CN104508136A - 重组微生物及其用途 - Google Patents

重组微生物及其用途 Download PDF

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Publication number
CN104508136A
CN104508136A CN201380040793.3A CN201380040793A CN104508136A CN 104508136 A CN104508136 A CN 104508136A CN 201380040793 A CN201380040793 A CN 201380040793A CN 104508136 A CN104508136 A CN 104508136A
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CN
China
Prior art keywords
clostridium
bacterium
microorganism
nucleic acid
malonyl
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Pending
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CN201380040793.3A
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English (en)
Chinese (zh)
Inventor
陈铱婷
M·科普克
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Lanzatech NZ Inc
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Lanzatech New Zealand Ltd
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Priority to CN202111160847.2A priority Critical patent/CN113832199A/zh
Publication of CN104508136A publication Critical patent/CN104508136A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01075—Malonyl CoA reductase (malonate semialdehyde-forming)(1.2.1.75)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/145—Clostridium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201380040793.3A 2012-05-30 2013-05-30 重组微生物及其用途 Pending CN104508136A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111160847.2A CN113832199A (zh) 2012-05-30 2013-05-30 重组微生物及其用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261653348P 2012-05-30 2012-05-30
US61/653,348 2012-05-30
PCT/NZ2013/000092 WO2013180581A1 (en) 2012-05-30 2013-05-30 Recombinant microorganisms and uses therefor

Related Child Applications (1)

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CN202111160847.2A Division CN113832199A (zh) 2012-05-30 2013-05-30 重组微生物及其用途

Publications (1)

Publication Number Publication Date
CN104508136A true CN104508136A (zh) 2015-04-08

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CN202111160847.2A Pending CN113832199A (zh) 2012-05-30 2013-05-30 重组微生物及其用途
CN201380040793.3A Pending CN104508136A (zh) 2012-05-30 2013-05-30 重组微生物及其用途

Family Applications Before (1)

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CN202111160847.2A Pending CN113832199A (zh) 2012-05-30 2013-05-30 重组微生物及其用途

Country Status (8)

Country Link
US (1) US9994878B2 (enExample)
EP (1) EP2855690B1 (enExample)
JP (1) JP6445970B2 (enExample)
KR (1) KR102098849B1 (enExample)
CN (2) CN113832199A (enExample)
CA (1) CA2874832C (enExample)
IN (1) IN2014DN10168A (enExample)
WO (1) WO2013180581A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104789516A (zh) * 2015-04-22 2015-07-22 天津大学 一种产三羟基丙酸的集胞藻6803基因工程菌及构建方法及应用
CN106350474A (zh) * 2015-07-13 2017-01-25 Sk新技术株式会社 包含编码甲基丙二酰‑CoA还原酶的基因的突变微生物及其用途

