CN104382907A - 注射用头孢哌酮钠他唑巴坦钠的加工工艺 - Google Patents

注射用头孢哌酮钠他唑巴坦钠的加工工艺 Download PDF

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CN104382907A
CN104382907A CN201410481478.0A CN201410481478A CN104382907A CN 104382907 A CN104382907 A CN 104382907A CN 201410481478 A CN201410481478 A CN 201410481478A CN 104382907 A CN104382907 A CN 104382907A
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sodium
tazobactam
cefoperazone
processing technique
cefoperazone sodium
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包莹
刘萍
陈继源
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Sichuan Pharmaceutical Inc
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Sichuan Pharmaceutical Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

本发明公开了一种注射用头孢哌酮钠他唑巴坦钠的加工工艺，该加工工艺先干燥头孢哌酮钠原料和他唑巴坦钠原料，再混粉，最后将混合好的头孢哌酮钠和他唑巴坦钠进行分装进准备好的抗生素瓶中压盖处理，压盖后进行灯检包装。本发明的加工工艺简单、成本低，能够有效的节约时间和经济成本，减少工人的劳动强度。

Description

注射用头孢哌酮钠他唑巴坦钠的加工工艺
 
技术领域
本发明涉及医药生物领域，具体地，涉及注射用头孢哌酮钠他唑巴坦钠的加工工艺。
背景技术
头孢哌酮钠的中文别名 7-(((4-乙基-2,3-二氧代-1-哌嗪基)甲酰氨基)(4-羟基苯基)乙酰氨基)-3-((1-甲基-1H-四唑-5-基)硫甲基)-8-氧代-5-硫-1-氮杂双环(4.2.0)辛-2-烯-2-甲酸钠盐，对阴性杆菌产生的广谱β-内酰胺酶有一定的稳定性，但较某些第三代头孢菌素差，抗阴性杆菌的作用优于第一、二代头孢菌素，但对绿脓杆菌有较好的抗菌活性。抗阳性菌的作用不如第一、二代头孢菌素，但对肺炎球菌、化脓性链球菌均有较好的作用。对厌氧菌的抗菌作用较弱。肠球菌及相当比例的肠杆菌科致病菌对该品耐药，支原体、衣原体、军团菌对头孢哌酮均耐药。抗菌性能与头孢噻肟相似。对革兰阳性菌的作用较弱，仅溶血性链球菌和肺炎链球菌较为敏感。对数的革兰阴性菌，该品的作用略次于头孢噻肟，对绿脓杆菌的作用较强。用于敏感产酶菌引起的各种感染的治疗，如呼吸系统、生殖泌尿系统、胆道、胃肠道、胸腹腔、皮肤软组织感染的治疗，及对流感杆菌、脑膜炎球菌引起的脑内感染也有较好的疗效。治疗绿脓杆菌引起的感染，头孢哌酮是一较好的第三代头孢菌素。
他唑巴坦钠与青霉素类和头孢菌素类抗生素具有明显的协同作用，因此临床上常常将他唑巴坦钠和青霉素类、头孢菌素类抗生素联合制剂以增强单一药剂的药效。但现有的注射用头孢哌酮钠他唑巴坦钠的加工工艺复杂，不能有效的节约时间和经济成本。
发明内容
本发明所要解决的技术问题是提供注射用头孢哌酮钠他唑巴坦钠的加工工艺，该加工工艺简单、成本低，能够有效的节约时间和经济成本。
本发明解决上述问题所采用的技术方案是：
注射用头孢哌酮钠他唑巴坦钠的加工工艺，包括以下步骤：
（1） 干燥头孢哌酮钠原料和他唑巴坦钠原料；
（2）再将头孢哌酮钠和他唑巴坦钠按配方比用多向混粉机进行混粉；
（3）洗涤好装粉用的抗生素瓶，并干燥灭菌待用； 
（4）将混合好的头孢哌酮钠和他唑巴坦钠进行分装进准备好的抗生素瓶中压盖处理，压盖后进行灯检包装。
所述混粉后还需进行过筛处理。
经过筛处理的头孢哌酮钠和他唑巴坦钠为80-200目的原料粉。
所述加工工艺的湿度条件为20-30%，温度为18-26℃。
综上，本发明的有益效果是：
本发明加工工艺简单、成本低，能够有效的节约时间和经济成本，减少工人的劳动强度。
具体实施方式
下面结合实施例，对本发明作进一步地的详细说明，但本发明的实施方式不限于此。
实施例1：
注射用头孢哌酮钠他唑巴坦钠的加工工艺，包括以下步骤：
（1） 干燥头孢哌酮钠原料和他唑巴坦钠原料；
（2）再将头孢哌酮钠和他唑巴坦钠按配方比用多向混粉机进行混粉；
（3）洗涤好装粉用的抗生素瓶，并干燥灭菌待用； 
（4）将混合好的头孢哌酮钠和他唑巴坦钠进行分装进准备好的抗生素瓶中压盖处理，压盖后进行灯检包装。
所述混粉后还需进行过筛处理。
经过筛处理的头孢哌酮钠和他唑巴坦钠为80-200目的原料粉。
所述加工工艺的湿度条件为20-30%，温度为18-26℃。

