CN104435627A - 治疗眼眉乱跳不止的中药组合物及制备方法 - Google Patents
治疗眼眉乱跳不止的中药组合物及制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗眼眉乱跳不止的中药组合物及其制备方法,取下述重量配比的主要原料药制备而成:山药12-24,覆盆子6-12,灯心草10-18,当归8-13,白芍5-10,川芎6-9,红花3-6,徐长卿8-12,羖羊角4-9,远志6-12,肉桂8-12,栝楼5-10,知母4-8,黄芪10-20。本发明疗程短、见效快,无复发、安全、有效、无副作用。
Description
技术领域
本发明涉及中医中药领域,特别是涉及一种治疗眼眉乱跳不止的中药组合物及其制备方法。
背景技术
胞轮振跳指上胞或下睑不能自控地搐惕瞤动(《证治准绳,杂病·七窍门》),俗称眼皮跳或眼眉跳。临床多见于成年人。若偶尔发生,不必治疗,可以自愈;若跳动过频或久跳不止,则须调治。本病与西医学之眼睑痉挛相似。每于胞睑振跳时,患者自觉不适,但检查胞睑外观正常。本病多因气血亏损或久病失调,劳瞻过度,损伤心脾,心脾两虚,筋肉失养而动。变有因肝脾血虚,日久生风,虚风内动,牵拽胞睑而振跳。本病发病于胞睑,与心肝脾关系密切。辩证以虚证为主。胞睑振跳,劳累加重,心烦失眠,食少神疲者为心脾血虚。胞睑振跳不休,不能自控者为血虚生风。治疗原则是补养心脾,养血熄风。临床表现:上胞或下睑跳动,时疏时频,不能自控。一般过劳、久视、睡眠不足时,则跳动更加频繁,休息之后症状可以减轻或消失。若胞睑跳动时,连同半侧面部肌肉及眉毛、口角皆困动者,日久不愈,恐有喁偏之变。
眼眉乱跳不止的治疗:1.药物治疗:(1)血虚生风。证候:胞睑振跳不休,或与眉、额、面、口角相引,不能自控,头晕目眩,面色少华,舌质淡红,苔薄,脉细弦。本证以胞睑振跳,头晕目眩,面色少华,以及舌象、脉象为辨证要点。治法:养血熄风。方药:当归活血饮(《审视瑶函》)加减。(2)心脾两虚。证候:胞睑振跳,时疏时频,劳累时重,兼心烦失眠,健忘怔忡,食少体倦,舌质淡,脉细弱。本证以健忘怔忡,食少体倦,以及舌象、脉象为辨证要点。治法:补养心脾。处方:归脾汤(《济生方》)加减。伴心烦失眠等症,加桑椹、龟板以奏补心养血之效。2.针灸治疗:(1)体针。基本处方:攒竹、丝竹空、四白、合谷、太冲、足三里。方中四白、攒竹、丝竹空均为眼周穴位,可疏调眼部气血以熄风止痉;合谷、太冲可养肝平肝、熄风止痉;足三里朴脾胃、生气血。全方共奏朴益气血,镇痉熄风以治胞睑振跳之功。加减运用:劳倦太过,心脾受损者,加心俞、脾俞、内关、商丘,以补益心脾;阴虚阳亢,风动筋挛者,加肝俞、肾俞、行间、照海、太阳、头维,以滋补肝肾。平肝熄风:肝风夹痰者,加太冲、脾俞、丰隆、合谷、申脉、鱼腰,以涤痰熄风。操作方法:针刺用补法或平补平泻法,留针30分钟,每日1次,10天为l疗程。(2)耳针:取眼、神门、肝、心、脾穴。每次选2—3穴。胞轮振跳频繁者用强刺激。留针20-30分钟。(3)更法:选用穴位足三里、阴陵泉、关元、气海,每穴用艾炷灸4—5壮,每日1次,或隔日1次,10次为1疗程。3.其他治疗。(1)穴位注射:翳风、阳白、下关、足三里。采用丹参注射液或维生素B族药物,每穴注入0.5—1mL,每日或隔日1次,10欢为1疗程。(2)按摩:患者自行按摩局部及胞睑周围穴位如攒竹、鱼腰、丝竹空、四白等穴,每日3次,每次5~10分钟。申请公布号 CN 103446289 A(申请号 201210186410.0)的中国专利文献提供了一种治疗眼皮跳的组合物中药,由连翘、牛蒡子、羌活、薄荷、大黄、赤芍药、防风等组成。
目前对于眼眉乱跳不止尚无特效治疗,主要还是补充大量维生素,注意休息,针对眼眉乱跳不止的药物很少,因此亟需一种治疗眼眉乱跳不止的药物。
发明内容
针对现有技术的不足,本发明的目的是提供一种治疗眼眉乱跳不止的中药组合物及其制备方法。本发明疗程短、见效快,无复发、安全、有效、无副作用。
本发明的技术方案是:
治疗眼眉乱跳不止的中药组合物,取下述重量配比的主要原料药制备而成:山药12-24,覆盆子6-12,灯心草10-18,当归8-13,白芍5-10,川芎6-9,红花3-6,徐长卿8-12,羖羊角4-9,远志6-12,肉桂8-12,栝楼5-10,知母4-8,黄芪10-20。
