CN102048059A - Feed additive used for preventing and treating vibrio gill-rot disease of aquatic animals and preparation method thereof - Google Patents
Feed additive used for preventing and treating vibrio gill-rot disease of aquatic animals and preparation method thereof Download PDFInfo
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- CN102048059A CN102048059A CN2010106062732A CN201010606273A CN102048059A CN 102048059 A CN102048059 A CN 102048059A CN 2010106062732 A CN2010106062732 A CN 2010106062732A CN 201010606273 A CN201010606273 A CN 201010606273A CN 102048059 A CN102048059 A CN 102048059A
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Abstract
The invention discloses a feed additive used for preventing and treating vibrio gill-rot disease of aquatic animals and a preparation method thereof. The feed additive used for preventing and treating the vibrio gill-rot disease is prepared from the following raw materials in parts by weight: 15-25 parts of agastache rugosus, 10-20 parts of coptis chinensis, 7-15 parts of gentian, 3-7 parts of common andrographis herb, 3-7 parts of rheum officinale, 3-7 parts of pulsatilla chinensis, 1-3 parts of spectinomycin and 4-6 parts of lincomycin. The feed additive used for preventing and treating the vibrio gill-rot disease can be used for improving the body immunity and antiviral capacity of the aquatic animals, lowering the infection probability of gill-rot disease bacterial virus and improving the prevention and treatment effect of the gill-rot disease, is convenient to administrate in a water drinking mode, high in absorption rate, wide in distribution and wide in safe range, and has no medicament residue and no toxic and side effects.
Description
[technical field]
The present invention relates to a kind of aquatic livestock vibrios fin rot feed addictive and preparation method thereof of using, belong to animal doctor's pharmaceutical composition and preparation method thereof field.
[background technology]
The gill is the respiratory apparatus of aquatic livestock, in the aquatic livestock body, be in comparatively responsive position, participate in functional metabolism, the tool function of carrying oxygen, each histoorgan of whole body in the whole vital movement of aquatic livestock, played important function such as coordination, support, so in case pathology is taken place for the gill portion of aquatic livestock, will be subjected to its effect and influence the realization of normal physiological function, when serious even cause death, give and culture the dealer and bring the tremendous economic loss aquatic livestock.Fin rot is that a kind of infection is rapid, and the course of disease is long, more common aquatic animal disease, and it spreads once the just difficult control of morbidity, this sick the generation suddenly, infection velocity is fast, death rate height, it is serious to handle bad loss.Fin rot mainly contains two kinds: parasitic fin rot and bacterial gill, and bacterial gill is normal concurrent with diseases such as enteritis, red skins, makes state of an illness complexity, and the death rate is very high, is exactly vibrios and cause the main bacteria virus of aquatic livestock bacterial gill.
For this reason, treating aquatic livestock vibrios fin rot need be placed on main energy in the prevention, improve breeding environment and the various vaccines of inoculation except extremely long-pending, be exactly immunity, the anti-virus ability of conscious raising animal body in breeding process, thereby reduce the infection probability of fin rot bacterial virus such as vibrios.
[summary of the invention]
The purpose of this invention is to provide a kind of immunity of organisms, anti-virus ability that can improve aquatic livestock, reduce the feed addictive preparation method of infection probability and the raising fin rot prevention effect of fin rot bacterial virus.
Vibrios fin rot feed addictive of the present invention mainly is to be made by the raw material of following weight portion: wrinkled giant hyssop 15-25 part, coptis 10-20 part, felwort 7-15 part, Herba Andrographitis 3-7 part, rheum officinale 3-7 part, Chinese bulbul 3-7 part, spectinomycin 1-3 part, lincomycin 4-6 part.
Be preferably:
20 parts of wrinkled giant hyssops, 15 parts of the coptiss, 10 parts of felworts, 5 parts of Herba Andrographitis, 5 parts of rheum officinales, 5 parts of the Chinese bulbuls, 2 parts of spectinomycins, 5 parts of lincomycins.
The preparation method of vibrios fin rot feed addictive of the present invention may further comprise the steps:
(1) takes by weighing each raw material by described weight ratio;
(2) will be except that the raw material boiling twice spectinomycin and the lincomycin, each amount of water was not advisable to have former charge level, merged decocting liquid twice, filtered to get filtrate, and spray-drying gets powder;
(3) add spectinomycin and lincomycin, promptly get vibrios fin rot feed addictive after mixing thoroughly.
The present invention selects the above-mentioned raw materials combination to make each component and effect produce synergy, thereby can improve immunity of organisms, the resistance against diseases of aquatic livestock, reduces the infection probability of fin rot bacterial virus and improves the fin rot prevention effect.
