CN104436043A - 一种治疗疮疡阳证的止痛消炎药膏及其制备方法 - Google Patents

一种治疗疮疡阳证的止痛消炎药膏及其制备方法 Download PDF

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CN104436043A
CN104436043A CN201410687795.8A CN201410687795A CN104436043A CN 104436043 A CN104436043 A CN 104436043A CN 201410687795 A CN201410687795 A CN 201410687795A CN 104436043 A CN104436043 A CN 104436043A
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姜晓明
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Abstract

本发明属于中医中药技术领域,特别涉及一种治疗疮疡阳证的止痛消炎药膏及其制备方法。由以下重量份数的中药原料配制而成:白芷10~20份、紫草5~10份、远志5~10份、黄连10~20份、黄柏10~20份、黄芩10~20份、松花粉15~25份、姜黄10~20份、血竭2~6份、当归5~10份、艾叶5~10份、赤芍5~10份、大黄10~20份、羌活3~6份、炙川乌2~6份、白蔹10~15份、败酱草3~6份、天南星3~6份、紫花地丁3~6份、苍术3~6份、厚朴3~6份、陈皮3~6份、锦灯笼5~10份、甘草5~10份、香油80~100份、煅炉甘石10~20份、蜂蜡200~300份。通过中药的清热解毒、散瘀止痛之效,快速消炎,促进疮疡面愈合,止痛效果明显。

Description

一种治疗疮疡阳证的止痛消炎药膏及其制备方法
技术领域
本发明属于中医中药技术领域,特别涉及一种治疗疮疡阳证的止痛消炎药膏及其制备方法。
背景技术
疮疡是指各种致病因素侵袭人体后引起的一切体表化脓感染性疾病的总称,如丹毒、热疖、蜂窝组织炎、急性乳腺炎、脓性指甲炎、结节性血管炎、浅静脉炎、褥疮及糖尿病足部溃疡、足癣感染等疾病。中国古代用以泛指外科疾病红肿热痛之疮疡阳证,后世将外科分为疮疡与杂证两大类。疮疡多由毒邪内侵,邪热灼血,以致气血凝滞而成。其包括了体表上的肿疡及溃疡、痈、疽、疔疮、疖肿、流注、流痰、瘰疬及有关皮肤病的内容,是中医外科疾病中最常见的一大类病证,症见红肿热痛或者有渗液,伴口干、口苦或身热,苔黄质红,脉弦滑数者。该证具有发病迅速,部分病情较重等特点,在面部可引起疔疮走黄(西医称为败血症或脓毒败血症),在手、足易引起伤筋损骨的严重后果。
目前临床在治疗疮疡时,西医通常是采用凡士林和雷夫诺尔纱条进行引流,同时合用大量的抗生素类药物进行杀菌消毒。该方法存在的问题是治疗效果不理想、伤口愈合慢、毒副作用大,且长期大量使用易产生抗药性。而现有治疗疮疡的中药制剂多数是以清热解毒为主,对疮疡缠绵反复、伤口久难愈合的病症效果不甚理想,尤其是对于由糖尿病引发的皮肤破溃,其疗效更为堪忧。中国专利(CN103083503A)公开了一种疮疡膏及其制备方法,具有活血排脓,生肌止痛之功效,但其消炎止痛效果不明显,痊愈率较低,成本较高,存在一定的局限性。
发明内容
本发明的目的是提供一种治疗疮疡阳证的止痛消炎药膏及其制备方法,通过中药的清热解毒、散瘀止痛、除湿消肿之效,快速消炎,促进疮疡面的愈合,止痛效果明显,能够显著减少病人的疼痛感,愈后不留疤痕,具有良好的疗效。
