CN106982844A - A kind of agricultural bactericidal composition of Bao Han famoxadones and hymexazol - Google Patents
A kind of agricultural bactericidal composition of Bao Han famoxadones and hymexazol Download PDFInfo
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- CN106982844A CN106982844A CN201710336226.2A CN201710336226A CN106982844A CN 106982844 A CN106982844 A CN 106982844A CN 201710336226 A CN201710336226 A CN 201710336226A CN 106982844 A CN106982844 A CN 106982844A
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- release agent
- bactericidal composition
- sustained release
- hymexazol
- famoxadones
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/18—Vapour or smoke emitting compositions with delayed or sustained release
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
- A01N47/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom containing >N—S—C≡(Hal)3 groups
Abstract
The present invention relates to a kind of Han famoxadones and the bactericidal composition of hymexazol, it is 1 that the bactericidal composition, which contains weight ratio,:20‑20:1 famoxadones and hymexazol.Further, the third component being selected from the group can also be included in the bactericidal composition：Triazolone, Triadimenol, metrafenone, Fluoxastrobin, captan or folpet；The weight ratio of the Famoxate, hymexazol and third component is：1‑10:1‑10:1:1‑3.Further, the present invention also provides the sterilization sustained release agent for the bactericidal composition of the present invention being made of specific composite slow release agent.Compared with single dose, binary or ternary bactericidal composition of the present invention is respectively provided with significant synergistic effect, and coefficient of synergism is more than 130；The present invention with lasting slow releasing function, and is had good stability using the obtained sterilization sustained release agent of specific sustained release agent.
Description
Technical field
The invention belongs to technical field of compounded pesticide, it is related to a kind of bactericidal composition, and in particular to one kind includes Yi oxazoles
Bacterium ketone, hymexazol are the agricultural bactericidal composition of fungicide active ingredient.There is sustained release the invention further relates to the bactericidal composition
The preparation formulation of effect, and it is in application agriculturally.
Famoxadone, English name：Famoxadone, chemical name：3- anilino- -5- methyl -5- (4- phenoxy group benzene
Base) -1,3- oxazoline -2,4- diketone , Shu oxazole series bactericidal agents.Famoxadone belongs to Mitochondrial electron transmission inhibitor, to compound
Cytochrome c oxidoreductase has inhibitory action in body m, also with protecting, treat, root out, permeating, systemic activity.Oxazole bacterium
Ketone is used as a kind of new and effective, wide-spectrum bactericide, suitable for crop such as wheat, barley, pea, beet, rape, grape, Ma Ling
Potato, pawl class, capsicum, tomato etc., it is mainly used in preventing and treating the important disease such as white powder in Ascomycetes, Basidiomycetes, oomycetes subclass
Disease, rust, glume blight, net blotch, downy mildew, late blight etc..
Hymexazol, English name is：Hymexazol, chemical name is：3- hydroxy-5-methyl base isoxazoles, category oxazole class is killed
Microbial inoculum.The medicament belong to efficiently, low toxicity, environmental protection, broad-spectrum germicide, have preferably to plant disease caused by a variety of disease funguses
Prevention effect, to mastigomycetes, sac fungus, basidiomycetes, the pythium spp of Deuteromycotina, sickle-like bacteria, rhizoctonia, photovoltaicing leather bacteria, snow
Rotten bacterium etc. has good therapeutic effect.Hymexazol has interior suction and conduction, and its bactericidal mechanism is to suppress pathogen line grain
Body respiration, but different from beta-methoxy acrylic ester bactericide.Meanwhile, hymexazol is a kind of soil sterilants again, right
Pythium spp in soil has efficiently, and the sprouting ability for suppressing germ spore can be improved with inorganic aluminum ions binding in soil.Dislike
Mould spirit is also act as plant growth regulator, and its metabolite in plant is two kinds of glucosides, can improve plant life
The active activity so as to promote plant strain growth, the tiller of root, the increase of root hair and root of reason is improved.Hymexazol is to micro- life in soil
The ecology of thing does not produce influence, and toxicity very low compound, safe noresidue can be resolved into soil.
