CN105766951B - A kind of bactericidal composition containing thifluzamide and sym-closene - Google Patents
A kind of bactericidal composition containing thifluzamide and sym-closene Download PDFInfo
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- CN105766951B CN105766951B CN201610200014.7A CN201610200014A CN105766951B CN 105766951 B CN105766951 B CN 105766951B CN 201610200014 A CN201610200014 A CN 201610200014A CN 105766951 B CN105766951 B CN 105766951B
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- thifluzamide
- closene
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- bactericidal composition
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a kind of bactericidal compositions containing thifluzamide and sym-closene, and wherein thifluzamide and sym-closene is 13 in the weight ratio of composition:1‑5.The bactericidal composition of the present invention is suitable for the prevention of rice sheath blight disease, thifluzamide and sym-closene have apparent synergistic effect in ratio range to banded sclerotial blight, actual control effect can be improved, reduce dosage and effectively reduces pesticide cost, and is conducive to delay the generation of Disease Resistance.
Description
Technical field
The present invention relates to technical field of pesticide, more particularly to a kind of Bactericidal composite containing thifluzamide and sym-closene
Object.
Background technology
Thifluzamide, English are general entitled：Thifluzamide is that phenylamide has the interior of the simultaneous therapeutic effect of prevention
Absorption fungicide inhibits the succinate dehydrogenase in fungi tricarboxylic acid cycle, influences pathogen respiratory chain electron transmission, cause
Thalline is dead, and the lasting period is long.Thifluzamide has the pathomycetes such as Rhizoctonia, Puccinia, Ustilago, nuclear cavity Pseudomonas
Activity especially has good preventive effect to the fungus-caused disease of Basidiomycetes such as banded sclerotial blight, damping-off etc..
Sym-closene, English are general entitled：Trichloroiso cyanuric acid, bactericidal property is excellent,
Wide spectrum, the fungicide efficiently, less toxic for being a new generation, all have certain killing effect, in agricultural to bacterium, virus, fungi
In production, energy effectively preventing Fusarium and Verticillium wilts, the bacterial leaf-blight of damping-off and rice, bacterial stripe, line are withered
Bacteriums and the fungal disease such as disease and rice blast.
Banded sclerotial blight is the Major Diseases of rice, relies primarily on jinggangmeisu in recent years and is prevented, Disease Resistance is caused to add
It is acute.It is the common methods for preventing agriculture resistance disease using the mixture of different pesticide species.It is screened by formulation of pesticide, synergy
The apparent formula of effect, can effectively improve actual control effect, reduce dosage, reduce cost, delay disease drug resistance
It generates, is the important means of disease comprehensive treatment.The present inventor has found that thifluzamide and sym-closene mix in experiment process
Matching rice sheath blight disease has apparent synergistic effect.
At present, the research of thifluzamide and sym-closene compounding be there are no into relevant report.
The content of the invention
It is an object of the present invention to provide a kind of bactericidal composition containing thifluzamide and sym-closene, synergy
Effect is notable, can effectively control rice sheath blight disease disease, and is conducive to alleviate the development of Disease Resistance.
The present invention adopts the technical scheme that：A kind of bactericidal composition containing thifluzamide and sym-closene, thiophene furan
Amide and sym-closene are 1-3 in the weight ratio of composition:1-5, it is preferred that the weight of thifluzamide and sym-closene
Measure ratio 1:5.
The bactericidal composition of the present invention can be configured to wettable powder, hang according to well known to a person skilled in the art method
The application forms of the suitable agricultural uses such as floating agent.
The present invention the bactericidal composition also usual auxiliaries containing pesticidal preparations, including solvent, filler, binding agent, point
Powder, wetting agent, disintegrant, emulsifier, antifoaming agent, thickener, stabilizer or other to be beneficial to active ingredient steady in the formulation
The substance that fixed and drug effect plays.
The bactericidal composition of the present invention is suitable for the banded sclerotial blight of prevention rice.
The present invention has the following advantages and significant technique effect:
(1) mechanism of action of thifluzamide and sym-closene is different, and germ is not easy to produce resistance.
(2) indoor biometrics the result shows that, thifluzamide and sym-closene are compounded according to a certain percentage to rice banded sclerotial blight
Disease has notable synergistic effect, advantageously reduces the amount of application of each single dose, helps to reduce pesticide cost.
Specific embodiment
Technical scheme and advantageous effect are described further with reference to embodiments, of the present invention hundred
Ratio is divided to be weight percentage.
