CN104511016B - Prevent and treat the medical composition and its use of aquatic animal disease - Google Patents
Prevent and treat the medical composition and its use of aquatic animal disease Download PDFInfo
- Publication number
- CN104511016B CN104511016B CN201310444074.XA CN201310444074A CN104511016B CN 104511016 B CN104511016 B CN 104511016B CN 201310444074 A CN201310444074 A CN 201310444074A CN 104511016 B CN104511016 B CN 104511016B
- Authority
- CN
- China
- Prior art keywords
- disease
- aquatic animal
- jamaicin
- animal disease
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000031295 Animal disease Diseases 0.000 title claims abstract description 12
- 239000000203 mixture Substances 0.000 title abstract description 10
- 239000003814 drug Substances 0.000 claims abstract description 31
- WITLAWYGGVAFLU-UHFFFAOYSA-N 3-(6-methoxy-1,3-benzodioxol-5-yl)-8,8-dimethylpyrano[2,3-f]chromen-4-one Chemical compound C1=CC(C)(C)OC2=CC=C(C(C(C3=CC=4OCOC=4C=C3OC)=CO3)=O)C3=C21 WITLAWYGGVAFLU-UHFFFAOYSA-N 0.000 claims abstract description 28
- 241000252230 Ctenopharyngodon idella Species 0.000 claims abstract description 21
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 230000003115 biocidal effect Effects 0.000 claims abstract description 14
- 241000700605 Viruses Species 0.000 claims abstract description 7
- 208000032843 Hemorrhage Diseases 0.000 claims description 32
- 201000010099 disease Diseases 0.000 claims description 24
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 24
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 16
- 241001609213 Carassius carassius Species 0.000 claims description 8
- 229960003405 ciprofloxacin Drugs 0.000 claims description 8
- 229960001180 norfloxacin Drugs 0.000 claims description 8
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 claims description 8
- 208000011580 syndromic disease Diseases 0.000 claims description 8
- SPFYMRJSYKOXGV-UHFFFAOYSA-N Baytril Chemical compound C1CN(CC)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 SPFYMRJSYKOXGV-UHFFFAOYSA-N 0.000 claims description 7
- 229960000740 enrofloxacin Drugs 0.000 claims description 7
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 6
- 241000700584 Simplexvirus Species 0.000 claims description 6
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims description 4
- 229960003512 nicotinic acid Drugs 0.000 claims description 4
- 235000001968 nicotinic acid Nutrition 0.000 claims description 4
- 239000011664 nicotinic acid Substances 0.000 claims description 4
- 229960001699 ofloxacin Drugs 0.000 claims description 3
- NRBJWZSFNGZBFQ-UHFFFAOYSA-N 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;2-hydroxypropanoic acid Chemical compound CC(O)C(O)=O.C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 NRBJWZSFNGZBFQ-UHFFFAOYSA-N 0.000 claims description 2
- JJWDELPVPRCLQN-UHFFFAOYSA-N 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride Chemical compound Cl.C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 JJWDELPVPRCLQN-UHFFFAOYSA-N 0.000 claims description 2
- VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 claims description 2
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 2
- OJVABJMSSDUECT-UHFFFAOYSA-L berberin sulfate Chemical compound [O-]S([O-])(=O)=O.C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2.C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 OJVABJMSSDUECT-UHFFFAOYSA-L 0.000 claims description 2
- DIOIOSKKIYDRIQ-UHFFFAOYSA-N ciprofloxacin hydrochloride Chemical compound Cl.C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 DIOIOSKKIYDRIQ-UHFFFAOYSA-N 0.000 claims description 2
- 229960001229 ciprofloxacin hydrochloride Drugs 0.000 claims description 2
- 229960004055 ciprofloxacin lactate Drugs 0.000 claims description 2
- 240000006413 Prunus persica var. persica Species 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 24
- 229940079593 drug Drugs 0.000 abstract description 19
- 230000000694 effects Effects 0.000 abstract description 14
- 241001465754 Metazoa Species 0.000 abstract description 10
- 206010059866 Drug resistance Diseases 0.000 abstract description 4
- 231100000053 low toxicity Toxicity 0.000 abstract description 2
- 235000019688 fish Nutrition 0.000 description 40
- 241000251468 Actinopterygii Species 0.000 description 35
- 238000002474 experimental method Methods 0.000 description 21
- 241000238557 Decapoda Species 0.000 description 18
- 210000002816 gill Anatomy 0.000 description 15
- 241001482311 Trionychidae Species 0.000 description 14
- 208000024891 symptom Diseases 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 210000004185 liver Anatomy 0.000 description 12
- 230000000740 bleeding effect Effects 0.000 description 11
- 241000276701 Oreochromis mossambicus Species 0.000 description 10
- 230000037396 body weight Effects 0.000 description 10
- 230000034994 death Effects 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 208000004232 Enteritis Diseases 0.000 description 7
- 241000702263 Reovirus sp. Species 0.000 description 7
- 208000015181 infectious disease Diseases 0.000 description 7
- 230000003902 lesion Effects 0.000 description 7
- 241001265687 Taura syndrome virus Species 0.000 description 6
- 208000025865 Ulcer Diseases 0.000 description 6
- 235000013527 bean curd Nutrition 0.000 description 6
- 231100000397 ulcer Toxicity 0.000 description 6
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 description 5
- 241000607528 Aeromonas hydrophila Species 0.000 description 5
- 208000007502 anemia Diseases 0.000 description 5
- 229960003760 florfenicol Drugs 0.000 description 5
- 229960005486 vaccine Drugs 0.000 description 5
- 230000003612 virological effect Effects 0.000 description 5