本发明提供一种治疗疮疡阳证的止痛消炎药膏,由以下重量份数的中药原料配制而成:白芷10~20份、紫草5~10份、远志5~10份、黄连10~20份、黄柏10~20份、黄芩10~20份、松花粉15~25份、姜黄10~20份、血竭2~6份、当归5~10份、艾叶5~10份、赤芍5~10份、大黄10~20份、羌活3~6份、炙川乌2~6份、白蔹10~15份、败酱草3~6份、天南星3~6份、紫花地丁3~6份、苍术3~6份、厚朴3~6份、陈皮3~6份、锦灯笼5~10份、甘草5~10份、香油80~100份、煅炉甘石10~20份、蜂蜡200~300份。
进一步优选为由以下重量份数的中药原料配制而成:白芷15份、紫草8份、远志6份、黄连15份、黄柏15份、黄芩15份、松花粉20份、姜黄15份、血竭3份、当归6份、艾叶7份、赤芍6份、大黄15份、羌活4份、炙川乌3份、白蔹12份、败酱草5份、天南星4份、紫花地丁4份、苍术4份、厚朴4份、陈皮4份、锦灯笼8份、甘草6份、香油90份、煅炉甘石15份、蜂蜡260份。
或进一步优选为由以下重量份数的中药原料配制而成:白芷16份、紫草8份、远志6份、黄连16份、黄柏13份、黄芩17份、松花粉20份、姜黄14份、血竭5份、当归6份、艾叶7份、赤芍6份、大黄15份、羌活5份、炙川乌4份、白蔹13份、败酱草4份、天南星4份、紫花地丁5份、苍术4份、厚朴5份、陈皮4份、锦灯笼7份、甘草7份、香油92份、煅炉甘石16份、蜂蜡230份。
制备方法按以下步骤进行:
(1)按上述比例称取白芷、紫草、黄连、黄柏、黄芩、松花粉、姜黄、血竭、当归、赤芍、大黄、羌活、炙川乌、败酱草、天南星、紫花地丁、苍术、厚朴、陈皮、锦灯笼、甘草、煅炉甘石,混合均匀,粉碎后过100~120目筛,干燥灭菌后备用;
(2)按比例称取远志,洗净后,加水没过药材3~4cm,文火熬煮15~20min后,药渣滤去,药液冷却备用;
(3)按比例称取白蔹,加入沸水中搅拌成团,后将药材取出,加入药材重量3~4倍的75%~95%酒精,调成糊状备用;
(4)按比例称取艾叶,研细后置于圆底烧瓶中,加入药材重量5~10倍的蒸馏水,冷浸2 h后按水蒸汽蒸馏法加热提取;经过4小时的回流后,分离出来艾叶挥发油,加入干燥剂无水硫酸钠少许,得到挥发油产品备用;
(5)将香油、蜂蜡倒入锅内,加热,炼制滴水成珠时离火降温至50~60℃;
(6)将步骤(1)、(2)、(3)的药物下到药液中,边下边搅拌,经搅拌均匀后再降温至常温时,加入步骤(4)的艾叶挥发油,搅拌均匀,分装灭菌密封。
药理分析:
白芷:解表散寒,祛风止痛,通鼻窍,燥湿止带,消肿排脓,治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤燥痒,疥癣。祛风除湿,通窍止痛,消肿排脓。
紫草:味甘、咸,性寒,归心、肝经。功能凉血活血、解毒透疹。主治血热毒盛,斑疹紫黑,麻疹不透,疮疡,湿疹,水火烫伤,尿血,血淋,血痢,疮疡,丹毒,烧伤,热结便秘,恶虫咬伤等。现代药理研究显示紫草有镇痛、镇静、解热、护肝、抗炎、抗菌、抗病毒等作用,并有一定的抗癌作用。
远志:苦、辛、温。归心、肾、肺经。具有安神益智、祛痰、消肿的功能,用于心肾不交引起的失眠多梦、健忘惊悸,神志恍惚,咳痰不爽,疮疡肿毒,乳房肿痛。
黄连:味苦,寒。功效清热燥湿,泻火解毒。用于湿热痞满,呕吐吞酸,泻痢,黄疸,高热神昏,心火亢盛,心烦不寐,血热吐衄,目赤,牙痛,消渴,痈肿疔疮;外治湿疹,湿疮,耳道流脓。现代药理证明,黄连具有抗菌作用、抗真菌作用、抗病毒作用、抗阿米巴作用和抗炎、抗腹泻等作用。
