CN105560662A - 一种治疗膝关节骨性关节炎的外用中药组合物 - Google Patents

一种治疗膝关节骨性关节炎的外用中药组合物 Download PDF

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CN105560662A
CN105560662A CN201510988959.5A CN201510988959A CN105560662A CN 105560662 A CN105560662 A CN 105560662A CN 201510988959 A CN201510988959 A CN 201510988959A CN 105560662 A CN105560662 A CN 105560662A
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chinese medicine
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邢健昆
刘晓云
杨少辉
王芳
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Abstract

本发明涉及一种治疗膝关节骨性关节炎的外用中药组合物，它是由下列重量配比的中药原料组成的：海桐皮10-30g、苏木10-30g、川芎9-20g、制川乌6-12g、制草乌6-12g、肉桂9-15g、大黄6-15g、牛膝6-12g、独活6-12g、伸筋草10-30g、麻黄6-12g、细辛6-12g、川楝子9-15g、路路通12-20g、乳香6-9g、没药6-9g、千年健10-20g、当归6-12g、赤芍6-12g、桃仁6-12g、白芷9-15g、红花6-12g、威灵仙6-12g、花椒6-12g。本发明的中药组合物采用天然的中药原料，具有舒筋通络、祛风除湿、温经止痛、消肿散寒、活血祛瘀的功效，其配制简便、药源广、成本低，可操作性强，熏洗治疗效果好，对人体无任何毒副作用，有效率达98.53％，治愈率达52.94％。