治疗眼眉乱跳不止的中药组合物,优选的方案是,取下述重量配比的主要原料药制备而成:山药15-20,覆盆子8-11,灯心草12-16,当归9-12,白芍6-9,川芎7-8,红花4-5,徐长卿9-11,羖羊角5-8,远志7-11,肉桂9-11,栝楼6-9,知母5-7,黄芪14-18。
治疗眼眉乱跳不止的中药组合物,更加优选的方案是,取下述重量配比的主要原料药制备而成:山药17,覆盆子10,灯心草14,当归10,白芍7,川芎7.5,红花4.5,徐长卿10,羖羊角6,远志9,肉桂10,栝楼7,知母6,黄芪16。
本发明还提供了将上述治疗眼眉乱跳不止的中药组合物制成药学上可接受的汤剂、散剂、丸剂和稠膏剂的制备方法。
所述汤剂的制备方法是:
(1)将羖羊角用洁白布包紧,置蒸笼内隔水加热至上大气取出,趁热镑极薄片,然后,用白酒闷润1.8-3.2小时(优选用白酒闷润2.5小时),白酒的量为羖羊角重量的1/3-3/5(优选白酒的量为羖羊角重量的2/5),阴干,研成细粉;
(2)取覆盆子用微火炒8-16分钟(优选取覆盆子用微火炒12分钟),加入蜜糖再炒7-12分钟(优选加入蜜糖再炒9分钟),每500g覆盆子用蜜糖35-52g(优选每500g覆盆子用蜜糖42g),取出,放凉,研成细粉;
(3)将除羖羊角、覆盆子、灯心草和红花外的其余10味药材放入砂锅中,煎煮两次,第一次煎煮时,加水至超过药物表面2.2~5.4cm(优选加水至超过药物表面3.6cm),先用大火煮至沸腾,后转小火煎煮35-55分钟(优选后转小火煎煮45分钟),第二次煎煮时,加水至超过药渣1.8~3.4cm(优选加水至超过药渣2.4cm),先用大火煮至沸腾,后转小火煎煮24-38分钟后(优选后转小火煎煮32分钟后),加入灯心草和红花,继续煎煮10-20分钟(优选继续煎煮14分钟),合并两次药液;
(4)将步骤(1)和步骤(2)所得细粉加入到步骤(3)所得药液中,即可。
所述散剂的制备方法是:
(1)将羖羊角用洁白布包紧,置蒸笼内隔水加热至上大气取出,趁热镑极薄片,然后,用白酒闷润1.8-3.2小时(优选用白酒闷润2.5小时),白酒的量为羖羊角重量的1/3-3/5(优选白酒的量为羖羊角重量的2/5),阴干,研成细粉,过140-160目筛(优选过150目筛);
(2)取覆盆子用微火炒8-16分钟(优选取覆盆子用微火炒12分钟),加入蜜糖再炒7-12分钟(优选加入蜜糖再炒9分钟),每500g覆盆子用蜜糖35-52g(优选每500g覆盆子用蜜糖42g),取出,放凉,研成细粉,过140-160目筛(优选过150目筛);
(3)将除羖羊角和覆盆子外的其余12味中药材共研成细粉,过140-160目筛(优选过150目筛);
(4)将步骤(1)、步骤(2)和步骤(3)所得细粉充分混匀,无菌封装即得。
所述丸剂的制备方法是:
(1)将羖羊角用洁白布包紧,置蒸笼内隔水加热至上大气取出,趁热镑极薄片,然后,用白酒闷润1.8-3.2小时(优选用白酒闷润2.5小时),白酒的量为羖羊角重量的1/3-3/5(优选白酒的量为羖羊角重量的2/5),阴干,研成细粉,过110-130目筛(优选过120目筛);
(2)取覆盆子用微火炒8-16分钟(优选取覆盆子用微火炒12分钟),加入蜜糖再炒7-12分钟(优选加入蜜糖再炒9分钟),每500g覆盆子用蜜糖35-52g(优选每500g覆盆子用蜜糖42g),取出,放凉,研成细粉,过110-130目筛(优选过120目筛);
(3)将除羖羊角、覆盆子和灯心草外的其余11味中药材共研成细粉,过110-130目筛(优选过120目筛);
(4)将灯心草放入砂锅中,加水煎煮两次,第一次煎煮时,加水量为灯心草重量的4.2-7.5倍(优选加水量为灯心草重量的6.2倍),先用大火煮至沸腾,后转小火煎煮18-35分钟(优选后转小火煎煮28分钟),第二次煎煮时,加水量为灯心草重量的3.5-5.5倍(优选加水量为灯心草重量的4倍),先用大火煮至沸腾,后转小火煎煮12-25分钟(优选后转小火煎煮18分钟),合并两次药液,并将药液静置1.5-2.5小时(优选并将药液静置2小时),得滤液;
