CN104491717A - 一种治疗乳腺增生的药物 - Google Patents

一种治疗乳腺增生的药物 Download PDF

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CN104491717A
CN104491717A CN201410770699.XA CN201410770699A CN104491717A CN 104491717 A CN104491717 A CN 104491717A CN 201410770699 A CN201410770699 A CN 201410770699A CN 104491717 A CN104491717 A CN 104491717A
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李洋
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Sun Jinxia
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Abstract

本发明提供了一种治疗乳腺增生的药物，它由如下重量份数的原料制备得到：绒毛鸭脚木、三点金草、党参、山药等，本发明能治疗乳腺增生。

Description

一种治疗乳腺增生的药物
技术领域
本发明涉及药物技术领域，具体涉及一种治疗乳腺增生的中药组合物及制备方法和应用。
背景技术
乳腺增生是由情志内伤，冲任失调，痰瘀凝结而成。乳房肿块和疼痛与月经周期相关。目前缺少有效的治疗药物。
发明内容
发明目的：为了解决上述问题，本发明的目的在于提供一种治疗乳腺增生的中药组合物及制备方法和应用。
技术方案：本发明的目的是通过如下的方案实现的：
一种治疗乳腺增生的药物，它由如下重量份数的原料药制备得到：绒毛鸭脚木15份、三点金草12份、党参20份、山药15份、郁金15份、川楝子10份、路路通10份、狗脊10份、当归15份、茯苓15份、浙贝母15份、香附6份、昆布20份、淫羊藿15份、柴胡12份、白术15份、王不留行15份、瓜蒌10份、甘草6份、夏枯草10份。
所述治疗乳腺增生的药物在制备治疗乳腺增生的药物中的应用。
本发明中绒毛鸭脚木为五加科植物穗序鹅掌柴Agalma delavayi(Franch.)Hutch.，以根入药。三点金草，学名：Desmodium triflorum(L.)DC.)，豆科，蝶形花亚科，山蚂蝗族，以全草入药。其余药物均符合药典标准或记载在中药大辞典中。
有益效果：本发明绒毛鸭脚木、三点金草祛风活络，补肝肾、行气止痛，温经散寒，解毒为君药，党参、山药、郁金、川楝子、路路通、狗脊、当归、茯苓、浙贝母、香附、昆布、淫羊藿补气，活血为臣药，柴胡、白术、王不留行、瓜蒌、甘草、夏枯草行气止痛，为佐使药，制得的药物能够安全有效治疗乳腺增生。
具体实施方式
以下通过实施例形式，对本发明的上述内容再作进一步的详细说明，但不应将此理解为本发明上述主题的范围仅限于以下的实例，凡基于本发明上述内容所实现的技术均属于本发明的范围。
1.制备实施例
1.1称取绒毛鸭脚木15g、三点金草12g、党参20g、山药15g、郁金15g、川楝子10g、路路通10g、狗脊10g、当归15g、茯苓15g、浙贝母15g、香附6g、昆布20g、淫羊藿15g、柴胡12g、白术15g、王不留行15g、瓜蒌10g、甘草6g、夏枯草10g，加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。用于治疗乳腺增生。口服，每日分早晚两次服用。
1.2称取绒毛鸭脚木15g、三点金草12g、党参20g、山药15g、郁金15g、川楝子10g、路路通10g、狗脊10g、当归15g、茯苓15g、浙贝母15g、香附6g、昆布20g、淫羊藿15g、柴胡12g、白术15g、王不留行15g、瓜蒌10g、甘草6g、夏枯草10g，加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，加淀粉，按常规工艺制粒，即得符合正常成人1天用量的颗粒剂。用于治疗乳腺增生。口服，每日分早晚两次服用。
1.3称取绒毛鸭脚木15g、三点金草12g、党参20g、山药15g、郁金15g、川楝子10g、路路通10g、狗脊10g、当归15g、茯苓15g、浙贝母15g、香附6g、昆布20g、淫羊藿15g、柴胡12g、白术15g、王不留行15g、瓜蒌10g、甘草6g、夏枯草10g，加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，加淀粉，按常规工艺制粒，压片，即可制得符合正常成人1天用量的片剂。用于治疗乳腺增生。口服，每日分早晚两次服用。
2.本发明对乳腺增生的临床研究
2.1一般资料：发明人2011年3月-2012年11月间共收集60例乳腺增生的门诊患者，年龄20-40岁，女性，随机分为：治疗组30例，空白组30例。两组年龄、病情等资料无显著性差异，具有可比性，孕妇忌服。
2.2诊断标准：
2.2.1多数在乳房外上限有一扁平肿块，扪之有豆粒大小韧硬结节，可有触痛。肿块边界欠清，与周围组织不粘连。
2.2.2乳房可有胀痛，每随喜怒而消长，常在月经前加重，月经后缓解。
2.2.3本病多见于20～40岁妇女。
2.2.4钼钯X线乳房摄片、冷光源强光照射、液晶热图像等检查有助诊断。必要时作组织病理学检查。
2.2.5证候分类
2.2.5.1肝郁痰凝：多见于青壮年妇女。乳房肿块随喜怒消长，伴有胸闷胁胀，善郁易怒，失眠多梦，心烦口苦。舌苔薄黄，脉弦滑。
2.2.5.2冲任失调：多见于中年妇女。乳房肿块月经前加重，经后缓减。伴有腰酸乏力，神疲倦怠，月经先后失调，量少色淡，或经闭。舌淡，苔白，脉沉细。
2.3试验方法
2.3.1治疗组口服本发明按照具体实施例1.1制得的胶囊，早晚各一次。疗程15天。
2.3.2空白组口服安慰剂胶囊，早晚各一次。疗程15天。
2.4疗效标准与治疗结果
2.4.1疗效标准
痊愈：乳房肿块及疼痛消失。好转：乳房肿块缩小，疼痛减轻或消失。无效：乳房肿块及疼痛无变化。
2.4.2治疗统计结果见表1。
表1两组疗效比较
组别 n 痊愈 好转 无效 总有效率(％)
治疗组 30 12 13 5 83.3
空白组 30 2 2 26 13.3
可见，本发明制得的药物能够安全有效治疗乳腺增生。
2.5典型病例
王某，女，35岁，乳房外上限有一扁平肿块，扪之有豆粒大小韧硬结节，可有触痛，常在月经前加重，月经后缓解。伴有胸闷胁胀，善郁易怒，失眠多梦，心烦口苦。舌苔薄黄，脉弦滑。诊断为肝郁痰凝，口服本发明按照具体实施例1.1制得的胶囊，早晚各一次，15天后乳房肿块及疼痛消失。

Claims (2)

1.一种治疗乳腺增生的药物，其特征在于，它由如下重量份数的原料药制备得到：绒毛鸭脚木15份、三点金草12份、党参20份、山药15份、郁金15份、川楝子10份、路路通10份、狗脊10份、当归15份、茯苓15份、浙贝母15份、香附6份、昆布20份、淫羊藿15份、柴胡12份、白术15份、王不留行15份、瓜蒌10份、甘草6份、夏枯草10份。
2.如权利要求1所述治疗乳腺增生的药物在治疗乳腺增生的药物中的应用。
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