黄柏:味苦,性寒;归肾、膀胱、大肠经。功能清热,燥湿,泻火,解毒;主治热痢,泄泻,消渴,黄疸,痿躄,梦遗,淋浊,痔疮,便血,赤白带下,骨蒸劳热,目赤肿痛,口舌生疮,疮疡肿毒。
黄芩:味苦、性寒,入心、肺、胆、大肠经;有清热燥湿、泻火解毒、止血、安胎等功效;主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、高血压、痈肿疖疮等症。现代药理证明,黄芩具有抗菌作用、抗真菌作用、抗病毒作用和抗炎抗变态反应等作用,而且不产生抗药性。
松花粉:性温,味甘。具有益气养血、平肝祛风、收湿、止血的功效;主治头旋眩晕,中虚胃疼,久痢,诸疮湿烂,创伤出血。
姜黄:辛苦,温;入脾、肝经。功能破血,行气,通经,止痛;主治心腹痞满胀痛,臂痛,症瘕,妇女血瘀经闭,产后瘀停腹痛,跌扑损伤,痈肿。
血竭:甘咸,平;入心、肝、脾经。功效内服活血散瘀,定痛,外用止血生肌,敛疮;主治淤血经闭、痛经,产后瘀阻;症瘕痞块,胸腹刺痛;跌打损伤,淤血肿痛;外伤出血,溃疡不敛。
当归:甘、辛、温;具有抗缺氧作用;调节机体免疫功能、具有抗癌作用;护肤美容作用;补血活血作用;抑菌、抗动脉硬化作用。
艾叶:味辛、苦,性温,无毒;归脾、肝、肾经。芳香温散,可升可降。具有温经止血,散寒止痛,降湿杀虫的功效;主治月经不调,痛经,宫寒不孕,胎动不安,心腹冷痛,吐血,衄血,咯血,便血,崩漏,妊娠下血,泄泻久痢,带下,湿疹,疥癣,痈肿,痔疮。
    赤芍:苦,微寒;归肝经。功能行瘀、止痛、凉血、消肿;主治瘀滞经闭、疝瘕积聚、腹痛、胁痛、衄血、血痢、肠风下血、目赤、痈肿、跌扑损伤。
大黄:味苦,寒;归脾、胃、大肠、肝、心包经。功效攻积滞,清湿热,泻火,凉血,祛瘀,解毒;主治实热便秘,热结胸痞,湿热泻痢,黄疸,淋病,水肿腹满,小便不利,目赤,咽喉肿痛,口舌生疮,胃热呕吐,吐血,咯血,衄血,便血,尿血,蓄血,经闭,产后瘀滞腹痛,症瘕积聚,跌打损伤,热毒痈疡,丹毒,烫伤。
羌活:味辛,苦,性温,祛寒湿;入膀胱、肾经。功效散表寒,祛风湿,利关节,止痛;主治外感风寒,头痛无汗,风水浮肿,疮疡肿毒,阳痿遗精,遗尿尿频,腰膝冷痛,肾虚作喘,五更泄泻;外用治白癜风,斑秃。解表散寒,祛风胜湿,止痛,亦用于外感风寒、头痛无汗、寒湿痹、上肢风湿疼痛。
炙川乌:辛、苦,热,有大毒;归心、肝、肾、脾经。功能祛风除湿,温经止痛。用于风寒湿痹、关节疼痛、心腹冷痛、寒疝作痛;用于治疗风寒湿痹、关节疼痛等病症。
白蔹:功能清热解毒;散结止痛;生肌敛疮;主治疮疡肿毒,瘰疬,烫伤,湿疮,温疟,惊痫,血痢,肠风,痔漏,白带,跌打损伤,外伤出血。现代药理学证明,白蔹具有辅助镇痛作用,可显著增强黑附片和炙川乌的镇痛作用。
败酱草:性凉,味辛、苦。有清热解毒,祛痰排脓之功效,常用于肠痈,肺痈,痢疾,产后瘀血腹痛,痈肿疔疮。
天南星:有祛风止痉、化痰散结之效;主治中风痰壅、口眼歪斜、半身不遂、手足麻痹、风痰眩晕、癫痫、惊风、破伤风、咳嗽多痰、痈肿、瘰疬、跌打麻痹、毒蛇咬伤。
紫花地丁:味苦、辛、寒。归心、肺经。具有清热解毒,凉血消肿,清热利湿的作用,主治疔疮,痈肿,瘰疬,黄疸,痢疾,腹泻,目赤,喉痹,毒蛇咬伤。
苍术:辛、苦,温;归脾、胃、肝经。主治脾为湿困引起的运化失调,食欲不振,呕吐烦闷,腹胀泄泻,关节疼痛。
