CN104381334B - Formula and preparation method of micro-capsule suspoemulsion containing abamectin and thymol - Google Patents
Formula and preparation method of micro-capsule suspoemulsion containing abamectin and thymol Download PDFInfo
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- CN104381334B CN104381334B CN201410792831.7A CN201410792831A CN104381334B CN 104381334 B CN104381334 B CN 104381334B CN 201410792831 A CN201410792831 A CN 201410792831A CN 104381334 B CN104381334 B CN 104381334B
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- thymol
- avilamycin
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- suspension emulsion
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- 239000003094 microcapsule Substances 0.000 title claims abstract description 48
- MGSRCZKZVOBKFT-UHFFFAOYSA-N Thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 239000005844 Thymol Substances 0.000 title claims abstract description 46
- 229960000790 thymol Drugs 0.000 title claims abstract description 46
- 229930007823 thymol Natural products 0.000 title claims abstract description 46
- 239000005660 Abamectin Substances 0.000 title abstract description 12
- 229950008167 Abamectin Drugs 0.000 title abstract description 7
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title abstract description 7
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 239000004548 suspo-emulsion Substances 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000004190 Avilamycin Substances 0.000 claims description 38
- XIRGHRXBGGPPKY-OTPQUNEMSA-N [(2R,3S,4R,6S)-6-[(2'R,3'S,3aR,4R,4'R,6S,7aR)-6-[(2S,3R,4R,5S,6R)-2-[(2R,3S,4S,5S,6S)-6-[(2R,3aS,3'aR,6'R,7R,7'S,7aR,7'aR)-7'-acetyl-7'-hydroxy-6'-methyl-7-(2-methylpropanoyloxy)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,4'-6,7a-dihydro-3aH- Chemical compound O([C@H]1[C@H](O)C[C@@H](O[C@@H]1C)O[C@H]1[C@H](O)CC2(O[C@]3(C)C[C@@H](O[C@H](C)[C@H]3O2)O[C@H]2[C@@H](OC)[C@@H](C)O[C@H]([C@@H]2O)O[C@H]2[C@H](O)[C@H](OC)[C@H](OC3[C@@H]([C@@H]4O[C@]5(O[C@H]4CO3)[C@@H]3OCO[C@H]3[C@@](O)([C@@H](C)O5)C(C)=O)OC(=O)C(C)C)O[C@@H]2COC)O[C@@H]1C)C(=O)C1=C(C)C(Cl)=C(O)C(Cl)=C1OC XIRGHRXBGGPPKY-OTPQUNEMSA-N 0.000 claims description 38
- 229960005185 avilamycin Drugs 0.000 claims description 38
- 235000019379 avilamycin Nutrition 0.000 claims description 38
- 239000000839 emulsion Substances 0.000 claims description 29
- 239000000725 suspension Substances 0.000 claims description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 240000000233 Melia azedarach Species 0.000 claims description 11
- 239000003921 oil Substances 0.000 claims description 11
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2R)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 claims description 6
- 239000002480 mineral oil Substances 0.000 claims description 6
- 235000010446 mineral oil Nutrition 0.000 claims description 6
- 229920001289 polyvinyl ether Polymers 0.000 claims description 6
- 241000488583 Panonychus ulmi Species 0.000 claims description 3
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims 2
- SRSXLGNVWSONIS-UHFFFAOYSA-N Benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 claims 1
- 229940092714 benzenesulfonic acid Drugs 0.000 claims 1
- 150000002469 indenes Chemical class 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 10
- 239000002904 solvent Substances 0.000 abstract description 10
- 239000002270 dispersing agent Substances 0.000 abstract description 9
- 239000003995 emulsifying agent Substances 0.000 abstract description 9
- 239000002562 thickening agent Substances 0.000 abstract description 9
- 239000000080 wetting agent Substances 0.000 abstract description 9
- 230000000749 insecticidal Effects 0.000 abstract description 5
- 239000000575 pesticide Substances 0.000 abstract description 5
- 241000238631 Hexapoda Species 0.000 abstract description 4
- 238000001228 spectrum Methods 0.000 abstract description 4
- 241001522129 Pinellia Species 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000002018 neem oil Substances 0.000 abstract 2
- 239000002518 antifoaming agent Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 150000001875 compounds Chemical group 0.000 abstract 1
- HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 125000003454 indenyl group Chemical class C1(C=CC2=CC=CC=C12)* 0.000 description 10
- 235000019198 oils Nutrition 0.000 description 10
- 206010011732 Cyst Diseases 0.000 description 8
- -1 lactone compounds Chemical class 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- KWKXNDCHNDYVRT-UHFFFAOYSA-N Dodecylbenzene Chemical group CCCCCCCCCCCCC1=CC=CC=C1 KWKXNDCHNDYVRT-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000012467 final product Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000001694 spray drying Methods 0.000 description 4
- 239000000375 suspending agent Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 239000004495 emulsifiable concentrate Substances 0.000 description 3
- 230000002045 lasting Effects 0.000 description 3
- 239000005645 nematicide Substances 0.000 description 3
