CN105052995A - Compound composition containing Dufulin and oxazole bactericide, and preparation thereof - Google Patents
Compound composition containing Dufulin and oxazole bactericide, and preparation thereof Download PDFInfo
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Abstract
The invention provides a compound composition containing Dufulin and an oxazole bactericide, and a preparation thereof. The compound composition and the preparation are mainly used for controlling diseases of various crops. The compound composition comprises Dufulin and the oxazole bactericide, and a weight ratio of Dufulin to the oxazole bactericide is 60:1-1:30. The invention also provides the pesticide preparation of the compound composition containing Dufulin and the oxazole bactericide, and the compound composition accounts for 0.1-80% of the total weight of the pesticide preparation. The dosage form of the pesticide preparation can be a wettable powder, a water dispersible granule, an emulsion in water, a suspension or a seed coating agent as demanded. The compound composition has obvious synergistic effects in control of crop diseases in a certain ratio; and compared with single doses, the compound composition has the advantages of control spectrum enlargement, delaying of the drug resistance, obvious effect improvement, reduction of the use amount and application frequency of single doses, and protection of ecologic environment.
Description
Technical field
The present invention relates to technical field of pesticide, particularly relate to toxic fluorine Lin with the complex composition of oxazole series bactericidal agent and preparation.
Background technology
Along with the change of weather and environment, the species survey of plant disease also changes, and the control efficiency of single pesticide species to disease is undesirable, because the resistance of disease to single pesticide species also strengthens gradually, and cannot prevent and treat multiple diseases simultaneously.Use for a long time as oxazole series bactericidal agents such as hymexazo, famoxadone, SYP-Z048, Evil frost Ling, prevent and treat crop pest preventive effect and decline.The spirit of hymexazo, famoxadone, SYP-Z048, Evil frost is all known in the art and disclosed pesticide species.
Hymexazo (hymexazo): CAS 10004-44-1, chemical name be 3-hydroxy-5-methyl base isoxazole ， hymexazo as being a kind of systemic fungicide and soil disinfectant, there is unique mechanism of action.
Famoxadone (Famoxadone): CAS 131807-57-3, chemical name is 3-phenylamino-5-methyl-5-(4-Phenoxyphenyl)-1,3-azoles quinoline-2,4-diketone, and Famoxate is new and effective, broad spectrum pesticide.
The molecular formula of SYP-Z048 is C16H17ClN2O, chemical name is N-methyl-3-(4-chlorine) phenyl-5-methyl-5-pyridine-3-methyl-oxazoline, developed by Shenyang Chemical Engineering Inst, effectively can be controlled the occurrence and infection of on the ground leaf not disease by root application.There is the bactericidal activity of wide spectrum, there is protection and therapeutic action and good interior absorption simultaneously.
Evil frost spirit (oxadixylanchor) is a kind of bactericide of broad spectrum activity, and the plant disease caused multiple disease fungus has higher prevents and treats result.
Poison fluorine phosphorus is that applicant is transferred the possession of the plant virus resistance product (patent No. ZL200510003041.7) of new generation come by Guizhou University, it is a kind of novel Antiphytoviral medicament of fluorine-containing amino phosphonate ester of novel structure, by activating tobacco bigcatkin willow acid signal conduction path, improve the salicylic content of signaling molecule, thus promote the expression of downstream pathogenesis-related proteins; Anti-virus ability is obtained by evoking tobacco PAL, POD, SOD Defense Enzyme Activities; The invasion of virus to host is reduced by assembling TMV particle.The characteristics such as novel structure, the mechanism of action in view of it are unique, it is remarkably productive that malicious fluorine phosphorus is used for preventing and treating virus disease, but control spectrum is narrow.
Applicant tests after deliberation, finds malicious fluorine Lin with oxazole series bactericidal agent mixture prevents and treats multiple diseases have comparatively outstanding control efficiency.The mixture of different pesticide species is also the common method of preventing and treating agricultural disease at present.Not only can effectively improve actual control efficiency, reduce dosage, reduce costs, also can delay the generation of disease drug resistance, extending the service life of medicament, is the important means of the disease comprehensive regulation.
Summary of the invention
The present invention is directed to the deficiency that prior art exists; there is provided a kind of toxic fluorine Lin with the complex composition of oxazole series bactericidal agent and preparation; this complex composition has obvious synergistic effect relative to single dose; effectively can prevent and treat crop pest; reduce the using dosage of agricultural chemicals; save drug cost, delay the pesticide resistance emergence and development of pathogen to malicious fluorine phosphorus, be conducive to the comprehensive regulation of environmental protection and agricultural disease.
For realizing above-mentioned object, technical scheme of the present invention is:
Toxic fluorine Lin with a complex composition for oxazole series bactericidal agent, this complex composition by malicious fluorine Lin with oxazole series bactericidal agent forms; Wherein, malicious fluorine Lin is with the weight ratio of oxazole series bactericidal agent is 60:1 to 1:30.
As preferably, any one on Yi in Suo Shu oxazole series bactericidal agent Xuan Zi hymexazo, famoxadone, the spirit of SYP-Z048, Evil frost.