Hymexazol is the bactericide kind of current domestic large usage quantity, but finds in use, the biodegradation of hymexazol
Excessive velocities, just lose bactericidal effect in only 5-10 days under conditions of use.And the duration of germ breaking-out is general 15 every time
It is to a wheat harvesting period, so the method for dispenser repeatedly is usually taken in hymexazol when in use, i.e., per dispenser in 5-10 days once, until
Germ stage of attack, terminates.Obviously, from artificial angle is saved, the method for dispenser is very uneconomical repeatedly, wastes time and energy, and peasant is urgent
Need a kind of preparation containing hymexazol of spacetabs type.
In the field of agrochemicals containing hymexazol active component, patent document have been disclosed hymexazol respectively with double alkynes acyls
Bacterium amine（CN105325428A）, mepanipyrim（CN105379731A）, fludioxonil（CN105104386A）, 2-cyano-3-amino-3-phenylancryic acetate
（CN104094942A）The bactericidal composition of compounding, but these bactericidal composition effects are general, and do not pay close attention to sustained release work(
The preparation formulation of effect.Patent CN103947673A discloses a kind of antibacterial root-growing agent of sustained release, is by sustained release agent, bactericide, reinforcing
The pasty state colloid that agent, root-growing agent and lytic agent are mixed to get, its sterilization component can select hymexazol.The pasty state that the patent is related to
Colloid belongs to physical sustained release agent.The sustained-release pesticides containing ammonium hydrogen carbonate are discussed in patent US5432148, it is mentioned that hymexazol
Composition, belongs to physical sustained release agent.Patent CN1419826A gives the polymer chemical slow release sterilization of the composition containing hymexazol
Agent, hymexazol is linked on macromolecule carrier, the drug effect lasting period of hymexazol is extended；But these slow release formulations are in the presence of slow
Release effect it is not good, with the deficiency such as the compatibility of active component is bad.
The content of the invention
Have bactericidal effect is good, low toxicity is low to stimulate it is an object of the invention to provide one kind, synergistic effect is notable after compounding, and
And resistance to the action of a drug famoxadones and the bactericidal composition of hymexazol can be delayed.
To realize the purpose of the present invention, technical scheme is as follows：
The bactericidal composition of a kind of Han famoxadones and hymexazol, it is characterised in that the bactericidal composition contains weight ratio
For 1:20-20:1 famoxadones and hymexazol.
It is preferred that the weight ratio of the two is 1:5-5:1.
Further, the third component being selected from the group can also be included in the bactericidal composition：Triazolone, Triadimenol,
Metrafenone, Fluoxastrobin, captan or folpet；The weight ratio of the Famoxate, hymexazol and third component is：1-10:1-
10:1:1-3；It is highly preferred that the weight ratio of three is 1-5:1-5:1-2, most preferably 3:3:1.
Further, the present invention provides the sterilization sustained release agent of above-mentioned bactericidal composition, it is characterised in that the sustained release agent by
Following component composition by weight percentage：
Bactericidal composition：1-15%；
Sustained release agent：50-70%；
Hardening agent：10-30%；
Surplus is water；
The hardening agent is aluminum sulfate, copper sulphate or ferrous sulfate；
The sustained release agent is that weight ratio is 1:2-4:The composite slow release agent of 1 sodium bentonite and cyclodextrin composition.
Sterilization sustained release agent preparation method of the present invention is as follows：
Step 1: according to described with measuring each raw material；
Step 2: active component and hardening agent are added in water successively, stir；
Step 3: adding the composite slow release agent of sodium bentonite and cyclodextrin composition and stirring, mixture is set fully to be fused into paste
Shape colloid.
Preferably, in the sterilization sustained release agent, bactericidal composition is 5-10%；Most preferably 8%.
Preferably, the sustained release agent is 60%, and the sustained release agent is that weight ratio is 1:1-3:1 sodium bentonite and ring paste
The composite slow release agent of essence composition；More preferably weight ratio is 2:The composite slow release agent of 1 sodium bentonite and cyclodextrin composition.
Unless otherwise indicated, " % " of the invention is weight percentage.