- 238000010008 shearing Methods 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-N sulfonic acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 3
- 210000000481 Breast Anatomy 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 241000985245 Spodoptera litura Species 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 230000003285 pharmacodynamic Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000002195 synergetic Effects 0.000 description 2
- HBGPNLPABVUVKZ-POTXQNELSA-N (1R,3aS,4S,5aR,5bR,7R,7aR,11aR,11bR,13aS,13bR)-4,7-dihydroxy-3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-2,3,4,5,6,7,7a,10,11,11b,12,13,13a,13b-tetradecahydro-1H-cyclopenta[a]chrysen-9-one Chemical compound C([C@@]12C)CC(=O)C(C)(C)[C@@H]1[C@H](O)C[C@]([C@]1(C)C[C@@H]3O)(C)[C@@H]2CC[C@H]1[C@@H]1[C@]3(C)CC[C@H]1C(=C)C HBGPNLPABVUVKZ-POTXQNELSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2R,3R,4S,5R,6S)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2S,3R,4S,5R,6R)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2R,3R,4S,5R,6R)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- QZEDXQFZACVDJE-UHFFFAOYSA-N 2,3-dibutylnaphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(O)(=O)=O)=C(CCCC)C(CCCC)=CC2=C1 QZEDXQFZACVDJE-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 206010049866 Aphagia Diseases 0.000 description 1
- 241001124076 Aphididae Species 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butanoic acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- 229960001631 Carbomer Drugs 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M Dioctyl sodium sulfosuccinate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 241001517923 Douglasiidae Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 240000001422 Laurus nobilis Species 0.000 description 1
- 235000017858 Laurus nobilis Nutrition 0.000 description 1
- 229920000877 Melamine resin Polymers 0.000 description 1
- 239000004640 Melamine resin Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- 210000001834 NPE Anatomy 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 240000005158 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 241000255969 Pieris brassicae Species 0.000 description 1
- 241000500437 Plutella xylostella Species 0.000 description 1
- 229920001228 Polyisocyanate Polymers 0.000 description 1
- 229920001451 Polypropylene glycol Polymers 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M Sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 1
- 241001414989 Thysanoptera Species 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000000507 anthelmentic Effects 0.000 description 1
- 230000000844 anti-bacterial Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000003115 biocidal Effects 0.000 description 1
- 229920005551 calcium lignosulfonate Polymers 0.000 description 1
- 239000004490 capsule suspension Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 230000002508 compound effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- MPVXINJRXRIDDB-VCDGYCQFSA-N dodecanoic acid;(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCCCCCC(O)=O MPVXINJRXRIDDB-VCDGYCQFSA-N 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M palmitate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 244000045947 parasites Species 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- HWGNBUXHKFFFIH-UHFFFAOYSA-I pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O HWGNBUXHKFFFIH-UHFFFAOYSA-I 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000004476 plant protection product Substances 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920001888 polyacrylic acid Polymers 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 239000005056 polyisocyanate Substances 0.000 description 1
- 230000002335 preservative Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003449 preventive Effects 0.000 description 1
- 230000004224 protection Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000001954 sterilising Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- YXFVVABEGXRONW-UHFFFAOYSA-N toluene Substances CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Abstract
The invention relates to micro-capsule suspoemulsion, in particular to a formula and a preparation method of the micro-capsule suspoemulsion containing abamectin, thymol, neem oil and raw pinellia ternate active ingredients. The micro-capsule suspoemulsion comprises components in percentage by weight as follows: 0.5%-3% of the abamectin, 1%-30% of the thymol, 5%-10% of the neem oil, 5%-10% of the raw pinellia ternate active ingredients, 2%-9% of a capsule wall material, 10%-30% of a solvent, 3%-8% of an emulsifier, 2%-5% of a dispersing agent, 0.5%-2% of a wetting agent, 2%-6% of a thickener, 0.15%-0.5% of an antifoaming agent and the balance of water. The abamectin and the thymol have a synergy function, the compound function is obvious, the using amount of pesticides is reduced greatly, an insecticidal spectrum can be enlarged, and the insect killing efficiency can be increased.