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HUE051262T2 (hu) 2014-01-28 2021-03-01 Lanzatech New Zealand Ltd Módszer rekombináns mirkoorganizmus elõállítására
KR20240160674A (ko) 2014-10-22 2024-11-11 란자테크 엔지, 인크. 가스 시험 유닛 및 방법
EA035153B1 (ru) 2014-10-22 2020-05-06 Ланцатек Нью Зилэнд Лимитед Многостадийные биореакторные процессы
US10131884B2 (en) 2015-02-23 2018-11-20 Lanzatech New Zealand Limited Recombinant acetogenic bacterium for the conversion of methane to products
AU2016339989B2 (en) 2015-10-13 2022-11-17 Lanzatech Nz, Inc. Genetically engineered bacterium comprising energy-generating fermentation pathway
KR20180127632A (ko) 2015-12-03 2018-11-29 란자테크 뉴질랜드 리미티드 가스 발효 아세토젠에서의 효율을 개선하기 위한 아르기닌 보충
US10358661B2 (en) 2015-12-28 2019-07-23 Lanzatech New Zealand Limited Microorganism with modified hydrogenase activity
GB201601558D0 (en) 2016-01-28 2016-03-16 Verdant Bioproducts Ltd Method for producing 3-hydroxypropionamide
KR20180118651A (ko) 2016-02-01 2018-10-31 란자테크 뉴질랜드 리미티드 통합형 발효 및 전해 공정
WO2017147555A1 (en) 2016-02-26 2017-08-31 Lanzatech New Zealand Limited Crispr/cas systems for c-1 fixing bacteria
SG11201810031RA (en) 2016-05-14 2018-12-28 Lanzatech Inc Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods
US20190233854A1 (en) * 2016-10-13 2019-08-01 Sekisui Chemical Co., Ltd. Obligately anaerobic acetic acid-producing microorganism, and recombinant microorganism
CN111051517B (zh) 2017-09-08 2023-10-27 朗泽科技有限公司 用于使用富氢气的含有c1的底物生产代谢物的方法和系统
CA3079761C (en) 2017-12-19 2023-09-19 Lanzatech, Inc. Microorganisms and methods for the biological production of ethylene glycol
CN111683731B (zh) 2018-02-12 2022-09-02 朗泽科技有限公司 用于提高碳转化效率的工艺
EA202092427A1 (ru) 2018-04-20 2021-02-02 Ланцатек, Инк. Интермиттентные электролизные потоки
CN109112156A (zh) * 2018-09-19 2019-01-01 江苏师范大学 一种生产3-羟基丙酸的重组假单胞菌、其构建方法及其应用
CA3120151C (en) 2018-11-19 2024-04-30 Lanzatech, Inc. Integration of fermentation and gasification
EP3921433A4 (en) 2019-02-08 2022-11-23 Lanzatech, Inc. PROCESS FOR RECOVERING NEAR BOILING POINT PRODUCTS
US12497635B2 (en) 2019-03-20 2025-12-16 Global Bioenergies Means and methods for producing isobutene from acetyl-CoA
CA3138589C (en) 2019-07-11 2024-04-02 Lanzatech, Inc. Methods for optimizing gas utilization
US11932818B2 (en) 2020-03-16 2024-03-19 Lanzatech, Inc. Tail gas of gas fermentation to dry gasification feedstock
BR112022018609A2 (pt) 2020-03-18 2022-11-08 Lanzatech Inc Microrganismo capaz de produzir 2-feniletanol, e, método de produção de 2-feniletanol
MX2022013570A (es) * 2020-04-29 2022-11-30 Lanzatech Inc Produccion fermentativa de b-cetoadipato a partir de sustratos gaseosos.
MY207363A (en) 2020-06-06 2025-02-22 Lanzatech Inc Microorganism with knock-in at acetolactate decarboxylase gene locus
CA3195088C (en) * 2021-02-08 2024-04-23 Fungmin Liew Recombinant microorganisms and their use in the production of 3-hydroxypropionate [3-hp]
CN117098850A (zh) 2021-04-09 2023-11-21 朗泽科技有限公司 用于提供原料的方法和设备
WO2023004293A1 (en) 2021-07-20 2023-01-26 Lanzatech, Inc. Recombinant microorganisms and uses therefor
TW202307202A (zh) 2021-08-06 2023-02-16 美商朗澤科技有限公司 用於改良乙二醇之生物產生的微生物及方法
US12091648B2 (en) 2021-11-03 2024-09-17 Lanzatech, Inc. System and method for generating bubbles in a vessel
US12280331B2 (en) 2022-04-29 2025-04-22 Lanzatech, Inc. Low residence time gas separator
US12077800B2 (en) 2022-06-16 2024-09-03 Lanzatech, Inc. Liquid distributor system and process of liquid distribution
US12371727B2 (en) 2022-06-21 2025-07-29 Lanzatech, Inc. Microorganisms and methods for the continuous co-production of tandem repeat proteins and chemical products from C1-substrates
WO2023250389A1 (en) 2022-06-21 2023-12-28 Lanzatech, Inc. Microorganisms and methods for the continuous co-production of high-value, specialized proteins and chemical products from c1-substrates
US12129503B2 (en) 2022-08-10 2024-10-29 Lanzatech, Inc. Carbon sequestration in soils with production of chemical products
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104789516A (zh) * 2015-04-22 2015-07-22 天津大学 一种产三羟基丙酸的集胞藻6803基因工程菌及构建方法及应用
CN104789516B (zh) * 2015-04-22 2017-12-22 天津大学 一种产三羟基丙酸的集胞藻6803基因工程菌及构建方法及应用
CN106350474A (zh) * 2015-07-13 2017-01-25 Sk新技术株式会社 包含编码甲基丙二酰‑CoA还原酶的基因的突变微生物及其用途
CN106350474B (zh) * 2015-07-13 2019-12-27 Sk新技术株式会社 包含编码甲基丙二酰-CoA还原酶的基因的突变微生物及其用途

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Publication number Publication date
IN2014DN10168A (enExample) 2015-08-21
CA2874832C (en) 2016-02-02
JP6445970B2 (ja) 2018-12-26
CN113832199A (zh) 2021-12-24
JP2015517823A (ja) 2015-06-25
WO2013180581A1 (en) 2013-12-05
KR20150021081A (ko) 2015-02-27
CA2874832A1 (en) 2013-12-05
KR102098849B1 (ko) 2020-04-09
EP2855690A1 (en) 2015-04-08
EP2855690B1 (en) 2018-07-11
US9994878B2 (en) 2018-06-12
EP2855690A4 (en) 2016-02-17
US20130323806A1 (en) 2013-12-05

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