Further, the present invention is provided is used to prevent and treat cucumber downy mildew, horse by above-mentioned bactericidal composition or sterilization sustained release agent
The purposes of bell potato late blight, watermelon blight or capsicum damping-off.
Principle is explained：The sterilization sustained release agent of the present invention is especially suitable for use as seedbed sustained release agent, and it focuses on to wherein closing
The selection of key component sustained release agent：First, sodium bentonite is the nonmetallic minerals using montmorillonite as main mineral constituent in itself,
There are some cations in the layer structure of montmorillonite structure cell formation, when sodium bentonite is contacted with water, these interlayer cations
There is a kind of trend for dissociating, spreading into water, with the disengaging of cation, bentonite surface is negatively charged, now can be in solution
Cation produce Electrostatic Absorption, a portion cation is closely attracting with sodium bentonite, forms adsorption layer, and remaining is positive
Ion is evenly distributed in the liquid phase of surrounding with their aqueous solvent and constitutes diffusion layer；Pasted when by sodium bentonite and ring
When essence is combined with special ratios, the two compatibility is good, can preferably excite the electric double layer characterization of adsorption of sodium bentonite so that kill
Bacterium active component is adsorbed to be gathered into condensation product, with very strong stability and lasting slow release.
Compared with prior art, beneficial effects of the present invention are：
（1）Compared with single dose, binary or ternary bactericidal composition of the present invention is respectively provided with significant synergistic effect, synergy system
Number is more than 130；
（2）The present invention with lasting slow releasing function, and is had good stability using the obtained sterilization sustained release agent of specific sustained release agent.
Embodiment
For the ease of understanding the purpose of the present invention, technical scheme and its effect, now the present invention will be done in conjunction with the embodiments into
One step is elaborated.
First, biological Examples
Embodiment 1, cucumber downy mildew indoor bioassay
In order to prevent and treat the downy mildew in agricultural production, the synergy that inventor Yi famoxadones, hymexazol have carried out mutual compounding is ground
Study carefully, specific method is：
Experiment uses bacterium of downy mildew of cucumber（Pseudoperonospora cubensis）For test object.Active compound is configured to need
The test medicine wanted, test method reference《People's Republic of China's agricultural industry criteria NY/T1156.3-2006》.
Single dose and each Mixed Pharmacy are set into 5 various concentrations gradients first（It is antibacterial on the basis of pilot study result
Rate is set in the range of 5%~90% by geometric progression）.Experiment target bacterium is the Huang for picking up from the field leaf of 4 leaves~6 position from up to down
Melon Pseudoperonospora cubensis blade, the Pseudoperonospora cubensis sporangium at the lower blade back side is washed with 4 DEG C of distillations, suspension is made into（Concentration control exists
Every milliliter 1 × 105Individual~1 × 107Individual sporangium）, deposit standby at 4 DEG C.Decoction is uniformly sprayed in the healthy leaves back side, treated
After decoction natural air drying, by it is each processing blade and blade dorsad on, by processing mark after be emitted in moisture preservation box.Experiment is set without medicament
Processing make blank control.Vacuum side of blade is inoculated in the ready μ L of Fresh spores capsule suspension drop 10.Per blade inoculation 4
Drop, no less than 5 leaves of often processing.Culture dish lid is covered after inoculation, growth cabinet is placed in or has the humidistat of illumination, daily
Cultivated under conditions of continuous illumination/dark 12h alternatings, 17 DEG C~22 DEG C of temperature, relative humidity more than 90%.Depending on processing and blank
Control incidence measures and records lesion diameter, and unit is millimeter（mm）, calculate prevention effect.Pass through the probability of prevention effect
Linear regression analysis between value and the logarithm value of series concentration, obtains the EC of each medicament50 Value, mixture is calculated with the abundant methods of Sun Yun
Co-toxicity coefficient（CTC）, activity of the reagent agent to germ is evaluated with this.
The co-toxicity coefficient of complex preparation（CTC）>=120 show as synergistic effect；CTC≤80 show as antagonism；80 ＜
CTC ＜ 120 show as summation action.
Cucumber downy mildew Toxicity Determination the results are shown in Table 1 described in the present embodiment.