- 206010003445 Ascites Diseases 0.000 description 4
- 241000252233 Cyprinus carpio Species 0.000 description 4
- 206010040047 Sepsis Diseases 0.000 description 4
- 210000001015 abdomen Anatomy 0.000 description 4
- 210000000683 abdominal cavity Anatomy 0.000 description 4
- 210000000514 hepatopancreas Anatomy 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 208000013223 septicemia Diseases 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000175212 Herpesvirales Species 0.000 description 3
- 206010020565 Hyperaemia Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 208000034158 bleeding Diseases 0.000 description 3
- 208000001936 exophthalmos Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 230000001960 triggered effect Effects 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- 241001519451 Abramis brama Species 0.000 description 2
- 241000607534 Aeromonas Species 0.000 description 2
- 241001487666 Cyprinid herpesvirus Species 0.000 description 2
- 241000607473 Edwardsiella <enterobacteria> Species 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 241000252234 Hypophthalmichthys nobilis Species 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 210000004943 gill filament Anatomy 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 208000037921 secondary disease Diseases 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- UHHHTIKWXBRCLT-VDBOFHIQSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide;ethanol;hydrate;dihydrochloride Chemical compound O.Cl.Cl.CCO.C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O.C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O UHHHTIKWXBRCLT-VDBOFHIQSA-N 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000881711 Acipenser sturio Species 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 241000604777 Flavobacterium columnare Species 0.000 description 1
- 229930195503 Fortimicin Natural products 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 241000609060 Grass carp reovirus Species 0.000 description 1
- 206010019842 Hepatomegaly Diseases 0.000 description 1
- 241000521257 Hydrops Species 0.000 description 1
- 241000252498 Ictalurus punctatus Species 0.000 description 1
- 241000701372 Iridovirus Species 0.000 description 1
- 241001596950 Larimichthys crocea Species 0.000 description 1
- 241000238367 Mya arenaria Species 0.000 description 1
- JVMRPSJZNHXORP-UHFFFAOYSA-N ON=O.ON=O.ON=O.N Chemical group ON=O.ON=O.ON=O.N JVMRPSJZNHXORP-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241001282110 Pagrus major Species 0.000 description 1
- 241000736919 Pelodiscus sinensis Species 0.000 description 1
- 241000157468 Reinhardtius hippoglossoides Species 0.000 description 1
- 241000277331 Salmonidae Species 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 206010047400 Vibrio infections Diseases 0.000 description 1
- 206010066397 Visceral congestion Diseases 0.000 description 1
- 241000696962 White spot syndrome virus Species 0.000 description 1
- KIPLYOUQVMMOHB-MXWBXKMOSA-L [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O Chemical compound [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O KIPLYOUQVMMOHB-MXWBXKMOSA-L 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- XKMRRTOUMJRJIA-UHFFFAOYSA-N ammonia nh3 Chemical group N.N XKMRRTOUMJRJIA-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- BIDUPMYXGFNAEJ-APGVDKLISA-N astromicin Chemical compound O[C@@H]1[C@H](N(C)C(=O)CN)[C@@H](OC)[C@@H](O)[C@H](N)[C@H]1O[C@@H]1[C@H](N)CC[C@@H]([C@H](C)N)O1 BIDUPMYXGFNAEJ-APGVDKLISA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000029162 bladder disease Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 229960001172 doxycycline hyclate Drugs 0.000 description 1
- 229940031962 doxycycline hyclate 20 mg Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 208000031169 hemorrhagic disease Diseases 0.000 description 1
- 230000007866 hepatic necrosis Effects 0.000 description 1
- 206010019692 hepatic necrosis Diseases 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 210000001847 jaw Anatomy 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003750 lower gastrointestinal tract Anatomy 0.000 description 1
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
- 230000036973 muscularity Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 208000013435 necrotic lesion Diseases 0.000 description 1
- -1 pH value Substances 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229940063650 terramycin Drugs 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 208000026533 urinary bladder disease Diseases 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Farming Of Fish And Shellfish (AREA)
Abstract
The invention discloses a kind of pharmaceutical composition for preventing and treating aquatic animal disease, the pharmaceutical composition of the preventing and treating aquatic animal disease is made up of following two compositions：Carbostyril antibiotic and jamaicin.Compared with the existing, the pharmaceutical composition preventing and treating Aquatic animals virus for the preventing and treating aquatic animal disease that the present invention protects（Particularly grass carp）, bacteriosis it is curative for effect, easy to use, moderate cost, be easy to promote the use of a large area, be not likely to produce the resistance to the action of a drug, drug resistance, to dispenser object security, low toxicity, low-residual.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for preventing and treating aquatic animal disease, the pharmaceutical composition can be used for preventing and treating grass carp
The hemorrhage triggered by reovirus and other aquatic animals（Fish, shrimp, crab, the frog, soft-shelled turtle）Viral, bacteriosis.
