IN2014DN08199A - - Google Patents

Info

Publication number
IN2014DN08199A
IN2014DN08199A IN8199DEN2014A IN2014DN08199A IN 2014DN08199 A IN2014DN08199 A IN 2014DN08199A IN 8199DEN2014 A IN8199DEN2014 A IN 8199DEN2014A IN 2014DN08199 A IN2014DN08199 A IN 2014DN08199A
Authority
IN
India
Prior art keywords
cxcl13
subject
effective amount
inhibits
activity
Prior art date
Application number
Inventor
Ernest S Smith
Maurice Zauderer
Original Assignee
Vaccinex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Publication of IN2014DN08199A publication Critical patent/IN2014DN08199A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Methods for treating diseases associated with CXCL13 expression including certain autoimmune and inflammatory diseases such as Sjogren's syndrome are provided herein. The methods comprise administering to a subject in need thereof an effective amount of an agent that inhibits CXCL13 activity. According to aspects of the invention illustrated herein there is provided a method of treating preventing or reducing the exacerbation of a B cell mediated inflammatory condition in a subject including administering to a subject an effective amount of an isolated binding molecule which specifically binds to CXCL13 wherein said molecule prevents or inhibits CXCL13 activity.
IN8199DEN2014 2012-03-02 2013-03-01 IN2014DN08199A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261606049P 2012-03-02 2012-03-02
PCT/US2013/028602 WO2013130959A1 (en) 2012-03-02 2013-03-01 Methods for the treatment of b cell-mediated inflammatory diseases

Publications (1)

Publication Number Publication Date
IN2014DN08199A true IN2014DN08199A (en) 2015-05-01

Family

ID=47844534

Family Applications (1)

Application Number Title Priority Date Filing Date
IN8199DEN2014 IN2014DN08199A (en) 2012-03-02 2013-03-01

Country Status (10)

Country Link
US (1) US9890213B2 (en)
EP (1) EP2820045B1 (en)
JP (1) JP6193275B2 (en)
KR (1) KR102090969B1 (en)
CN (1) CN104520323B (en)
AU (1) AU2013225812B2 (en)
CA (1) CA2865928C (en)
IN (1) IN2014DN08199A (en)
NZ (1) NZ629828A (en)
WO (1) WO2013130959A1 (en)

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EP2766093B1 (en) 2011-10-11 2018-02-21 Vaccinex, Inc. Use of semaphorin-4d binding molecules for modulation of blood brain barrier permeability
US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
US9790271B2 (en) 2013-01-31 2017-10-17 Vaccinex, Inc. Methods for increasing immunoglobulin A levels
SG10201902380SA (en) 2013-06-25 2019-04-29 Vaccinex Inc Use of semaphorin-4d inhibitory molecules in combination with an immune modulating therapy to inhibit tumor growth and metastases
EP3445397B1 (en) 2016-04-22 2022-11-09 Vaccinex, Inc. Integral membrane protein display on poxvirus extracellular enveloped virions
CA3032512C (en) 2016-08-02 2025-05-06 Vaccinex, Inc. Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells
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BR112020022892A2 (en) * 2018-05-31 2021-02-23 Glycom A/S mixture of hmos for treatment of autoimmune diseases
MX2021002605A (en) * 2018-09-18 2021-07-21 I Mab Biopharma Us Ltd Anti-cxcl13 antibodies for treating autoimmune diseases and cancer.

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Also Published As

Publication number Publication date
KR20140138830A (en) 2014-12-04
EP2820045A1 (en) 2015-01-07
CN104520323B (en) 2018-05-04
CN104520323A (en) 2015-04-15
NZ629828A (en) 2017-05-26
KR102090969B1 (en) 2020-03-19
CA2865928A1 (en) 2013-09-06
JP2015509960A (en) 2015-04-02
AU2013225812B2 (en) 2017-11-30
AU2013225812A1 (en) 2014-09-25
CA2865928C (en) 2021-02-16
EP2820045B1 (en) 2018-08-22
US9890213B2 (en) 2018-02-13
US20150125467A1 (en) 2015-05-07
JP6193275B2 (en) 2017-09-06
WO2013130959A1 (en) 2013-09-06

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