The famoxadone of table 1 is determined with hymexazol mixture to the synergy of cucumber downy mildew
, famoxadones and hymexazol are respectively with 1 as can be seen from Table 1:20、1:15、1:10、1:8、1:5、1:2、1:1、2:1、5:
1、8:1、10:1、15:1、20:1 combination to cucumber downy mildew CTC values be 167.61,171.42,163.93,172.51,
163.84th, 143.29,155.95,171.69,148.72,144.98,133.10,174.57,146.54, Shuo Ming famoxadones with
Hymexazol is with mass ratio 1:20~20:1 is applied in combination and has synergistic effect to cucumber downy mildew germ, can be used for preventing and treating cucumber cream
Mildew.
Embodiment 2, late blight of potato indoor bioassay
Subjects are the late blight of potato（Potato Late Bright）.The test medicine that active compound is configured to need, will
Single dose and each Mixed Pharmacy set 5 various concentrations gradients（On the basis of pilot study result, bacteriostasis rate is 5%~90%
In the range of by geometric progression setting）.If clear water is compareed, it is repeated 3 times.Experiment uses mycelial growth rate method, by cultured disease
Opportunistic pathogen, aseptically with a diameter of 5 mm card punch, bacteria cake is cut from colony edge, bacteria cake is connected into difference with transfer needle
On the culture medium flat plate of drug concentration, 28 DEG C are put, cultivate in saturated humidity incubator；When control group bacterium colony is covered with, bacterium colony is measured
Diameter, calculates the percentage that each chemicals treatment suppresses mycelial growth, passes through the probit value and the logarithm value of series concentration of inhibiting rate
Between linear regression analysis, obtain the EC of each medicament50Value, the co-toxicity coefficient of mixture is calculated with the abundant methods of Sun Yun（CTC）, with this
To evaluate activity of the reagent agent to germ.
The co-toxicity coefficient of complex preparation（CTC）>=120 show as synergistic effect；CTC≤80 show as antagonism；80 ＜
CTC ＜ 120 show as summation action.
Late blight of potato Toxicity Determination the results are shown in Table 2 described in the present embodiment.
The famoxadone of table 2 is determined with hymexazol mixture to the synergy of the late blight of potato
, famoxadones and hymexazol are respectively with 1 as can be seen from Table 2:20、1:15、1:10、1:8、1:5、1:2、1:1、2:1、5:
1、8:1、10:1、15:1、20:1 combination to late blight of potato CTC values be 148.77,150.69,158.51,168.73,
171.04th, 177.54,156.80,171.66,160.20,147.04,142.01,129.29,139.89, Shuo Ming famoxadones
With hymexazol with mass ratio 1:20~20:1 is applied in combination and has synergistic effect to late blight of potato germ, can be used for preventing and treating horse
Bell potato late blight.
Embodiment 3, watermelon blight indoor bioassay
Subjects are the sharp fusarium of watermelon（Fusarium oxysporum）.By famoxadone, hymexazol active compound, according to setting
Matched proportion density, be configured to required decoction, it is standby.Experiment uses mycelial growth rate method.
Aseptically, the culture medium melted in advance is quantitatively adding in sterile conical flask, from low concentration to high concentration
Decoction is quantitatively drawn successively, is separately added into above-mentioned conical flask, is fully shaken up.Then equivalent pours into 4 a diameter of 9cm culture dish
In, the pastille flat board of respective concentration is made.Processing without medicament is repeated 4 times as blank control.
By cultured pathogen, aseptically, with diameter 5mm card punch, bacteria cake is cut from colony edge, used
Bacterium disease is inoculated in pastille flat board center by inoculator, and mycelia up, covers ware lid, puts 26 DEG C of incubator culture.According to sky
The growing state investigation pathogen mycelial growth situation of bacterium, uses vernier caliper measurement colony diameter, cross in white control culture dish
Interior extrapolation method is vertically respectively surveyed once, is averaged.