(5)将步骤(1)、步骤(2)和步骤(3)所得细粉混匀,用步骤(4)所得滤液泛丸,制得的每丸的重量为0.15-0.4g(优选制得的每丸的重量为0.3g),干燥,即得。
所述稠膏剂的制备方法是:
(1)将羖羊角用洁白布包紧,置蒸笼内隔水加热至上大气取出,趁热镑极薄片,然后,用白酒闷润1.8-3.2小时用(优选用白酒闷润2.5小时),白酒的量为羖羊角重量的1/3-3/5(优选白酒的量为羖羊角重量的2/5),阴干,研成细粉,过130-150目筛(优选过140目筛);
(2)取覆盆子用微火炒8-16分钟(优选取覆盆子用微火炒12分钟),加入蜜糖再炒7-12分钟(优选加入蜜糖再炒9分钟),每500g覆盆子用蜜糖35-52g(优选每500g覆盆子用蜜糖42g),取出,放凉,研成细粉,过130-150目筛(优选过140目筛);
(3)将除羖羊角、覆盆子、灯心草和红花外的其余10味药材放入砂锅中,煎煮两次,第一次煎煮时,加水至超过药物表面2.5~5.8cm(优选加水至超过药物表面3.8cm),先用大火煮至沸腾,后转小火煎煮40-70分钟(优选后转小火煎煮55分钟),第二次煎煮时,加水至超过药渣1.6~3.6cm(优选加水至超过药渣2.6cm),先用大火煮至沸腾,后转小火煎煮30-45分钟后(优选后转小火煎煮38分钟后),加入灯心草和红花,继续煎煮8-16分钟(优选继续煎煮13分钟),合并两次药液,将药液静置2.5-4.5小时(优选将药液静置3.5小时),得滤液;
(4)将步骤(3)所得滤液置蒸发锅中,先以武火加热至沸并随时除去浮沫,待滤液变浓时改用文火,浓缩成稠膏状时,沾取少许滴于滤纸上,检查,无渗润水迹为度;
(5)取步骤(4)所得稠膏状药物1.4-2.2倍量的炼蜜加入稠膏状药物中(优选取步骤(4)所得稠膏状药物1.7倍量的炼蜜加入稠膏状药物中),待冷却后,加入步骤(1)和步骤(2)所得细粉,分装在洁净干燥灭菌的容器中,待充分冷却后加盖密闭即可。
本发明提供的中药组合物经科学配伍,各种剂型的制备方法简单,所得产品服用方便。除此之外,本发明的优良效果还表现在:
1、具有补养心脾、补血活血、补气固表等功效,对于眼眉乱跳不止有良好的治疗效果;
2、疗程短、见效快,无复发;
3、安全、有效、无副作用;
4、减轻患者的精神和身体痛苦。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案,但保护范围不限于此。
本发明所用主要中药原料的药理如下:
山药:基原:本品为薯蓣科植物薯蓣的干燥根茎。药性:甘,平。归脾、肺、肾经。 功用主治:补脾养胃,生津益肺,补肾涩精。用于脾虚食少,久泻不止,肺虚喘咳,肾虚遗精,带下,尿频,虚热消渴。
覆盆子:基原:为蔷薇科悬钩子属植物华东覆盆子的干燥果实。药性:甘、酸,温。归肾、膀胱经。功用主治:益肾,固精,缩尿。用于肾虚遗尿,小便频数,阳痿早泄,遗精滑精。
灯心草:基原:为灯心草科植物灯心草的干燥茎髓。茎髓含多种菲类衍生物,已分离得到:灯心草二酚,6-甲基灯心草二酚,灯心草酚,2,6-二羟基-1,7-二甲基-5-乙烯基-9,10-二氢菲,2,7-二羟基-1,8-二甲基-5-乙烯基-9,10-二氢菲,2,8-二羟基-1,6-二甲基-5-乙烯基-9,10-二氢菲,8-羟基-2-甲氧基-1,6-二甲基-5-乙烯基-9,10-二氢菲等。药性:甘、淡,微寒。归心、肺、小肠经。功用主治:清心火,利小便。用于心烦失眠,尿少涩痛,口舌生疮。现代研究作用:具有止血作用。治疗小儿流行性腮腺炎,疗效显著。治鼻衄,有显效。还可治疗慢性肾小球肾炎,胃肠型感冒。可治喉痹。
当归:基原:为伞形科植物当归的干燥根。药性:甘、辛,温。归肝、心、脾经。功用主治:补血活血,调经止痛,润肠通便。用于血虚萎黄,眩晕心悸,月经不调,经闭痛经,虚寒腹痛,肠燥便秘,风湿痹痛,跌扑损伤,痈疽疮疡。
白芍:基原:为毛茛科植物芍药的干燥根。药性:苦、酸,微寒。归肝、脾经。功用主治:平肝止痛,养血调经,敛阴止汗。用于头痛眩晕,胁痛,腹痛,四肢挛痛,血虚萎黄,月经不调,自汗,盗汗。
