CN104508136A - 重组微生物及其用途 - Google Patents

重组微生物及其用途 Download PDF

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Publication number
CN104508136A
CN104508136A CN201380040793.3A CN201380040793A CN104508136A CN 104508136 A CN104508136 A CN 104508136A CN 201380040793 A CN201380040793 A CN 201380040793A CN 104508136 A CN104508136 A CN 104508136A
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CN
China
Prior art keywords
clostridium
bacterium
microorganism
nucleic acid
malonyl
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Pending
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CN201380040793.3A
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English (en)
Chinese (zh)
Inventor
陈铱婷
M·科普克
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Lanzatech NZ Inc
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Lanzatech New Zealand Ltd
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Application filed by Lanzatech New Zealand Ltd filed Critical Lanzatech New Zealand Ltd
Priority to CN202111160847.2A priority Critical patent/CN113832199A/zh
Publication of CN104508136A publication Critical patent/CN104508136A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01075—Malonyl CoA reductase (malonate semialdehyde-forming)(1.2.1.75)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/145—Clostridium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201380040793.3A 2012-05-30 2013-05-30 重组微生物及其用途 Pending CN104508136A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111160847.2A CN113832199A (zh) 2012-05-30 2013-05-30 重组微生物及其用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261653348P 2012-05-30 2012-05-30
US61/653,348 2012-05-30
PCT/NZ2013/000092 WO2013180581A1 (en) 2012-05-30 2013-05-30 Recombinant microorganisms and uses therefor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202111160847.2A Division CN113832199A (zh) 2012-05-30 2013-05-30 重组微生物及其用途

Publications (1)

Publication Number Publication Date
CN104508136A true CN104508136A (zh) 2015-04-08

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CN201380040793.3A Pending CN104508136A (zh) 2012-05-30 2013-05-30 重组微生物及其用途
CN202111160847.2A Pending CN113832199A (zh) 2012-05-30 2013-05-30 重组微生物及其用途

Family Applications After (1)

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Country Status (8)

Country Link
US (1) US9994878B2 (enExample)
EP (1) EP2855690B1 (enExample)
JP (1) JP6445970B2 (enExample)
KR (1) KR102098849B1 (enExample)
CN (2) CN104508136A (enExample)
CA (1) CA2874832C (enExample)
IN (1) IN2014DN10168A (enExample)
WO (1) WO2013180581A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
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CN104789516A (zh) * 2015-04-22 2015-07-22 天津大学 一种产三羟基丙酸的集胞藻6803基因工程菌及构建方法及应用
CN106350474A (zh) * 2015-07-13 2017-01-25 Sk新技术株式会社 包含编码甲基丙二酰‑CoA还原酶的基因的突变微生物及其用途
CN121065057A (zh) * 2025-11-05 2025-12-05 珠海麦得发生物科技股份有限公司 一种生产3-羟基丙酸的重组菌及其构建方法和应用

