suspension seed-coating agent, wettable powder, soluble powder, granule, water dispersible granules etc., and solvent, various auxiliary agent, filler all can adopt conventional commercial product.Wherein preferred dosage form is suspending agent.
These preparations all can be prepared according to the routine operation of pesticide field, and liquid dosage form such as cream, aqueous emulsion, microemulsion, suspending agent, microcapsule suspending agent, water preparation, soluble concentrate, suspension seed-coating agent etc., all can adopt conventional commercial product；Solid dosage forms as: wettable powder, soluble powder, granule, water dispersible granules etc., filler, various auxiliary agent all can adopt conventional commercial product.
The compositions of the present invention has significant prevention fungus and invades and fungicidal action, it is used in particular for agricultural production, for preventing and treating the fungal disease of the crops such as Semen Tritici aestivi, Semen Maydis, Oryza sativa L., oil crop, water fruits and vegetables, it may also be used for the disease control of ornamental plant, prevent and treat fungal disease.
Heretofore described fungal disease is more representational as follows: cucumber downy mildew, peronophythora litchi, Phytophthora capsici disease, cotton-wilt fusarium, Citrullus vulgaris damping off, the late blight of potato, early blight of tomato, Semen Maydis droop, watermelon anthrax, leaf spot of peanut, pear scab, alternaria leaf spot of apple, rice sheath blight disease, wheat powdery mildew, sigatoka, the cercospora brown spot of peanut, soybean sclerotinia crown rot, rice blast, watermelon grafting, leaf muld of tomato etc..
The using method of the present composition, can adopt routine to be watered spraying, ditch spread, spread manuer in holes or seed dressing etc..
The invention have the benefit that compositions activity exceedes to be used alone, there occurs synergistic function.Screened by rational component ratio, it is determined that the proportionate relationship of excellent composite component, achieve purpose less than effect.The following effect data for different ratio, is specifically shown in table 1.
5F represents 5-fluorine cytosine in the present invention, and FM represents fluorine ether bacterium amide.
Table 1 is to phytophthora blight of pepper (Phytophthoracapsici) mixture toxicity test
Evaluate the potentiation of pharmacy mix according to coefficient of synergism (SR), SR < 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is potentiation.From above coefficient of synergism it can be seen that the mixture of 5F and FM all presents potentiation.
Detailed description of the invention:
Below in conjunction with specific embodiment, technical scheme is described in detail.
Test example is further provided below, and the synergistic effect that the present invention is obtained is illustrated.
Test example 1: for the evaluation of the Fungicidal compounds of cucumber downy mildew
This test adopts pot-culture method.Choosing the two panels leaf period cucumber seedling that growing way is consistent, each process selects 5 basins for examination melon Seedling, numbers standby.Each medicament arranges 5 Concentraton gradient and processes, with spray equivalent clear water for blank.Spray under 50PSI pressure with Potter spray tower, often process 5mL.Spray inoculation bacterium of downy mildew of cucumber Sporangium suspending agent after chemicals treatment 24h, the process for preparation of Sporangium suspending agent is as follows: take the cucumber leaves with Pseudoperonospora cubensis picking up from field, dip the Sporangium in the distillation washing lower back face of about 10 DEG C with brush pen, be made into the sporangia suspension that concentration is 3 × 105/mL.It is placed in growth cabinet by cucumber seedling after inoculation (relative humidity 100%, temperature 15-20 DEG C) cultivate, after 24h, maintenance temperature 15-24 DEG C, relative humidity about 90% moisturizing are brought out, and 5d " Invest, Then Investigate " records incidence, calculate disease index and prevention effect.
Cucumber downy mildew grade scale:
0 grade: blade is without scab；
1 grade: lesion area accounts for less than the 5% of whole blade area；
3 grades: lesion area accounts for the 6-10% of whole blade area；
5 grades: lesion area accounts for the 11-25% of whole blade area；
7 grades: lesion area accounts for the 26-50% of whole blade area；
9 grades: lesion area accounts for more than the 50% of whole blade area.
Disease refers to and drug effect and computational methods:
The expection effect (i.e. theoretical prevention effect, %) of mixture of active principles uses Colby formula to determine and compares with the effect observed:
Colby formula: E=X+Y-X*Y/100
E: when in compositions, active components A working concentration is a, active component B working concentration is compositions contemplated effect during b,
X: active components A using dosage is effect during a,
Y: active component B using dosage is effect during b.