Background technology
Aquatic animal（Fish, shrimp, crab, the frog, soft-shelled turtle etc.）Viral disease（The grass carp especially triggered by reovirus
Viral hemorrhagic disease）Including research of hemorrhage of grass carp, fulminant hemorrhage, crucian carp Simplex Virus, taura syndrome virus disease
With tarda disease and the disease such as gill rot, enteritis, ulcer, the rotten tail of rotten fin etc..
The symptom of research of hemorrhage of grass carp：The sick main infection endangers grass carp young fish of two years, fingerlings of two years, in addition an age fish and
Seed and two age above adult fishes can also infect, and outward appearance symptom is mainly presented with three kinds：1. the red red gill cover type of fin：See each fin ray of fish
And base portion hyperemia is rubescent, the gill cover and lower jaw are congested, rouge swelling, anaemia, the middle and later periods abdominal cavity have ascites, hepatopancrease turns white or is in
Red, white alternate flower liver shape.2. red muscularity：Fish body table hyperemia is rubescent, or in patch shape bleeding, subdermal muscle hyperemia is rubescent,
Di inflammation lesion, hepatopancrease turn white.3. enteritis gill rot type：Except the gill cover, jaw portion, fin ray and base portion body surface fill in various degree
Outside blood, bowel symptoms are congested, hindgut inflammation or ulcer, abdominal cavity have ascites, internal organ anaemia, gill rot.
Research of hemorrhage of grass carp epidemiology situation, early stage symptom unobvious, intermediary and later stages fish body matter is weak, secondary sense
Dye bacterium shows the symptoms such as body surface and each organ hemorrhage of internal organ, inflammation, anaemia, gill rot, enteritis, ulcer, hepatopancrease be impaired, should
The sick death rate is up to 60-90%, very harmful, insensitive to antibiotic, antibiotic, in the past mainly using injecting immune vaccine and
The method prevention of soaking vaccine, but immersion immunity vaccine climate, water temperature, water quality impact, effect is unstable, and operation is multiple in addition
It is miscellaneous, it can not be widely applied, injecting immune vaccine is inconvenient for operation, wastes time and energy, and fish body is damaged greatly, therefore except net cage is supported in addition
Outside growing, it is difficult to be widely applied in actual production.
Fulminant hemorrhage, cause of disease are Aeromonas hydrophila（Aeromonas hydrophila,AH）, the cause of disease is condition
Property pathogenic bacteria, be currently known can cause carp, crucian carp, bream, triangular bream, flower, silver carp, salmon, trout, sturgeon, Channel-catfish, Nian, Tilapia mossambica, large yellow croaker,
The aquatic animal such as the seas such as turbot, eel, eel, fresh-water fishes and the frog, soft-shelled turtle is caused a disease, and because its infection rate is high, dead fast, is generally called " fulminant
Hemorrhage " or " bacterial septicemia ", are a kind of typical people, animal, fish ill cause of disease altogether, cardinal symptom：Fish body table, the gill cover,
Lower jaw, fin bar, belly are congested rubescent in various degree, and severe patient's muscle is in patch or mottled bleeding, and gill filament anaemia, internal organ are each
There is hydrops in organ anaemia, severe patient abdominal cavity, and some individuals have the rotten tail symptom of gill rot, enteritis, Beancurd sheet, liver and gall syndrome, rotten fin.