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US20130323820A1 (en) 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
ES2828707T3 (es) 2014-01-28 2021-05-27 Lanzatech New Zealand Ltd Método para producir un microorganismo recombinante
FI3209786T3 (fi) 2014-10-22 2023-06-13 Lanzatech Nz Inc Monivaiheisia bioreaktoriprosesseja
CA2965319C (en) 2014-10-22 2018-05-15 Lanzatech New Zealand Limited Gas testing unit and method
WO2016138050A1 (en) 2015-02-23 2016-09-01 Lanzatech New Zealand Limited Recombinant acetogenic bacterium for the conversion of methane to products
JP6905518B2 (ja) 2015-10-13 2021-07-21 ランザテク・ニュージーランド・リミテッド エネルギー発生発酵経路を含む遺伝子操作細菌
CN108431208A (zh) 2015-12-03 2018-08-21 朗泽科技新西兰有限公司 增补精氨酸以改善气体发酵产乙酸菌的效率
US10358661B2 (en) 2015-12-28 2019-07-23 Lanzatech New Zealand Limited Microorganism with modified hydrogenase activity
GB201601558D0 (en) 2016-01-28 2016-03-16 Verdant Bioproducts Ltd Method for producing 3-hydroxypropionamide
JP6896748B2 (ja) 2016-02-01 2021-06-30 ランザテク・ニュージーランド・リミテッド 統合型発酵電解プロセス
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WO2018070141A1 (ja) * 2016-10-13 2018-04-19 積水化学工業株式会社 偏性嫌気性酢酸生成微生物、並びに、組換え微生物
PT3679149T (pt) 2017-09-08 2022-09-05 Lanzatech Inc Processos para produção de metabolitos usando substratos contendo c1 ricos em hidrogénio
BR112020008718A2 (pt) 2017-12-19 2020-11-24 Lanzatech, Inc. microrganismo geneticamente modificado, e, método de produção de etilenoglicol ou de um precursor de etilenoglicol.
CN111683731B (zh) 2018-02-12 2022-09-02 朗泽科技有限公司 用于提高碳转化效率的工艺
EA202092427A1 (ru) 2018-04-20 2021-02-02 Ланцатек, Инк. Интермиттентные электролизные потоки
CN109112156A (zh) * 2018-09-19 2019-01-01 江苏师范大学 一种生产3-羟基丙酸的重组假单胞菌、其构建方法及其应用
EP3884060A4 (en) 2018-11-19 2022-08-10 Lanzatech, Inc. FERMENTATION AND GASIFICATION INTEGRATION
EP3921433A4 (en) 2019-02-08 2022-11-23 Lanzatech, Inc. PROCESS FOR RECOVERING NEAR BOILING POINT PRODUCTS
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US11932818B2 (en) 2020-03-16 2024-03-19 Lanzatech, Inc. Tail gas of gas fermentation to dry gasification feedstock
KR20220140619A (ko) 2020-03-18 2022-10-18 란자테크, 인크. 가스성 기질로부터의 2-페닐에탄올의 발효 제조
MX2022013570A (es) * 2020-04-29 2022-11-30 Lanzatech Inc Produccion fermentativa de b-cetoadipato a partir de sustratos gaseosos.
US11760989B2 (en) 2020-06-06 2023-09-19 Lanzatech, Inc. Microorganism with knock-in at acetolactate decarboxylase gene locus
AU2022218205A1 (en) * 2021-02-08 2023-05-25 Lanzatech, Inc. Recombinant microorganisms and uses therefor
BR112023020761A2 (pt) 2021-04-09 2023-12-12 Lanzatech Inc Processo para fornecer uma matéria-prima, e, aparelho para fornecer uma matéria-prima de fermentação gasosa
US12241105B2 (en) 2021-07-20 2025-03-04 Lanzatech, Inc. Recombinant microorganisms and uses therefor
TW202307202A (zh) 2021-08-06 2023-02-16 美商朗澤科技有限公司 用於改良乙二醇之生物產生的微生物及方法
US12091648B2 (en) 2021-11-03 2024-09-17 Lanzatech, Inc. System and method for generating bubbles in a vessel
US12280331B2 (en) 2022-04-29 2025-04-22 Lanzatech, Inc. Low residence time gas separator
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EP4544062A1 (en) 2022-06-21 2025-04-30 Lanzatech, Inc. Microorganisms and methods for the continuous co-production of high-value, specialized proteins and chemical products from c1-substrates
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104789516A (zh) * 2015-04-22 2015-07-22 天津大学 一种产三羟基丙酸的集胞藻6803基因工程菌及构建方法及应用
CN104789516B (zh) * 2015-04-22 2017-12-22 天津大学 一种产三羟基丙酸的集胞藻6803基因工程菌及构建方法及应用
CN106350474A (zh) * 2015-07-13 2017-01-25 Sk新技术株式会社 包含编码甲基丙二酰‑CoA还原酶的基因的突变微生物及其用途
CN106350474B (zh) * 2015-07-13 2019-12-27 Sk新技术株式会社 包含编码甲基丙二酰-CoA还原酶的基因的突变微生物及其用途
CN121065057A (zh) * 2025-11-05 2025-12-05 珠海麦得发生物科技股份有限公司 一种生产3-羟基丙酸的重组菌及其构建方法和应用

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Publication number Publication date
KR102098849B1 (ko) 2020-04-09
KR20150021081A (ko) 2015-02-27
EP2855690A4 (en) 2016-02-17
EP2855690B1 (en) 2018-07-11
JP2015517823A (ja) 2015-06-25
US9994878B2 (en) 2018-06-12
US20130323806A1 (en) 2013-12-05
CA2874832A1 (en) 2013-12-05
CN113832199A (zh) 2021-12-24
EP2855690A1 (en) 2015-04-08
JP6445970B2 (ja) 2018-12-26
CA2874832C (en) 2016-02-02
IN2014DN10168A (enExample) 2015-08-21
WO2013180581A1 (en) 2013-12-05

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