Illustrate there is potentiation when the prevention effect observed exceedes expection preventive effect.
Table 2:
Note: synergism factor > 1.0, namely has synergism.
Table 3:
Note: synergism factor > 1.0, namely has synergism.
Test example 2: for the evaluation of the Fungicidal compounds of the late blight of potato
Table 4:
Note: synergism factor > 1.0, namely has synergism.
Table 5:
Note: synergism factor > 1.0, namely has synergism.
Test example 3,
Synergy according to GB NY/T1156.6-2006 Part VI mixture measures, respectively the 5-flurocytosine of different ratio and fluorine ether bacterium amide being carried out toxicity test, subjects is the funguses such as the late blight of potato, Semen Maydis droop, watermelon anthrax, leaf spot of peanut, alternaria leaf spot of apple, rice sheath blight disease, wheat powdery mildew, soybean sclerotinia crown rot, rice blast.
Table 6: Phytophthora infestans mixture toxicity test
Table 7: to cotton-wilt fusarium mixture toxicity test
Table 8: to watermelon anthrax bacteria mixture toxicity test
Table 9: to leaf spot of peanut bacterium mixture toxicity test
Table 10: to apple peels and cores bacterium mixture toxicity test
Table 11: to Rhizoctonia solani Kuhn mixture toxicity test
Table 12: to wheat powdery mildew mixture toxicity test
Table 13: to soybean sclerotinia crown rot bacterium mixture toxicity test
Table 14: to rice blast fungus mixture toxicity test
Evaluate the potentiation of pharmacy mix according to coefficient of synergism (SR), SR < 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is potentiation.From above coefficient of synergism it can be seen that the mixture of 5F and FM all presents potentiation.
Several concrete dosage form proportioning of following offer.
The wettable powder of embodiment 1:40%5-fluorine cytosine and fluorine ether bacterium amide
5-fluorine cytosine 30%
Fluorine ether bacterium amide 10%
Sodium lignin sulfonate (dispersant) 6%
Sodium butylnaphthalenesulfonate (wetting agent) 4.5%
Poly-trisiloxanes (penetrating agent) 2%
Alkyl benzene sulphonate ammonium (stabilizer) 2%
White carbon (filler) surplus
Preventing and treating Phytophthora capsici disease field test data:
The suspending agent of embodiment 2:40%5-fluorine cytosine and fluorine ether bacterium amide
5-fluorine cytosine 30%
Fluorine ether bacterium amide 10%
Poly-methyl carboxylic acids sodium (dispersant) 2.5%
Di-2-ethylhexylphosphine oxide ethylnaphthalene sodium sulfonate (wetting dispersing agent) 1.5%
Sodium metnylene bis-naphthalene sulfonate (dispersion aids) 1.2
Poly-trisiloxanes (defoamer) 0.5%
Propylene glycol (antifreezing agent) 4.5%
Xanthan gum (thickening agent) 0.2%
Water (solvent) surplus
Preventing and treating cucumber downy mildew field test data
Embodiment 3:40%5-fluorine cytosine and fluorine ether bacterium amide dispersible oil-suspending agent
5-fluorine cytosine 30%
Fluorine ether bacterium amide 10%
Calcium dodecyl benzene sulfonate (emulsifying agent, dispersant) 2%
Lauryl alcohol ether polyoxypropylene ester (emulsifying agent, dispersant) 12%
Organobentonite (thickening agent) 2%
Methyl oleate (solvent) surplus
Prevent and treat late blight of potato field data
The soluble concentrate of embodiment 4:50%5-fluorine cytosine and fluorine ether bacterium amide
5-fluorine cytosine 40%
Fluorine ether bacterium amide 10%
Cattle ester amine (emulsifying, dispersion, wetting agent) 7%
N-Methyl pyrrolidone (solvent) surplus
Preventing and treating peronophythora litchi field data
The water dispersible granules of embodiment 5:60%5-fluorine cytosine and fluorine ether bacterium amide
5-fluorine cytosine 50%
Fluorine ether bacterium amide 10%
Sodium lauryl sulphate (wetting agent) 2%
Naphthalenesulfonic acid-formaldehyde condensate (dispersant) 7%
Sodium sulfate (disintegrating agent) 10%
Soluble starch (carrier) 10%
Precipitated calcium carbonate (carrier) surplus
Preventing and treating cucumber downy mildew field data
。
Claims (12)
1., containing a bactericidal composition for 5-flurocytosine and fluorine ether bacterium amide, effective ingredient is 5-flurocytosine and fluorine ether bacterium amide, and the weight ratio of 5-flurocytosine and fluorine ether bacterium amide is, 5-flurocytosine: fluorine ether bacterium amide=1:2-20:1.