Synergistic effect of the bactericidal composition provided using the co-toxicity coefficient method evaluation present invention to watermelon blight, with medicament
The logarithm and preventive effect niqueMin of concentration seek regression equation, and calculate the EC of medicament pair50Value, then tries to achieve co-toxicity coefficient.With
Co-toxicity coefficient evaluates synergy of the compound drug to watermelon blight, co-toxicity coefficient>120 are expressed as synergistic effect, altogether poison system
Number is expressed as summation action, co-toxicity coefficient between 80~120<80 are expressed as antagonism.
The famoxadone of table 3 is determined with hymexazol mixture to the synergy of watermelon blight
, famoxadones and hymexazol are respectively with 1 as can be seen from Table 3:20、1:15、1:10、1:8、1:5、1:2、1:1、2:1、5:
1、8:1、10:1、15:1、20:1 combination to watermelon point fusarium CTC values be 148.87,159.21,163.47,160.13,
154.02nd, 143.64,174.52,149.24,141.44,132.80,133.30,145.43,125.75, Shuo Ming famoxadones with
Hymexazol is with mass ratio 1:20~20:1 is applied in combination and has synergistic effect to watermelon blight, can be used for preventing and treating potato late blight
Disease.
Embodiment 4, capsicum damping-off indoor bioassay
Subjects are Rhizoctonia solani Kuhn（Rizoctonia solani）.By famoxadone, hymexazol active compound, according to setting
Matched proportion density, is configured to required decoction, standby.Experiment uses mycelial growth rate method.
Aseptically, the culture medium melted in advance is quantitatively adding in sterile conical flask, from low concentration to high concentration
Decoction is quantitatively drawn successively, is separately added into above-mentioned conical flask, is fully shaken up.Then equivalent pours into 4 a diameter of 9cm culture dish
In, the pastille flat board of respective concentration is made.Processing without medicament is repeated 4 times as blank control.
By cultured pathogen, aseptically, with diameter 5mm card punch, bacteria cake is cut from colony edge, used
Bacterium disease is inoculated in pastille flat board center by inoculator, and mycelia up, covers ware lid, puts 25 DEG C of incubator culture.According to sky
The growing state investigation pathogen mycelial growth situation of bacterium, uses vernier caliper measurement colony diameter, cross in white control culture dish
Interior extrapolation method is vertically respectively surveyed once, is averaged.
Synergistic effect of the bactericidal composition provided using the co-toxicity coefficient method evaluation present invention to capsicum damping-off, with medicament
The logarithm and preventive effect niqueMin of concentration seek regression equation, and calculate the EC50 values of medicament pair, then try to achieve co-toxicity coefficient.With
Co-toxicity coefficient evaluates synergy of the compound drug to capsicum damping-off, co-toxicity coefficient>120 are expressed as synergistic effect, altogether poison system
Number is expressed as summation action, co-toxicity coefficient between 80~120<80 are expressed as antagonism.
The famoxadone of table 4 is determined with hymexazol mixture to the synergy of capsicum damping-off
, famoxadones and hymexazol are respectively with 1 as can be seen from Table 4:20、1:15、1:10、1:8、1:5、1:2、1:1、2:1、5:
1、8:1、10:1、15:1、20:1 combination Rhizoctonia solani CTC values are 146.70,141.48,155.36,159.07,
161.46th, 174.67,151.41,167.97,163.14,159.27,147.18,140.66,130.31, Shuo Ming famoxadones with
Hymexazol is with mass ratio 1:20~20:1 is applied in combination and has synergistic effect to capsicum damping-off, can be used for preventing and treating capsicum and stands withered
Disease.
In addition, the ternary bactericidal composition of the present invention, compared to single component, and compared to the component of binary, same tool
There is synergistic effect, its coefficient of synergism is also all higher than 120；The ternary that for example Yi famoxadones, hymexazol and Fluoxastrobin are constituted is killed
Exemplified by bacteria composition, its Xiang Bi famoxadone, hymexazol or the specific monomer of Fluoxastrobin three, and Xiang Bi famoxadones and dislike it is mould
Spirit, hymexazol and Fluoxastrobin, Yi increase Ji three binary compositions of famoxadone and Fluoxastrobin composition, are respectively provided with synergistic effect
Imitate coefficient and be more than 120.
