CN104381334A - Formula and preparation method of micro-capsule suspoemulsion containing abamectin and thymol - Google Patents
Formula and preparation method of micro-capsule suspoemulsion containing abamectin and thymol Download PDFInfo
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- CN104381334A CN104381334A CN201410792831.7A CN201410792831A CN104381334A CN 104381334 A CN104381334 A CN 104381334A CN 201410792831 A CN201410792831 A CN 201410792831A CN 104381334 A CN104381334 A CN 104381334A
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- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 title claims abstract description 106
- 239000005660 Abamectin Substances 0.000 title claims abstract description 60
- 239000003094 microcapsule Substances 0.000 title claims abstract description 57
- 239000005844 Thymol Substances 0.000 title claims abstract description 53
- 229960000790 thymol Drugs 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 title abstract description 7
- 229950008167 abamectin Drugs 0.000 title abstract description 7
- 239000004548 suspo-emulsion Substances 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title 1
- 241001522129 Pinellia Species 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000002904 solvent Substances 0.000 claims abstract description 16
- 239000002270 dispersing agent Substances 0.000 claims abstract description 14
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 14
- 239000002562 thickening agent Substances 0.000 claims abstract description 14
- 239000000080 wetting agent Substances 0.000 claims abstract description 14
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims description 53
- 239000000839 emulsion Substances 0.000 claims description 36
- 239000000725 suspension Substances 0.000 claims description 36
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 16
- 206010011732 Cyst Diseases 0.000 claims description 13
- 240000000233 Melia azedarach Species 0.000 claims description 13
- 208000031513 cyst Diseases 0.000 claims description 13
- 239000013530 defoamer Substances 0.000 claims description 13
- 150000002469 indenes Chemical class 0.000 claims description 13
- 239000003921 oil Substances 0.000 claims description 13
- 235000019198 oils Nutrition 0.000 claims description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 12
- -1 polyoxyethylene monopalmitate Polymers 0.000 claims description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical group [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 claims description 7
- 239000002480 mineral oil Substances 0.000 claims description 7
- 235000010446 mineral oil Nutrition 0.000 claims description 7
- 229920001289 polyvinyl ether Polymers 0.000 claims description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 5
- 239000000375 suspending agent Substances 0.000 claims description 5
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 241001454293 Tetranychus urticae Species 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 241000985245 Spodoptera litura Species 0.000 claims description 3
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 238000002137 ultrasound extraction Methods 0.000 claims description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 2
- LWEAHXKXKDCSIE-UHFFFAOYSA-M 2,3-di(propan-2-yl)naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S([O-])(=O)=O)=C(C(C)C)C(C(C)C)=CC2=C1 LWEAHXKXKDCSIE-UHFFFAOYSA-M 0.000 claims description 2
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 claims description 2
- RNMDNPCBIKJCQP-UHFFFAOYSA-N 5-nonyl-7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-ol Chemical compound C(CCCCCCCC)C1=C2C(=C(C=C1)O)O2 RNMDNPCBIKJCQP-UHFFFAOYSA-N 0.000 claims description 2
- 244000215068 Acacia senegal Species 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 229920001817 Agar Polymers 0.000 claims description 2
- 241001124076 Aphididae Species 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 2
- 241001517923 Douglasiidae Species 0.000 claims description 2
- 229920000084 Gum arabic Polymers 0.000 claims description 2
- 244000147568 Laurus nobilis Species 0.000 claims description 2
- 235000017858 Laurus nobilis Nutrition 0.000 claims description 2
- 239000004640 Melamine resin Substances 0.000 claims description 2
- 229920000877 Melamine resin Polymers 0.000 claims description 2
- 241000357318 Melanagromyza sojae Species 0.000 claims description 2
- 239000004368 Modified starch Substances 0.000 claims description 2
- 229920000881 Modified starch Polymers 0.000 claims description 2
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims description 2
- 235000007164 Oryza sativa Nutrition 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 241000907661 Pieris rapae Species 0.000 claims description 2
- 241000500437 Plutella xylostella Species 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 235000005212 Terminalia tomentosa Nutrition 0.000 claims description 2
- 241001414989 Thysanoptera Species 0.000 claims description 2
- 239000000205 acacia gum Substances 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
- 239000008272 agar Substances 0.000 claims description 2
- 235000010419 agar Nutrition 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 229920005551 calcium lignosulfonate Polymers 0.000 claims description 2
