CN104381259B - Containing flutolanil and the bactericidal composition of SYP-3375 - Google Patents
Containing flutolanil and the bactericidal composition of SYP-3375 Download PDFInfo
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- CN104381259B CN104381259B CN201410706054.XA CN201410706054A CN104381259B CN 104381259 B CN104381259 B CN 104381259B CN 201410706054 A CN201410706054 A CN 201410706054A CN 104381259 B CN104381259 B CN 104381259B
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- flutolanil
- bactericidal composition
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Abstract
The present invention relates to a kind of containing flutolanil with the bactericidal composition of SYP-3375, active ingredient is made up of flutolanil and SYP-3375, and flutolanil is 5: 1～1: 5 with the percentage by weight of SYP-3375.According to method known in those skilled in the art, add corresponding additive and filler, it is possible to make water dispersible granules, the wettable powder commonly used on agricultural chemicals.Flutolanil belongs to two series bactericidal agents that the mechanism of action is different with SYP-3375, has therebetween significantly synergy, it is possible to drug effect is greatly improved, reduces Pesticide use amount and drug cost.Meanwhile, the composition of the present invention significantly reduces existing germ to flutolanil and the potential resistance risk of SYP-3375.
Description
Technical field
The present invention relates to a kind of pesticide synergistic composition, specifically containing flutolanil and the pesticide synergistic composition of SYP-3375.
Background technology
SYP-3375, chemical name: (E)-2-(2-((3-butyl-4-methyl-coumarin-7-base epoxide) methyl) phenyl)-3-methoxy
Base methyl acrylate.Have protection and therapeutic action, be the disinfectant use in agriculture of a kind of high-efficiency broad spectrum, to by mastigomycetes, zygomycete,
The plant disease that sac fungus, basidiomycetes and Fungi Imperfecti cause such as sclerotinia rot of colza, apple tree canker, rice blast, perfume (or spice)
Any of several broadleaf plants leaf spot, alternaria leaf spot of apple etc. have good preventive effect.SYP-3375 for the preventing and treating of rice sheath blight disease it has been reported that Song
" six kinds of new type bactericides such as SYP-3375 can effectively prevent and treat rice sheath blight disease " that the benefit people, Diao Yamei deliver confirms SYP-3375
Rice sheath blight disease is had preferable prevention effect.
Flutolanil, chemical name: 3'-isopropoxy-2-(trifluoromethyl) benzanilide, is Nihon Nihyaku Co., Ltd's exploitation
New benzoyl for aniline fungicides, there is protection and therapeutic action, the lasting period is long, and its mechanism of action is respiratory electricity
Succinate dehydrogenase inhibitors in sub-transfer chain, suppression aspartate and the synthesis of glutamate, hinder on infected body
The growth of mycelia and penetrating, causes the disappearance of mycelia.Flutolanil is the new medicament preventing and treating rice sheath blight disease, has EDD long,
Prevention effect is good, the advantage that can improve Seed-Setting Percentage in Rice.
The single medicament of Long-Time Service carries out disease control, easily makes germ develop immunity to drugs, and uses the agricultural chemicals that the mechanism of action is different
Compounding, it is to delay pest and disease damage to develop immunity to drugs conventional method.Flutolanil is different with the mechanism of action of SYP-3375, and both are one
Fixed ratio mixture, and according to the effect in production application, judge this compounds whether have synergistic effect.Synergistic effect
Obvious formula, can significantly improve drug effect, is substantially reduced the usage amount of agricultural chemicals and agricultural cost, expands fungicidal spectrum simultaneously,
Alleviate the pollution to environment.At present, flutolanil and the compounding mixture of SYP-3375, the preventing and treating for rice sheath blight disease does not also have phase
The report closed.
Summary of the invention
The technical problem to be solved is, it is provided that a kind of Bactericidal composite with flutolanil, SYP-3375 as active ingredient
Thing, this bactericidal composition is mainly used in the preventing and treating of rice sheath blight disease, can significantly improve treatment, the effect of protection, reduce spraying times
And dosage, delay the generation of germ resistance, reduce cost accounting.
The present invention is to be achieved through the following technical solutions:
Containing flutolanil and the bactericidal composition of SYP-3375, active ingredient is made up of flutolanil and SYP-3375, flutolanil and cloves
The percentage by weight of bacterium ester is 5: 1～1: 5.
Described containing flutolanil and the bactericidal composition of SYP-3375, wherein effective active composition accounts for the 20%～50% of gross weight.
The described bactericidal composition containing flutolanil and SYP-3375, according to method known in those skilled in the art, adds corresponding
Auxiliary agent and filler, make water dispersible granules, the wettable powder commonly used on agricultural chemicals.