First, example of formulations
Embodiment 1：25% thifluzamide trichloro-isocyanuric acid wettable powder
Formula:Weigh 15% thifluzamide, 10% sym-closene, 3% lauryl sodium sulfate (wetting agent), 5%
Sodium lignin sulfonate (dispersant), kaolin (filler) complement to 100%.By above-mentioned each component in the ratio coarse crushing of formula
Afterwards, it is uniformly mixed into mixer, then 25% thifluzamide sym-closene wettable is made after air-flow crushing
Pulvis.
Embodiment 2：30% thifluzamide trichloro-isocyanuric acid wettable powder
Formula:Weigh 5% thifluzamide, 25% sym-closene, 4% lauryl sodium sulfate (wetting agent), 5% wood
Quality sodium sulfonate (dispersant), 15% white carbon (filler), kaolin (filler) complement to 100%.By above-mentioned each component by matching somebody with somebody
It after the ratio coarse crushing of side, is uniformly mixed into mixer, then 30% thifluzamide trichlorine is made after air-flow crushing
Isocyanuric acid wettable powder.
Embodiment 3：35% thifluzamide sym-closene suspending agent
Formula：Weigh 10% thifluzamide, 25% sym-closene, 3% alkyl naphthalene sulfonate (wetting agent), 4%
Polycarboxylate (dispersant), 0.2% xanthans (thickener), 2% ethylene glycol (antifreezing agent), 0.2% silicone oil (antifoaming agent), go from
Sub- water is mended to 100%.After above-mentioned raw materials are mixed by formula rate, 20% thifluzamide three is made by high speed shearing emulsification
Symclosene suspending agent.
Embodiment 4：40% thifluzamide sym-closene suspending agent
Formula：Weigh 20% thifluzamide, 20% sym-closene, 2% alkyl naphthalene sulfonate (wetting agent), 5%
Polycarboxylate (dispersant), 0.5% xanthans (thickener), 2% ethylene glycol (antifreezing agent), 0.3% silicone oil (antifoaming agent), go from
Sub- water is mended to 100%.After above-mentioned raw materials are mixed by formula rate, 40% thifluzamide three is made by high speed shearing emulsification
Symclosene suspending agent.
2nd, Application Example
Embodiment 1:Thifluzamide and sym-closene mixture are to the Toxicity Determination of the sheath and culm blight of rice
Thifluzamide, sym-closene and its mixed agent are diluted into 5 concentration by active constituent content gradient series, with
Space management is control, indoor measurement is carried out to the inhibitory action of Rhizoctonia solani Kuhn, using mycelial growth rate method.It will be through two
It is secondary be separately cultured after rice sheath blight disease germ punched with the aseptic card punch of a diameter of 0.5CM in blade edge it is spare, then
It moves on the PDA plate culture medium of drug containing, being placed in culture in 25 ± 1 DEG C of incubators, culture measures colony diameter after 6 days, each
Handle 6 repetitions.Measured result calculates mycelial growth inhibition rate compared with blank control.
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) is converted into numerical value (x), with minimum
Square law acquires virulence regression equation (y=a+bx), and thus calculates the EC of each medicament50Value.
The synergistic effect of pharmacy mix is evaluated according to the co-toxicity coefficient method (CTC) of the abundant methods of Sun Yun, i.e. CTC≤80 are antagonism
Effect, 80<CTC<120 be summation action, and CTC >=120 are synergistic effect.Statistical result is as shown in table 1：
1 thifluzamide of table, sym-closene and its mixture are to the Toxicity Determination of rice sheath blight disease
| Reagent agent | Proportioning | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| Thifluzamide (A) | / | 1.42 | / |
| Sym-closene (B) | / | 2.75 | / |
| A：B | 1:1 | 1.47 | 127.8 |
| A：B | 1:2 | 1.54 | 136.4 |
| A：B | 1:5 | 1.42 | 168.2 |
| A：B | 2:1 | 1.30 | 130.2 |
| A：B | 2:3 | 1.39 | 144.1 |
| A：B | 2:5 | 1.31 | 166.3 |
| A：B | 3:1 | 1.27 | 127.2 |
| A：B | 3:2 | 1.29 | 136.4 |
| A：B | 3:5 | 1.43 | 142.6 |
| A：B | 10:1 | 1.41 | 105.1 |
Measurement result shows that when the proportioning of thifluzamide and sym-closene be 1-3:During 1-5, co-toxicity coefficient (CTC)
More than 120, synergistic effect is apparent.
Embodiment 2:The field trial of thifluzamide, sym-closene and mixed agent prevention rice sheath blight disease
(1) experimental design, test group 1#：25% thifluzamide trichloro-isocyanuric acid wettable powder (15:10), mu is used
50 grams of preparation；Test group 2#：30% thifluzamide sym-closene suspending agent (5:25), 50 grams of preparation of mu；Control group
1#：24% thifluzamide suspending agent, 75 grams of amount of formulation of mu；Control group 2#：42% trichloro-isocyanuric acid wettable powder, mu are used
80 grams of amount of formulation；One blank control is set simultaneously.