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 229920006184 cellulose methylcellulose Polymers 0.000 claims description 2
- 239000008367 deionised water Substances 0.000 claims description 2
- 229910021641 deionized water Inorganic materials 0.000 claims description 2
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- MPVXINJRXRIDDB-VCDGYCQFSA-N dodecanoic acid;(2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCCCCCC(O)=O MPVXINJRXRIDDB-VCDGYCQFSA-N 0.000 claims description 2
- 239000000017 hydrogel Substances 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 235000019426 modified starch Nutrition 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 2
- 239000005056 polyisocyanate Substances 0.000 claims description 2
- 229920001228 polyisocyanate Polymers 0.000 claims description 2
- 229940099429 polyoxyl 40 stearate Drugs 0.000 claims description 2
- 229920001451 polypropylene glycol Polymers 0.000 claims description 2
- 235000009566 rice Nutrition 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 238000002791 soaking Methods 0.000 claims description 2
- 239000001488 sodium phosphate Substances 0.000 claims description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 2
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 239000013638 trimer Substances 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 210000002268 wool Anatomy 0.000 claims description 2
- 241000238631 Hexapoda Species 0.000 abstract description 4
- 230000000749 insecticidal effect Effects 0.000 abstract description 4
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 3
- 239000000575 pesticide Substances 0.000 abstract description 2
- 239000002018 neem oil Substances 0.000 abstract 2
- 239000002518 antifoaming agent Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 150000001875 compounds Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 6
- 239000003905 agrochemical Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 241000244206 Nematoda Species 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000004495 emulsifiable concentrate Substances 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 238000010008 shearing Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000013270 controlled release Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
- 208000035943 Aphagia Diseases 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 230000003129 miticidal effect Effects 0.000 description 1
- 230000007830 nerve conduction Effects 0.000 description 1
- 230000036403 neuro physiology Effects 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 239000004476 plant protection product Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
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- 239000001585 thymus vulgaris Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to micro-capsule suspoemulsion, in particular to a formula and a preparation method of the micro-capsule suspoemulsion containing abamectin, thymol, neem oil and raw pinellia ternate active ingredients. The micro-capsule suspoemulsion comprises components in percentage by weight as follows: 0.5%-3% of the abamectin, 1%-30% of the thymol, 5%-10% of the neem oil, 5%-10% of the raw pinellia ternate active ingredients, 2%-9% of a capsule wall material, 10%-30% of a solvent, 3%-8% of an emulsifier, 2%-5% of a dispersing agent, 0.5%-2% of a wetting agent, 2%-6% of a thickener, 0.15%-0.5% of an antifoaming agent and the balance of water. The abamectin and the thymol have a synergy function, the compound function is obvious, the using amount of pesticides is reduced greatly, an insecticidal spectrum can be enlarged, and the insect killing efficiency can be increased.
Description
Technical field
The present invention relates to a kind of composite micro-capsule suspension emulsion, the formula of the micro-capsule suspension emulsion particularly containing Avermectin, Thymol, indenes chinaberry oil, raw tuber of pinellia active component, and preparation method.
Background technology
Avermectin is a kind of ten hexa-atomic Macrocyclic lactone compounds, belongs to a class antibiotic that is efficient, wide spectrum, has desinsection, kills mite, eelworm-killing activity.It can disturb the neurophysiology of the animals such as worm, mite, nematode movable, discharges γ-aminobutyric acid, suppress its nerve conduction to cause paralysis then stiff, aphagia under stimulation, 2 ~ 4 days can be dead.Avermectin energy broad-spectrum high efficacy ground desinsection, kill mite, kill nematode, also have at plant surface residual few, the features such as little are damaged to beneficial insect, makes it can play in economic crops and field crop and important effect, in the agricultural chemicals insect countermeasure system of China, occupy more important status.But unreasonable and blindness uses Avermectin to cause the animal intraindividual variations such as worm, mite, nematode for a long time, makes it develop immunity to drugs to Avermectin single dose.Along with drug-fast increase, Avermectin single dose also develops into present 8% from initial amount 0.1% in 2000, and dosage also increases increasingly, thus causes the residual problem such as to exceed standard of crop, is unfavorable for environment sustainable development.