In order to ensure that complex composition has good preventive effect and synergistic effect, further preferably, above-described toxic fluorine Lin is with the weight ratio of oxazole series bactericidal agent is 40:1 to 1:20.
The present invention also provides a kind of pesticidal preparations, and this pesticidal preparations comprises acceptable auxiliary material on complex composition described above and agricultural chemicals, is then prepared into the pesticidal preparations for preventing and treating agricultural disease.
Above-described pesticidal preparations, as preferably, described complex composition accounts for 0.1% ~ 80% of described pesticidal preparations gross weight.More preferably, described complex composition accounts for 5% ~ 50% of described pesticidal preparations gross weight.
According to different user demands, pesticidal preparations provided by the invention can be made into multiple formulation well known in the art.As preferably, in embodiment provided by the invention, the formulation of pesticidal preparations is wettable powder, water dispersible granules, seed treatment dry powder doses, suspending agent, suspension seed-coating agent, ultra low volume liquids or granule.Be not limited only to formulation provided by the invention.
On described agricultural chemicals, acceptable auxiliary material is the mixture of a kind of and auxiliary agent in filler, solvent.
Described auxiliary agent comprises surfactant, wetting dispersing agent, also can add other conventional functionality auxiliary agents such as antifreezing agent, thickener, stabilizing agent, defoamer, disintegrant, film forming agent if desired.
Described filler comprises white carbon, diatomite, kaolin, precipitated calcium carbonate, earth powder, bentonite, diatomite, humic acid, chitin, urea, ammonium dihydrogen phosphate (ADP), medium trace element.
Described solvent comprises water, solvent naphtha, cyclohexanone, two wires oil, trimethylbenzene, 1-METHYLPYRROLIDONE, methyl oleate.
Described auxiliary agent comprises alkylbenzenesulfonate, lauryl sodium sulfate, dispersing agent MF, lignosulfonates, sodium butylnaphthalenesulfonate, PO-EO block polyether, REAX-82P, naphthalenesulfonic acid-formaldehyde condensate, calcium dodecyl benzene sulfonate, two phenethyl phenol polyethenoxy ether, Sodium Polyacrylate, phenethyl phenol polyethenoxy ether phosphate, acrylic acid and propionamide copolymer, fatty alcohol-polyoxyethylene ether, sodium carboxymethylcellulose, condensation compound of alkyl phenol and epoxy ethane, alkylphenol polyoxyethylene, Negel.
Described disintegrant comprises ammonium carbonate, sodium sulphate, ammonium chloride, ammonium sulfate.
Binding agent comprises starch, polyvinyl alcohol, ethyl cellulose, sucrose.
Thickener comprises xanthans, aluminium-magnesium silicate, pectin, ethyl cellulose.
Antifreezing agent comprises propane diols, glycerine, isopropyl alcohol, ethylene glycol.
Warning colouration comprises magenta, acid red.
Pesticidal preparations of the present invention is mainly used in controlling plant diseases.
Complex composition of the present invention can be used by commonsense method, as the process of spraying cauline leaf, also root filling can execute or spread fertilizer over the fields, can also dress seed or seed pelleting use.
Compared with present technology, complex composition of the present invention and pesticidal preparations have following beneficial effect:
1, toxic fluorine Lin is with oxazole series bactericidal agent carries out composite, and the mechanism of action of two kinds of medicaments is different, and when the two is composite with certain weight ratio, the co-toxicity coefficient preventing and treating crop pest is greater than 120, shows obvious synergistic effect.
2, when pesticidal preparations of the present invention is used for the diseases such as control of plant bacterial wilt, tomato late blight, black streaked dwarf virus of rice, preventive effect is higher by more than 20% than the preventive effect of malicious fluorine phosphorus single dose Huo oxazole series bactericidal agent single dose, reduce the usage amount of agricultural chemicals, reduce 2g/667m than the usage amount of single dose
2.
3, preventive effect is good, and the lasting period reaches 14 days.Oxazole series bactericidal agent and malicious fluorine phosphorus is composite not easily develops immunity to drugs, efficacy stability, can meet the demand of peasant.
Embodiment
The present invention's the following example is described, but does not limit the scope of the invention.The former medicine of malicious fluorine phosphorus used in the present invention is provided by Guangxi Tianyuan Biochemical Co., Ltd., and other former medicines used and preparation are commercial.
Embodiment prepared by preparation:
Embodiment 161% malicious Fu Lin hymexazo wettable powder (60:1)
Poison fluorine phosphorus 60% ， hymexazo 1%, alkylbenzenesulfonate 6%, lauryl sodium sulfate 2%, white carbon 6%, diatomite supplies 100%.By above-mentioned formula rate, each mixing of materials is carried out air-flow crushing, obtained 61% malicious Fu Lin hymexazo wettable powder.
Embodiment 241% malicious Fu Lin famoxadone wettable powder (40:1)
Poison fluorine phosphorus 40% ， famoxadone 1%, dispersing agent MF 7%, lauryl sodium sulfate 2%, kaolin supplies 100%.By above-mentioned formula rate, each material is carried out mixed airflow pulverizing, obtained 41% malicious Fu Lin famoxadone wettable powder.