厚朴:味苦,辛;归脾经、胃经、大肠经;功能行气消积,燥湿除满,降逆平喘;主治食积气滞,腹胀便秘,湿阻中焦,脘痞吐泻,痰壅气逆,胸满喘咳。现代药理证明,厚朴具有抗病原微生物作用。
陈皮:性味苦、辛,温;归肺、脾经;功能理气健脾,调中,燥湿,化痰。 主治脾胃气滞之脘腹胀满或疼痛、消化不良。湿浊阻中之胸闷腹胀、纳呆便溏。痰湿壅肺之咳嗽气喘。
锦灯笼:性寒,味苦;入肺、脾二经。功能清热解毒,利咽,化痰,利尿,疏肝;主治肝气不舒,肾炎,肝炎;坏血病,痰热咳嗽。
甘草:补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。用于此处是取其缓解药物毒性、烈性作用,同时,寓清于补,以平衡配方。
香油:又称麻油,即可食用,又作药用,是润滑剂和赋形剂。适用于皮肤受伤、枯糙,身体虚弱,头发早白,贫血萎黄,津液不足,大便燥结,头晕耳鸣等。内服可润泽皮肤毛发、补血、润肠、润肺生津、通乳,外用做软膏及硬膏基质,即赋形剂,既能使其他药物与患部充分接触发挥药效,本身又能促进皮肤自身修复。
煅炉甘石:无臭,味微涩。功能解毒明目退翳,收湿止痒敛疮;主治目赤肿痛,眼缘赤烂,翳膜胬肉,溃疡不敛,脓水淋漓,湿疮,皮肤瘙痒。
蜂蜡:甘,微温。功能收涩,敛疮,生肌,止痛,调理;外用做软膏及硬膏基质,即赋形剂,并主治溃疡不敛,臁疮糜烂,创伤,烧、烫伤。
本发明纯属中药制剂,经多年的研究和临床实践证明:通过中药的清热解毒、散瘀止痛、除湿消肿之效,快速消炎,促进疮疡面的愈合,止痛效果明显,能够显著减少病人的疼痛感,愈后不留疤痕,具有良好的疗效。
用法:膏剂50g/盒,根据病变范围,在医生指导下取适量药物,外敷患处。每日更换一次。注意事项:1、对上述诸药过敏者禁用。2、孕产妇慎用。
疗效判定:
一、皮肤刺激性实验
  (一)实验材料
普通级家兔;8只,雄性;平均体重2.8kg/只,由中国海洋大学实验动物中心提供。
(二)实验方法
1.急性皮肤刺激实验
取家兔4只将背部脊柱两侧毛脱掉,每侧各50cm2,一侧为受试物区,一侧为阴性对照区;在受试物区和阴性对照区,将本发明实施例2的膏剂1.0g涂于受试物区,赋形剂涂于阴性对照区;24小时后用温水去除残留受试物及赋形剂;去除受试物后1小时、24小时、48小时和72小时观察涂抹部位,均无红斑和水肿等情况,与阴性对照组无差异,证明本发明对皮肤无急性刺激性。
2.多次皮肤刺激实验
取家兔4只将背部脊柱两侧毛脱掉,每侧各50cm2,一侧为受试物区,一侧为阴性对照区;在受试物区和阴性对照区,每日将本发明实施例2的膏剂1.0g涂于受试物区,赋形剂涂于阴性对照区;24小时后用温水去除残留受试物及赋形剂,更换新的药物;连续一周后观察涂抹部位,均无红斑和水肿等情况,与阴性对照组无差异,结合急性皮肤刺激实验证明本发明对皮肤无刺激性。
二、对疮疡模型大鼠治疗作用的实验研究
(一)实验材料
健康SD种大白鼠,雌雄各半,平均体重250g/只,由中国海洋大学实验动物中心提供。
(二)实验方法
1.大鼠疮疡模型制备
健康SD大鼠30只,雌雄各半,平均体重250g/只,用1.5 %戊巴比妥钠
0.2ml /100gi.p麻醉。取麻醉后大鼠于背部右侧剪毛,用刀片划一1cm×1cm的十字切口,深达皮下,注入10亿/ ml的金黄色葡萄球菌悬液1ml,并用棉签沾少许化脓性链球菌涂布伤口。
2.分组
大鼠疮伤感染2d后,均见食量减少,俯卧少动,有触痛, 伤口有脓性分泌物, 伤口周围出现红、肿、热、痛现象。将大鼠随机分组:阴性对照组(0.2g赋形剂)、阳性药物组(0.2g金诺疮疡膏)、实验组(本发明实施例1的中药药膏0.2g) , 每日用消毒NS清洗疮口并给药1次 ,连续给药9d, 观察每日疮口脓性分泌物量及疮面变化。另设一组由10只健康SD大鼠组成的空白对照组,不造模,不给药。