Crucian carp Simplex Virus（Cyprinid Herpesvirus）, dead fish symptom：Gill filament swelling, bleeding are notable, the gill cover, under
Jaw portion, belly are in patch shape or point bleeding, fin ray is rubescent, fin base portion is rubescent, abdominal cavity ascites, hepatopancrease turn white or in red white phase
Between " flower liver shape ", rear enteremia or have dope, anus is congested red and swollen, exophthalmos, tail fin fringing, and serious tail fin eats into fin, liver
In khaki or " bean curd slag specimen " lesion, indivedual fish dorsals are in " furuncle sore sample " lesion.
Taura syndrome virus（TSV）Disease is that Taura syndrome virus.TSV performances symptom is：Shrimp tail, palpus, body
Table is rubescent, some individual outward appearance symptom unobvious, and body colour is ash, red, and shoal of shrimps often occurs touring around phenomenon, and indivedual shrimp tail fans occur
Blue spot, liver pancreas enlargement or in pale red, muscle is muddy, later stage symptom：Red palpus, red tail, soft shell etc..
Tarda（Edwardsiella lctalarus）Symptom：Soft-shelled turtle belly is in patch piece bleeding, neck enlargement, is carried on the back
Onychohelcosis, dissection find liver enlargement, and indivedual focuses fester, and have ascites, and frog leg is in petechial hemorrhage, exophthalmos, with it a little
Shape bleeding, visceral congestion, hepatic necrosis, Tilapia mossambica exophthalmos, the gill, jaw, belly bleeding are rubescent, liver be in flower liver, khaki,
Turning white has necrotic lesion, and body has furuncle sore sample focus, and some individuals are in symptoms such as gill rot, enteritis, Beancurd sheet.
The viral disease of aquatic animal, existing treatment method is in addition to using injection or immersion immunity vaccine, always
Without effective medical treatment, in addition, by the gill rot of the aquatic animals such as the fish of bacterium infection initiation, shrimp, crab, the frog, soft-shelled turtle, intestines
Scorching, red skin（Beancurd sheet）, ulcer, rotten fin, rotten tail, liver and gall syndrome, bleeding（Septicemia）Deng disease using traditional sulfa drug, big ring
Lactone antibiotic（Florfenicol, first alum mycin）, Tetracyclines（Terramycin, fortimicin）Produced sternly Deng because of long-term medication
The open defect such as the resistance to the action of a drug, drug resistance, dosage is big, effect is poor, high expensive again.
The content of the invention
An object of the present invention, which is that, provides a kind of pharmaceutical composition for preventing and treating aquatic animal disease, the drug regimen
Thing can be used for preventing and treating grass carp by the hemorrhage that reovirus triggers and other aquatic animals（Fish, shrimp, crab, the frog, soft-shelled turtle）Virus
Property, bacteriosis.
Technical scheme is：A kind of pharmaceutical composition for preventing and treating aquatic animal disease, the medicine of the preventing and treating aquatic animal disease
Composition is made up of following two compositions：Carbostyril antibiotic and jamaicin.
Preferably, the carbostyril antibiotic：Jamaicin weight ratio is 10-40：3.3-9.
Preferably, the carbostyril antibiotic is Norfloxacin, Enrofloxacin, Ofloxacin or Ciprofloxacin.
Preferably, the Norfloxacin is lactic norfloxacini, niacin norfloxacin or norfloxacin hydrochloride；The ring
Third husky star is Ciprofloxacin Hydrochloride, Ciprofloxacin Lactate or nicotinic acid Ciprofloxacin.
Preferably, the jamaicin is Berberine hydrochloride or berberine sulfate.
The second object of the present invention is to provide a kind of purposes of pharmaceutical composition.
Technical scheme is：A kind of purposes of aforementioned pharmaceutical compositions：The pharmaceutical composition be used for prevent and treat grass carp it is viral go out
Blood disease, fulminant hemorrhage, crucian carp Simplex Virus, peach draw syndrome virus or tarda disease
Beneficial effect：
1) pharmaceutical composition in vitro test of the present invention is to reovirus, irido virus, infectious hematopoietic necrosis
Poison, rhabdovirus, herpesviral, white spot syndrome virus, taura syndrome virus have notable preventive effect, and in vitro test confirms to increase
The phagocytic activity of strong leucocyte and liver reticuloendothelial system；Alkaloid has a broad antifungal spectrum simultaneously, to a variety of Gram-negative bacterias, sun
Property bacterium has inhibitory action.To Cytophaga Columnaris, Aeromonas hydrophila, pseudomonad, Aeromonas, tarda, viscous
Bacterium, vibrios, streptococcus have a stronger inhibitory action, and Norfloxacin（Ciprofloxacin, Enrofloxacin）It is mainly used in preventing and treating
The phytosis as caused by Aeromonas, pseudomonad, tarda, slime bacteria.
