CN104520295B - 用于制备c‑fms激酶抑制剂的方法 - Google Patents
用于制备c‑fms激酶抑制剂的方法 Download PDFInfo
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- CN104520295B CN104520295B CN201380041841.0A CN201380041841A CN104520295B CN 104520295 B CN104520295 B CN 104520295B CN 201380041841 A CN201380041841 A CN 201380041841A CN 104520295 B CN104520295 B CN 104520295B
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- 0 C[*@](C(C(*)=C)=CC(N)=C(C)*)*(C)=O Chemical compound C[*@](C(C(*)=C)=CC(N)=C(C)*)*(C)=O 0.000 description 21
- GBALQCPJMZTOCO-GDNZZTSVSA-N C[C@@](C1)(C=C[C@]2(C)C[C@]1(C)O)N2C(OC)=O Chemical compound C[C@@](C1)(C=C[C@]2(C)C[C@]1(C)O)N2C(OC)=O GBALQCPJMZTOCO-GDNZZTSVSA-N 0.000 description 1
- MIJUUUVYIGYDHH-IWSPIJDZSA-N C[C@@](C[C@]1(CO)O[C@@H](CO)CC1)(N)O Chemical compound C[C@@](C[C@]1(CO)O[C@@H](CO)CC1)(N)O MIJUUUVYIGYDHH-IWSPIJDZSA-N 0.000 description 1
- LLPKQRMDOFYSGZ-UHFFFAOYSA-N Cc1c[nH]c(C)n1 Chemical compound Cc1c[nH]c(C)n1 LLPKQRMDOFYSGZ-UHFFFAOYSA-N 0.000 description 1
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
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- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
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- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
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- Immunology (AREA)
- Diabetes (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710504413.7A CN107266405A (zh) | 2012-08-07 | 2013-08-05 | 用于制备c‑fms激酶抑制剂的方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261680446P | 2012-08-07 | 2012-08-07 | |
| US61/680446 | 2012-08-07 | ||
| PCT/US2013/053602 WO2014025679A1 (en) | 2012-08-07 | 2013-08-05 | Process for the preparation of c-fms kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710504413.7A Division CN107266405A (zh) | 2012-08-07 | 2013-08-05 | 用于制备c‑fms激酶抑制剂的方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104520295A CN104520295A (zh) | 2015-04-15 |
| CN104520295B true CN104520295B (zh) | 2017-07-18 |
Family
ID=48980367
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380041841.0A Expired - Fee Related CN104520295B (zh) | 2012-08-07 | 2013-08-05 | 用于制备c‑fms激酶抑制剂的方法 |
| CN201710504413.7A Pending CN107266405A (zh) | 2012-08-07 | 2013-08-05 | 用于制备c‑fms激酶抑制剂的方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710504413.7A Pending CN107266405A (zh) | 2012-08-07 | 2013-08-05 | 用于制备c‑fms激酶抑制剂的方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9029352B2 (enExample) |
| EP (2) | EP3091006B1 (enExample) |
| JP (1) | JP6290884B2 (enExample) |
| CN (2) | CN104520295B (enExample) |
| AR (2) | AR092070A1 (enExample) |
| AU (2) | AU2013299926B2 (enExample) |
| ES (2) | ES2658773T3 (enExample) |
| IN (1) | IN2015DN00660A (enExample) |
| JO (2) | JOP20180012A1 (enExample) |
| TW (2) | TWI646090B (enExample) |
| UY (1) | UY34972A (enExample) |
| WO (1) | WO2014025679A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2815352T3 (es) * | 2014-02-18 | 2021-03-29 | Daiichi Sankyo Co Ltd | Procedimiento de producción de un inhibidor de factor X de la coagulación sanguínea activado (FXa) |
| TW201811326A (zh) | 2016-07-18 | 2018-04-01 | 比利時商健生藥品公司 | 4-氰基-n-(2-(4,4-二甲基環己-1-烯-1-基)-6-(2,2,6,6-四甲基四氫-2h-哌喃-4-基)吡啶-3-基)-1h-咪唑-2-甲醯胺之鹽形式 |
