CN104402905B - 从7‑氨基头孢烷酸母液中回收7‑氨基头孢烷酸的方法 - Google Patents
从7‑氨基头孢烷酸母液中回收7‑氨基头孢烷酸的方法 Download PDFInfo
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- CN104402905B CN104402905B CN201410604543.4A CN201410604543A CN104402905B CN 104402905 B CN104402905 B CN 104402905B CN 201410604543 A CN201410604543 A CN 201410604543A CN 104402905 B CN104402905 B CN 104402905B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
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CN201410604543.4A CN104402905B (zh) | 2014-10-30 | 2014-10-30 | 从7‑氨基头孢烷酸母液中回收7‑氨基头孢烷酸的方法 |
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CN201410604543.4A CN104402905B (zh) | 2014-10-30 | 2014-10-30 | 从7‑氨基头孢烷酸母液中回收7‑氨基头孢烷酸的方法 |
Publications (2)
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CN104402905A CN104402905A (zh) | 2015-03-11 |
CN104402905B true CN104402905B (zh) | 2017-02-01 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104651439A (zh) * | 2015-03-23 | 2015-05-27 | 石药集团中诺药业(石家庄)有限公司 | 一种7-氨基头孢烷酸的酶法制备工艺 |
CN106117245B (zh) * | 2016-06-16 | 2019-01-22 | 天俱时工程科技集团有限公司 | 一种从7-aca结晶母液中直接回收7-aca的方法 |
CN107936041B (zh) * | 2017-12-01 | 2019-08-23 | 焦作健康元生物制品有限公司 | 去乙酰基-7-氨基头孢烷酸母液回收方法 |
CN108129491A (zh) * | 2017-12-25 | 2018-06-08 | 伊犁川宁生物技术有限公司 | 一种7-aca晶体的纯化方法 |
CN113999253B (zh) * | 2021-11-17 | 2023-01-24 | 国药集团威奇达药业有限公司 | N-卤代乙酰-7-aca结晶母液中有效成分的综合回收方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998055484A1 (en) * | 1997-06-04 | 1998-12-10 | Biochemie Gesellschaft Mbh | Improved precipitation process of 7-aminocephalosporanic acid (7-aca) |
CN101747340A (zh) * | 2008-12-18 | 2010-06-23 | 焦作健康元生物制品有限公司 | 7-氨基头孢烷酸溶媒回收工艺 |
CN101768169A (zh) * | 2008-12-30 | 2010-07-07 | 焦作健康元生物制品有限公司 | 用于7-氨基头孢烷酸生产中的母液回收工艺 |
CN102321099A (zh) * | 2011-08-15 | 2012-01-18 | 华北制药河北华民药业有限责任公司 | 一种头孢烷酸的结晶方法 |
CN103014114A (zh) * | 2012-12-27 | 2013-04-03 | 华北制药河北华民药业有限责任公司 | 一种酶法制备7-氨基头孢烷酸的方法 |
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2014
- 2014-10-30 CN CN201410604543.4A patent/CN104402905B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998055484A1 (en) * | 1997-06-04 | 1998-12-10 | Biochemie Gesellschaft Mbh | Improved precipitation process of 7-aminocephalosporanic acid (7-aca) |
CN101747340A (zh) * | 2008-12-18 | 2010-06-23 | 焦作健康元生物制品有限公司 | 7-氨基头孢烷酸溶媒回收工艺 |
CN101768169A (zh) * | 2008-12-30 | 2010-07-07 | 焦作健康元生物制品有限公司 | 用于7-氨基头孢烷酸生产中的母液回收工艺 |
CN102321099A (zh) * | 2011-08-15 | 2012-01-18 | 华北制药河北华民药业有限责任公司 | 一种头孢烷酸的结晶方法 |
CN103014114A (zh) * | 2012-12-27 | 2013-04-03 | 华北制药河北华民药业有限责任公司 | 一种酶法制备7-氨基头孢烷酸的方法 |
Non-Patent Citations (2)
Title |
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大孔吸附树脂法分离7-氨基头孢烷酸和头孢菌素C的条件探索;王益民,等;《中国抗生素杂志》;19950831;第20卷(第4期);第278-281页 * |
用阳离子交换树脂和pH梯度洗脱分离头孢菌素混合物;冯蕾,等;《离子交换与吸附》;20101231;第26卷(第2期);第132-138页 * |
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Inventor after: Hou Hongjie Inventor after: Wei Weijun Inventor after: Wang Mengtan Inventor after: Cheng Junshan Inventor after: Hu Bin Inventor after: Li Jianqiang Inventor after: Wang Gang Inventor after: Yu Peien Inventor before: Hou Hongjie Inventor before: Wei Weijun Inventor before: Wang Mengtan Inventor before: Cheng Junshan Inventor before: Hu Bin Inventor before: Li Jianqiang Inventor before: Wang Gang Inventor before: Yu Peien |
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Effective date of registration: 20171212 Address after: 052165 Hainan Road, Shijiazhuang economic and Technological Development Zone, Shijiazhuang, Hebei Province Patentee after: Hebei's North China Pharmaceutical Pharmaceutical Co. Ltd. Address before: 052165 No. 98, Hainan Road, Shijiazhuang economic and Technological Development Zone, Hebei, China Patentee before: NCPC Hebei Huamin Pharma Co., Ltd. |