Thymol is a separation and Extraction class plant resource active component out from thyme, and can degrade in large natural environment, pleasant aroma, has very strong sterilization and insecticidal action.Its safety is very high, toxicity is also lower, on June 19th, 2013, and EU Committee has ratified Thymol to put on market as plant protection products.Thymol is used for processing wound at present, makes preservative, medical bactericide, stores dissec, pest repellant and spices etc.Zhang Jing, Feng Gang etc. of Geng You Research Institute of Environment and Plant Protection, Chinese Academy of Tropi invent thymol mite-killing microemulsion Thymol research, and its miticidal effect clearly.
The method that solution pesticide resistance is commonly used is undertaken composite by the active ingredient of the different mechanism of action.Provided by the invention a kind ofly have synergistic function containing Avermectin and Thymol in the micro-capsule suspension emulsion of Avermectin and Thymol, and complex role is obvious, greatly reduces the dosage of agricultural chemicals, also can expand insecticidal spectrum, improves insecticide efficiency.The invention provides a kind of micro-capsule suspension emulsion, wherein the effect of micro-capsule is that suppression causes the decomposition of active component because of environmental factor and other factors etc., improves the stability of medicament itself; Controlled release release can extend its lasting period, reduce quantity and the frequency of dispenser, improve the pressure of agricultural chemicals to environment.And about the micro-capsule suspension emulsion of Avermectin and Thymol, there is not yet relevant report at home and abroad at present.
A kind of micro-capsule suspension emulsion containing Avermectin and Thymol provided by the present invention, it all has excellent control efficiency to the harmful mite insect of thin dish, fruit tree, particularly has good control efficiency to two spotted spider mite, blister mite, tarsonemid, thrips, Americal rice leaf miner, M. sojae, aphid, diamond-back moth, imported cabbageworm, prodenia litura etc.
Summary of the invention
The invention provides and a kind of there is low, the effective micro-capsule suspension emulsion containing Avermectin and Thymol of synergistic function, use cost.
A kind of micro-capsule suspension emulsion containing Avermectin and Thymol provided by the present invention, is made up of the component of following weight percent:
Avermectin 0.5 ~ 8%,
Thymol 1% ~ 30%,
Indenes chinaberry oil 2% ~ 19%,
Raw tuber of pinellia active component 1% ~ 20%,
Cyst material 1 ~ 15%,
Solvent 5% ~ 40%,
Emulsifier 1% ~ 8%,
Dispersant 0.5% ~ 5%,
Wetting agent 0.1% ~ 5%
Thickener 0.5% ~ 6%,
Defoamer 0.1% ~ 0.5%,
Surplus is water.
Described cyst material is that one or more in Lauxite, polyisocyanates, gelatin, modified starch, gum Arabic or melamine resin mix arbitrarily.Solvent is that one or more in toluene, acetone, isopropyl alcohol, chloroform, ethanol, methyl alcohol, cyclohexane mix arbitrarily.Emulsifier is anhydrous sorbitol laurate, one or more in Tripolyglycerol monostearates, polyoxyethylene monopalmitate, polyoxyethylene laurel ether, polyoxypropylene wool alcohol ether, polyoxyl 40 stearate mix arbitrarily.Dispersant is sodium lignin sulfonate, one or more in calcium lignosulfonate, alkylphenol-polyethenoxy base phosphate, sodium phosphate trimer mix arbitrarily.Wetting agent is that one or more in lauryl sodium sulfate, DBSA, nekal, dioctyl sodium sulfosuccinate mix arbitrarily.Thickener is that one or more in starch, pectin, agar, gelatin, methylcellulose, Sodium Polyacrylate, white carbon, Silica hydrogel, carbomer, CMC, polyvinylether mix arbitrarily.Defoamer is that one or more in mineral oil, vegetable oil, polyoxyethylene nonylphenol ether, higher alcohols mix arbitrarily.Water is the one in running water, distilled water or deionized water.The weight percentage of described Thymol is preferably 10 ~ 20%.Described cyst material is Lauxite.Described solvent is preferably the one in ethanol or methyl alcohol.Described emulsifier is preferably Tripolyglycerol monostearates.Described dispersant is preferably sodium lignin sulfonate.Described wetting agent is preferably DBSA.Described thickener is preferably polyvinylether.Described defoamer is preferably mineral oil.The weight percentage of described Avermectin is preferably 1% ~ 3%.The weight percentage of described Thymol is preferably 10% ~ 20%.The weight percentage of described indenes chinaberry oil is preferably 5% ~ 9%.The weight percentage of described raw tuber of pinellia active component is preferably 5% ~ 10%.The weight percentage of described cyst material is preferably 2 ~ 6%.The weight percentage of described solvent is preferably 10% ~ 30%.The weight percentage of described emulsifier is preferably 3% ~ 6%.The weight percentage of described dispersant is preferably 1% ~ 3%.The weight percentage of described wetting agent is preferably 0.5% ~ 2%.The weight percentage of described thickener is preferably 1% ~ 3%.The weight percentage of described defoamer is preferably 0.15% ~ 0.25%.