川芎:基原:为伞形科植物川穹的干燥根茎。药性:辛,温。归肝、胆、心包经。功用主治:活血行气,祛风止痛。用于月经不调,经闭痛经,癥瘕腹痛,胸胁刺痛,跌扑肿痛,头痛,风湿痹痛。
红花:基原:为菊科植物红花的干燥花。药性:辛,温。归心、肝经。功用主治:活血通经,散瘀止痛。用于经闭,痛经,恶露不行,癥瘕痞块,跌扑损伤,疮疡肿痛。
徐长卿:基原:为萝藦科植物徐长卿的根及根茎或带根全草。化学成分:全草含牡丹酚约l%。又找出有与肉珊瑚甙元、去酚牛皮消甙元、茸毛牛 奶藤甙元和去酰萝甙元极为相似的物质以及醋酸 、桂皮酸等。根含黄酮甙、糖类、氨基酸、牡丹酚。含C21甾类化合物。水解产物中含肉珊瑚甙元、去乙酰萝藦甙元、去乙酰牛皮消甙元及托曼甙元,尚含D-加拿大麻糖、D-洋地黄毒糖、L-夹竹桃糖和D-沙门糖。另有报道含C21变形甾甙类化合物,由芫花叶白前甙元D和不同糖链成的徐长卿甙A,B,C及芫花叶白前甙元B所形成的白薇甙B。此外还含牡丹酚、异丹皮酚、硬脂酸癸酯、蜂花烷、十六烯、β-谷甾醇和D-赤丝草醇。药性:辛,温。①《本经》:“味辛,温。”②《别录》:“无毒。”功用主治:镇痛,止咳,利水消肿,活血解毒。治胃痛,牙痛,风湿疼痛,经期腹痛,慢性气管炎,腹水,水肿,痢疾,肠炎,跌打损伤,湿疹,荨麻疹,毒蛇咬伤。
羖羊角:基原:为牛科动物雄性山羊或雄性绵羊的角。药性:苦、咸,寒。归肝、心经。功用主治:清热、镇惊、明目、解毒。主风热头痛、温病发热神昏、烦闷、吐血、小儿惊痫、惊悸、青盲内障、痈肿疮毒。
远志:基原:为远志科植物远志或卵叶远志的干燥根。药性:苦、辛,温。归心、肾、肺经。功用主治:安神益智,祛痰,消肿。用于心肾不交引起的失眠多梦,健忘惊悸,神志恍惚,咳痰不爽,疮疡肿毒,乳房肿痛。
肉桂:基原:为樟科樟属植物肉桂的干皮、枝皮。成分:桂皮含挥发油1.89%-2.06%,其主要成分为桂皮醛,占52.92%-61.20%,还有乙酸桂皮酯,桂皮酸乙酯,苯甲醛苄酯,苯甲醛,香豆素等。药性:辛、甘,热。归肾、脾、心、肝经。功用主治:补火助阳,散寒止痛,温经通脉。主治肾阳不足,命门火衰之畏寒肢冷,腰膝酸软,阳痿遗精,小便不利或频数,短气喘促,浮肿尿少诸症、命门火衰,火不归源,戴阳、格阳,及上热下寒,面赤足冷,头晕耳鸣,口舌糜破、脾肾虚寒,脘腹冷痛,食减便溏、肾虚腰痛、寒湿痹痛、寒疝疼痛,宫冷不孕,痛经闭经,产后淤滞腹痛、阴疽流注,或虚寒痈疡脓成不溃,或溃后不敛。
栝楼:基原:为葫芦科栝楼属植物栝楼及双边栝楼的果实。药性:甘、微苦,寒。归肺、胃、大肠经。功用主治:清热化痰,宽胸散结,润燥滑肠。主治肺热咳嗽,胸痹,结胸,消渴,便秘,痈肿疮毒。
知母:基原:为百合科植物知母的根茎。化学成分:主含皂甙。根茎含总皂甙约6%,从中检出6种皂甙,分别称为知母皂甙A-Ⅰ,A-Ⅱ,A-Ⅲ、A-Ⅳ、B-Ⅰ和B-Ⅱ,其中知母皂甙A-Ⅲ是萨尔萨皂甙元与知母双糖结合而成的双糖甙,知母皂甙A-Ⅰ是萨尔萨皂甙元β-D-吡喃半乳糖甙。知母根茎中的皂甙元主要是萨尔萨皂甙元,干根中的含量约0.5%,此外还有吗尔考皂甙元、新芰脱皂甙元。以前从知母根茎中分出的皂甙曾称为知母宁,推测是吗尔考皂甙、知母皂甙A-Ⅲ、A-Ⅳ、B等的混合物。根茎尚含多量的还原糖和粘液质、鞣酸、脂肪油等,又每克含尼克酸188微克。尼克酰胺12微克。另含芒果甙0.5%。地上部分含芒果甙和异芒果甙。叶含芒果甙约0.7%。花含皂甙,水解后得熔点为246~248℃的甙元C27H42O4。药性:苦,寒。归肺、胃、肾经。功用主治:滋阴降火,润燥滑肠。治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。
黄芪:为豆科植物蒙古黄芪或膜荚黄芪的干燥根。药性:甘,温。归肺、脾经。功用主治:补气固表,利尿托毒,排脓,敛疮生肌。用于气虚乏力,食少便溏,中气下陷,久泻脱肛,便血崩漏,表虚自汗,气虚水肿,痈疽难溃,久溃不敛,血虚痿黄,内热消渴,慢性肾炎蛋白尿,糖尿病 。
实施例1治疗眼眉乱跳不止的中药组合物,取下述重量份的主要原料药制备而成(每份为50g):山药12份,覆盆子6份,灯心草10份,当归8份,白芍5份,川芎6份,红花3份,徐长卿8份,羖羊角4份,远志6份,肉桂8份,栝楼5份,知母4份,黄芪10份。