Description

一种治疗膝关节骨性关节炎的外用中药组合物
技术领域
本发明涉及一种传统草药的未确定结构的医用配制品，具体地说是一种治疗膝关节骨性关节炎的外用中药组合物。
背景技术
膝关节骨性关节炎是指由于膝关节软骨变性、骨质增生而引起的一种慢性骨关节疾患，又称为膝关节增生性关节炎、退行性关节炎及骨性关节病等。本病多发生于中老年人，也可发生于青年人，可单侧发病，也可双侧发病。一般长期姿势不良，负重用力，体重过重，慢性劳损都是造成膝关节骨性关节炎的病因，导致的痛苦和残疾严重地损害患者的生存质量。膝关节骨性关节炎治疗的目的是缓解关节疼痛、改善功能并重建受损的软骨及骨结构。目前从西医来说，尚缺乏能够达到目的的可靠药物，即使仅以缓解症状、改善功能为目的，也缺少疗效更好、不良反应更少的非手术方法。同样地，手术治疗(如关节融合术、关节置换术)不论价格还是技术都还只能在少数患者中开展。中医综合治疗是目前较理想的治疗方法。大多数的治疗是通过缓解、消除关节及其周围组织的炎症而达到缓解疼痛、改善功能的目的。
发明内容
本发明的目的就是为了克服上述现有的技术不足，根据中医理论，通过数年的药物筛选和反复临床验证，提供一种配伍合理，药源广，成本低，疗效显著，无毒副作用的治疗膝关节骨性关节炎的外用中药组合物，具有舒筋通络、祛风除湿、温经止痛、消肿散寒、活血祛瘀的功能，治疗膝关节骨性关节炎的疗效显著。
本发明解决其技术问题所采用的技术方案是：一种治疗膝关节骨性关节炎的外用中药组合物，其特征在于它是由下列重量配比的中药原料组成的：海桐皮10-30g、苏木10-30g、川芎9-20g、制川乌6-12g、制草乌6-12g、肉桂9-15g、大黄6-15g、牛膝6-12g、独活6-12g、伸筋草10-30g、麻黄6-12g、细辛6-12g、川楝子9-15g、路路通12-20g、乳香6-9g、没药6-9g、千年健10-20g、当归6-12g、赤芍6-12g、桃仁6-12g、白芷9-15g、红花6-12g、威灵仙6-12g、花椒6-12g。
本发明的优选技术方案是：一种治疗膝关节骨性关节炎的外用中药组合物，其特征在于它是由下列重量配比的中药原料组成的：海桐皮30g、苏木30g、川芎20g、制川乌10g、制草乌10g、肉桂15g、大黄10g、牛膝12g、独活10g、伸筋草25g、麻黄10g、细辛10g、川楝子15g、路路通15g、乳香6g、没药6g、千年健15g、当归10g、赤芍10g、桃仁10g、白芷15g、红花10g、威灵仙10g、花椒12g。
本发明中药组合物是在传统中医理论和临床经验指导下，精选药物组方，其原料成本低，治疗膝关节骨性关节炎疗效高，无毒副作用。本发明中药组合物中：海桐皮【性味】苦辛，平【归经】入肝、脾经【功能主治】祛风湿，通经络，杀虫。治风湿痹痛，痢疾，牙痛，疥癣。苏木【性味】甘咸，平【归经】入心、肝经【功能主治】行血，破瘀，消肿，止痛。治妇人血气心腹痛，经闭，产后瘀血胀痛喘急，痢疾，破伤风，痈肿，扑损瘀滞作痛。川芎【性味】辛，温【归经】归肝、胆、心包经【功能主治】活血行气，祛风止痛。用于月经不调，经闭痛经，癥瘕腹痛，胸胁刺痛，跌扑肿痛，头痛，风湿痹痛。制川乌【性味】辛、苦，热；有毒【归经】归心、肝、肾、脾经【功能主治】同川乌。祛风除湿，温经止痛。用于风寒湿痹，关节疼痛，心腹冷痛，寒疝作痛，麻醉止痛。制草乌【性味】热；辛、苦；大毒【归经】归心、肝、肾、脾经；【功能主治】祛风除湿，温经止痛。用于风寒湿痹，关节疼痛，心腹冷痛，寒疝作痛，麻醉止痛。肉桂【性味】辛甘，热【归经】入肾、脾，膀胱经【功能主治】补元阳，暖脾胃，除积冷，通血脉。治命门火衰，肢冷脉微，亡阳虚脱，腹痛泄泻，寒疝奔豚，腰膝冷痛，经闭癥瘕，阴疽，流注，及虚阳浮越，上热下寒。大黄【性味】苦，寒【归经】归肝、脾、胃、大肠经【功能主治】攻积滞，清湿热，泻火凉血，祛瘀解毒。主治实热便秘，热结胸痞，湿热泻痢，黄疸，淋病，水肿腹满，小便不利，目赤，咽喉肿痛，口舌生疮，胃热呕吐，吐血，咯血，衄血，便血，尿血，蓄血，经闭，产后瘀滞腹痛，癥瘕积聚，跌打损伤，热毒痈疡，丹毒，烫伤。牛膝【性味】苦、酸，平【归经】归肝、肾经【功能主治】补肝肾，强筋骨，逐瘀通经，引血下行。