CN104507940B - 杂环化合物 - Google Patents
杂环化合物 Download PDFInfo
- Publication number
- CN104507940B CN104507940B CN201380040684.1A CN201380040684A CN104507940B CN 104507940 B CN104507940 B CN 104507940B CN 201380040684 A CN201380040684 A CN 201380040684A CN 104507940 B CN104507940 B CN 104507940B
- Authority
- CN
- China
- Prior art keywords
- alkyl
- optionally
- group
- base
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC=CC(N)=C(C(N)O)C(*)=CC Chemical compound CC=CC(N)=C(C(N)O)C(*)=CC 0.000 description 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012-126462 | 2012-06-01 | ||
JP2012126462 | 2012-06-01 | ||
PCT/JP2013/065183 WO2013180265A1 (ja) | 2012-06-01 | 2013-05-31 | 複素環化合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104507940A CN104507940A (zh) | 2015-04-08 |
CN104507940B true CN104507940B (zh) | 2017-01-25 |
Family
ID=49673448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201380040684.1A Expired - Fee Related CN104507940B (zh) | 2012-06-01 | 2013-05-31 | 杂环化合物 |
Country Status (8)
Country | Link |
---|---|
US (2) | US9371320B2 (ru) |
EP (1) | EP2857400A4 (ru) |
JP (1) | JPWO2013180265A1 (ru) |
CN (1) | CN104507940B (ru) |
BR (1) | BR112014029705A2 (ru) |
CA (1) | CA2874987A1 (ru) |
EA (1) | EA201492250A1 (ru) |
WO (1) | WO2013180265A1 (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014146246A1 (en) * | 2013-03-19 | 2014-09-25 | Merck Sharp & Dohme Corp. | Cycloalkyl nitrile pyrazolo pyridones as janus kinase inhibitors |
KR20150130311A (ko) * | 2013-03-19 | 2015-11-23 | 머크 샤프 앤드 돔 코포레이션 | 야누스 키나제 억제제로서의 n-(2-시아노 헤테로시클릴)피라졸로 피리돈 |
CN105189508B (zh) * | 2013-03-19 | 2018-11-23 | 默沙东公司 | 作为janus激酶抑制剂的环烷基腈吡唑并吡啶酮 |
AU2014234909B2 (en) * | 2013-03-19 | 2017-10-05 | Merck Sharp & Dohme Corp. | Acyclic cyanoethylpyrazolo pyridones as Janus kinase inhibitors |
WO2014146249A1 (en) * | 2013-03-19 | 2014-09-25 | Merck Sharp & Dohme Corp. | Geminally substituted cyanoethylpyrazolo pyridones as janus kinase inhibitors |
EA201591881A1 (ru) * | 2013-03-28 | 2016-04-29 | Такеда Фармасьютикал Компани Лимитед | Гетероциклическое соединение |
CN112585147B (zh) | 2017-10-13 | 2023-12-05 | 帝国理工学院创新有限公司 | Map4k4抑制剂 |
KR102094802B1 (ko) * | 2017-10-24 | 2020-03-31 | 고려대학교 산학협력단 | 소변 대사체 분석을 이용한 베체트병의 진단방법 |
CN110343103A (zh) * | 2019-07-04 | 2019-10-18 | 深圳市格物致欣化学技术有限公司 | 吡唑并吡啶类化合物及其制备方法 |
WO2022175752A1 (en) | 2021-02-19 | 2022-08-25 | Sudo Biosciences Limited | Tyk2 inhibitors and uses thereof |
CN113671064B (zh) * | 2021-07-15 | 2022-05-17 | 中国海洋大学 | 一种定量分析血浆中氨来占诺的血药浓度的检测方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004050658A1 (de) * | 2002-12-03 | 2004-06-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte imidazo-pyridinone und imidazo-pyridazinone, ihre herstellung und ihre verwendung als arzneimittel |
CN1636005A (zh) * | 1999-06-03 | 2005-07-06 | 克诺尔股份有限公司 | 苯并噻嗪酮和苯并噁嗪酮化合物 |
CN1656079A (zh) * | 2002-05-31 | 2005-08-17 | 卫材株式会社 | 吡唑化合物和含有该化合物的药物组合物 |
WO2006003440A1 (en) * | 2004-07-05 | 2006-01-12 | Astex Therapeutics Limited | 3,4-disubstituted pyrazoles as cyclin dependent kinases (cdk) or aurora kinase or glycogen synthase 3 (gsk-3) inhibitors |
WO2008047831A1 (fr) * | 2006-10-17 | 2008-04-24 | Kyowa Hakko Kirin Co., Ltd. | Inhibiteurs de JAK |