The invention provides a kind of micro-capsule suspension emulsion containing Avermectin and Thymol, wherein in formula, the extracting method of raw tuber of pinellia active component first the life tuber of pinellia is cleaned oven dry to pulverize 100 mesh sieves and obtain giving birth to Pinellia Tuber, add ammoniacal liquor, after stirring, add a certain amount of chloroform, after cold soaking 3h, ultrasonic extraction 1h under ice bath, filter, at 80 DEG C, reclaim chloroform evaporate to dryness gains is exactly raw tuber of pinellia active component.
A kind of preparation method containing the micro-capsule suspension emulsion of Avermectin and Thymol provided by the present invention, that Avermectin and raw tuber of pinellia active component are added in solvent, cyst material is added under insulated and stirred, the spraying dry that sieves obtains micro-capsule, in micro-capsule, add dispersant, wetting agent and water make avermectin microcapsule suspending agent, take out for subsequent use, fixing tentatively is I.Emulsifier, thickener, defoamer be added to the water and stir to dissolving completely, take out for subsequent use, fixing tentatively is II.Thymol, indenes chinaberry oil add in solvent and stir to dissolving completely, and take out for subsequent use, fixing tentatively is III. and add III in II, high speed shear, then add I, mix and obtain the micro-capsule suspension emulsion of Avermectin and Thymol.
The invention provides a kind of micro-capsule suspension emulsion, wherein the effect of micro-capsule is that suppression causes the decomposition of active component because of environmental factor and other factors etc., improves the stability of medicament itself; Controlled release release can extend its lasting period, reduce quantity and the frequency of dispenser, improve the pressure of agricultural chemicals to environment.
Embodiment
Embodiment one: the extraction of raw tuber of pinellia active component is cleaned by raw for the 10kg tuber of pinellia to dry in an oven, in disintegrating machine, 100 mesh sieves are crossed in fragmentation, the ammoniacal liquor of 12% is added in the raw Pinellia Tuber stirring of gained, treat its moistening chloroform evenly adding 180L again, soak 3h at 4 DEG C, under ice bath, have ultrasonic extraction 1h, filter, 80 DEG C are reclaimed chloroform evaporate to dryness, and gains are exactly raw tuber of pinellia active component.
Embodiment two: a kind of micro-capsule suspension emulsion containing Avermectin and Thymol provided by the present invention, is made up of the component of following weight percent:
Avermectin 2%,
Thymol 10%,
Indenes chinaberry oil 6%,
Raw tuber of pinellia active component 6%,
Cyst material 3%,
Solvent 18%,
Emulsifier 5%,
Dispersant 2%,
Wetting agent 1%,
Thickener 2%,
Defoamer 0.2%,
Surplus is water.
0.2kg Avermectin and the raw tuber of pinellia active component of 0.6kg are added in 1L ethanol, 0.3kg Lauxite is added under insulated and stirred, the spraying dry that sieves obtains micro-capsule, in micro-capsule, add 0.2kg sodium lignin sulfonate, 0.1kg DBSA and enough water stirs to dissolving obtained avermectin microcapsule suspending agent completely, take out for subsequent use, fixing tentatively is I.0.2kg Tripolyglycerol monostearates, 0.2kg polyvinylether, 0.02kg mineral oil, be added to the water and stir to dissolving completely, takes out for subsequent use, and fixing tentatively is II.Add 1kg Thymol, 0.6kg indenes chinaberry oil adds 0.8L ethanol and stir to dissolving completely, take out for subsequent use, fixing tentatively is III. add III in II, use high-speed shearing Mixer high speed shear, add I again, namely shear-mixed evenly obtains the micro-capsule suspension emulsion of Avermectin and Thymol.