The primary raw material wrinkled giant hyssop of wherein selecting for use contains Pogostone, Patchoulicalcohol, benzaldehyde, Eugenol, cinnaldehydrum, flavone compound is (as the celery flavine, rhamnocitrin, ombuin etc.), estragole, anisole, anisaldehyde, the d-citrene, right-the methoxyl group cinnaldehydrum, australene, nopinene, the 3-octanone, the 3-octanol, right-poly-umbrella ellagic acid, acacetin, the linden element, linarin, agastachoside, different agastachoside, agastachin, tannin, compositions such as amaroid have stronger antimycotic, antivirus action, the stimulation stomach lining is arranged, promote gastric secretion, digestive effect.The selected coptis contains multiple isoquinoline alkaloid, as jamaicin, coptisine, worenine, palmatine, jateorrhizine, epiberberine and magnoflorine etc., also contain forulic acid, chlorogenic acid etc., it is having stronger effect as antibiotic, antiviral, antiprotozoan aspect antimicrobial pathogen, simultaneously to the influence of cardiovascular system, detoxication, anti-inflammatory, analgesic, suppress aspect such as platelet aggregation and also have better action.Selected felwort is because it has effects such as heat-clearing, dehumidifying, detoxifcation, pain relieving, indigestion, inflammation-diminishing and cough-controlling.Select for use Herba Andrographitis to be because it has stronger antibiotic, antivirus action.The rheum officinale of selecting for use has stronger good influence and anti-infective, immunological regulation aspect to digestive system, hematological system effect is all arranged.It is clearing heat and detoxicating to select for use the Chinese bulbul to have, and controls waist knee podomere wind pain, edema and heart disease.
The selected spectinomycin of Western medicine has medium antibacterial action to aerobic gram-negative bacterias such as Escherichia coli, Klebsiella, enterobacteriaceae, proteus, acinetobacter calcoaceticus, haemophilus influenzae, bacterium morganis, and is very effective to the Neisser gonococcus.In gram positive bacteria, effective to A group of streptococcus and MRSE.In atypical pathogenic bacteria, to molten urine mycoplasma sensitivity.The lincomycin of selecting for use is that to suppress protein of bacteria synthetic, the gram-negative bacteria of most of gram positive bacterias and anaerobism is had antibacterial action, as vibrios, streptococcus pneumonia, micrococcus scarlatinae, viridans streptococci, staphylococcus aureus, corynebacterium diphtheriae etc.
Vibrios fin rot feed addictive of the present invention has clearing heat and detoxicating, but the collaborative poison, purging intense heat, cleaning endotoxin, anti-inflammation, blood stasis dispersing and deswelling of attacking kills the virus, controls characteristic of disease, prevents accompanying infection.Can effectively control the various fin rots of aquatic livestock, the enteritis disease, the growth of bacterial viruses such as red skin disease, purge away the poison in one's blood, can also eliminate the virus element that engine body exterior is invaded, have clearing heat and detoxicating, can kill multiple fin rot virus, fungi, mould, bacterium, the growth breeding of inhibition and eliminating pathogen, improve body immune system, promote the body rehabilitation, obvious mitigation symptoms especially at the initial stage of a disease, sb.'s illness took a turn for the worse in control, make aquatic livestock produce immunity, prevent the generation of aquatic livestock fin rot, the fin rot sent out etc. is also had very strong therapeutic action.And the drinking-water convenient drug administration, the absorptivity height, widely distributed, drug residue free has no side effect, and safe range is wide.
Vibrios fin rot feed addictive of the present invention can be by 0.4% (be 40g virus of the present invention steal dead sick feed addictive mix in 10 kilograms of feeds) sneaks in the feed and throws something and feeds, also can be made into concentration and be 40% oral liquid of (be 40g virus of the present invention steal dead sick feed addictive be dissolved in the 100ml sterilized water), and mix by every 100ml and to throw something and feed after 10 kilograms of feeds are mixed thoroughly.Connect and fed 3-7 days, severe can suitably strengthen consumption.
[specific embodiment]
Embodiment one: vibrios fin rot feed addictive 1 preparation of the present invention
(1) takes by weighing wrinkled giant hyssop 15g, coptis 10g, felwort 7g, Herba Andrographitis 3g, rheum officinale 3g, Chinese bulbul 3g, spectinomycin 1g, lincomycin 4g.