2) after medication, by the research of hemorrhage of grass carp protective rate of reovirus initiation, two age large size fingerlings are more than
80%, yearlings or two age above adult fish protective rates are more than 90%, for gill rot, enteritis, red skin（Beancurd sheet）, it is ulcer, rotten fin, rotten
Tail, bleeding（Septicemia）Sick cure rate is more than 90%, efficient to liver and gall syndrome more than 86% with the medicine compounding of liver and bladder disease.
3) preventing and treating effective percentage of the pharmaceutical composition of the present invention to hemorrhage caused by GCRV be up to more than 80%,
As long as grass carp can have enough pharmaceutical chemistry, just there is obvious curative effects, have it is easy to operate, curative for effect, cost is cheap, easy to spread
The characteristics of use, it is the up to now the only effective medicine of the prevention and control grass carp disease.In addition, the compound medicine can also have
Imitate prevention and control shrimp, crab, the gill rot triggered by virus or bacterium infection of fish, enteritis, bleeding（Septicemia）, red skin（Beancurd sheet）, ulcer,
Rotten fin, rotten tail, liver and gall syndrome.Compared with other drugs have effect it is good, it is easy to use, be not likely to produce the resistance to the action of a drug, drug resistance,
There is obvious control effect using this product to medication animal subject safety, low toxicity, when other drugs are invalid or effect is undesirable
Significant advantage.
4) pharmaceutical composition preventing and treating Aquatic animals virus of the present invention（Particularly grass carp）Bacteriosis is curative for effect,
It is easy to use, moderate cost, it is easy to promote the use of a large area, is not likely to produce the resistance to the action of a drug, drug resistance, to dispenser object security, low
Poison, low-residual.
Embodiment
Experiment 1
1）, pharmaceutical composition A preparation：Norfloxacin 10-20 parts by weight are taken, jamaicin 3.3-4.5 parts by weight are blended in
Together.
2）, treatment research of hemorrhage of grass carp
5 × 5 × 2 meters of specifications of net cage are chosen, every net cage puts 500 gram/fish of two 3000 kilograms of age Grass carp, totally 6000 tail,
If experimental box 1, No. 2, control case 3, No. 4, blank case 5, No. 6, experimental situation condition such as water temperature, pH value, weather etc. are managed
It is basically identical to change index, perfect compound feed used is bred as material from logical prestige grass carp, and managerial skills are identical, 2012 during experiment
March 1 to September 30 days, May 16 day No. 1, No. 2, No. 3, No. 4, No. 5, No. 6 casees start to fall ill in succession, be because of grass carp disease on inspection
Toxicity hemorrhage, cause of disease passes through is accredited as reovirus with fixed separation（gross Corp nemorrhoge virus ,GCHV）,
1 is shown in Table to each group case infection on May 19 and dead fish situation, after making a definite diagnosis, the drug regimen A configured is used for chamber 1,2
Number (by every 1 kilogram of fish body weight 13.3-24.5mg calculate dose), be used in conjunction 5 days, control case take Florfenicol（Content >=98%）Press
Every 1 kilogram of fish body weight 15mg calculates dose, mixes feeding（Bait）Material feeds No. 3, No. 4 casees 5 days, No. 5, No. 6 casees make blank group and do not offer medicine,
On May 20 to 24 offerd medicine, and the effect observation post administration phase 25 to 30 May, each group case dead fish situation is shown in Table 1.
Each case dead fish of table 1（Tail）Situation counts
It can be seen that from the result of experiment 1：Drug regimen A significantly falls ill in research of hemorrhage of grass carp early stage or mid-term
（The death rate is up to 20%）When feed protective rate up to more than 70%, and feed Florfenicol antimicrobial and group death rate of not offeing medicine is all high
Up to more than 90%.Prove that this drug regimen A has notable preventive effect to the research of hemorrhage of grass carp as caused by reovirus.
Experiment 2
1）, pharmaceutical composition B configuration：Enrofloxacin 15-20 parts by weight are taken, jamaicin 3.3-4.5 parts by weight are blended in
Together.
2）, treatment fulminant hemorrhage
Every net cage chooses the tail of carp 10000,500 grams/fish of specification, sets up 6, net cage separately, 4 × 7 × 2 meters of cage size, and 1
Number, No. 2 casees be experimental group, No. 3, No. 4 casees be control group, No. 5, No. 6 casees be blank group, 6 days to 6 March in 2012 during experiment
The moon 30, environmental condition each group is essentially identical during experiment, records temperature, water temperature, dissolved oxygen, pH value change, 3 days measure one daily
Secondary nitrite nitrogen, ammonia nitrogen index, it is feeds utilized to be bred as material for logical prestige carp.
May 10, each case phase secondary disease, from sick fish lesions position, fulminant bleeding was confirmed as by bacteriology classification is same surely
Disease.