Description
Technical field
The present invention relates to a kind of compounding microcapsule suspension emulsion, particularly contain avilamycin, thymol, indenes chinaberry oil, life half
The formula of the microcapsule suspension emulsion of summer active component, and preparation method.
Background technology
Avilamycin is a kind of ten hexa-atomic Macrocyclic lactone compounds, belongs to an efficient, class antibiotic of wide spectrum, has and kill
Worm, mite killing, eelworm-killing activity.It can disturb and discharge gamma-amino under the nervous physiology activity of the animals such as worm, demodicid mite, nematicide, stimulation
Butanoic acid, suppresses its nerve conduction to cause to benumb then stiff, aphagia, 2～4 days can death.Avilamycin can be wide
Spectrum efficiently parasite killing, mite killing, nematicide, also few in plant surface residual, the features such as little to beneficial insect damage, so that it is made economical
Can play in thing and field crop and its important effect, in the pesticide insect countermeasure system of China, occupy heavier strategic point
Position.But it is unreasonable for a long time and blindly lead to the animal intraindividual variation such as worm, demodicid mite, nematicide using avilamycin so as to Avermectin
Plain single dose develops immunity to drugs.With drug-fast increase, VM single dose also develops into now from initial amount 0.1% in 2000
8%, dosage also increases increasingly, thus cause crop residual exceeded the problems such as, be unfavorable for environment sustainable development.
Thymol is a separation and Extraction class plant source active component out, energy in large natural environment from Herba thymi vulgariss
Degraded, pleasant aroma, there are very strong sterilization and insecticidal action.Its safety is very high, toxicity is relatively low, on June 19th, 2013,
EU Committee has been approved by putting thymol on market as plant protection products.Thymol is used for processing wound at present
Mouthful, make preservative, medical bactericide, storage dissec, anthelmintic and spice etc..Geng You Chinese Academy of Tropical Agricultural Sciences environment
With Zhang Jing, Feng Gang of Plant Protection Institute etc., thymol research is invented thymol mite-killing microemulsion, its mite killing is imitated
Fruit is apparent.
Solving the conventional method of Drug resistance is to be compounded with the effective ingredient of the different mechanisms of action.The one of present invention offer
Plant avilamycin and thymol in the microcapsule suspension emulsion containing avilamycin and thymol and there is synergistic function, compound
Effect substantially, substantially reduces the dosage of pesticide, also can expand insecticidal spectrum, improves insecticide efficiency.The invention provides it is a kind of micro-
The effect of capsule suspension emulsion, wherein microcapsule is to suppress to cause the decomposition of active component because of environmental factorss and other factors etc., improves medicine
The stability of agent itself；Controlled release release can extend its lasting period, reduce quantity and the frequency of dispenser, improve pesticide to environment
Pressure.And the microcapsule suspension emulsion about avilamycin and thymol, at present at home and abroad there is not yet relevant report.
A kind of microcapsule suspension emulsion containing avilamycin and thymol provided by the present invention, it is to vegetable, fruit tree
Evil mite insect all has excellent prevention effect, particularly to red spider, blister mite, tarsonemid, thrips, Americal rice leaf miner, bean bar
Black latent fly, aphid, diamondback moth, cabbage butterfly, Prodenia litura etc. have good prevention effect.
Content of the invention
The invention provides a kind of have that synergistic function, use cost be low, effect is good containing avilamycin and hundred
In fragrant phenol microcapsule suspension emulsion.
A kind of microcapsule suspension emulsion containing avilamycin and thymol provided by the present invention, is contained by following weight percentage
The group of amount is grouped into：
Avilamycin 0.5～8%,
Thymol 1%～30%,
Indenes chinaberry oil 2%～19%,
Rhizoma Pinelliae active component 1%～20%,
Cyst material 1～15%,
Solvent 5%～40%,
Emulsifying agent 1%～8%,
Dispersant 0.5%～5%,
Wetting agent 0.1%～5%
Thickening agent 0.5%～6%,
Defoamer 0.1%～0.5%,
Balance of water.