上述治疗眼眉乱跳不止的中药组合物汤剂的制备方法是:
(1)将羖羊角用洁白布包紧,置蒸笼内隔水加热至上大气取出,趁热镑极薄片,然后,用白酒闷润1.8小时,白酒的量为羖羊角重量的1/3,阴干,研成细粉;
(2)取覆盆子用微火炒8分钟,加入蜜糖再炒7分钟,每500g覆盆子用蜜糖35g,取出,放凉,研成细粉;
(3)将除羖羊角、覆盆子、灯心草和红花外的其余10味药材放入砂锅中,煎煮两次,第一次煎煮时,加水至超过药物表面2.2cm,先用大火煮至沸腾,后转小火煎煮35分钟,第二次煎煮时,加水至超过药渣1.8cm,先用大火煮至沸腾,后转小火煎煮24分钟后,加入灯心草和红花,继续煎煮10分钟,合并两次药液;
(4)将步骤(1)和步骤(2)所得细粉加入到步骤(3)所得药液中,即可。
本发明治疗眼眉乱跳不止的中药组合物汤剂的服用方法:口服,每日两次,每次290mL(温热)。
实施例2治疗眼眉乱跳不止的中药组合物,取下述重量份的主要原料药制备而成(每份为50g):山药24份,覆盆子12份,灯心草18份,当归13份,白芍10份,川芎9份,红花6份,徐长卿12份,羖羊角9份,远志12份,肉桂12份,栝楼10份,知母8份,黄芪20份。
上述治疗眼眉乱跳不止的中药组合物散剂的制备方法是:
(1)将羖羊角用洁白布包紧,置蒸笼内隔水加热至上大气取出,趁热镑极薄片,然后,用白酒闷润2.5小时,白酒的量为羖羊角重量的2/5,阴干,研成细粉,过150目筛;
(2)取覆盆子用微火炒12分钟,加入蜜糖再炒9分钟,每500g覆盆子用蜜糖42g,取出,放凉,研成细粉,过150目筛;
(3)将除羖羊角和覆盆子外的其余12味中药材共研成细粉,过150目筛;
(4)将步骤(1)、步骤(2)和步骤(3)所得,充分混匀,无菌封装即得。
典型病例一:秦XX,男,25岁。主诉:一周前发热,伴口干、咽痛。近二日来,眼红、干涩痒感,眼睑振跳频繁而不能自控。诊其脉浮数,舌红、苔薄黄。诊断为胞轮振跳,证属风热相侵,筋脉失养。服用本实施例所得治疗眼眉乱跳不止的中药组合物散剂,每日两次,每次5g,开水冲服。服用1天后,症状明显减轻。服用3天痊愈。随访未复发。
实施例3治疗眼眉乱跳不止的中药组合物,取下述重量份的主要原料药制备而成(每份为50g):山药15份,覆盆子8份,灯心草12份,当归9份,白芍6份,川芎7份,红花4份,徐长卿9份,羖羊角5份,远志7份,肉桂9份,栝楼6份,知母5份,黄芪14份。
上述治疗眼眉乱跳不止的中药组合物丸剂的制备方法是:
(1)将羖羊角用洁白布包紧,置蒸笼内隔水加热至上大气取出,趁热镑极薄片,然后,用白酒闷润2.5小时,白酒的量为羖羊角重量的2/5,阴干,研成细粉,过120目筛;
(2)取覆盆子用微火炒12分钟,加入蜜糖再炒9分钟,每500g覆盆子用蜜糖42g,取出,放凉,研成细粉,过120目筛;
(3)将除羖羊角、覆盆子和灯心草外的其余11味中药材共研成细粉,过120目筛;
(4)将灯心草放入砂锅中,加水煎煮两次,第一次煎煮时,加水量为灯心草重量的6.2倍,先用大火煮至沸腾,后转小火煎煮28分钟,第二次煎煮时,加水量为灯心草重量的4倍,先用大火煮至沸腾,后转小火煎煮18分钟,合并两次药液,并将药液静置2小时,得滤液;
(5)将步骤(1)、步骤(2)和步骤(3)所得细粉混匀,用步骤(4)所得滤液泛丸,制得的每丸的重量为0.3g,干燥,即得。
典型病例二:卜XX,女,31岁。主诉:产后两月,于半月前因外出当风,右目上胞跳动不已,虽视物尚清,但心烦意乱。检查:右目无有异变,唯上睑不时跳动,患者面白体弱,倦怠乏力,舌淡脉细,此为产后气血两亏,风邪乘虚客于胞睑所致。服用本实施例所得治疗眼眉乱跳不止的中药组合物丸剂,每日三次,每次15丸。服用2天,症状明显减轻。继续服用3天胞轮振跳即止。随访未复发。
实施例4治疗眼眉乱跳不止的中药组合物,取下述重量份的主要原料药制备而成(每份为50g):山药20份,覆盆子11份,灯心草16份,当归12份,白芍9份,川芎8份,红花5份,徐长卿11份,羖羊角8份,远志11份,肉桂11份,栝楼9份,知母7份,黄芪18份。
上述治疗眼眉乱跳不止的中药组合物稠膏剂的制备方法是:
(1)将羖羊角用洁白布包紧,置蒸笼内隔水加热至上大气取出,趁热镑极薄片,然后,用白酒闷润2.5小时,白酒的量为羖羊角重量的2/5,阴干,研成细粉,过140目筛;
(2)取覆盆子用微火炒12分钟,加入蜜糖再炒9分钟,每500g覆盆子用蜜糖42g,取出,放凉,研成细粉,过140目筛;
(3)将除羖羊角、覆盆子、灯心草和红花外的其余10味药材放入砂锅中,煎煮两次,第一次煎煮时,加水至超过药物表面3.8cm,先用大火煮至沸腾,后转小火煎煮55分钟,第二次煎煮时,加水至超过药渣2.6cm,先用大火煮至沸腾,后转小火煎煮38分钟后,加入灯心草和红花,继续煎煮13分钟,合并两次药液,将药液静置3.5小时,得滤液;
(4)将步骤(3)所得滤液置蒸发锅中,先以武火加热至沸并随时除去浮沫,待滤液变浓时改用文火,浓缩成稠膏状时,沾取少许滴于滤纸上,检查,无渗润水迹为度;
(5)取步骤(4)所得稠膏状药物1.7倍量的炼蜜加入稠膏状药物中,待冷却后,加入步骤(1)和步骤(2)所得细粉,分装在洁净干燥灭菌的容器中,待充分冷却后加盖密闭即可。
典型病例三:范XX,男,24岁。主诉:眼眉乱跳不止,不能自控半年,伴心烦易躁,手足心热。曾服卡马西平、利他林、谷维素等药物效果不佳。诊查:舌红少苔,脉细数。证属阴血亏虚,血虚生风。服用本实施例所得治疗眼眉乱跳不止的中药组合物稠膏剂,每日三次,每次22g。服用2天,症状有所缓解。继续服用2天,眼眉乱跳止,症状得以控制。随访至今未复发。
实施例5治疗眼眉乱跳不止的中药组合物,取下述重量份的主要原料药制备而成(每份为50g):山药17份,覆盆子10份,灯心草14份,当归10份,白芍7份,川芎7.5份,红花4.5份,徐长卿10份,羖羊角6份,远志9份,肉桂10份,栝楼7份,知母6份,黄芪16份。
上述治疗眼眉乱跳不止的中药组合物汤剂的制备方法是:
(1)将羖羊角用洁白布包紧,置蒸笼内隔水加热至上大气取出,趁热镑极薄片,然后,用白酒闷润2.5小时,白酒的量为羖羊角重量的2/5,阴干,研成细粉;
(2)取覆盆子用微火炒12分钟,加入蜜糖再炒9分钟,每500g覆盆子用蜜糖42g,取出,放凉,研成细粉;
(3)将除羖羊角、覆盆子、灯心草和红花外的其余10味药材放入砂锅中,煎煮两次,第一次煎煮时,加水至超过药物表面3.6cm,先用大火煮至沸腾,后转小火煎煮45分钟,第二次煎煮时,加水至超过药渣2.4cm,先用大火煮至沸腾,后转小火煎煮32分钟后,加入灯心草和红花,继续煎煮14分钟,合并两次药液;
(4)将步骤(1)和步骤(2)所得细粉加入到步骤(3)所得药液中,即可。
试验例1实施例5所得治疗眼眉乱跳不止的中药组合物的临床应用:2008年9月-2011年6月,在5所医院筛选260例眼眉乱跳不止患者,其中女150例,男110例,年龄16-65岁,平均年龄40.5岁,病程4天-2.5年。随机分为两组,实验组和对照组。实验组女76例,男性54例,年龄16-65岁,平均年龄40.5岁,病程4天-2.5年。对照组女74例,男性56例,年龄16-65岁,平均年龄40.5岁,病程4天-2.5年。两组患者间年龄、性别、病程等方面进行比较,差异无统计学意义(P>0.05),具有可比性。实验组服用实施例5所得产品,口服,每日两次,每次290mL(温热)。对照组使用常规治疗眼眉乱跳不止的药品(如谷维素、维生素B1、卡马西平片等)。
诊断标准参照国家中医药管理局1994年发布的《中医病症诊断疗效标准》确诊,纳入标准的患者均经视力裂隙灯眼底带状光检影等眼科检查,除外屈光不正倒睫结膜炎结膜及角膜异物角膜溃疡虹膜炎等眼部疾患。
疗效判定标准:痊愈:胞轮振跳消失,随访3个月无复发;显效:胞轮振跳基本停止,偶尔出现且持续时间较短,不影响正常工作;有效:胞轮振跳每日出现次数减少,且持续时间明显缩短;无效:胞轮振跳症状无明显改善,亦无加重倾向。总有效包括痊愈和显效。治疗5天后,结果如表1所示。
表1:实施例5所得治疗眼眉乱跳不止的中药组合物效果验证
从表1可以看出,使用实施例5所得治疗眼眉乱跳不止的中药组合物汤剂的实验组治愈率为86.92%,总有效率达到了98.46%。而对照组的无效例数为10例,总有效率为71.54%。实验组的痊愈率比对照组的痊愈率提高了36.92%,总有效率增加了26.92%。试验表明,实验组的效果明显优于对照组。