The auxiliary agent that the described bactericidal composition containing flutolanil and SYP-3375 uses includes dispersant, wetting agent, antifreeze, collapses
Solve agent, emulsifying agent, stabilizer or other be of value to the material that active ingredient is stable in the formulation and drug effect plays, be all agricultural chemicals system
Conventional or the various compositions of permission use in agent.
The present invention has the following advantages two classes belonging to the mechanism of action different with significant technique effect, flutolanil and SYP-3375 and kills
Microbial inoculum, has therebetween significantly synergy, it is possible to drug effect is greatly improved, reduces Pesticide use amount and drug cost.With
Time, the composition of the present invention significantly reduces existing germ to flutolanil and the potential resistance risk of SYP-3375.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and technique effect are described further, of the present invention hundred
Proportion by subtraction is all weight percentage.
The embodiment of the present invention is the method using Toxicity Determination and field test to combine.
Implementation of an application example one: flutolanil is compounding with SYP-3375 to rice sheath blight disease Toxicity Determination
After prerun determines each medicament effective inhibition concentration scope, by flutolanil, SYP-3375 and mixture preparation thereof by active ingredient
5 concentration of concentration gradients serial dilution, compare with sterilized water.Enter with reference to " farm-chemical indoor determination test rule bactericide "
OK, use growth rate method to measure, variable concentrations medicament is added in sterilizing culture dish, every ware 1mL, add sterilizing fusing
PDA culture medium 10mL, is sufficiently mixed and makes flat board, the bacterium colony spread cultivation then breaks into=bacterium the dish of 0.8cm, 1, every ware, often processes 4
Secondary repetition, is placed in 25 DEG C of insulating boxs cultivation, and every 24h measures colony diameter 1 time.Calculating Net growth rate, relative inhibition, will
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) is converted into logarithm value (x), tries to achieve with least square method
Virulence regression equation (y=a+bx), and thus calculate the EC of every kind of medicament50.The computing formula of bacteriostasis rate is as follows:
Mycelial growth inhibition rate (%)=(comparison colony diameter processes colony diameter)/comparison colony diameter × 100
It is antagonism that co-toxicity coefficient method (CTC) according to the abundant method of Sun Yun evaluates the synergistic effect of pharmacy mix, i.e. CTC≤80,
80 CTC 120 are summation action, and CTC >=120 are synergistic effect.
Result of the test is as shown in table 1:
Table 1 flutolanil, SYP-3375 and built agent thereof the toxicity test analysis of results table to rice sheath blight disease
| Reagent agent | Proportioning | Regression equation (y=a+bx) | Coefficient correlation | EC50(mg/L) | Co-toxicity coefficient |
| SYP-3375 | / | Y=3.1508+1.8861x | 0.9902 | 9.56 | / |
| Flutolanil | / | Y=3.1725+1.5956x | 0.9912 | 13.97 | / |
| SYP-3375: flutolanil | 5:1 | Y=3.5334+1.6985x | 0.9945 | 7.30 | 138.2 |
| SYP-3375: flutolanil | 4:1 | Y=3.1968+1.9806x | 0.9939 | 8.14 | 125.4 |
| SYP-3375: flutolanil | 2:1 | Y=3.7058+1.5467x | 0.9952 | 6.87 | 155.6 |
| SYP-3375: flutolanil | 1:1 | Y=3.5989+1.6362x | 0.9902 | 7.18 | 158.1 |
| SYP-3375: flutolanil | 1:2 | Y=3.4705+1.6838x | 0.9989 | 8.10 | 149.5 |
| SYP-3375: flutolanil | 1:3 | Y=3.6841+1.4198x | 0.9924 | 8.45 | 151.4 |
| SYP-3375: flutolanil | 1:4 | Y=3.4541+1.7959x | 0.9977 | 7.56 | 169.1 |
| SYP-3375: flutolanil | 1:5 | Y=3.6539+1.4629x | 0.9948 | 8.32 | 156.0 |
As shown in Table 1, flutolanil, the SYP-3375 EC to rice sheath blight disease50It is respectively 13.97mg/L and 9.56mg/L, fourth
The toxicity index of fragrant bacterium ester is higher than the toxicity index of flutolanil, and SYP-3375 and flutolanil mixture in 5:1～1:5 proportioning all shows
Go out obvious synergistic function, and when the percentage by weight of flutolanil Yu SYP-3375 is 1:4, co-toxicity coefficient be 169.1,
Co-toxicity coefficient is the highest.