Described cyst material is Lauxite, polyisocyanates, gelatin, modified starch, arabic gum or melamine resin
One of or two or more any mixing.Solvent is toluene, acetone, isopropanol, chloroform, ethanol, methanol, in hexamethylene one
Plant or two or more any mixing.Emulsifying agent is anhydrous sorbitol laurate, Tripolyglycerol monostearates, polyoxyethylene list
One of cetylate, polyoxyethylene laurel ether, polyoxypropylene lanonol ether, polyoxyethylene monostearate or two or more
Arbitrarily mix.Dispersant is sodium lignin sulfonate, calcium lignosulfonate, alkylphenol-polyethenoxy base phosphate ester, sodium tripolyphosphate
One of or two or more any mixing.Wetting agent is sodium lauryl sulphate, DBSA, dibutyl naphthalenesulfonic acid
One of sodium, dioctyl sodium sulfosuccinate or two or more any mixing.Thickening agent be starch, pectin, agar, gelatin,
One of methylcellulose, sodium polyacrylate, white carbon, Silica hydrogel, carbomer, CMC, polyvinylether or two or more
Meaning mixing.Defoamer is one of mineral oil, vegetable oil, NPE, higher alcohols or two or more arbitrarily mixed
Close.Water is one of tap water, distilled water or deionized water.The weight percentage of described thymol be preferably 10～
20%.Described cyst material is Lauxite.Described solvent is preferably one of ethanol or methanol.Described emulsifying agent is preferred
For Tripolyglycerol monostearates.Described dispersant is preferably sodium lignin sulfonate.Described wetting agent is preferably detergent alkylate
Sulfonic acid.Described thickening agent is preferably polyvinylether.Described defoamer is preferably mineral oil.The weight percent of described avilamycin contains
Amount is preferably 1%～3%.The weight percentage of described thymol is preferably 10%～20%.The weight hundred of described indenes chinaberry oil
Content is divided to be preferably 5%～9%.The weight percentage of described Rhizoma Pinelliae active component is preferably 5%～10%.Described cyst wall material
The weight percentage of material is preferably 2～6%.The weight percentage of described solvent is preferably 10%～30%.Described emulsifying agent
Weight percentage be preferably 3%～6%.The weight percentage of described dispersant is preferably 1%～3%.Described wetting agent
Weight percentage be preferably 0.5%～2%.The weight percentage of described thickening agent is preferably 1%～3%.Described froth breaking
The weight percentage of agent is preferably 0.15%～0.25%.
The invention provides a kind of microcapsule suspension emulsion containing avilamycin and thymol, wherein in formula, Rhizoma Pinelliae is lived
Property composition extracting method be first Rhizoma Pinelliae to be cleaned dries pulverizing and cross 100 mesh sieves to obtain Rhizoma Pinelliae powder, add ammonia, stirring
Afterwards, add a certain amount of chloroform, after merceration 3h, supersound extraction 1h under ice bath, filters, reclaims chloroform and be evaporated gains at 80 DEG C
It is exactly Rhizoma Pinelliae active component.
A kind of preparation method containing avilamycin and the microcapsule suspension emulsion of thymol provided by the present invention, be by Ah
Dimension rhzomorph and Rhizoma Pinelliae active component add in solvent, add cyst material under insulated and stirred, and the spray drying that sieves obtains microcapsule,
Add dispersant, wetting agent and water to make avermectin microcapsule suspending agent in microcapsule, take out standby, fix tentatively as I.By emulsifying
Agent, thickening agent, defoamer are added to the water and are evenly stirred until and are completely dissolved, and take out standby, fix tentatively as II.Thymol, indenes chinaberry oil
It is evenly stirred until in addition solvent and is completely dissolved, take out standby, fix tentatively as III. III is added in II, high speed shear, add I,
Mix homogeneously obtains final product the microcapsule suspension emulsion of avilamycin and thymol.
The invention provides a kind of microcapsule suspension emulsion, the effect of wherein microcapsule is suppression because of environmental factorss and other factors etc.
Cause the decomposition of active component, improve the stability of medicament itself；Controlled release release can extend its lasting period, reduce the number of dispenser
Amount and frequency, improve the pressure to environment for the pesticide.