本发明选择山药、覆盆子、灯心草和当归等进行配伍,制成治疗眼眉乱跳不止的中药组合物。方中山药补脾养胃,生津益肺,补肾涩精。覆盆子益肾,固精,缩尿。灯心草清心火,利小便。当归补血活血,调经止痛,润肠通便。白芍平肝止痛,养血调经,敛阴止汗。川芎活血行气,祛风止痛。红花活血通经,散瘀止痛。徐长卿镇痛,止咳,利水消肿,活血解毒。羖羊角清热、镇惊、明目、解毒。远志安神益智,祛痰,消肿。肉桂补火助阳,散寒止痛,温经通脉。栝楼有镇咳祛痰功效。知母滋阴降火,润燥滑肠。黄芪补气固表,利尿托毒,排脓,敛疮生肌。诸药合用,具有补养心脾、补血活血、补气固表等功效,对于眼眉乱跳不止有良好的治疗效果。
最后应说明的是,实施例只是本发明最优的具体实施方式而已,并不用于限制本发明,尽管参照前述实施例对本发明进行了详细的说明,对于本领域的技术人员来说,其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (10)
1.治疗眼眉乱跳不止的中药组合物,其特征在于,取下述重量配比的主要原料药制备而成:山药12-24,覆盆子6-12,灯心草10-18,当归8-13,白芍5-10,川芎6-9,红花3-6,徐长卿8-12,羖羊角4-9,远志6-12,肉桂8-12,栝楼5-10,知母4-8,黄芪10-20。
2.如权利要求1所述的治疗眼眉乱跳不止的中药组合物,其特征在于,取下述重量配比的主要原料药制备而成:山药15-20,覆盆子8-11,灯心草12-16,当归9-12,白芍6-9,川芎7-8,红花4-5,徐长卿9-11,羖羊角5-8,远志7-11,肉桂9-11,栝楼6-9,知母5-7,黄芪14-18。
3.如权利要求1所述的治疗眼眉乱跳不止的中药组合物,其特征在于,取下述重量配比的主要原料药制备而成:山药17,覆盆子10,灯心草14,当归10,白芍7,川芎7.5,红花4.5,徐长卿10,羖羊角6,远志9,肉桂10,栝楼7,知母6,黄芪16。
4.如权利要求1~3任一所述的治疗眼眉乱跳不止的中药组合物,其特征在于,将该治疗眼眉乱跳不止的中药组合物制成药学上可接受的汤剂,所述汤剂的制备方法是:
(1)将羖羊角用洁白布包紧,置蒸笼内隔水加热至上大气取出,趁热镑极薄片,然后,用白酒闷润1.8-3.2小时(优选用白酒闷润2.5小时),白酒的量为羖羊角重量的1/3-3/5(优选白酒的量为羖羊角重量的2/5),阴干,研成细粉;
(2)取覆盆子用微火炒8-16分钟(优选取覆盆子用微火炒12分钟),加入蜜糖再炒7-12分钟(优选加入蜜糖再炒9分钟),每500g覆盆子用蜜糖35-52g(优选每500g覆盆子用蜜糖42g),取出,放凉,研成细粉;
(3)将除羖羊角、覆盆子、灯心草和红花外的其余10味药材放入砂锅中,煎煮两次,第一次煎煮时,加水至超过药物表面2.2~5.4cm(优选加水至超过药物表面3.6cm),先用大火煮至沸腾,后转小火煎煮35-55分钟(优选后转小火煎煮45分钟),第二次煎煮时,加水至超过药渣1.8~3.4cm(优选加水至超过药渣2.4cm),先用大火煮至沸腾,后转小火煎煮24-38分钟后(优选后转小火煎煮32分钟后),加入灯心草和红花,继续煎煮10-20分钟(优选继续煎煮14分钟),合并两次药液;
(4)将步骤(1)和步骤(2)所得细粉加入到步骤(3)所得药液中,即可。
5.如权利要求1~3任一所述的治疗眼眉乱跳不止的中药组合物,其特征在于,将该治疗眼眉乱跳不止的中药组合物制成药学上可接受的散剂,所述散剂的制备方法是:
(1)将羖羊角用洁白布包紧,置蒸笼内隔水加热至上大气取出,趁热镑极薄片,然后,用白酒闷润1.8-3.2小时(优选用白酒闷润2.5小时),白酒的量为羖羊角重量的1/3-3/5(优选白酒的量为羖羊角重量的2/5),阴干,研成细粉,过140-160目筛(优选过150目筛);
(2)取覆盆子用微火炒8-16分钟(优选取覆盆子用微火炒12分钟),加入蜜糖再炒7-12分钟(优选加入蜜糖再炒9分钟),每500g覆盆子用蜜糖35-52g(优选每500g覆盆子用蜜糖42g),取出,放凉,研成细粉,过140-160目筛(优选过150目筛);