3.检测指标
第9d给药后1h , 大鼠眼眶后静脉丛取血,各取大白鼠血清10μl分别注入IgG、IgA、IgM及补体C3检测板中反应孔内 , 37℃孵育24h,测量沉淀圈直径, 作为免疫球蛋白 IgG、IgA、IgM 及补体C3含量高低的指标。取10μl血清, 加入溶菌酶检测板中反应孔内, 37℃孵育4h,测量溶菌圈直径,作为血清溶菌酶含量高低的指标。
取3d、6d、9d大鼠疮口脓性分泌物加0.1ml生理盐水稀释,取10μl混悬脓液加入溶菌酶检测板中反应孔内,37℃孵育4h, 测量溶菌圈直径,作为脓性分泌物中溶菌酶含量高低的指标。
大鼠称重、取血后断头处死,取胸腺及脾脏称重,并计算脏器指数。
创面愈合积分值评分标准:无脓性分泌物,积分为0分;少量脓性分泌物和血液混合物,积分为1分;脓性分泌物0.1~0.2ml,积分为2分;脓性分泌物0.3~0.4ml,积分为3分;脓性分泌物0.5ml以上,积分为4分。
统计方法:实验结果进行组间t-检验。
(三)实验结果
1.本发明止痛消炎药膏对大白鼠疮疡模型疮口愈合积分值的影响见下表:
    注:与阴性对照组比较*P<0.05,**P小于0.01;与阳性药物组比较#P小于0.05,##P<0.01。以下表格皆相同。
由上表数据可以看出,采用本发明止痛消炎药膏的实验组显效显著快于阴性对照组与阳性药物组,且愈合情况良好,证明了本发明的药物具有显效快、疗效好的优点。
2.对大鼠疮疡模型血清免疫球蛋白及补体C3的影响见下表:
组别 动物数(只) IgG IgA IgM C3
空白对照组 10 5.60±0.26 5.59±0.20** 5.24±0.79 5.98±0.08**
阴性对照组 10 6.11±0.13 5.73±0.20 5.84±0.82 5.02±0.21
阳性药物组 10 6.17±0.31 6.03±0.89** 6.15±0.06* 6.1±0.10**
实验组 10 6.22±0.47 6.04±0.06 6.18±0.24 6.23±0.54**
由上表数据可以看出,采用本发明止痛消炎药膏的实验组增加补体 C3 及 IgG、IgA、IgM含量,表面本发明药物具有增加机体自身免疫力,抗菌消炎的作用。
3.对大鼠疮疡模型脓性分泌物中溶菌酶及血清溶菌酶的影响见下表:
    由上表数据可以看出,采用本发明止痛消炎药膏的实验组增加脓性分泌物中溶菌酶及血清溶菌酶含量,表面本发明药物具有良好的抗菌消炎抗病毒的作用。
4.对胸腺指数及脾脏指数的影响见下表:
由上表数据可以看出,采用本发明止痛消炎药膏的实验组可显著增加胰腺指数和脾脏指数,表面本发明药物具有良好的提高免疫力的作用。
三、临床判定:
出血或局部红肿未溃破的或急性局部化脓性感染的,直接涂抹本实施例的疮疡膏,并用纱布包扎,每日涂抹一次;疮面溃破、有脓性分泌物的或慢性局部化脓性感染的,清创后再涂抹本实施例的疮疡膏,并用纱布包扎,每日换药一次。
(1)外伤出血,在第4天判定疗效。凡创面基本愈合,未发生感染为痊愈;创面愈合达到或超过2/3为显效;创面愈合不足2/3或发生感染为无效。
(2)局部组织红肿未溃破的,在第4天判定疗效。凡红肿消退,症状消失为治愈;红肿消退或愈合面积超过 2/3,症状基本消失为显效;红肿消不退或愈合面积未达到 2/3,为无效。
