CN104520323B - 用于治疗b细胞介导的炎性疾病的方法 - Google Patents

用于治疗b细胞介导的炎性疾病的方法 Download PDF

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Publication number
CN104520323B
CN104520323B CN201380022683.4A CN201380022683A CN104520323B CN 104520323 B CN104520323 B CN 104520323B CN 201380022683 A CN201380022683 A CN 201380022683A CN 104520323 B CN104520323 B CN 104520323B
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cxcl13
antibody
binding
cxcr5
domain
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Chinese (zh)
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CN104520323A (zh
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E·S·史密斯
M·左德勒
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Vaccinex Inc
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Vaccinex Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380022683.4A 2012-03-02 2013-03-01 用于治疗b细胞介导的炎性疾病的方法 Active CN104520323B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261606049P 2012-03-02 2012-03-02
US61/606,049 2012-03-02
PCT/US2013/028602 WO2013130959A1 (en) 2012-03-02 2013-03-01 Methods for the treatment of b cell-mediated inflammatory diseases

Publications (2)

Publication Number Publication Date
CN104520323A CN104520323A (zh) 2015-04-15
CN104520323B true CN104520323B (zh) 2018-05-04

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Country Link
US (1) US9890213B2 (enExample)
EP (1) EP2820045B1 (enExample)
JP (1) JP6193275B2 (enExample)
KR (1) KR102090969B1 (enExample)
CN (1) CN104520323B (enExample)
AU (1) AU2013225812B2 (enExample)
CA (1) CA2865928C (enExample)
IN (1) IN2014DN08199A (enExample)
NZ (1) NZ629828A (enExample)
WO (1) WO2013130959A1 (enExample)

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BR112014008885B1 (pt) 2011-10-11 2021-02-17 Vaccinex, Inc uso de um anticorpo isolado ou fragmento de ligação ao antígeno do mesmo que se liga especificamente à semaforina-4d para diminuir permeabilidade da barreira hematoencefálica (bbb) em um indivíduo com permeabilidade da bbb aumentada e um transtorno neuroinflamatório
US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
KR102176962B1 (ko) 2013-01-31 2020-11-10 백시넥스 인코포레이티드 면역글로불린 a 수준을 증가시키기 위한 방법
EA036591B1 (ru) 2013-06-25 2020-11-26 Вэксинекс, Инк. Способ ингибирования, замедления или уменьшения роста раковой опухоли у субъекта
SG11201808554TA (en) 2016-04-22 2018-11-29 Vaccinex Inc Integral membrane protein display on poxvirus extracellular enveloped virions
RU2747557C2 (ru) 2016-08-02 2021-05-06 Вэксинекс, Инк. Улучшенные способы получения библиотек полинуклеотидов в вирусах осповакцины/эукариотических клетках
KR101953706B1 (ko) * 2016-09-19 2019-03-05 아이-맵 항-gm-csf 항체 및 이것의 사용
KR20210016557A (ko) * 2018-05-31 2021-02-16 글리콤 에이/에스 자가면역 질환 치료를 위한 hmo 혼합물
SG11202010499UA (en) * 2018-09-18 2020-11-27 I Mab Biopharma Us Ltd Anti-cxcl13 antibodies for treating autoimmune diseases and cancer

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Also Published As

Publication number Publication date
JP6193275B2 (ja) 2017-09-06
KR102090969B1 (ko) 2020-03-19
CN104520323A (zh) 2015-04-15
US20150125467A1 (en) 2015-05-07
WO2013130959A1 (en) 2013-09-06
JP2015509960A (ja) 2015-04-02
NZ629828A (en) 2017-05-26
KR20140138830A (ko) 2014-12-04
AU2013225812A1 (en) 2014-09-25
EP2820045B1 (en) 2018-08-22
US9890213B2 (en) 2018-02-13
EP2820045A1 (en) 2015-01-07
CA2865928A1 (en) 2013-09-06
AU2013225812B2 (en) 2017-11-30
CA2865928C (en) 2021-02-16
IN2014DN08199A (enExample) 2015-05-01

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