Embodiment three: a kind of micro-capsule suspension emulsion containing Avermectin and Thymol provided by the present invention, is made up of the component of following weight percent:
Avermectin 2%,
Thymol 15%,
Indenes chinaberry oil 6%,
Raw tuber of pinellia active component 6%,
Cyst material 3%,
Solvent 20%,
Emulsifier 7%,
Dispersant 3%,
Wetting agent 1.5%,
Thickener 3%,
Defoamer 0.4%,
Surplus is water.
0.2kg Avermectin and the raw tuber of pinellia active component of 0.6kg are added in 1L ethanol, 0.3kg Lauxite is added under insulated and stirred, the spraying dry that sieves obtains micro-capsule, in micro-capsule, add 0.3kg sodium lignin sulfonate, 0.15kg DBSA and enough water stirs to dissolving obtained avermectin microcapsule suspending agent completely, take out for subsequent use, fixing tentatively is I.0.7kg Tripolyglycerol monostearates, 0.2kg polyvinylether, 0.04kg mineral oil, be added to the water and stir to dissolving completely, takes out for subsequent use, and fixing tentatively is II.Add 1.5kg Thymol, the stirring of 0.6kg indenes chinaberry oil adds 1L ethanol evenly to dissolving completely, take out for subsequent use, fixing tentatively is III. add III in II, use high-speed shearing Mixer high speed shear, add I again, namely shear-mixed evenly obtains the micro-capsule suspension emulsion of Avermectin and Thymol.
Embodiment four: a kind of micro-capsule suspension emulsion containing Avermectin and Thymol provided by the present invention, is made up of the component of following weight percent:
Avermectin 2%,
Thymol 20%,
Indenes chinaberry oil 6%,
Raw tuber of pinellia active component 6%,
Cyst material 3%,
Solvent 25%,
Emulsifier 8%,
Dispersant 5%,
Wetting agent 2.5%,
Thickener 3%,
Defoamer 0.4%,
Surplus is water.
0.2kg Avermectin and the raw tuber of pinellia active component of 0.6kg are added in 1L ethanol, 0.3kg Lauxite is added under insulated and stirred, the spraying dry that sieves obtains micro-capsule, in micro-capsule, add 0.5kg sodium lignin sulfonate, 0.25kg DBSA and enough water stirs to dissolving obtained avermectin microcapsule suspending agent completely, take out for subsequent use, fixing tentatively is I.0.8kg Tripolyglycerol monostearates, 0.3kg polyvinylether, 0.04kg mineral oil, be added to the water and stir to dissolving completely, takes out for subsequent use, and fixing tentatively is II.Add 2kg Thymol, 0.6kg indenes chinaberry oil adds 1.5L ethanol and stir to dissolving completely, take out for subsequent use, fixing tentatively is III. add III in II, use high-speed shearing Mixer high speed shear, add I again, namely shear-mixed evenly obtains the micro-capsule suspension emulsion of Avermectin and Thymol.
Get the micro-capsule suspension emulsion that above embodiment joins and do following indoor pharmacodynamic test and field trial, wherein the micro-capsule suspension emulsion of 2% Avermectin that is made into of embodiment two and 10% Thymol is A, the micro-capsule suspension emulsion of 2% Avermectin that embodiment three is made into and 15% Thymol is B, and the micro-capsule suspension emulsion of 2% Avermectin that embodiment four is made into and 20% Thymol is C.
Embodiment five: the micro-capsule suspension emulsion of the Avermectin be made in embodiment two, three, four and Thymol is done indoor pharmacodynamic test to two spotted spider mite, contrasts with 2% abamectin emulsifiable concentrate.Result of the test is in table one.
Table one:
A, B, C of the present invention tri-kinds of Avermectin are more much better than the effect of 2% abamectin emulsifiable concentrate with the insecticidal effect of the micro-capsule suspension emulsion of Thymol as can be known from the above table, especially C best results, and C is the micro-capsule suspension emulsion of 2% Avermectin and 20% Thymol.
Embodiment six: the micro-capsule suspension emulsion of the Avermectin be made in embodiment two, three, four and Thymol is carried out field trial.2% abamectin emulsifiable concentrate contrasts.Experiment place: Sanya, Hainan, object of experiment: tomato two spotted spider mite, result of the test is in table two:
From upper table, the micro-capsule suspension emulsion of known Avermectin of the present invention and Thymol is given prominence to banana prodenia litura preventive effect, and the lasting period can reach more than 14 days, and the effect of C is the most outstanding, and C is the micro-capsule suspension emulsion of 2% Avermectin and 20% Thymol.