WO2012030924A1 (en) * | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Azolopyridine and azolopyrimidine compounds and methods of use thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3663559A (en) | 1969-12-03 | 1972-05-16 | Union Carbide Corp | Preparation of oxo-furo-pyridines from furylvinyl isocyanates |
JPS5814437B2 (ja) | 1975-12-25 | 1983-03-18 | タイホウヤクヒンコウギヨウ カブシキガイシヤ | ピラゾロピリジン −3− カルボンサンユウドウタイノセイゾウホウ |
JPS5814438B2 (ja) | 1975-12-27 | 1983-03-18 | タイホウヤクヒンコウギヨウ カブシキガイシヤ | ピラゾロピリジンユウドウタイノ セイゾウホウホウ |
JP2759227B2 (ja) | 1990-09-28 | 1998-05-28 | 大鵬薬品工業株式会社 | ピラゾロピリジン誘導体 |
TWI339206B (en) | 2003-09-04 | 2011-03-21 | Vertex Pharma | Compositions useful as inhibitors of protein kinases |
RU2008100165A (ru) | 2005-06-14 | 2009-07-20 | Шеринг Корпорейшн (US) | Ингибиторы аспартильных протеаз |
WO2007115231A2 (en) | 2006-03-30 | 2007-10-11 | Chemocentryx, Inc. | Cxcr4 modulators |
BRPI0720131A2 (pt) | 2006-12-06 | 2014-02-04 | Boehringer Ingelheim Int | Glicocorticoides miméticos, métodos para fazê-los, composições farmacêuticas e usos dos mesmos. |
TW201103904A (en) | 2009-06-11 | 2011-02-01 | Hoffmann La Roche | Janus kinase inhibitor compounds and methods |
JPWO2013125543A1 (ja) | 2012-02-20 | 2015-07-30 | 武田薬品工業株式会社 | 複素環化合物 |
WO2014146246A1 (en) * | 2013-03-19 | 2014-09-25 | Merck Sharp & Dohme Corp. | Cycloalkyl nitrile pyrazolo pyridones as janus kinase inhibitors |
-
2013
- 2013-05-31 EA EA201492250A patent/EA201492250A1/ru unknown
- 2013-05-31 US US14/404,126 patent/US9371320B2/en not_active Expired - Fee Related
- 2013-05-31 CA CA2874987A patent/CA2874987A1/en not_active Abandoned
- 2013-05-31 EP EP13797604.9A patent/EP2857400A4/en not_active Withdrawn
- 2013-05-31 BR BR112014029705A patent/BR112014029705A2/pt not_active IP Right Cessation
- 2013-05-31 CN CN201380040684.1A patent/CN104507940B/zh not_active Expired - Fee Related
- 2013-05-31 WO PCT/JP2013/065183 patent/WO2013180265A1/ja active Application Filing
- 2013-05-31 JP JP2014518750A patent/JPWO2013180265A1/ja not_active Withdrawn
-
2016
- 2016-05-06 US US15/148,276 patent/US20160251352A1/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1636005A (zh) * | 1999-06-03 | 2005-07-06 | 克诺尔股份有限公司 | 苯并噻嗪酮和苯并噁嗪酮化合物 |
CN1656079A (zh) * | 2002-05-31 | 2005-08-17 | 卫材株式会社 | 吡唑化合物和含有该化合物的药物组合物 |
WO2004050658A1 (de) * | 2002-12-03 | 2004-06-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte imidazo-pyridinone und imidazo-pyridazinone, ihre herstellung und ihre verwendung als arzneimittel |
WO2006003440A1 (en) * | 2004-07-05 | 2006-01-12 | Astex Therapeutics Limited | 3,4-disubstituted pyrazoles as cyclin dependent kinases (cdk) or aurora kinase or glycogen synthase 3 (gsk-3) inhibitors |
WO2008047831A1 (fr) * | 2006-10-17 | 2008-04-24 | Kyowa Hakko Kirin Co., Ltd. | Inhibiteurs de JAK |
WO2012030924A1 (en) * | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Azolopyridine and azolopyrimidine compounds and methods of use thereof |
Also Published As
Publication number | Publication date |
---|---|
EP2857400A4 (en) | 2015-12-09 |
US20150141406A1 (en) | 2015-05-21 |
JPWO2013180265A1 (ja) | 2016-01-21 |
CN104507940A (zh) | 2015-04-08 |
EA201492250A1 (ru) | 2015-08-31 |
BR112014029705A2 (pt) | 2017-06-27 |
US20160251352A1 (en) | 2016-09-01 |
WO2013180265A1 (ja) | 2013-12-05 |
EP2857400A1 (en) | 2015-04-08 |
US9371320B2 (en) | 2016-06-21 |
CA2874987A1 (en) | 2013-12-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170125 Termination date: 20170531 |
|
CF01 | Termination of patent right due to non-payment of annual fee |