CN104411297B - 尼古丁制剂 - Google Patents

尼古丁制剂 Download PDF

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Publication number
CN104411297B
CN104411297B CN201380017041.5A CN201380017041A CN104411297B CN 104411297 B CN104411297 B CN 104411297B CN 201380017041 A CN201380017041 A CN 201380017041A CN 104411297 B CN104411297 B CN 104411297B
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CN
China
Prior art keywords
nicotine
film
solution
weight
aqueous solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380017041.5A
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English (en)
Chinese (zh)
Other versions
CN104411297A (zh
Inventor
F.赫比内特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Uppsalagruppen Medical AB
Original Assignee
Uppsalagruppen Medical AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uppsalagruppen Medical AB filed Critical Uppsalagruppen Medical AB
Publication of CN104411297A publication Critical patent/CN104411297A/zh
Application granted granted Critical
Publication of CN104411297B publication Critical patent/CN104411297B/zh
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
CN201380017041.5A 2012-03-27 2013-03-15 尼古丁制剂 Active CN104411297B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261615997P 2012-03-27 2012-03-27
US61/615,997 2012-03-27
US61/615997 2012-03-27
EP12161483.8 2012-03-27
EP12161483 2012-03-27
PCT/EP2013/055456 WO2013143891A1 (en) 2012-03-27 2013-03-15 Nicotine formulation

Publications (2)

Publication Number Publication Date
CN104411297A CN104411297A (zh) 2015-03-11
CN104411297B true CN104411297B (zh) 2017-10-24

Family

ID=49258262

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380017041.5A Active CN104411297B (zh) 2012-03-27 2013-03-15 尼古丁制剂

Country Status (21)

Country Link
US (1) US20150096572A1 (cg-RX-API-DMAC10.html)
EP (1) EP2830589B1 (cg-RX-API-DMAC10.html)
JP (2) JP6412492B2 (cg-RX-API-DMAC10.html)
KR (1) KR102038342B1 (cg-RX-API-DMAC10.html)
CN (1) CN104411297B (cg-RX-API-DMAC10.html)
AU (1) AU2013242200B2 (cg-RX-API-DMAC10.html)
BR (1) BR112014023823B1 (cg-RX-API-DMAC10.html)
CA (1) CA2868445C (cg-RX-API-DMAC10.html)
IN (1) IN2014DN08879A (cg-RX-API-DMAC10.html)
MX (1) MX362918B (cg-RX-API-DMAC10.html)
MY (1) MY183216A (cg-RX-API-DMAC10.html)
NZ (1) NZ626974A (cg-RX-API-DMAC10.html)
PL (1) PL2830589T3 (cg-RX-API-DMAC10.html)
RS (1) RS58677B1 (cg-RX-API-DMAC10.html)
RU (1) RU2625836C2 (cg-RX-API-DMAC10.html)
SG (1) SG11201405958RA (cg-RX-API-DMAC10.html)
SI (1) SI2830589T1 (cg-RX-API-DMAC10.html)
SM (1) SMT201900220T1 (cg-RX-API-DMAC10.html)
UA (1) UA116440C2 (cg-RX-API-DMAC10.html)
WO (1) WO2013143891A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201407677B (cg-RX-API-DMAC10.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3166563T3 (da) * 2014-07-08 2021-02-15 Fertin Pharma As Oralt administrationssystem omfattende to rum
US11007144B2 (en) 2016-11-15 2021-05-18 Klaria Pharma Holding Ab Pharmaceutical formulation
EP3558267B1 (en) * 2016-12-20 2023-04-26 Fertin Pharma A/S A mucoadhesive oromucosal formulation comprising a nicotine complex
GB201808462D0 (en) * 2018-05-23 2018-07-11 Klaria Pharma Holding Ab Pharmaceutical formulation
GB201812499D0 (en) * 2018-07-31 2018-09-12 Nicoventures Holdings Ltd Method of making aerosol-forming substrate
WO2020136062A1 (en) * 2018-12-28 2020-07-02 Philip Morris Products S.A. Nicotine formulation comprising metal salt
WO2020141177A1 (en) * 2018-12-31 2020-07-09 Philip Morris Products S.A. Liquid nicotine formulation comprising water-immiscible solvents
GB201912505D0 (en) * 2019-08-30 2019-10-16 Klaria Pharma Holding Ab Pharmaceutical formulation
SE544672C2 (en) * 2020-05-07 2022-10-11 Liw Innovation Ab New compositions for oral or nasal use
WO2024037043A1 (zh) * 2023-04-28 2024-02-22 深圳华宝协同创新技术研究院有限公司 用于口腔粘膜的包含尼古丁的薄膜组合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010104464A1 (en) * 2009-03-13 2010-09-16 Excellens Tech. Products Aps Oral delivery product