Claims (4)
1. a kind of micro-capsule suspension emulsion containing Avermectin and Thymol provided by the present invention, is made up of the component of following weight percent:
Avermectin 0.5 ~ 8%,
Thymol 1% ~ 30%,
Indenes chinaberry oil 2% ~ 19%,
Raw tuber of pinellia active component 1% ~ 20%,
Cyst material 1 ~ 15%,
Solvent 5% ~ 40%,
Emulsifier 1% ~ 8%,
Dispersant 0.5% ~ 5%,
Wetting agent 0.1% ~ 5%
Thickener 0.5% ~ 6%,
Defoamer 0.1% ~ 0.5%,
Surplus is water,
It is characterized in that described cyst material is that one or more in Lauxite, polyisocyanates, gelatin, modified starch, gum Arabic or melamine resin mix arbitrarily; Described cyst material is preferably Lauxite; Solvent is that one or more in toluene, acetone, isopropyl alcohol, chloroform, ethanol, methyl alcohol, cyclohexane mix arbitrarily; Described solvent is preferably the one in ethanol or methyl alcohol; Emulsifier is anhydrous sorbitol laurate, one or more in Tripolyglycerol monostearates, polyoxyethylene monopalmitate, polyoxyethylene laurel ether, polyoxypropylene wool alcohol ether, polyoxyl 40 stearate mix arbitrarily; Described emulsifier is preferably Tripolyglycerol monostearates; Dispersant is sodium lignin sulfonate, one or more in calcium lignosulfonate, alkylphenol-polyethenoxy base phosphate, sodium phosphate trimer mix arbitrarily; Described dispersant is preferably sodium lignin sulfonate; Wetting agent is that one or more in lauryl sodium sulfate, DBSA, nekal, dioctyl sodium sulfosuccinate mix arbitrarily; Described wetting agent is preferably DBSA; Thickener is that one or more in starch, pectin, agar, gelatin, methylcellulose, Sodium Polyacrylate, white carbon, Silica hydrogel, carbomer, CMC, polyvinylether mix arbitrarily; Described thickener is preferably polyvinylether; Defoamer is that one or more in mineral oil, vegetable oil, polyoxyethylene nonylphenol ether, higher alcohols mix arbitrarily; Described defoamer is preferably mineral oil; Water is the one in running water, distilled water or deionized water; The weight percentage of described Avermectin is preferably 1% ~ 3%; The weight percentage of described Thymol is preferably 10% ~ 20%; The weight percentage of described indenes chinaberry oil is preferably 5% ~ 9%; The weight percentage of described raw tuber of pinellia active component is preferably 5% ~ 10%; The weight percentage of described cyst material is preferably 2 ~ 6%; The weight percentage of described solvent is preferably 10% ~ 30%; The weight percentage of described emulsifier is preferably 3% ~ 6%; The weight percentage of described dispersant is preferably 1% ~ 3%; The weight percentage of described wetting agent is preferably 0.5% ~ 2%; The weight percentage of described thickener is preferably 1% ~ 3%; The weight percentage of described defoamer is preferably 0.15% ~ 0.25%.
2. according to a kind of micro-capsule suspension emulsion containing Avermectin and Thymol described in claim 1, it is characterized in that the extracting method of described raw tuber of pinellia active component first the life tuber of pinellia is cleaned oven dry to pulverize 100 mesh sieves and obtain raw Pinellia Tuber, add 12% ammoniacal liquor, after stirring, add the chloroform of 18 times of volumes, after cold soaking 3h, ultrasonic extraction 1h under ice bath, filter, at 80 DEG C, reclaim chloroform evaporate to dryness gains is exactly raw tuber of pinellia active component.
3. according to a kind of micro-capsule suspension emulsion containing Avermectin and Thymol described in claim 1, it is characterized in that the preparation method of described micro-capsule suspension emulsion, that Avermectin and raw tuber of pinellia active component are added in solvent, cyst material is added under insulated and stirred, the spraying dry that sieves obtains micro-capsule, in micro-capsule, add dispersant, wetting agent and water make avermectin microcapsule suspending agent, take out for subsequent use, fixing tentatively is I; Emulsifier, thickener, defoamer be added to the water and stir to dissolving completely, take out for subsequent use, fixing tentatively is II; Thymol, indenes chinaberry oil add in solvent and stir to dissolving completely, and take out for subsequent use, fixing tentatively is III; Add III in II, high speed shear, then add I, mix and obtain the micro-capsule suspension emulsion of Avermectin and Thymol.