May 12 day No. 1, No. 2 casees take the pharmaceutical composition B prepared, and 18.3- is pressed by every 1 kilogram of fish body weight daily dose
24.5mg, mix bait（Raise）Material feeds No. 1 lighter case of the state of an illness and is used in conjunction 3 days, and No. 2 case state of an illness are heavier to be used in conjunction 5 days, control group 3,4
Number case is used in conjunction 5 days by every 1 kilogram of fish body weight daily dose by Doxycycline Hyclate 20mg, blank group not medication, on May 10 to 19
Each group net cage dead fish situation is shown in Table 2.
Each net cage dead fish of table 2（Tail）Situation counts
Experiment shows more than：Pharmaceutical composition B is used in conjunction 3 to fulminant hemorrhage treatment caused by Aeromonas hydrophila
My god, severe, which is used in conjunction, significant curative effect for 5 days, and Doxycycline Hyclate ratio has obvious reduction without the antibiotic group death rate, after drug withdrawal
The death rate persistently rises, and shows not good enough to aeromonas hydrophila disease curative effect.
Experiment 3
1）, pharmaceutical composition C preparation：Enrofloxacin 15-20 parts by weight are taken, jamaicin 3.3-4.5 parts by weight are blended in
Together.
2）, treatment crucian carp Simplex Virus
Experiment choose 2 mu of areas, 1.8 meters of the depth of water, 6 mouthfuls of pond, wherein No. 1, No. 3 ponds make experiment pool, No. 2, No. 4 ponds
Compare group, No. 5, No. 6 ponds make blank group, every mu is put in a suitable place to breed the tail of crucian 3000,50 grams/fish of specification, the tail of grass carp 100, specification 250
Gram/fish, the tail of silver carp 100,250 grams/fish of specification, the tail of variegated carp 20,500 grams/fish of specification, the environment such as each pond water source, weather, water temperature
Consistent, managerial skills are identical, from logical prestige crucian carp feed.On April 1st, 2012 to June 30 during experiment.
Each fishpond phase secondary disease, separated from sick fish lesions position and identified, it is crucian carp Simplex Virus to make a definite diagnosis April 20
（Cyprinid Herpesvirus）.
April 21 day No. 1, No. 3 experiment pools take the pharmaceutical composition C prepared, by every 1 kilogram of fish body weight daily dose 18.5-
24.5mg mix bait（Raise）Feed, No. 1 pond disease is gentlier used in conjunction 3 days, and No. 3 ponds are heavier to be used in conjunction 5 days, and No. 2 ponds, No. 4 ponds compare, by 1
Kilogram fish body weight daily dose Enrofloxacin 40mg, No. 2 ponds are used in conjunction 5 days, and No. 4 ponds are used in conjunction 7 days, No. 5, No. 6 ponds make blank not medication,
On April 20 to 29, each pond dead fish situation was shown in Table 3.
Each pond dead fish of table 3（Tail）Statistics
More than experiment as can be seen that herpesviral it is insensitive to antimicrobials such as Enrofloxacins, death rate ratio during dispensing
The blank group do not offerd medicine has declined, it may be possible to which each organ scabies secondary infection bacterium has one after antimicrobial infects herpesviral to sick fish
Determine inhibitory action, but after drug withdrawal, the death rate is on the rise, and the final death rate is close with group of not offeing medicine, and C pairs of drug regimen
The disease has significant curative effect.
Experiment 4
1）, pharmaceutical composition D preparation：Enrofloxacin 20-40 parts by weight are taken, jamaicin 4.5-9 parts by weight are blended in one
Rise.
2) taura syndrome virus disease, is treated
Choose 1 mu of area, 0.8 meter of the depth of water, 6 mouthfuls of pond, wherein No. 1, No. 3 ponds make experiment pool, No. 2, No. 4 ponds compare pond,
No. 5, No. 6 are made blank group, and the tail of shrimp 1500, each pond water source, temperature, dissolved oxygen, pH value, water quality physical and chemical index phase are put in every mu of pond
Together, managerial skills are consistent, the Prawn material of feed selected stars feed companies production.On June 10th, 2013 is to August 20 during experiment
Day, June 20 found lesion, confirmed as after diagnosing：Taura syndrome virus（TSV）.
The pharmaceutical composition D prepared is taken to mix feeding by 1 kilogram of shrimp daily dose by every 1 kg body weight daily dose（Bait）Material is fed
24.5-49 mg, No. 1 pond are used in conjunction 3 days, and No. 3 ponds are used in conjunction 5 days, mix feeding（Bait）Material is fed.
No. 2, No. 4 ponds mix feeding by 1 kilogram of shrimp daily dose（Bait）Material feeds Florfenicol 15mg, and No. 2 ponds are used in conjunction 3 days, No. 4 ponds
It is used in conjunction 5 days.