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86170A (en) 1987-05-01 1992-12-01 Elan Transdermal Ltd Preparations and compositions comprising nicotine for percutaneous administration
CA2178021C (en) * 1996-04-19 1999-09-28 Theodore H. Stanley Tobacco substitute
SE9900215D0 (sv) 1999-01-26 1999-01-26 Pharmacia & Upjohn Ab New use
JP5089840B2 (ja) * 2001-09-25 2012-12-05 救急薬品工業株式会社 ニコチン含有フィルム製剤
GB0508306D0 (en) * 2005-04-25 2005-06-01 Bioprogress Technology Ltd Nicotine dosage forms
SE530184C2 (sv) * 2005-12-23 2008-03-18 Kjell Stenberg Bioadhesiv farmaceutisk filmkomposition innehållande lågviskösa alginater
US20080286340A1 (en) * 2007-05-16 2008-11-20 Sven-Borje Andersson Buffered nicotine containing products
US20080286341A1 (en) * 2007-05-16 2008-11-20 Sven-Borje Andersson Buffered coated nicotine containing products
AU2008311350B2 (en) * 2007-10-11 2014-04-03 Philip Morris Products S.A. Smokeless tobacco product
KR20100095581A (ko) * 2007-12-11 2010-08-31 노파르티스 아게 다-영역 필름

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010104464A1 (en) * 2009-03-13 2010-09-16 Excellens Tech. Products Aps Oral delivery product

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Nicotine-loaded sodium alginate–magnesium aluminum silicate (SA–MAS) films: Importance of SA–MAS ratio";Thaned Pongjanyakul et al.;《Carbohydrate Polymers》;20100115;第80卷;第1018-1027页 *

Also Published As

Publication number Publication date
NZ626974A (en) 2016-09-30
AU2013242200B2 (en) 2017-03-02
SI2830589T1 (sl) 2019-06-28
BR112014023823A2 (cg-RX-API-DMAC10.html) 2017-06-20
EP2830589A1 (en) 2015-02-04
KR102038342B1 (ko) 2019-10-30
CA2868445A1 (en) 2013-10-03
JP6412492B2 (ja) 2018-10-24
BR112014023823B1 (pt) 2022-04-26
JP2017226686A (ja) 2017-12-28
CA2868445C (en) 2020-01-28
WO2013143891A1 (en) 2013-10-03
IN2014DN08879A (cg-RX-API-DMAC10.html) 2015-05-22
SMT201900220T1 (it) 2019-07-11
SG11201405958RA (en) 2014-10-30
MX2014010760A (es) 2015-03-20
RU2014143003A (ru) 2016-05-20
CN104411297A (zh) 2015-03-11
RU2625836C2 (ru) 2017-07-19
ZA201407677B (en) 2016-05-25
MY183216A (en) 2021-02-18
KR20140140021A (ko) 2014-12-08
HK1205679A1 (en) 2015-12-24
EP2830589B1 (en) 2019-02-13
AU2013242200A1 (en) 2014-10-16
PL2830589T3 (pl) 2019-07-31
JP2015516948A (ja) 2015-06-18
UA116440C2 (uk) 2018-03-26
US20150096572A1 (en) 2015-04-09
MX362918B (es) 2019-02-26
RS58677B1 (sr) 2019-06-28

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