(2) will add 8 times of amounts of water for the first time except that the raw material boiling twice spectinomycin and the lincomycin, decoct 2 hours, and add 6 times of amounts of water for the second time, decoct 1 hour, and merge decocting liquid twice, and filter to get filtrate, spray-drying gets powder 4.75g;
(3) add spectinomycin and the lincomycin that takes by weighing, promptly get vibrios fin rot feed addictive 1 after mixing thoroughly.
Embodiment two: vibrios fin rot feed addictive 2 preparations of the present invention
(1) takes by weighing wrinkled giant hyssop 25g, coptis 20g, felwort 15g, Herba Andrographitis 7g, rheum officinale 73g, Chinese bulbul 7g, spectinomycin 3g, lincomycin 6g.
(2) will add 8 times of amounts of water for the first time except that the raw material boiling twice spectinomycin and the lincomycin, decoct 2 hours, and add 6 times of amounts of water for the second time, decoct 1 hour, and merge decocting liquid twice, and filter to get filtrate, spray-drying gets powder 8.35g;
(3) add spectinomycin and the lincomycin that takes by weighing, promptly get vibrios fin rot feed addictive 2 after mixing thoroughly.
Embodiment three: vibrios fin rot feed addictive 3 preparations of the present invention
(1) takes by weighing wrinkled giant hyssop 20g, coptis 15g, felwort 10g, Herba Andrographitis 5g, rheum officinale 5g, Chinese bulbul 5g, spectinomycin 2g, lincomycin 5g.
(2) will add 8 times of amounts of water for the first time except that the raw material boiling twice spectinomycin and the lincomycin, decoct 2 hours, and add 6 times of amounts of water for the second time, decoct 1 hour, and merge decocting liquid twice, and filter to get filtrate, spray-drying gets powder 4.75g;
(3) add spectinomycin and the lincomycin that takes by weighing, promptly get vibrios fin rot feed addictive 3 after mixing thoroughly.
Embodiment four: feed addictive of the present invention is to the anti-preact of grass carp vibrios fin rot
Get 250 healthy young grass carps, be divided into 5 groups at random, every group 50, add 5 and suffer from vibrios fin rot grass carp in every group of fish, feed after three days, 1 group in the normal nursing of continuation every day, 2 groups add the medicine that feed weighs 0.4% commercially available treatment fin rot, 3 groups add feed and weigh 1,4 group of 0.4% feed addictive of the present invention and add feed and weigh 0.4% feed addictive of the present invention and add feed for 2,5 groups and weigh 0.4% feed addictive of the present invention 3.Observe the growth and dead, infection conditions of grass carp in the feeding process, observed for two weeks.
The results are shown in Table 1.The result shows, in to the grass carp feeding process, under the normal condition vibrios fin rot death rate up to 36%, infection rate 86%; And showing the commercially available medicine death rate up to 16%, infection rate 54% has certain anti-preact to the vibrios fin rot; And feed addictive of the present invention can make the vibrios fin rot death rate drop to 4-8%, and infection rate 26-32% can significantly prevent the death and the infection effect of grass carp vibrios fin rot.
Table-1 feed addictive of the present invention is to the anti-pre-effect of the vibrios fin rot of grass carp
| The group number | 1 group | 2 groups | 3 groups | 4 groups | 5 groups |
| Death toll | 18 | 8 | 4 | 3 | 2 |
| Infect number | 25 | 19 | 12 | 13 | 11 |
| Healthy number | 7 | 23 | 34 | 34 | 37 |
| The death rate | 36％ | 16％ | 8％ | 6％ | 4％ |
| Infection rate | 86％ | 54％ | 32％ | 32％ | 26％ |
Embodiment five: feed addictive of the present invention is to the therapeutic action of eel vibrios fin rot
In the eel culture pond of finding the vibrios fin rot on a large scale, fish for the eel that 100 sizes evenly also all suffer from fin rot, random packet has 20 eels in each experiment pool in above-mentioned five experiment pool.Normally feed for the 1st group, the 2nd group adds the medicine that feed weighs 0.4% commercially available treatment fin rot when feeding, add feed during the 3rd group of nursing and weigh 0.4% feed addictive of the present invention 1, add feed during the 4th group of nursing and weigh 0.4% feed addictive of the present invention 2, add feed during the 5th group of nursing and weigh 0.4% feed addictive of the present invention 3, observe growth and the death condition of eel in the feeding process, observed for two weeks.
The results are shown in Table 2.The result shows, in to the eel feeding process that has the vibrios fin rot, do not carry out the experiment pool of any treatment processing and have only 60% survival rate, and the experiment pool that adopts commercially available fin rot drug therapy to handle has 75% survival rate, vibrios fin rot to eel has certain therapeutic action, and the survival rate of feeding feed addictive of the present invention can reach 85%-95%, and visible feed addictive of the present invention has the obvious treatment effect to the vibrios fin rot of eel.