Specific embodiment
Embodiment one：The extraction of Rhizoma Pinelliae active component is to clean 10kg Rhizoma Pinelliae to dry in an oven, in disintegrating machine
In crushed 100 mesh sieves, add 12% ammonia in the Rhizoma Pinelliae powder stirring of gained, treat that it moistening uniformly adds 180L's
Chloroform, soaks 3h at 4 DEG C, has supersound extraction 1h under ice bath, filters, and 80 DEG C are reclaimed chloroform and are evaporated, and gains are exactly that Rhizoma Pinelliae is lived
Property composition.
Embodiment two：A kind of microcapsule suspension emulsion containing avilamycin and thymol provided by the present invention, by following
The group of weight percentage is grouped into：
Avilamycin 2%,
Thymol 10%,
Indenes chinaberry oil 6%,
Rhizoma Pinelliae active component 6%,
Cyst material 3%,
Solvent 18%,
Emulsifying agent 5%,
Dispersant 2%,
Wetting agent 1%,
Thickening agent 2%,
Defoamer 0.2%,
Balance of water.
0.2kg avilamycin and 0.6kg Rhizoma Pinelliae active component are added in 1L ethanol, under insulated and stirred, adds 0.3kg
Lauxite, the spray drying that sieves obtains microcapsule, adds 0.2kg sodium lignin sulfonate, 0.1kg detergent alkylate sulphur in microcapsule
Sour and enough water is evenly stirred until and is completely dissolved prepared avermectin microcapsule suspending agent, takes out standby, fixes tentatively as I.0.2kg tri-
Polyglycerol monostearate, 0.2kg polyvinylether, 0.02kg mineral oil, are added to the water and are evenly stirred until and are completely dissolved, and take out standby
With fixing tentatively as II.Add 1kg thymol, 0.6kg indenes chinaberry oil to add 0.8L ethanol to be evenly stirred until to be completely dissolved, take out standby
With fixing tentatively as III. by III add II in, use high-speed shearing Mixer high speed shear, add I, shear-mixed uniformly obtain final product Ah
Dimension rhzomorph and the microcapsule suspension emulsion of thymol.
Embodiment three：A kind of microcapsule suspension emulsion containing avilamycin and thymol provided by the present invention, by following
The group of weight percentage is grouped into：
Avilamycin 2%,
Thymol 15%,
Indenes chinaberry oil 6%,
Rhizoma Pinelliae active component 6%,
Cyst material 3%,
Solvent 20%,
Emulsifying agent 7%,
Dispersant 3%,
Wetting agent 1.5%,
Thickening agent 3%,
Defoamer 0.4%,
Balance of water.
0.2kg avilamycin and 0.6kg Rhizoma Pinelliae active component are added in 1L ethanol, under insulated and stirred, adds 0.3kg
Lauxite, the spray drying that sieves obtains microcapsule, adds 0.3kg sodium lignin sulfonate, 0.15kg detergent alkylate in microcapsule
Sulfonic acid and enough water are evenly stirred until and are completely dissolved prepared avermectin microcapsule suspending agent, take out standby, fix tentatively as I.0.7kg
Tripolyglycerol monostearates, 0.2kg polyvinylether, 0.04kg mineral oil, are added to the water and are evenly stirred until and are completely dissolved, and take out
Standby, fix tentatively as II.Add 1.5kg thymol, the oil stirring of 0.6kg indenes chinaberry to add 1L ethanol uniformly to being completely dissolved, take out
Standby, fix tentatively as III. III is added in II, uses high-speed shearing Mixer high speed shear, add I, shear-mixed uniformly obtains final product
Avilamycin and the microcapsule suspension emulsion of thymol.
Example IV：A kind of microcapsule suspension emulsion containing avilamycin and thymol provided by the present invention, by following
The group of weight percentage is grouped into：
Avilamycin 2%,
Thymol 20%,
Indenes chinaberry oil 6%,
Rhizoma Pinelliae active component 6%,
Cyst material 3%,
Solvent 25%,
Emulsifying agent 8%,
Dispersant 5%,
Wetting agent 2.5%,
Thickening agent 3%,
Defoamer 0.4%,
Balance of water.