2. the bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide according to claim 1, it is characterised in that the weight ratio of 5-flurocytosine and fluorine ether bacterium amide is, 5-flurocytosine: fluorine ether bacterium amide=1:1-5:1.
3. the bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide according to claim 2, it is characterised in that the weight ratio of 5-flurocytosine and fluorine ether bacterium amide is, 5-flurocytosine: fluorine ether bacterium amide=3:1.
4. the bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide according to claim 1-3 any claim, it is characterised in that the weight percentage that the effective ingredient of 5-flurocytosine and fluorine ether bacterium amide is total is 9%-63%.
5. the bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide according to claim 4, it is characterised in that the weight percentage that the effective ingredient of 5-flurocytosine and fluorine ether bacterium amide is total is 30%-50%.
6. the bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide according to claim 5, it is characterised in that the weight percentage that the effective ingredient of 5-flurocytosine and fluorine ether bacterium amide is total is 40%.
7. the bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide according to claim 1 or 2 or 3 or 6, dosage form includes cream, aqueous emulsion, microemulsion, suspending agent, microcapsule suspending agent, soluble concentrate, suspension seed-coating agent, wettable powder, soluble powder, granule, water dispersible granules.
8. the bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide according to claim 4, dosage form includes cream, aqueous emulsion, microemulsion, suspending agent, microcapsule suspending agent, soluble concentrate, suspension seed-coating agent, wettable powder, soluble powder, granule, water dispersible granules.
9. the bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide according to claim 7, described dosage form is suspending agent.
10. the bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide according to claim 1 is for preventing and treating the fungal disease of Semen Tritici aestivi, Semen Maydis, Oryza sativa L., oil crop, ornamental plant, water fruits and vegetables.
11. the bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide according to claim 10 is used for preventing and treating cucumber downy mildew, peronophythora litchi, Phytophthora capsici is sick, cotton-wilt fusarium, Citrullus vulgaris damping off, the late blight of potato, early blight of tomato, Semen Maydis droop, watermelon anthrax, leaf spot of peanut, pear scab, alternaria leaf spot of apple, rice sheath blight disease, wheat powdery mildew, sigatoka, the cercospora brown spot of peanut, soybean sclerotinia crown rot, rice blast, watermelon grafting, leaf muld of tomato.
12. the bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide according to claim 10 is used for preventing and treating cucumber downy mildew, peronophythora litchi, Phytophthora capsici disease, cotton-wilt fusarium, the late blight of potato, leaf spot of peanut, soybean sclerotinia crown rot, rice blast.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410776702.9A CN104542604B (en) | 2014-12-15 | 2014-12-15 | A kind of bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide |
| PCT/CN2015/000027 WO2016095287A1 (en) | 2014-12-15 | 2015-01-16 | Fungicidal composition containing 5-fluorocytosine and fluoride ether bacteria amide |
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| CN201410776702.9A CN104542604B (en) | 2014-12-15 | 2014-12-15 | A kind of bactericidal composition containing 5-flurocytosine and fluorine ether bacterium amide |
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| CN104542604A CN104542604A (en) | 2015-04-29 |
| CN104542604B true CN104542604B (en) | 2016-06-29 |
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| CN114774457B (en) * | 2022-05-12 | 2023-10-20 | 华南农业大学 | Application of gene Placement 1 in regulation and control of growth, antioxidation and pathogenicity of phytophthora litchi |
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| JP5580310B2 (en) * | 2008-08-01 | 2014-08-27 | ダウ アグロサイエンシィズ エルエルシー | Use of 5-fluorocytosine as a fungicide |
| CN102754650A (en) * | 2012-07-24 | 2012-10-31 | 山东省联合农药工业有限公司 | Desflurane bacteria amide compound bactericide |
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| CN104542604A (en) | 2015-04-29 |
| WO2016095287A1 (en) | 2016-06-23 |
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