(3)将除羖羊角和覆盆子外的其余12味中药材共研成细粉,过140-160目筛(优选过150目筛);
(4)将步骤(1)、步骤(2)和步骤(3)所得细粉充分混匀,无菌封装即得。
6.如权利要求1~3任一所述的治疗眼眉乱跳不止的中药组合物,其特征在于,将该治疗眼眉乱跳不止的中药组合物制成药学上可接受的丸剂,所述丸剂的制备方法是:
(1)将羖羊角用洁白布包紧,置蒸笼内隔水加热至上大气取出,趁热镑极薄片,然后,用白酒闷润1.8-3.2小时(优选用白酒闷润2.5小时),白酒的量为羖羊角重量的1/3-3/5(优选白酒的量为羖羊角重量的2/5),阴干,研成细粉,过110-130目筛(优选过120目筛);
(2)取覆盆子用微火炒8-16分钟(优选取覆盆子用微火炒12分钟),加入蜜糖再炒7-12分钟(优选加入蜜糖再炒9分钟),每500g覆盆子用蜜糖35-52g(优选每500g覆盆子用蜜糖42g),取出,放凉,研成细粉,过110-130目筛(优选过120目筛);
(3)将除羖羊角、覆盆子和灯心草外的其余11味中药材共研成细粉,过110-130目筛(优选过120目筛);
(4)将灯心草放入砂锅中,加水煎煮两次,第一次煎煮时,加水量为灯心草重量的4.2-7.5倍(优选加水量为灯心草重量的6.2倍),先用大火煮至沸腾,后转小火煎煮18-35分钟(优选后转小火煎煮28分钟),第二次煎煮时,加水量为灯心草重量的3.5-5.5倍(优选加水量为灯心草重量的4倍),先用大火煮至沸腾,后转小火煎煮12-25分钟(优选后转小火煎煮18分钟),合并两次药液,并将药液静置1.5-2.5小时(优选并将药液静置2小时),得滤液;
(5)将步骤(1)、步骤(2)和步骤(3)所得细粉混匀,用步骤(4)所得滤液泛丸,制得的每丸的重量为0.15-0.4g(优选制得的每丸的重量为0.3g),干燥,即得。
7.如权利要求1~3任一所述的治疗眼眉乱跳不止的中药组合物,其特征在于,将该治疗眼眉乱跳不止的中药组合物制成药学上可接受的稠膏剂,所述稠膏剂的制备方法是:
(1)将羖羊角用洁白布包紧,置蒸笼内隔水加热至上大气取出,趁热镑极薄片,然后,用白酒闷润1.8-3.2小时,白酒的量为羖羊角重量的1/3-3/5,阴干,研成细粉,过130-150目筛(优选过140目筛);
(2)取覆盆子用微火炒8-16分钟(优选取覆盆子用微火炒12分钟),加入蜜糖再炒7-12分钟(优选加入蜜糖再炒9分钟),每500g覆盆子用蜜糖35-52g,取出,放凉,研成细粉,过130-150目筛(优选过140目筛);
(3)将除羖羊角、覆盆子、灯心草和红花外的其余10味药材放入砂锅中,煎煮两次,第一次煎煮时,加水至超过药物表面2.5~5.8cm(优选加水至超过药物表面3.8cm),先用大火煮至沸腾,后转小火煎煮40-70分钟(优选后转小火煎煮55分钟),第二次煎煮时,加水至超过药渣1.6~3.6cm(优选加水至超过药渣2.6cm),先用大火煮至沸腾,后转小火煎煮30-45分钟后(优选后转小火煎煮38分钟后),加入灯心草和红花,继续煎煮8-16分钟(优选继续煎煮13分钟),合并两次药液,将药液静置2.5-4.5小时(优选将药液静置3.5小时),得滤液;
(4)将步骤(3)所得滤液置蒸发锅中,先以武火加热至沸并随时除去浮沫,待滤液变浓时改用文火,浓缩成稠膏状时,沾取少许滴于滤纸上,检查,无渗润水迹为度;
(5)取步骤(4)所得稠膏状药物1.4-2.2倍量的炼蜜加入稠膏状药物中(优选取步骤(4)所得稠膏状药物1.7倍量的炼蜜加入稠膏状药物中),待冷却后,加入步骤(1)和步骤(2)所得细粉,分装在洁净干燥灭菌的容器中,待充分冷却后加盖密闭即可。
8.如权利要求7所述的治疗眼眉乱跳不止的中药组合物的制备方法,其特征在于,步骤(1)中用白酒闷润2.5小时。
9.如权利要求7所述的治疗眼眉乱跳不止的中药组合物的制备方法,其特征在于,步骤(1)中白酒的量为羖羊角重量的2/5。
10.如权利要求7所述的治疗眼眉乱跳不止的中药组合物的制备方法,其特征在于,步骤(2)中每500g覆盆子用蜜糖42g。
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