| TWI752980B (zh) | 2016-07-18 | 2022-01-21 | 比利時商健生藥品公司 | 4-氰基-n-(2-(4,4-二甲基環己-1-烯-1-基)-6-(2,2,6,6-四甲基四氫-2h-哌喃-4-基)吡啶-3-基)-1h-咪唑-2-甲醯胺之晶型 |
| JP6831558B2 (ja) * | 2016-08-23 | 2021-02-17 | 株式会社Hbcフナト | 脳機能改善組成物 |
| WO2018160917A1 (en) * | 2017-03-03 | 2018-09-07 | Janssen Biotech, Inc. | Co-therapy comprising a small molecule csf-1r inhibitor and an agonistic antibody that specifically binds cd40 for the treatment of cancer |
| WO2020222109A1 (en) | 2019-05-02 | 2020-11-05 | Janssen Biotech, Inc. | Csf-1/csf-1r gene set |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5900484A (en) * | 1996-09-18 | 1999-05-04 | Lonza Ag | Process for the preparation of arylamides of heteroaromatic carboxylic acids |
| CN101084208A (zh) * | 2004-10-22 | 2007-12-05 | 詹森药业有限公司 | 作为c-fms激酶抑制剂的芳族酰胺 |
| CN101679282A (zh) * | 2007-06-01 | 2010-03-24 | 巴斯夫欧洲公司 | 生产n-取代的(3-二卤甲基-1-甲基吡唑-4-基)羧酰胺的方法 |
| CN101889009A (zh) * | 2007-10-17 | 2010-11-17 | 詹森药业有限公司 | c-fms激酶抑制剂 |
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| US2466420A (en) | 1947-11-26 | 1949-04-05 | Eastman Kodak Co | Ketene condensation products with aldehydes |
| US3226394A (en) | 1964-06-16 | 1965-12-28 | Shulton Inc | Pyridylethylated anthranilamides and derivatives thereof |
| CH504416A (de) | 1966-12-05 | 1971-03-15 | Ciba Geigy Ag | Verfahren zur Herstellung von aromatischen Sulfamoylverbindungen |
| US4551540A (en) | 1983-01-17 | 1985-11-05 | Borg-Warner Chemicals, Inc. | Substituted 2,5-dimethylpyrroles |
| US5190541A (en) | 1990-10-17 | 1993-03-02 | Boston Scientific Corporation | Surgical instrument and method |
| CA2131528C (en) | 1992-03-05 | 2004-07-13 | Philip E. Thorpe | Methods and compositions for targeting the vasculature of solid tumors |
| US5474765A (en) | 1992-03-23 | 1995-12-12 | Ut Sw Medical Ctr At Dallas | Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells |
| US5686472A (en) | 1992-10-29 | 1997-11-11 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5593992A (en) | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
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| Publication number | Publication date |
|---|---|
| HK1210616A1 (en) | 2016-04-29 |
| TW201408664A (zh) | 2014-03-01 |
| AR117002A2 (es) | 2021-06-30 |
| TWI646090B (zh) | 2019-01-01 |
| US20140045789A1 (en) | 2014-02-13 |
| US20150232439A1 (en) | 2015-08-20 |
| EP3091006A1 (en) | 2016-11-09 |
| JO3248B1 (ar) | 2018-09-16 |
| EP2882744A1 (en) | 2015-06-17 |
| IN2015DN00660A (enExample) | 2015-06-26 |
| UY34972A (es) | 2014-02-28 |
| CN104520295A (zh) | 2015-04-15 |
| EP2882744B8 (en) | 2016-11-09 |
| JP2015524471A (ja) | 2015-08-24 |
| TW201741292A (zh) | 2017-12-01 |
| EP3091006B1 (en) | 2018-01-17 |
| CN107266405A (zh) | 2017-10-20 |
| AR092070A1 (es) | 2015-03-18 |
| JP6290884B2 (ja) | 2018-03-07 |
| EP2882744B1 (en) | 2016-09-21 |
| HK1209418A1 (en) | 2016-04-01 |
| AU2017201415A1 (en) | 2017-03-16 |
| ES2658773T3 (es) | 2018-03-12 |
| TWI608004B (zh) | 2017-12-11 |
| WO2014025679A1 (en) | 2014-02-13 |
| AU2017201415B2 (en) | 2019-01-03 |
| JOP20180012A1 (ar) | 2019-01-30 |
| AU2013299926A1 (en) | 2015-05-21 |
| ES2607807T3 (es) | 2017-04-04 |
| AU2013299926B2 (en) | 2017-06-01 |
| US9029352B2 (en) | 2015-05-12 |
| AU2017201415C1 (en) | 2019-05-23 |
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