用于腰膝酸痛，筋骨无力，经闭癥瘕，肝阳眩晕。独活【性味】辛、苦，微温【归经】归肾、膀胱经【功能主治】祛风除湿，通痹止痛。用于风寒湿痹，腰膝疼痛，少阴伏风头痛。伸筋草【性味】苦辛，温【归经】入肝、脾、肾三经【功能主治】祛风散寒，除湿消肿，舒筋活血。治风寒湿痹，关节酸痛，皮肤麻木，四肢软弱，水肿，跌打损伤。麻黄【性味】辛、微苦，温【归经】归肺、膀胱经【功能主治】发汗散寒，宣肺平喘，利水消肿。用于风寒感冒，胸闷喘咳，风水浮肿；支气管哮喘。蜜麻黄润肺止咳。多用于表症已解，气喘咳嗽。细辛【性味】辛，温【归经】入肺、肾经【功能主治】祛风，散寒，行水，开窍。治风冷头痛，鼻渊，齿痛，痰饮咳逆，风湿痹痛。川楝子【性味】寒；苦；小毒【归经】归肝、小肠、膀胱经【功能主治】舒肝行气止痛，驱虫。用于胸胁、脘腹胀痛，疝痛，虫积腹痛。路路通【性味】苦，平【归经】《纲目拾遗》：通行十二经【功能主治】祛风通络，利水除湿。治肢体痹痛，手足拘挛，胃痛，水肿，胀满，经闭，乳少，痈疽，痔漏，疥癣，湿疹。乳香【性味】辛苦，温【归经】入心、肝、脾经【功能主治】调气活血，定痛，追毒。治气血凝滞、心腹疼痛，痈疮肿毒，跌打损伤，痛经，产后瘀血刺痛。没药【性味】苦；平【归经】肝；脾；心；肾经【功能主治】活血止痛；消肿生肌。主治胸腹瘀痛；痛经；经闭；症瘕；跌打损伤；痈肿疮疡；肠痈；目赤肿痛。千年健【性味】苦、辛，温【归经】归肝、肾经【功能主治】祛风湿，强筋骨，止痹痛。用于风湿痹痛，筋骨无力。当归【性味】甘、辛、温【归经】归肝、心、脾经【功能主治】具有补血，活血，调经止痛，润肠通便的功效。主治血虚、血瘀诸症；眩晕头痛，心悸肢麻，月经不调，经闭，痛经，崩漏，结聚，虚寒腹痛，痿痹，赤痢后重，肠燥便难，跌打肿痛，痈疽疮疡。赤芍【性味】微寒；苦【归经】归肝经【功能主治】清热凉血；活血祛瘀。用于温毒发斑；吐血衄血；肠风下血；目赤肿痛；痈肿疮疡；闭经；痛经；崩带淋浊；瘀滞胁痛；疝瘕积聚；跌扑损伤。桃仁【性味】苦甘，平【归经】入心、肝、大肠经【功能主治】破血行瘀，润燥滑肠。治经闭，癥瘕，热病蓄血，风痹，疟疾，跌打损伤，瘀血肿痛，血燥便秘。白芷【性味】辛，温【归经】归胃、大肠、肺经【功能主治】散风除湿，通窍止痛，消肿排脓。用于感冒头痛，眉棱骨痛，鼻塞，鼻渊，牙痛，白带，疮疡肿痛。红花【性味】辛，温【归经】入心、肝【功能主治】活血通经，去瘀止痛。治经闭，癥瘕，难产，死胎，产后恶露不行、瘀血作痛，痈肿，跌扑损伤。威灵仙【性味】辛咸，温，有毒【归经】入膀胱经【功能主治】祛风湿，通经络，消痰涎，散癖积。治痛风、顽痹、腰膝冷痛，脚气，疟疾，癥瘕积聚，破伤风，扁桃体炎，诸骨鲠咽。花椒【性味】温；辛【归经】归脾、胃、肾经【功能主治】温中止痛，杀虫止痒。用于脘腹冷痛，呕吐泄泻，虫积腹痛，蛔虫症；外治湿疹瘙痒。以上诸药合用，具有舒筋通络、祛风除湿、温经止痛、消肿散寒、活血祛瘀的功效，对膝关节骨性关节炎达到标本兼治的目的。
本发明组合物采用天然的中药原料，其配制简便、药源广、成本低。制备的具体方法如下：将上述重量配比的原料，加工成粗粉末，混合均匀，分装成袋，加适量冷水浸泡30分钟，煮沸文火煎30分钟后，将药液倒入盆中，将患膝置于其上方，患膝覆盖毛巾，利用蒸气熏蒸患膝15分钟，待药液温度降至皮肤能耐受时，用毛巾浸药液热敷患膝20～30分钟，擦干勿晾，1天2次。7日为一疗程，共4个疗程。中药熏蒸使局部组织温度升高，毛细血管扩张，血液循环加速，增加局部血流及营养，消除代谢瘀积产物。从而使病变膝关节肌肉痉挛解除、炎症水肿消失、关节内压降低、病变组织恢复，且药物通过皮肤直接进入体内发挥作用，避免了药物对胃、肠道的刺激和对肝肾的损害，对人体无任何毒副作用。因此中药熏洗治疗具有治疗效果好，实施简单等优点。经临床应用验证，其疗效显著，总有效率98.53％，治愈率达52.94％。
具体实施方式
实施例1：一种治疗膝关节骨性关节炎的外用中药组合物，其特征在于它是由下列重量配比的中药原料组成的：海桐皮30g、苏木30g、川芎20g、制川乌10g、制草乌10g、肉桂15g、大黄10g、牛膝12g、独活10g、伸筋草25g、麻黄10g、细辛10g、川楝子15g、路路通15g、乳香6g、没药6g、千年健15g、当归10g、赤芍10g、桃仁10g、白芷15g、红花10g、威灵仙10g、花椒12g。
