CN104447244A - 罗氟司特中间体及罗氟司特的制备方法 - Google Patents
罗氟司特中间体及罗氟司特的制备方法 Download PDFInfo
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- CN104447244A CN104447244A CN201410592820.4A CN201410592820A CN104447244A CN 104447244 A CN104447244 A CN 104447244A CN 201410592820 A CN201410592820 A CN 201410592820A CN 104447244 A CN104447244 A CN 104447244A
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- Prior art keywords
- roflumilast
- level intermediate
- preparation
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- reaction
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/80—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201410592820.4A CN104447244B (zh) | 2014-10-29 | 2014-10-29 | 罗氟司特中间体及罗氟司特的制备方法 |
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CN201410592820.4A CN104447244B (zh) | 2014-10-29 | 2014-10-29 | 罗氟司特中间体及罗氟司特的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN104447244A true CN104447244A (zh) | 2015-03-25 |
CN104447244B CN104447244B (zh) | 2017-06-06 |
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CN201410592820.4A Active CN104447244B (zh) | 2014-10-29 | 2014-10-29 | 罗氟司特中间体及罗氟司特的制备方法 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104892500A (zh) * | 2015-05-18 | 2015-09-09 | 武汉利宝瑞医药科技有限公司 | 罗氟司特的合成工艺 |
CN106518834A (zh) * | 2016-11-03 | 2017-03-22 | 上海微巨实业有限公司 | 一种胡椒酸的合成工艺 |
CN117558983A (zh) * | 2023-12-07 | 2024-02-13 | 广东聚圣科技有限公司 | 一种低温电解液、制备方法及锂电池 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005026095A1 (en) * | 2003-09-12 | 2005-03-24 | Ranbaxy Laboratories Limited | Process for the preparation of roflumilast |
CN101490004A (zh) * | 2006-07-14 | 2009-07-22 | 奇斯药制品公司 | 作为磷酸二酯酶抑制剂的1-苯基-2-吡啶基烯基醇的衍生物 |
CN102532011A (zh) * | 2012-01-05 | 2012-07-04 | 四川百利药业有限责任公司 | 一种罗氟司特原料及中间体的制备方法 |
CN102603623A (zh) * | 2011-12-26 | 2012-07-25 | 北京赛林泰医药技术有限公司 | 制备高纯度罗氟司特的方法 |
WO2012147098A2 (en) * | 2011-04-28 | 2012-11-01 | Glenmark Generics Limited | Novel process for the preparation of 3-(cyclopropylmethoxy)-n-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy) benzamide |
CN103012256A (zh) * | 2012-12-11 | 2013-04-03 | 四川科伦药物研究有限公司 | 罗氟司特的合成方法 |
-
2014
- 2014-10-29 CN CN201410592820.4A patent/CN104447244B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005026095A1 (en) * | 2003-09-12 | 2005-03-24 | Ranbaxy Laboratories Limited | Process for the preparation of roflumilast |
CN101490004A (zh) * | 2006-07-14 | 2009-07-22 | 奇斯药制品公司 | 作为磷酸二酯酶抑制剂的1-苯基-2-吡啶基烯基醇的衍生物 |
WO2012147098A2 (en) * | 2011-04-28 | 2012-11-01 | Glenmark Generics Limited | Novel process for the preparation of 3-(cyclopropylmethoxy)-n-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy) benzamide |
CN102603623A (zh) * | 2011-12-26 | 2012-07-25 | 北京赛林泰医药技术有限公司 | 制备高纯度罗氟司特的方法 |
CN102532011A (zh) * | 2012-01-05 | 2012-07-04 | 四川百利药业有限责任公司 | 一种罗氟司特原料及中间体的制备方法 |
CN103012256A (zh) * | 2012-12-11 | 2013-04-03 | 四川科伦药物研究有限公司 | 罗氟司特的合成方法 |
Non-Patent Citations (2)
Title |
---|
林艳等: "罗氟司特的合成方法研究进展", 《化学通报》 * |
钟永刚等: "罗氟司特的合成", 《中国医药工业杂志》, vol. 42, no. 12, 31 December 2011 (2011-12-31) * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104892500A (zh) * | 2015-05-18 | 2015-09-09 | 武汉利宝瑞医药科技有限公司 | 罗氟司特的合成工艺 |
CN106518834A (zh) * | 2016-11-03 | 2017-03-22 | 上海微巨实业有限公司 | 一种胡椒酸的合成工艺 |
CN117558983A (zh) * | 2023-12-07 | 2024-02-13 | 广东聚圣科技有限公司 | 一种低温电解液、制备方法及锂电池 |
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CN104447244B (zh) | 2017-06-06 |
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Effective date of registration: 20191119 Address after: 620000 No. 6, Xiang Zhang Road, new economic development zone, Meishan, Sichuan Patentee after: Sichuan Senke Pharmaceutical Co. Ltd. Address before: 610500, No. 145 East Street, new town, Xindu District, Sichuan, Chengdu Patentee before: CHENGDU SENKE PHARMACEUTICAL CO., LTD. |
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Effective date of registration: 20210107 Address after: Room 406, no.3020 Huling Road, Linghu Town, Nanxun District, Huzhou City, Zhejiang Province Patentee after: Huzhou lingchuang Technology Co., Ltd Address before: 6 Xiangzhang Road, new economic development zone, Meishan, Sichuan 620000 Patentee before: SICHUAN SENKE PHARMACEUTICAL Co.,Ltd. |
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Effective date of registration: 20210112 Address after: Room 201, No.5, Lane 3399, Kangxin Road, Pudong New Area, Shanghai Patentee after: SHANGHAI LINKCHEM TECHNOLOGY Co.,Ltd. Address before: Room 406, no.3020 Huling Road, Linghu Town, Nanxun District, Huzhou City, Zhejiang Province Patentee before: Huzhou lingchuang Technology Co., Ltd |