The field control effectiveness test of rice sheath blight disease prevented and treated by implementation of an application example 2 20% flutolanil SYP-3375 wettable powder
This EE is in suburb, Xingye County, Yulin City of Guangxi Zhuang Autonomous, and spraying time is on August 26th, 2013 for the first time, former with flutolanil
Medicine and SYP-3375 mother's medicine make 20% flutolanil fourth according to method known in those skilled in the art, addition corresponding additive, filler
Fragrant bacterium ester wettable powder, flutolanil is 4:1 with the percentage by weight of SYP-3375, and this formula is used for preventing and treating rice sheath blight disease, medicine
The front investigation rice sheath blight disease state of an illness, dosage is 40 grams/acre, and water consumption is 45KG/ mu, and after medicine, the preventive effect of 7 days is 89.76%, and single
Agent 20% flutolanil wettable powder is 100 grams/acre by dosage 60 grams/acre and 10% SYP-3375 suspending agent by dosage, with same
Method when using identical dose, after medicine, the preventive effect of 7 days is respectively 62.36% and 67.95%.
Implementation of an application example 3 30% flutolanil SYP-3375 water dispersible granules prevents and treats the field control effectiveness test of rice sheath blight disease
This EE is in suburb, Xingye County, Yulin City of Guangxi Zhuang Autonomous, and spraying time is on September 22nd, 2013 for the first time, by flutolanil,
The former medicine of SYP-3375 and powder carrier, wetting agent and binding agent etc. carry out co-grinding, after adding water kneading, are equipped with certain
The comminutor of specification screen cloth carries out granulation, is then dried, sieve and i.e. obtain 50% flutolanil SYP-3375 water dispersible granules, wherein
Flutolanil is 5:1 with the percentage by weight of SYP-3375, and this formula is used for preventing and treating rice sheath blight disease, investigates rice sheath blight disease sick before medicine
Feelings, dosage is 25 grams/acre, and water consumption is 45KG/ mu, and after medicine, the preventive effect of 7 days is 88.56%, and single dose 20% flutolanil wettable
Pulvis is 60 grams/acre by dosage 80 grams/acre and 20% SYP-3375 suspending agent by dosage, uses identical dose by same method
Time, after medicine, the preventive effect of 7 days is respectively 63.36% and 68.76%.
This explanation flutolanil has obvious synergistic effect, to rice sheath blight disease with SYP-3375 mixture for the preventing and treating of rice sheath blight disease
Having obvious prevention effect, all growths of the rice seedling in process of the test Zhong Ge community are normal.
Claims (1)
1., containing flutolanil and the bactericidal composition of SYP-3375, active ingredient is made up of flutolanil and SYP-3375, it is characterised in that
SYP-3375 is 5:1,4:1,2:1,1:2 or 1:5 with the weight ratio of flutolanil.
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| CN107006479A (en) * | 2016-01-28 | 2017-08-04 | 响水县智诚知识产权信息服务有限公司 | A kind of bactericidal composition containing SYP-3375 Yu fluorobenzene ether amide |
| CN108064850A (en) * | 2016-11-11 | 2018-05-25 | 华中师范大学 | A kind of composition pesticide and its application containing benzothiostrobin and flutolanil |
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| CN102626074A (en) * | 2012-04-01 | 2012-08-08 | 广西田园生化股份有限公司 | Ultra-low volume liquid containing flutolanil |
| CN104430357A (en) * | 2014-11-10 | 2015-03-25 | 吉林省八达农药有限公司 | Bactericide composition containing coumoxystrobin with synergistic effect |
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| CN103371184A (en) * | 2013-06-27 | 2013-10-30 | 王学权 | Fungicidal composition containing prochloraz manganese complex |
| CN103355343A (en) * | 2013-07-26 | 2013-10-23 | 海南正业中农高科股份有限公司 | Agricultural composition containing sulphur |
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| CN102626074A (en) * | 2012-04-01 | 2012-08-08 | 广西田园生化股份有限公司 | Ultra-low volume liquid containing flutolanil |
| CN104430357A (en) * | 2014-11-10 | 2015-03-25 | 吉林省八达农药有限公司 | Bactericide composition containing coumoxystrobin with synergistic effect |
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Inventor after: Lu Ninghai Inventor after: Shi Hongli Inventor after: Wu Limin Inventor after: Deng Tianfu Inventor after: Liu Runqiang Inventor after: Chen Jun Inventor after: Hu Linfeng Inventor before: Luo Xiaodan |
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Effective date of registration: 20160801 Address after: 453003 East District, Hongqi District, Henan, Xinxiang Applicant after: Henan Institute of Science and Technology Address before: 530409, No. 12, Dalong village, Longsheng village committee, Litang Town, Nanning County, the Guangxi Zhuang Autonomous Region, Binyang Applicant before: Luo Xiaodan |
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