实施例2：一种治疗膝关节骨性关节炎的外用中药组合物，其特征在于它是由下列重量配比的中药原料组成的：海桐皮10g、苏木10g、川芎15g、制川乌6g、制草乌6g、肉桂15g、大黄6g、牛膝12g、独活12g、伸筋草10g、麻黄12g、细辛12g、川楝子10g、路路通20g、乳香8g、没药8g、千年健20g、当归6g、赤芍6g、桃仁12g、白芷9g、红花6g、威灵仙6g、花椒10g。
实施例3：一种治疗膝关节骨性关节炎的外用中药组合物，其特征在于它是由下列重量配比的中药原料组成的：海桐皮20g、苏木20g、川芎10g、制川乌12g、制草乌8g、肉桂9g、大黄15g、牛膝6g、独活6g、伸筋草20g、麻黄6g、细辛6g、川楝子9g、路路通12g、乳香9g、没药9g、千年健10g、当归12g、赤芍12g、桃仁6g、白芷12g、红花12g、威灵仙8g、花椒6g。
实施例4：一种治疗膝关节骨性关节炎的外用中药组合物，其特征在于它是由下列重量配比的中药原料组成的：海桐皮25g、苏木15g、川芎9g、制川乌8g、制草乌12g、肉桂12g、大黄12g、牛膝10g、独活10g、伸筋草30g、麻黄10g、细辛10g、川楝子12g、路路通20g、乳香6g、没药8g、千年健15g、当归10g、赤芍10g、桃仁12g、白芷10g、红花10g、威灵仙12g、花椒8g。
一种治疗膝关节骨性关节炎的外用中药组合物的临床疗效总结：
一、一般性资料：本中药组合物应用于临床观察病136例，其中男66例，女70例，年龄40～83岁。病程最短者3个月，最长者达10多年。
二、诊断标准：
1、反复劳损或创伤史。
2、膝关节疼痛和发僵，早晨起床时较明显，活动后减轻，活动多时又加重，休息后症状缓解。
3、后期疼痛持续，关节活动明显受限，股四头肌萎缩，关节积液，甚至出现畸形和关节内游离体。
4、膝关节屈伸活动时可扪及摩擦音。
5、膝关节正、侧位X照片，显示髌骨、股骨髁、胫骨平台关节缘呈唇样骨质增生，胫骨髁间隆突变尖，关节间隙变窄，软骨下骨质致密，有时可见关节内游离体。
三、用法用量：将上述重量配比的原料，加工成粗粉末，混合均匀，分装成袋，加适量冷水浸泡30分钟，煮沸文火煎30分钟后，将药液倒入盆中，将患膝置于其上方，患膝覆盖毛巾，利用蒸气熏蒸患膝15分钟，待药液温度降至皮肤能耐受时，用毛巾浸药液热敷患膝20～30分钟，擦干勿晾。一天一剂，一天熏蒸2次，治疗期间注意休息和保暖。7日为一疗程，共4个疗程。
四、疗效标准：
痊愈：患肢疼痛完全消失，关节活动自如。
显效：患肢疼痛基本消失，劳累后出现轻微疼痛或不适，关节活动自如。
有效：患肢疼痛减轻，劳累后疼痛加重，关节功能无改变。
无效：患肢症状体征无改善。
五、治疗效果：临床观察病例136例中，连续治疗4个疗程后，痊愈72例，显效35例、有效27例，无效2例。治疗期间未发生毒副作用。治疗结果表明用本发明的中药组合物熏洗治疗膝关节骨性关节炎有显著疗效，其中2例无效患者皆为后期病变较重者，本方法在病变早、中期疗效显著。
六、典型病例：
病例1：王某，女，60岁。患者双腿膝关节不断疼痛，劳累后加重。关节畸形肿大，久行久站均疼痛，上下楼疼痛加重。下蹲困难，膝关节伸屈功能障碍，影响生活和劳动。拍X线片报告显示：髁间出现骨刺，关节间隙变窄。确诊为：膝关节骨性关节炎。采用本方案进行治疗，连续治疗四个疗程后，双膝行走、上下楼均无疼痛，下蹲活动自如，恢复日常生活和劳动，经医院确诊病情痊愈。
病例2：李某，男，58岁，患者右膝关节不明原因肿胀，疼痛，屈伸不利，蹲时疼痛，不能下蹲，上下楼时疼痛加重。夜间影响睡眠，影响劳动。浮髌试验阳性，经膝关节核磁共振检查，确诊为：右膝骨性关节炎，关节腔积液。采用本方案进行治疗，连续治疗四个疗程后，右膝关节肿痛消失，上下楼行走自如。能参加田间劳动，经医院确诊，该患者已完全治愈。
病例3、闫某，女，59岁。患者行走跛行，左膝疼痛较重，畸形，不能伸屈膝关节，下蹲困难，有时突然刺痛，腿软欲跌倒，医院确诊为双膝骨性关节炎。患病1年多，采用本方案进行治疗，连续治疗四个疗程后，经医院确诊，该患者已完全治愈，恢复劳动。