(2) experiment and investigation method：Rice sheath blight disease early stage dispenser, is watered even spraying.The state of an illness is investigated before medicine to refer to
It counts, 7 days after medicine, carries out result investigation respectively within 14 days, calculate preventive effect.Result of the test is shown in Table 2.
Table 2：The field trial table of the mixed agent prevention banded sclerotial blight of the isocyanide of trichlorine containing thifluzamide urine
| Test process | Preparation usage amount (gram/acre) | 7 days preventive effects (%) after medicine | 14 days preventive effects (%) after medicine |
| Test group 1# | 50 | 81.6 | 92.7 |
| Test group 2# | 50 | 85.3 | 94.3 |
| Control group 1# | 75 | 71.4 | 78.2 |
| Control group 2# | 80 | 67.8 | 72.6 |
| Blank control | / | / | / |
Result of the test can be seen that：7 days after dispenser, thifluzamide of the invention and sym-closene mixture composition pair
Banded sclerotial blight preventive effect is all more than 80%, hence it is evident that is better than the single dose of control；14 days after dispenser, thifluzamide of the invention and trichlorine are different
Cyanuric acid mixture composition all more than 90%, is also significantly better than the single dose of control to rice sheath blight disease preventive effect；During experiment
Each medicament is showed no poisoning generation, to crop safety.Illustrate the thifluzamide of the present invention and sym-closene mixture composition
Synergy is notable, can reduce each single dose amount of application, advantageously reduce dispenser cost, has great significance to agricultural synthesis improvement.
Claims (3)
1. a kind of bactericidal composition containing thifluzamide and sym-closene, which is characterized in that thifluzamide and trichlorine isocyanide
Uric acid is 1-3 in the weight ratio of composition:1-5.
2. the bactericidal composition according to claim 1 containing thifluzamide and sym-closene, thifluzamide and trichlorine
The weight ratio of isocyanuric acid is 1:5.
3. the bactericidal composition according to claim 1 or 2 containing thifluzamide and sym-closene is suitable for anti-harness the river
The sheath and culm blight of rice.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610200014.7A CN105766951B (en) | 2016-04-01 | 2016-04-01 | A kind of bactericidal composition containing thifluzamide and sym-closene |
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|---|---|---|---|
| CN201610200014.7A CN105766951B (en) | 2016-04-01 | 2016-04-01 | A kind of bactericidal composition containing thifluzamide and sym-closene |
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|---|---|
| CN105766951A CN105766951A (en) | 2016-07-20 |
| CN105766951B true CN105766951B (en) | 2018-05-18 |
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| CN201610200014.7A Active CN105766951B (en) | 2016-04-01 | 2016-04-01 | A kind of bactericidal composition containing thifluzamide and sym-closene |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102823603A (en) * | 2012-09-13 | 2012-12-19 | 王学权 | Sterilization compound containing chloroisobromine cyanuric acid |
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2016
- 2016-04-01 CN CN201610200014.7A patent/CN105766951B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102823603A (en) * | 2012-09-13 | 2012-12-19 | 王学权 | Sterilization compound containing chloroisobromine cyanuric acid |
Non-Patent Citations (2)
| Title |
|---|
| 三氯异氰尿酸与氯溴异氰尿酸部分性能的比较;谈智等;《中国消毒学杂志》;20021215(第04期);全文 * |
| 噻呋酰胺24%悬浮剂防治水稻纹枯病试验;甄洁等;《农药科学与管理》;20090315(第03期);全文 * |
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| CN105766951A (en) | 2016-07-20 |
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Effective date of registration: 20180413 Address after: 318050 17A04 room, peninsula garden, Tengda Road, road, Taizhou Road, Luqiao District, Zhejiang, China Applicant after: Taizhou lace Agel Ecommerce Ltd. Address before: 530000 the Guangxi Zhuang Autonomous Region Nanning Qingxiu District National Road No. 131 international air ocean city C, room 3106 Applicant before: GUANGXI NANNING YITU BIOTECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20221013 Address after: 016000 Comprehensive Processing Park, Haibowan District, Wuhai City, Inner Mongolia Autonomous Region (Wuhai Haiyao Glass Co., Ltd.) Patentee after: Inner Mongolia Senhong Xinjia Environmental Protection Technology Co.,Ltd. Address before: 318050 17A04 room 2, Peninsular garden, Tengda Road, Luqiao District, Taizhou, Zhejiang. Patentee before: Taizhou lace Agel Ecommerce Ltd. |
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