Claims (4)

1.注射用头孢哌酮钠他唑巴坦钠的加工工艺，其特征在于，包括以下步骤：
（1） 干燥头孢哌酮钠原料和他唑巴坦钠原料；
（2）再将头孢哌酮钠和他唑巴坦钠按配方比用多向混粉机进行混粉；
（3）洗涤好装粉用的抗生素瓶，并干燥灭菌待用； 
（4）将混合好的头孢哌酮钠和他唑巴坦钠进行分装进准备好的抗生素瓶中压盖处理，压盖后进行灯检包装。
2.根据权利要求1所述的加工工艺，其特征在于，所述混粉后还需进行过筛处理。
3.根据权利要求2所述的加工工艺，其特征在于，经过筛处理的头孢哌酮钠和他唑巴坦钠为80-200目的原料粉。
4.根据权利要求1-3任一项所述的加工工艺，其特征在于，所述加工工艺的湿度条件为20-30%，温度为18-26℃。
CN201410481478.0A 2014-09-21 2014-09-21 注射用头孢哌酮钠他唑巴坦钠的加工工艺 Pending CN104382907A (zh)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105640963A (zh) * 2016-01-23 2016-06-08 邓爱相 头孢哌酮钠和他唑巴坦钠药物组合物
CN111973558A (zh) * 2020-09-04 2020-11-24 四川制药制剂有限公司 一种注射用头孢哌酮钠他唑巴坦钠的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1868478A (zh) * 2005-05-26 2006-11-29 广东诺康药业有限公司 注射用头孢哌酮钠和他唑巴坦钠复方制剂
CN101348493A (zh) * 2008-09-02 2009-01-21 海南数尔药物研究有限公司 高纯度药物及其制备方法
CN102274233A (zh) * 2011-09-05 2011-12-14 周晓东 一种头孢哌酮钠他唑巴坦钠药物组合物
CN102512374A (zh) * 2011-12-16 2012-06-27 苏州二叶制药有限公司 一种注射用头孢哌酮钠他唑巴坦钠的制备工艺
CN103120692A (zh) * 2011-11-21 2013-05-29 辽宁海思科制药有限公司 一种注射用头孢哌酮钠他唑巴坦钠组合物的制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1868478A (zh) * 2005-05-26 2006-11-29 广东诺康药业有限公司 注射用头孢哌酮钠和他唑巴坦钠复方制剂
CN101348493A (zh) * 2008-09-02 2009-01-21 海南数尔药物研究有限公司 高纯度药物及其制备方法
CN102274233A (zh) * 2011-09-05 2011-12-14 周晓东 一种头孢哌酮钠他唑巴坦钠药物组合物
CN103120692A (zh) * 2011-11-21 2013-05-29 辽宁海思科制药有限公司 一种注射用头孢哌酮钠他唑巴坦钠组合物的制备方法
CN102512374A (zh) * 2011-12-16 2012-06-27 苏州二叶制药有限公司 一种注射用头孢哌酮钠他唑巴坦钠的制备工艺

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105640963A (zh) * 2016-01-23 2016-06-08 邓爱相 头孢哌酮钠和他唑巴坦钠药物组合物
CN111973558A (zh) * 2020-09-04 2020-11-24 四川制药制剂有限公司 一种注射用头孢哌酮钠他唑巴坦钠的制备方法

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Application publication date: 20150304