2nd, embodiment is prepared
Prepare embodiment 1：4 Chong Liang Fen famoxadones, 4 parts by weight hymexazols, and 15 parts sulfuric acid aluminium are added in water, stirred
Mix uniform, be subsequently added 20 parts by weight sodium bentonites and 40 parts by weight of cyclodextrin, stir the mixture for uniformly, filling mixture
Divide and be fused into pasty state colloid, finished product.
Prepare embodiment 2：In addition to 48 parts by weight sodium bentonites and 12 parts by weight of cyclodextrin are added, remaining is implemented with preparation
Example 1；
Prepare embodiment 3：In addition to 30 parts by weight sodium bentonites and 30 parts by weight of cyclodextrin are added, remaining is with preparation embodiment 1；
Prepare embodiment 4：In addition to 45 parts by weight sodium bentonites and 15 parts by weight of cyclodextrin are added, remaining is with preparation embodiment 1；
Prepare embodiment 5：In addition to 40 parts by weight sodium bentonites and 20 parts by weight of cyclodextrin are added, remaining is with preparation embodiment 1；
Comparative example 1：In addition to 60 parts by weight sodium bentonites are added, remaining is with preparation embodiment 1；
Comparative example 2：In addition to 60 parts by weight of cyclodextrin are added, remaining is with preparation embodiment 1；
Comparative example 3：In addition to 60 parts by weight talcum powder are added, remaining is with preparation embodiment 1；
Comparative example 4：In addition to 15 parts by weight sodium bentonites and 45 parts by weight of cyclodextrin are added, remaining is with preparation embodiment 1；
Comparative example 5：In addition to 50 parts by weight sodium bentonites and 10 parts by weight of cyclodextrin are added, remaining is with preparation embodiment 1.
3rd, field control effectiveness test.
1, cucumber downy mildew field control effectiveness test
Preventing and treating cucumber downy mildew field test is carried out in Shouguang City of Shandong Province within 2016, demonstrated above-mentioned test medicine and contrast
Prevention effect of the medicament to cucumber downy mildew and the security to cucumber.
Trial crops are cucumber, and controlling object is cucumber downy mildew（Pseudoperonospora cubensis）.Experiment
Shouguang City rice field Zhen Dong rice fields village is located at, experimental plot physical features is flat, soil is loam, middle fertility, pH value 6.9, during experiment
Rich water quality management is medium.Test medicine and dosage refer to table 5.Blank control separately is set, 4 repetitions are often handled, per cell 30 ㎡, totally 10
Individual cell, random district's groups arrangement.Using conventional spray-on process, mu dispenser liquid 45kg is uniformly sprayed at leave dual sides.
Investigation and statistical method：State of an illness radix is investigated before dispenser, 10~14d is reinvestigated once after last time dispenser, altogether
Investigation 2 times.Take at random per cell at 4 points, investigate 2 plants, and the whole blades of every plant of investigation, every leaf accounts for leaf area according to scab at every
Percentage classification record.Stage division：
0 grade：Disease-free spot；
1 grade：Lesion area accounts for less than the 5% of whole leaf area；
3 grades：Lesion area accounts for the 6%~10% of whole leaf area；
5 grades：Lesion area accounts for the 11%~25% of whole leaf area；
7 grades：Lesion area accounts for the 26%~50% of whole leaf area；
9 grades：Lesion area accounts for more than the 50% of whole leaf area.
Disease index=[∑ (the sick numbers of sheets at different levels × relative value of series)/(investigation total leaf number × 9)] × 100
Prevention effect (%)=[1- (disease index after disease index × processing dispenser before control dispenser)/（The state of an illness refers to after control dispenser
Disease index before number × processing dispenser）×100
Table 5 prevents and treats cucumber downy mildew field test results
As can be seen from the above table, example of formulations of the invention is better than comparative example, particularly when example of formulations 5 selects spy
During the composite slow release agent of certainty ratio, its best results；Compared to single sustained release agent, other sustained release agents and in proportion of the present invention
Outer composite slow release agent, the present invention has more excellent prevention effect, shows that its slow release effect is more excellent.
Observe within some days after the 1st day and medicine after security survey to cucumber, spray, each test process of the invention is to cucumber
Occur without poisoning phenomenon.