(3)原发或继发的急性局部组织化脓感染,在第4天判定疗效。凡皮损完全愈合症状消失为痊愈;凡愈合面积达到或超过2/3,症状基本消失为显效;凡愈合面积未达到2/3,为无效。
(4)原发或继发的慢性局部组织化脓感染,在第14天判定疗效。凡皮损完全愈合,症状消失为痊愈;愈合面积达到或超过2/3,症状基本消失为显效;愈合面积未达到2/3,为无效。
治疗结果:治疗267名治疗疮疡阳证患者,使用本发明药物后,疼痛感均有不同程度的减轻,且痊愈251例,占94.0%,显效15例,占5.6%,无效1例,占0.4%。
    附几例病例作进一步说明:
病例1:杨某某,男,44岁,肛门边肿痛反复近2周,加重并流出脓水3天,经西医门诊治疗手术后伤口未愈,膝胸位见3点外周2处疮疡并列,近肛门者已破溃留出淡黄色稀脓水,遂给与本发明中药使用,5天后皮损完全愈合,随访半年无复发,无疤痕。
病例2:郑某某,女,58岁,患有糖尿病,但症状较轻,能够进行简单的农务劳动,因农作时鞋内灌进异物,导致我的右足足底被磨破,两三天后伤口扩大,伴有感染,在村办诊所用碘伏治疗大约10天左右,创面无好转,且足底皮肤逐渐出现感染坏死,遂来我处就诊,给予本发明中药使用,10天后症状消失,创面基本愈合,又使用了2天后,皮损完全愈合,无疤痕残留,随访一年无复发。
具体实施方式
实施例1:
一种治疗疮疡阳证的止痛消炎药膏,由以下重量份数的中药原料配制而成:白芷15份、紫草8份、远志6份、黄连15份、黄柏15份、黄芩15份、松花粉20份、姜黄15份、血竭3份、当归6份、艾叶7份、赤芍6份、大黄15份、羌活4份、炙川乌3份、白蔹12份、败酱草5份、天南星4份、紫花地丁4份、苍术4份、厚朴4份、陈皮4份、锦灯笼8份、甘草6份、香油90份、煅炉甘石15份、蜂蜡260份。
制备方法按以下步骤进行:
(1)按上述比例称取白芷、紫草、黄连、黄柏、黄芩、松花粉、姜黄、血竭、当归、赤芍、大黄、羌活、炙川乌、败酱草、天南星、紫花地丁、苍术、厚朴、陈皮、锦灯笼、甘草、煅炉甘石,混合均匀,粉碎后过100目筛,干燥灭菌后备用;
(2)按比例称取远志,洗净后,加水没过药材3cm,文火熬煮15min后,药渣滤去,药液冷却备用;
(3)按比例称取白蔹,加入沸水中搅拌成团,后将药材取出,加入药材重量3倍的95%酒精,调成糊状备用;
(4)按比例称取艾叶,研细后置于圆底烧瓶中,加入药材重量7倍的蒸馏水,冷浸2 h后按水蒸汽蒸馏法加热提取;经过4小时的回流后,分离出来艾叶挥发油,加入干燥剂无水硫酸钠少许,得到挥发油产品备用;
(5)将香油、蜂蜡倒入锅内,加热,炼制滴水成珠时离火降温至55℃;
(6)将步骤(1)、(2)、(3)的药物下到药液中,边下边搅拌,经搅拌均匀后再降温至常温时,加入步骤(4)的艾叶挥发油,搅拌均匀,分装灭菌密封。
实施例2:
一种治疗疮疡阳证的止痛消炎药膏,由以下重量份数的中药原料配制而成:白芷16份、紫草8份、远志6份、黄连16份、黄柏13份、黄芩17份、松花粉20份、姜黄14份、血竭5份、当归6份、艾叶7份、赤芍6份、大黄15份、羌活5份、炙川乌4份、白蔹13份、败酱草4份、天南星4份、紫花地丁5份、苍术4份、厚朴5份、陈皮4份、锦灯笼7份、甘草7份、香油92份、煅炉甘石16份、蜂蜡230份。
制备方法按以下步骤进行:
(1)按上述比例称取白芷、紫草、黄连、黄柏、黄芩、松花粉、姜黄、血竭、当归、赤芍、大黄、羌活、炙川乌、败酱草、天南星、紫花地丁、苍术、厚朴、陈皮、锦灯笼、甘草、煅炉甘石,混合均匀,粉碎后过110目筛,干燥灭菌后备用;
(2)按比例称取远志,洗净后,加水没过药材3.5cm,文火熬煮18min后,药渣滤去,药液冷却备用;