No. 5, No. 6 pond not medications.
August receives shrimp situation on the 20th and is shown in Table 4.
Table 4 tests each pond and receives shrimp situation statistics
Remarks：Because shrimp life habit is special, it is not easy to observe in pond bottom, and after death decomposes quickly, can not testing
Period determines the accurate quantity of dead shrimp.
Experiment shows above：The antibiotic prawn Taura syndrome such as Florfenicol is without positive effect, with unused antibacterials
Without significant difference, and pharmaceutical composition D prawn Taura syndromes have remarkable result, and protective rate is up to more than 80%.
Experiment 5
1）, pharmaceutical composition H preparation：Take Ciprofloxacin（Ofloxacin）20-40 parts by weight, jamaicin 4.5-9 weight
Part mixes.
2）, treatment tarda disease
Choose 300 square metres of 6 mouthfuls of cement pits, No. 1, No. 3 ponds make experiment pool, No. 2, No. 4 ponds compare pond, No. 5, No. 6 ponds
Make blank group, 1.2 meters of the depth of water, each water source, water quality physical and chemical index are identical, and managerial skills are consistent, and soft-shelled turtle 150, the frog 30 are put per pond
Only, the tail of Tilapia mossambica 100, on May 30th, 2013, feed was from logical prestige trionyx sinensis feed to August 30 days during experiment.
Found that soft-shelled turtle is sick on July 3, July 4, the frog, Tilapia mossambica were sick, same from soft-shelled turtle, the frog, the separation of Tilapia mossambica lesions position respectively
It is fixed to find to be same cause of disease：Tarda（Edwardsiella lctalarus）.
Started July 4 to get it filled compositions H by every 1 kg body weight soft-shelled turtle, the frog, Tilapia mossambica daily dose, by every 1 kg body weight
Soft-shelled turtle, the frog, Tilapia mossambica 24.5-49mg, No. 1 pond are used in conjunction 5 days, and No. 3 ponds are used in conjunction 7 days.
No. 2, No. 4 ponds take Ciprofloxacin by every 1 kg body weight soft-shelled turtle, the frog, Tilapia mossambica（Ofloxacin）5-7 is used in conjunction in 40-80mg
My god.
No. 5, No. 6 pond not medications.
4 to 11 July each pond soft-shelled turtle, the frog, Tilapia mossambica necrology is shown in Table 5
Table 5
Experiment proves that pharmaceutical composition H has significant curative effect to the tarda disease of soft-shelled turtle, the frog, Tilapia mossambica etc. more than.
Claims (3)
1. a kind of purposes of carbostyril antibiotic and jamaicin in the medicine for preparing treatment aquatic animal disease, described
Disease is that research of hemorrhage of grass carp, fulminant hemorrhage, crucian carp Simplex Virus, peach drawing syndrome virus or tarda are sick,
The carbostyril antibiotic：Jamaicin weight ratio is 10-40： 3.3-9；The carbostyril antibiotic be Norfloxacin,
Enrofloxacin, Ofloxacin or Ciprofloxacin.
2. carbostyril antibiotic according to claim 1 and jamaicin are in the medicine for preparing treatment aquatic animal disease
Purposes in thing, it is characterised in that：The Norfloxacin is lactic norfloxacini, niacin norfloxacin or norfloxacin hydrochloride；
The Ciprofloxacin is Ciprofloxacin Hydrochloride, Ciprofloxacin Lactate or nicotinic acid Ciprofloxacin.