2, late blight of potato field control effectiveness test
Carry out the 7-8 months in 2016 preventing and treating late blight of potato field test in Fugu County of Shaanxi Province.Test arrangement is sent out over the years
Seriously ill plot, test medicine and dosage are shown in Table 6, separately set blank control, often handle 4 repetitions, per the ㎡ of plot area 25, altogether
10 cells, random district's groups arrangement.Using conventional spray-on process, blade positive and negative are uniformly squirted, liter/mu of decoction consumption 50.First
Secondary dispenser is when blade begins to see, second of dispenser after 14d, and dispenser is secondary altogether.
Investigation and statistical method：14 d carry out disease index investigation after second of dispenser, and per cell diagonal, 5 points take
Sample, every is investigated 3 plants, and the whole blades of investigation record total number of sheets, the sick number of sheets at different levels and sick series, calculate disease index.
Grade scale is:
0 grade, disease-free spot；
1 grade, lesion area accounts for less than the 5% of whole leaf area；
3 grades, lesion area accounts for the 6%-10% of whole leaf area；
5 grades, lesion area accounts for the 11%-20% of whole leaf area；
7 grades, lesion area accounts for the 21%-50% of whole leaf area；
9 grades, lesion area accounts for more than the 50% of whole leaf area.
Disease index and prevention effect computational methods：
Disease index=Σ（The sick numbers of sheets at different levels × relative value of series）/（Investigate total number of sheets × 9）×100
Prevention effect（%）=[（Disease index after disease index-chemicals treatment district dispenser after blank district dispenser）/ blank pair
According to disease index after area's dispenser] × 100
Table 6 prevents and treats late blight of potato field test results
As can be seen from the above table, example of formulations of the invention is better than comparative example, particularly when example of formulations 5 selects spy
During the composite slow release agent of certainty ratio, its best results；Compared to single sustained release agent, other sustained release agents and in proportion of the present invention
Outer composite slow release agent, the present invention has more excellent prevention effect, shows that its slow release effect is more excellent.
Security survey to potato, is observed, at each medicament of the invention for some days after the 1st day and medicine after spray every time
Potato occurs reason without poisoning phenomenon.
3, watermelon blight field control effectiveness test
In August, 2016 has carried out preventing and treating watermelon blight field test in Shaanxi Province Weinan City Dali County.Test arrangement is over the years
The plot of morbidity weight, test medicine and dosage are shown in Table 7, separately set blank control, often handle 4 repetitions, per the ㎡ of plot area 30,
Totally 10 cells, random district's groups arrangement.Using conventional spray-on process, liter/mu of decoction consumption 45.Disease first time at initial stage dispenser, 14d
Second of dispenser afterwards, dispenser is secondary altogether.
Investigation and statistical method：Whether all plant have the classical symptom of droop in investigation cell, record droop
Strain number of falling ill and investigation total strain number.
Disease index and prevention effect computational methods：
Diseased plant rate（%）=diseased plant number/investigation total strain number × 100
Prevention effect（%）=（Blank district diseased plant rate-chemicals treatment district diseased plant rate）/ blank district diseased plant rate × 100
Table 7 prevents and treats watermelon blight field test results
As can be seen from the above table, example of formulations of the invention is better than comparative example, particularly when example of formulations 5 selects spy
During the composite slow release agent of certainty ratio, its best results；Compared to single sustained release agent, other sustained release agents and in proportion of the present invention
Outer composite slow release agent, the present invention has more excellent prevention effect, shows that its slow release effect is more excellent.
Security survey to watermelon, is observed, each chemicals treatment of the invention for some days after the 1st day and medicine after spray every time
Watermelon occurs without poisoning phenomenon.
4, capsicum damping-off field control effectiveness test
In October, 2016 has carried out preventing and treating capsicum damping-off field test in Baoji, Shaanxi province city Mei County.Test arrangement is sent out over the years
Seriously ill plot, test medicine and dosage are shown in Table 8, separately set blank control, often handle 4 repetitions, per the ㎡ of plot area 20, altogether
10 cells, random district's groups arrangement.Using conventional spray-on process, blade positive and negative are uniformly squirted, liter/mu of decoction consumption 45.Disease
Second of dispenser after the dispenser of first time at initial stage, 14d, dispenser is secondary altogether.