Claims (2)

1.一种治疗膝关节骨性关节炎的外用中药组合物，其特征在于它是由下列重量配比的中药原料组成的：海桐皮10-30g、苏木10-30g、川芎9-20g、制川乌6-12g、制草乌6-12g、肉桂9-15g、大黄6-15g、牛膝6-12g、独活6-12g、伸筋草10-30g、麻黄6-12g、细辛6-12g、川楝子9-15g、路路通12-20g、乳香6-9g、没药6-9g、千年健10-20g、当归6-12g、赤芍6-12g、桃仁6-12g、白芷9-15g、红花6-12g、威灵仙6-12g、花椒6-12g。
2.根据权利要求1所述的一种治疗膝关节骨性关节炎的外用中药组合物，其特征在于它是由下列重量配比的中药原料组成的：海桐皮30g、苏木30g、川芎20g、制川乌10g、制草乌10g、肉桂15g、大黄10g、牛膝12g、独活10g、伸筋草25g、麻黄10g、细辛10g、川楝子15g、路路通15g、乳香6g、没药6g、千年健15g、当归10g、赤芍10g、桃仁10g、白芷15g、红花10g、威灵仙10g、花椒12g。
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CN106266000A (zh) * 2016-09-28 2017-01-04 昆明市中医医院 一种治疗骨痹的祛风除湿止痛外洗药液及制备方法
CN106963923A (zh) * 2017-05-15 2017-07-21 吉林省命之元生物科技有限公司 一种具有镇痛作用的中药组合物及制备方法和应用
CN110051525A (zh) * 2019-05-21 2019-07-26 漳州卫生职业学院 膝关节中药负压熏洗仪
CN112691157A (zh) * 2020-12-08 2021-04-23 付钢 一种风湿类关节炎药材组合物的配方及制备方法

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106073979A (zh) * 2016-06-14 2016-11-09 大连盐化集团有限公司 天然海盐中药热敷理疗袋
CN106266000A (zh) * 2016-09-28 2017-01-04 昆明市中医医院 一种治疗骨痹的祛风除湿止痛外洗药液及制备方法
CN106963923A (zh) * 2017-05-15 2017-07-21 吉林省命之元生物科技有限公司 一种具有镇痛作用的中药组合物及制备方法和应用
CN110051525A (zh) * 2019-05-21 2019-07-26 漳州卫生职业学院 膝关节中药负压熏洗仪
CN112691157A (zh) * 2020-12-08 2021-04-23 付钢 一种风湿类关节炎药材组合物的配方及制备方法

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