(3)按比例称取白蔹,加入沸水中搅拌成团,后将药材取出,加入药材重量3.5倍的80%酒精,调成糊状备用;
(4)按比例称取艾叶,研细后置于圆底烧瓶中,加入药材重量8倍的蒸馏水,冷浸2 h后按水蒸汽蒸馏法加热提取;经过4小时的回流后,分离出来艾叶挥发油,加入干燥剂无水硫酸钠少许,得到挥发油产品备用;
(5)将香油、蜂蜡倒入锅内,加热,炼制滴水成珠时离火降温至55℃;
(6)将步骤(1)、(2)、(3)的药物下到药液中,边下边搅拌,经搅拌均匀后再降温至常温时,加入步骤(4)的艾叶挥发油,搅拌均匀,分装灭菌密封。
实施例3:
一种治疗疮疡阳证的止痛消炎药膏,由以下重量份数的中药原料配制而成:白芷10份、紫草10份、远志5份、黄连20份、黄柏10份、黄芩20份、松花粉15份、姜黄20份、血竭2份、当归10份、艾叶5份、赤芍10份、大黄10份、羌活6份、炙川乌2份、白蔹15份、败酱草3份、天南星6份、紫花地丁3份、苍术6份、厚朴3份、陈皮6份、锦灯笼5份、甘草10份、香油80份、煅炉甘石20份、蜂蜡200份。
制备方法按以下步骤进行:
(1)按上述比例称取白芷、紫草、黄连、黄柏、黄芩、松花粉、姜黄、血竭、当归、赤芍、大黄、羌活、炙川乌、败酱草、天南星、紫花地丁、苍术、厚朴、陈皮、锦灯笼、甘草、煅炉甘石,混合均匀,粉碎后过120目筛,干燥灭菌后备用;
(2)按比例称取远志,洗净后,加水没过药材4cm,文火熬煮20min后,药渣滤去,药液冷却备用;
(3)按比例称取白蔹,加入沸水中搅拌成团,后将药材取出,加入药材重量4倍的75%酒精,调成糊状备用;
(4)按比例称取艾叶,研细后置于圆底烧瓶中,加入药材重量9倍的蒸馏水,冷浸2 h后按水蒸汽蒸馏法加热提取;经过4小时的回流后,分离出来艾叶挥发油,加入干燥剂无水硫酸钠少许,得到挥发油产品备用;
(5)将香油、蜂蜡倒入锅内,加热,炼制滴水成珠时离火降温至60℃;
(6)将步骤(1)、(2)、(3)的药物下到药液中,边下边搅拌,经搅拌均匀后再降温至常温时,加入步骤(4)的艾叶挥发油,搅拌均匀,分装灭菌密封。

Claims (4)

1.一种治疗疮疡阳证的止痛消炎药膏,其特征在于由以下重量份数的中药原料配制而成:白芷10~20份、紫草5~10份、远志5~10份、黄连10~20份、黄柏10~20份、黄芩10~20份、松花粉15~25份、姜黄10~20份、血竭2~6份、当归5~10份、艾叶5~10份、赤芍5~10份、大黄10~20份、羌活3~6份、炙川乌2~6份、白蔹10~15份、败酱草3~6份、天南星3~6份、紫花地丁3~6份、苍术3~6份、厚朴3~6份、陈皮3~6份、锦灯笼5~10份、甘草5~10份、香油80~100份、煅炉甘石10~20份、蜂蜡200~300份。
2.如权利要求1所述的治疗疮疡阳证的止痛消炎药膏,其特征在于由以下重量份数的中药原料配制而成:白芷15份、紫草8份、远志6份、黄连15份、黄柏15份、黄芩15份、松花粉20份、姜黄15份、血竭3份、当归6份、艾叶7份、赤芍6份、大黄15份、羌活4份、炙川乌3份、白蔹12份、败酱草5份、天南星4份、紫花地丁4份、苍术4份、厚朴4份、陈皮4份、锦灯笼8份、甘草6份、香油90份、煅炉甘石15份、蜂蜡260份。
3.如权利要求1所述的治疗疮疡阳证的止痛消炎药膏,其特征在于由以下重量份数的中药原料配制而成:白芷16份、紫草8份、远志6份、黄连16份、黄柏13份、黄芩17份、松花粉20份、姜黄14份、血竭5份、当归6份、艾叶7份、赤芍6份、大黄15份、羌活5份、炙川乌4份、白蔹13份、败酱草4份、天南星4份、紫花地丁5份、苍术4份、厚朴5份、陈皮4份、锦灯笼7份、甘草7份、香油92份、煅炉甘石16份、蜂蜡230份。