3. carbostyril antibiotic according to claim 1 and jamaicin are in the medicine for preparing treatment aquatic animal disease
Purposes in thing, it is characterised in that：The jamaicin is Berberine hydrochloride or berberine sulfate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310444074.XA CN104511016B (en) | 2013-09-26 | 2013-09-26 | Prevent and treat the medical composition and its use of aquatic animal disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310444074.XA CN104511016B (en) | 2013-09-26 | 2013-09-26 | Prevent and treat the medical composition and its use of aquatic animal disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104511016A CN104511016A (en) | 2015-04-15 |
| CN104511016B true CN104511016B (en) | 2018-01-09 |
Family
ID=52787254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310444074.XA Active CN104511016B (en) | 2013-09-26 | 2013-09-26 | Prevent and treat the medical composition and its use of aquatic animal disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104511016B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111838032A (en) * | 2020-06-29 | 2020-10-30 | 中国水产科学研究院长江水产研究所 | Method for efficiently preventing rhabdovirus outbreak in ricefield eel seedling stage |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101347432A (en) * | 2008-09-05 | 2009-01-21 | 郑州后羿制药有限公司 | Long-acting enrofloxacin injection for livestock and poultry and method of preparing the same |
| CN101491292A (en) * | 2008-01-23 | 2009-07-29 | 北京因科瑞斯医药科技有限公司 | Natural feed additive and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101264098A (en) * | 2008-04-15 | 2008-09-17 | 天津生机集团股份有限公司 | Medicinal composition for preventing and controlling livestock and fowls from infection disease |
-
2013
- 2013-09-26 CN CN201310444074.XA patent/CN104511016B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491292A (en) * | 2008-01-23 | 2009-07-29 | 北京因科瑞斯医药科技有限公司 | Natural feed additive and preparation method thereof |
| CN101347432A (en) * | 2008-09-05 | 2009-01-21 | 郑州后羿制药有限公司 | Long-acting enrofloxacin injection for livestock and poultry and method of preparing the same |
Non-Patent Citations (1)
| Title |
|---|
| 西药治疗局部压疮的进展;梁雁芳;《护理研究》;20060821;第20卷(第8期);第2168页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104511016A (en) | 2015-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103006792B (en) | A kind of herbal medicine for preventing and treating livestock and poultry intestinal canal diseases and preparation method thereof and feed | |
| CN101711528B (en) | Compound medicinal composition for destroying and expelling rotifers and protozoa and preparation method thereof | |
| CN103006772B (en) | Wall-broken Chinese herb medicine feed for prevention and cure of fish diseases | |
| Abdel-Wahab et al. | Effects of humic acid as feed additive in improvement of nonspecific immune response and disease resistance in common carp (Cyprinus carpio) | |
| Taraschewski et al. | Treatment of fish parasites: 3. Effects of levamisole HCl, metrifonate, fenbendazole, mebendazole, and ivermectin on Anguillicola crassus (nematodes) pathogenic in the air bladder of eels | |
| CN103860715B (en) | A kind of compound Chinese medicine extract and application thereof preventing and treating coccidiosis of domestic fowls | |
| CN103202409B (en) | Special feed additive for grass carp | |
| CN104887843B (en) | Traditional Chinese medicine composition for preventing and treating fish gill rot disease and preparation method thereof | |
| BR112019020225A2 (en) | berberine alkaloids in the prevention and / or treatment of intestinal disease | |
| CN101112429A (en) | Medicine for treating hemorrhage and fin rot of aquatic animals | |
| CN104511016B (en) | Prevent and treat the medical composition and its use of aquatic animal disease | |
| CN107088221B (en) | Chinese herbal medicine and medicinal bait for preventing and treating fish trichodiniasis and preparation method thereof | |
| CN104523897B (en) | A kind of enema medicament composition for treating piglet epidemic diarrhea | |
| CN101670005A (en) | Anticoccidiosis pharmaceutical composition and preparation method and use thereof | |
| CN104306388A (en) | Compound ivermectin injection and preparation method thereof | |
| CN108578476A (en) | A kind of composition and its preparation method and application of prevention fish nocardiasis | |
| CN102048059A (en) | Feed additive used for preventing and treating vibrio gill-rot disease of aquatic animals and preparation method thereof | |
| Suryadi et al. | The Effect of Potassium Diformate as Feed Additive on Immune Performances of Nilem (Osteochilus hasselti Valenciennes, 1842) Under Infection of Aeromonas hydrophila | |
| RU2276989C1 (en) | Method for treating the cases of agricultural young animals dyspepsia | |
| CN109620877A (en) | Pure Chinese medicine fowl antibacterium disease preparation and preparation method thereof and application method | |
| CN107158023A (en) | Prevent and treat the pharmaceutical composition and preparation method of the viral hemorrhagic disease of grass carp and black carp | |
| García-Esquivel et al. | Oxytetracycline water bath treatment of juvenile blue abalone Haliotis fulgens (Philippi 1845) affected by the withering syndrome | |
| CN110279792B (en) | Traditional Chinese medicine composition for preventing and treating ichthyophthiriasis of fishes and preparation method thereof | |
| KR101248946B1 (en) | A pharmaceutical composition for treating a bacterially caused disease of fish | |
| CN105998207B (en) | A kind of Chinese medicine composition for preventing and treating bacteriosis of aquatic livestock and preparation method thereof and bouvardin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190807 Address after: 610000 No. 13, No. 1, No. 2, No. 11, No. 1, No. 3, West First Ring Road, Jinniu District, Chengdu City, Sichuan Province Co-patentee after: He Yuhao Patentee after: He Xianrong Co-patentee after: Chengdu Sanyou Pharmaceutical Co., Ltd. Address before: 610000 No. 13, No. 1, No. 2, No. 11, No. 1, No. 3, West First Ring Road, Jinniu District, Chengdu City, Sichuan Province Patentee before: He Xianrong |
|
| TR01 | Transfer of patent right |