4., according to a kind of micro-capsule suspension emulsion containing Avermectin and Thymol described in claim 1, it is characterized in that described micro-capsule suspension emulsion has good control efficiency to two spotted spider mite, blister mite, tarsonemid, thrips, Americal rice leaf miner, M. sojae, aphid, diamond-back moth, imported cabbageworm, prodenia litura etc.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105123699A (en) * | 2015-10-22 | 2015-12-09 | 唐睿 | Miticide and insecticide composite containing thymol and pyriproxyfen |
| CN105638648A (en) * | 2016-01-08 | 2016-06-08 | 广州市生物防治站 | Thymol-emamectin benzoate emulsion in water |
| CN106035239A (en) * | 2016-05-30 | 2016-10-26 | 中国农业大学 | Method for studying influences exerted by approach-avoidance substances on oviposition behaviors of diamondback moths |
| PL422293A1 (en) * | 2017-07-21 | 2019-01-28 | Instytut Inżynierii Materiałów Polimerowych I Barwników | Method for producing biodegradable carrier with insecticidal properties against Alphitobius diaperinus Panzer |
| CN109833296A (en) * | 2019-03-28 | 2019-06-04 | 佛山市正典生物技术有限公司 | Can the new merit chigger disease of prevention and control plants essential oil microemulsion formulation and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1676001A (en) * | 2005-05-10 | 2005-10-05 | 龚鸿昌 | Nim oil-water emulsion and its use |
| CN102224830A (en) * | 2011-05-30 | 2011-10-26 | 杨凌农科大无公害农药研究服务中心 | Plant source synergistic complex acaricide and preparation method thereof |
| CN103563892A (en) * | 2013-10-14 | 2014-02-12 | 广东中迅农科股份有限公司 | Novel water-based preparation formulation of methylamino abamectin benzoate |
-
2014
- 2014-12-20 CN CN201410792831.7A patent/CN104381334B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1676001A (en) * | 2005-05-10 | 2005-10-05 | 龚鸿昌 | Nim oil-water emulsion and its use |
| CN102224830A (en) * | 2011-05-30 | 2011-10-26 | 杨凌农科大无公害农药研究服务中心 | Plant source synergistic complex acaricide and preparation method thereof |
| CN103563892A (en) * | 2013-10-14 | 2014-02-12 | 广东中迅农科股份有限公司 | Novel water-based preparation formulation of methylamino abamectin benzoate |
Non-Patent Citations (1)
| Title |
|---|
| 中国土农药志编辑委员会: "《中国土农药志》", 31 May 1959, 科学出版社 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105123699A (en) * | 2015-10-22 | 2015-12-09 | 唐睿 | Miticide and insecticide composite containing thymol and pyriproxyfen |
| CN105123699B (en) * | 2015-10-22 | 2017-03-29 | 海南博士威农用化学有限公司 | A kind of insecticide and acaricide containing thymol and Nylar |
| CN105638648A (en) * | 2016-01-08 | 2016-06-08 | 广州市生物防治站 | Thymol-emamectin benzoate emulsion in water |
| CN105638648B (en) * | 2016-01-08 | 2018-05-18 | 广州市生物防治站 | A kind of Thymol-emamectin-benzoate aqueous emulsion |
| CN106035239A (en) * | 2016-05-30 | 2016-10-26 | 中国农业大学 | Method for studying influences exerted by approach-avoidance substances on oviposition behaviors of diamondback moths |
| CN106035239B (en) * | 2016-05-30 | 2018-11-09 | 中国农业大学 | A method of research walks quickly and keeps away substance to Oviposition of Diamondback Moth behavioral implications |
| PL422293A1 (en) * | 2017-07-21 | 2019-01-28 | Instytut Inżynierii Materiałów Polimerowych I Barwników | Method for producing biodegradable carrier with insecticidal properties against Alphitobius diaperinus Panzer |
| CN109833296A (en) * | 2019-03-28 | 2019-06-04 | 佛山市正典生物技术有限公司 | Can the new merit chigger disease of prevention and control plants essential oil microemulsion formulation and preparation method thereof |
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