4.一种制备如权利要求1所述的治疗疮疡阳证的止痛消炎药膏的方法,其特征在于由以下步骤组成:
(1)按上述比例称取白芷、紫草、黄连、黄柏、黄芩、松花粉、姜黄、血竭、当归、赤芍、大黄、羌活、炙川乌、败酱草、天南星、紫花地丁、苍术、厚朴、陈皮、锦灯笼、甘草、煅炉甘石,混合均匀,粉碎后过100~120目筛,干燥灭菌后备用;
(2)按比例称取远志,洗净后,加水没过药材3~4cm,文火熬煮15~20min后,药渣滤去,药液冷却备用;
(3)按比例称取白蔹,加入沸水中搅拌成团,后将药材取出,加入药材重量3~4倍的75%~95%酒精,调成糊状备用;
(4)按比例称取艾叶,研细后置于圆底烧瓶中,加入药材重量5~10倍的蒸馏水,冷浸2 h后按水蒸汽蒸馏法加热提取;经过4小时的回流后,分离出来艾叶挥发油,加入干燥剂无水硫酸钠少许,得到挥发油产品备用;
(5)将香油、蜂蜡倒入锅内,加热,炼制滴水成珠时离火降温至50~60℃;
 (6)将步骤(1)、(2)、(3)的药物下到药液中,边下边搅拌,经搅拌均匀后再降温至常温时,加入步骤(4)的艾叶挥发油,搅拌均匀,分装灭菌密封。
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105770254A (zh) * 2016-04-28 2016-07-20 邱定武 一种治疗臀痈的绑带及其制备与使用方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100079858A (ko) * 2008-12-31 2010-07-08 지에스씨 영농조합법인 천연광물과 한약재를 주원료로 한 피부질환 치료용 외용제
CN103599491A (zh) * 2013-11-29 2014-02-26 苏国仁 一种治疗疮疡阳证的药物及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100079858A (ko) * 2008-12-31 2010-07-08 지에스씨 영농조합법인 천연광물과 한약재를 주원료로 한 피부질환 치료용 외용제
CN103599491A (zh) * 2013-11-29 2014-02-26 苏国仁 一种治疗疮疡阳证的药物及其制备方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
刘小平等: "《常见中药速查手册》", 31 August 2014 *
四川省卫生厅科教处: "《乡村医生考试题解》", 28 February 1989 *
王竹鑫等: "《袖珍中药安全速查手册》", 31 March 2008 *
谢宇: "《中医经典普及丛书 本草纲目全彩全真图本》", 30 September 2014 *
陈雪清等: "金黄膏治疗疮疡阳证183例临床观察", 《时珍国医国药》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105770254A (zh) * 2016-04-28 2016-07-20 邱定武 一种治疗臀痈的绑带及其制备与使用方法

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