Table-2 medicines of the present invention are to the vibrios fin rot result of treatment of eel
Claims (3)
1. one kind is used to prevent and treat aquatic livestock vibrios fin rot feed addictive, it is characterized in that it mainly is to be made by the raw material of following weight portion: wrinkled giant hyssop 15-25 part, coptis 10-20 part, felwort 7-15 part, Herba Andrographitis 3-7 part, rheum officinale 3-7 part, Chinese bulbul 3-7 part, spectinomycin 1-3 part, lincomycin 4-6 part.
2. vibrios fin rot feed addictive as claimed in claim 1 is characterized in that the consumption of raw material is: 20 parts of wrinkled giant hyssops, 15 parts of the coptiss, 10 parts of felworts, 5 parts of Herba Andrographitis, 5 parts of rheum officinales, 5 parts of the Chinese bulbuls, 2 parts of spectinomycins, 5 parts of lincomycins.
3. the preparation method of vibrios fin rot feed addictive as claimed in claim 1 or 2 may further comprise the steps:
(1) takes by weighing each raw material by described weight ratio;
(2) will be except that the raw material boiling twice spectinomycin and the lincomycin, each amount of water was not advisable to have former charge level, merged decocting liquid twice, filtered to get filtrate, and spray-drying gets powder;
(3) add spectinomycin and lincomycin, promptly get vibrios fin rot feed addictive after mixing thoroughly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010106062732A CN102048059B (en) | 2010-12-27 | 2010-12-27 | Feed additive used for preventing and treating vibrio gill-rot disease of aquatic animals and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010106062732A CN102048059B (en) | 2010-12-27 | 2010-12-27 | Feed additive used for preventing and treating vibrio gill-rot disease of aquatic animals and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102048059A true CN102048059A (en) | 2011-05-11 |
| CN102048059B CN102048059B (en) | 2012-12-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010106062732A Expired - Fee Related CN102048059B (en) | 2010-12-27 | 2010-12-27 | Feed additive used for preventing and treating vibrio gill-rot disease of aquatic animals and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104222486A (en) * | 2014-09-28 | 2014-12-24 | 浙江海洋学院 | Feed for treating fin rot of large yellow croaker |
| CN104814327A (en) * | 2015-05-11 | 2015-08-05 | 四川农业大学 | Feed additive for preventing fish gill hyperemia and rotted gill diseases caused by ammonia nitrogen and feed |
| CN111973613A (en) * | 2020-07-30 | 2020-11-24 | 瑞普（天津）生物药业有限公司 | Compound spectinomycin powder injection and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1415365A (en) * | 2002-10-25 | 2003-05-07 | 广西南宁悦丰天然生物工程有限公司 | Chinese medical preparation for preventing and curing blaze of shrimps corpus hemorrhagicum, gill rot and pond syndrome |
| CN101112429A (en) * | 2007-08-02 | 2008-01-30 | 王安林 | Medicine for treating hemorrhage and fin rot of aquatic animals |
-
2010
- 2010-12-27 CN CN2010106062732A patent/CN102048059B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1415365A (en) * | 2002-10-25 | 2003-05-07 | 广西南宁悦丰天然生物工程有限公司 | Chinese medical preparation for preventing and curing blaze of shrimps corpus hemorrhagicum, gill rot and pond syndrome |
| CN101112429A (en) * | 2007-08-02 | 2008-01-30 | 王安林 | Medicine for treating hemorrhage and fin rot of aquatic animals |
Non-Patent Citations (2)
| Title |
|---|
| 《International Journal of Zoological Research》 20080331 Soundarapandian,P.et 《Effect of Probiotics on the Survival and Production of Black Tiger Shrimp Penaeus monodon (Fabricius) 》 第35-41页 1-3 第4卷, 第1期 * |
| 《现代农业科技》 20100731 杨再明等 《防治鱼病常用中草药的特征特性及使用方法》 第385－386页 1－3 , 第13期 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104222486A (en) * | 2014-09-28 | 2014-12-24 | 浙江海洋学院 | Feed for treating fin rot of large yellow croaker |
| CN104814327A (en) * | 2015-05-11 | 2015-08-05 | 四川农业大学 | Feed additive for preventing fish gill hyperemia and rotted gill diseases caused by ammonia nitrogen and feed |
| CN111973613A (en) * | 2020-07-30 | 2020-11-24 | 瑞普（天津）生物药业有限公司 | Compound spectinomycin powder injection and preparation method thereof |
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| CN102048059B (en) | 2012-12-19 |
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