Investigation and statistical method：Per the 5 points of samplings of cell diagonal, every is investigated 20 plants, records morbidity strain number and total strain number.
Disease index and prevention effect computational methods：
Diseased plant rate（%）=diseased plant number/investigation total strain number × 100
Prevention effect（%）=（Blank district diseased plant rate-chemicals treatment district diseased plant rate）/ blank district diseased plant rate × 100
Table 8 prevents and treats capsicum damping-off field test results
As can be seen from the above table, example of formulations of the invention is better than comparative example, particularly when example of formulations 5 selects spy
During the composite slow release agent of certainty ratio, its best results；Compared to single sustained release agent, other sustained release agents and in proportion of the present invention
Outer composite slow release agent, the present invention has more excellent prevention effect, shows that its slow release effect is more excellent.
Security survey to capsicum, is observed, each chemicals treatment of the invention for some days after the 1st day and medicine after spray every time
Capsicum occurs without poisoning phenomenon.
A kind of Bao Han famoxadones of the present invention and the agricultural bactericidal composition of hymexazol are entered by specific example
Description is gone, those skilled in the art can use for reference present invention, the link such as appropriate feed change, process conditions is corresponding to realize
Other purposes, its correlation change all without departing from present disclosure, all similar replacements and change for this area skill
It is it will be apparent that being considered as being included within the scope of the present invention for art personnel.
Claims (10)
1. the bactericidal composition of a kind of Han famoxadones and hymexazol, it is characterised in that the bactericidal composition contains weight
Than for 1:20-20:1 famoxadones and hymexazol.
2. bactericidal composition according to claim 1, it is characterised in that the weight ratio of the two is 1:5-5:1.
3. bactericidal composition according to claim 1, it is characterised in that can also include and be selected from the group in bactericidal composition
Third component：Triazolone, Triadimenol, metrafenone, Fluoxastrobin, captan or folpet；The Famoxate, hymexazol and the
The weight ratio of three components is：1-10:1-10:1:1-3.
4. bactericidal composition according to claim 3, it is characterised in that the weight ratio of three is 1-5:1-5:1-2.
5. bactericidal composition according to claim 3, it is characterised in that the weight ratio of three is 3:3:1.
6. according to the sterilization sustained release agent of any described bactericidal composition of claim 1 to 5, it is characterised in that the sustained release agent
It is made up of following component by weight percentage：
Bactericidal composition：1-15%；
Sustained release agent：50-70%；
Hardening agent：10-30%；
Surplus is water；
The hardening agent is aluminum sulfate, copper sulphate or ferrous sulfate；
The sustained release agent is that weight ratio is 1:2-4:The composite slow release agent of 1 sodium bentonite and cyclodextrin composition.
7. sterilization sustained release agent according to claim 6, it is characterised in that the bactericidal composition is 8%.
8. sterilization sustained release agent according to claim 6, it is characterised in that the sustained release agent is 60%.
9. sterilization sustained release agent according to claim 6, it is characterised in that the sustained release agent is that weight ratio is 2:1 sodium base
The composite slow release agent of bentonite and cyclodextrin composition.
10. according to any described bactericidal composition of claim 1 to 5 or any described sterilization sustained release agent of claim 6 to 9
For preventing and treating cucumber downy mildew, the late blight of potato, watermelon blight or the purposes of capsicum damping-off.
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| WO2020245384A1 (en) * | 2019-06-05 | 2020-12-10 | UPL Corporation Limited | Fungicide composition for controlling zymoseptoria infection in plant |
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| CN107711863A (en) * | 2017-11-27 | 2018-02-23 | 广东广康生化科技股份有限公司 | Agricultural bactericidal composition and purposes |
| CN107980791A (en) * | 2017-12-14 | 2018-05-04 | 广东广康生化科技股份有限公司 | Containing captan He the bactericidal composition of famoxadone and its application |
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| CN106982844B (en) | 2018-09-14 |
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