0.2kg avilamycin and 0.6kg Rhizoma Pinelliae active component are added in 1L ethanol, under insulated and stirred, adds 0.3kg
Lauxite, the spray drying that sieves obtains microcapsule, adds 0.5kg sodium lignin sulfonate, 0.25kg detergent alkylate in microcapsule
Sulfonic acid and enough water are evenly stirred until and are completely dissolved prepared avermectin microcapsule suspending agent, take out standby, fix tentatively as I.0.8kg
Tripolyglycerol monostearates, 0.3kg polyvinylether, 0.04kg mineral oil, are added to the water and are evenly stirred until and are completely dissolved, and take out
Standby, fix tentatively as II.Add 2kg thymol, 0.6kg indenes chinaberry oil to add 1.5L ethanol to be evenly stirred until to be completely dissolved, take out
Standby, fix tentatively as III. III is added in II, uses high-speed shearing Mixer high speed shear, add I, shear-mixed uniformly obtains final product
Avilamycin and the microcapsule suspension emulsion of thymol.
The microcapsule suspension emulsion that above example is joined is taken to do following indoor pharmacodynamic test and field test, wherein embodiment two
2% avilamycin being made into and the microcapsule suspension emulsion of 10% thymol are A, 2% avilamycin that embodiment three is made into
The microcapsule suspension emulsion of 15% thymol is B, and 2% avilamycin that example IV is made into and the microcapsule of 20% thymol hang breast
Agent is C.
Embodiment five：By the microcapsule suspension emulsion of the avilamycin being made in embodiment two, three, four and thymol to red
Aranea is cooked indoor pharmacodynamic test, is compareed with 2% abamectin emulsifiable concentrate.Result of the test is shown in Table one.
Table one：
The insecticidal effect ratio of the microcapsule suspension emulsion of tri- kinds of avilamycin of A, B, C of the present invention and thymol as can be known from the above table
The effect of 2% abamectin emulsifiable concentrate is much better, especially C best results, and C is the outstanding breast of microcapsule of 2% avilamycin and 20% thymol
Agent.
Embodiment six：The microcapsule suspension emulsion of the avilamycin being made in embodiment two, three, four and thymol is carried out
Field test.2% abamectin emulsifiable concentrate compares.Experiment place：Sanya, Hainan, object of experiment：Fructus Lycopersici esculenti red spider, result of the test
It is shown in Table two：
The avilamycin of the present invention knowable to from upper table and the microcapsule suspension emulsion of thymol are to Fructus Musae Prodenia litura preventive effect
Prominent, the lasting period was up to more than 14 days, and the effect of C is the most prominent, and C is that 2% avilamycin is outstanding with the microcapsule of 20% thymol
Emulsion.
Claims (1)
1. a kind of microcapsule suspension emulsion containing avilamycin and thymol prevent and treat Fructus Lycopersici esculenti red spider purposes it is characterised in that：
Described microcapsule suspension emulsion each component is by mass percentage：Avilamycin 2%, thymol 20%, indenes chinaberry oil 6%, Rhizoma Pinelliae
Active component 6%, Lauxite 3%, ethanol 25%, Tripolyglycerol monostearates 8%, sodium lignin sulfonate 5%, dodecane
Base benzenesulfonic acid 2.5%, polyvinylether 3%, mineral oil 0.4%, balance of water.
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| CN105638648B (en) * | 2016-01-08 | 2018-05-18 | 广州市生物防治站 | A kind of Thymol-emamectin-benzoate aqueous emulsion |
| CN106035239B (en) * | 2016-05-30 | 2018-11-09 | 中国农业大学 | A method of research walks quickly and keeps away substance to Oviposition of Diamondback Moth behavioral implications |
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| CN1676001A (en) * | 2005-05-10 | 2005-10-05 | 龚鸿昌 | Nim oil-water emulsion and its use |
| CN102224830A (en) * | 2011-05-30 | 2011-10-26 | 杨凌农科大无公害农药研究服务中心 | Plant source synergistic complex acaricide and preparation method thereof |
| CN103563892A (en) * | 2013-10-14 | 2014-02-12 | 广东中迅农科股份有限公司 | Novel water-based preparation formulation of methylamino abamectin benzoate |
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| CN1676001A (en) * | 2005-05-10 | 2005-10-05 | 龚鸿昌 | Nim oil-water emulsion and its use |
| CN102224830A (en) * | 2011-05-30 | 2011-10-26 | 杨凌农科大无公害农药研究服务中心 | Plant source synergistic complex acaricide and preparation method thereof |
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