Embodiment 331% malicious fluorine phosphorus SYP-Z048 wettable powder (30:1)
Poison fluorine phosphorus 30%, SYP-Z048 1%, alkylbenzenesulfonate 8%, lignosulfonates 6%, white carbon 10%, kaolin supplies 100%.By above-mentioned formula rate, each material is carried out mixed airflow pulverizing, obtained 31% malicious fluorine phosphorus SYP-Z048 wettable powder.
The embodiment 480% malicious Fu Lin Evil clever wettable powder of frost (1:1)
Poison fluorine phosphorus 40% ， Evil frost spirit 40%, lignosulfonates 5%, lauryl sodium sulfate 2%, precipitated calcium carbonate 2%, white carbon supplies 100%.By above-mentioned formula rate, each material is carried out mixed airflow pulverizing, the clever wettable powder of obtained 80% malicious Fu Lin Evil frost.
Embodiment 532.8% malicious Fu Lin hymexazo water dispersible granules (40:1)
Poison fluorine P 32 % ， hymexazo 0.8%, alkylbenzenesulfonate 5%, di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate 3%, ammonium carbonate 10%, starch 2%, kaolin supplies 100%.Above-mentioned raw materials is pulverized through airslide disintegrating mill, and is uniformly mixed rear kneading, then enter fluidized bed prilling, dry, screening i.e. obtained 32.8% malicious Fu Lin hymexazo water dispersible granules.
Embodiment 649.6% malicious Fu Lin famoxadone water dispersible granules (1:30)
Poison fluorine phosphorus 48% ， famoxadone 1.6%, naphthalenesulfonic acid-formaldehyde condensate 4%, lauryl sodium sulfate 3%, starch 3%, earth powder supplies 100%.Above-mentioned raw materials is pulverized through airslide disintegrating mill, and is uniformly mixed rear kneading, then enter in fluidized-bed granulation dryer and carry out granulation, dry, screening i.e. obtained 49.6% malicious Fu Lin famoxadone water dispersible granules.
Embodiment 742% malicious fluorine phosphorus SYP-Z048 water dispersible granules (1:20)
Poison fluorine phosphorus 2%, SYP-Z048 40%, sodium butylnaphthalenesulfonate 5%, PO-EO block polyether 3%, sodium sulphate 4%, ethyl cellulose 2%, bentonite supplies 100%.Above-mentioned raw materials is pulverized through airslide disintegrating mill, and is uniformly mixed rear kneading, then enter in fluidized-bed granulation dryer and carry out granulation, dry, screening i.e. obtained 42% malicious fluorine phosphorus SYP-Z048 water dispersible granules.
Embodiment 841% malicious Fu Lin Evil frost Lingshui Spring dispersible granule (40:1)
Poison fluorine phosphorus 40% ， Evil frost spirit 1%, REAX-82P4%, naphthalenesulfonic acid-formaldehyde condensate 4%, sodium sulphate 6%, diatomite supplies 100%.Above-mentioned raw materials is pulverized through airslide disintegrating mill, and is uniformly mixed rear kneading, then enter in fluidized-bed granulation dryer and carry out granulation, dry, screening i.e. obtained 41% malicious Fu Lin Evil frost Lingshui Spring dispersible granule.
Embodiment 912% malicious Fu Lin hymexazo seed treatment dry powder doses (1:5)
Poison fluorine phosphorus 2% ， hymexazo 10%, naphthalenesulfonic acid-formaldehyde condensate 4%, calcium dodecyl benzene sulfonate 2.5%, polyvinyl alcohol 3.2%, pinkish red 1.5%, diatomite 10%, kaolin supplies 100%.Above-mentioned raw materials will be pulverized through airslide disintegrating mill, and be uniformly mixed, obtained 12% malicious Fu Lin hymexazo seed treatment dry powder doses.
Embodiment 1021% malicious Fu Lin famoxadone seed treatment dry powder doses (1:20)
Poison fluorine phosphorus 1% ， famoxadone 20%, lignosulfonates 2%, PO-EO block polyether 2.5%, polyvinyl alcohol 2%, pinkish red 0.5%, bentonite supplies 100%.Above-mentioned raw materials will be pulverized through airslide disintegrating mill, and be uniformly mixed, obtained 21% malicious Fu Lin famoxadone seed treatment dry powder doses.
Embodiment 1112.2% malicious fluorine phosphorus SYP-Z048 seed treatment dry powder doses (60:1)
Poison fluorine phosphorus 12%, SYP-Z048 0.2%, lauryl sodium sulfate 2%, di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate 3%, aluminium-magnesium silicate 2.5%, acid red 0.5%, kaolin supplies 100%.Above-mentioned raw materials will be pulverized through airslide disintegrating mill, and be uniformly mixed, obtained 12.2% malicious fluorine phosphorus SYP-Z048 seed treatment dry powder doses.
The clever seed treatment dry powder doses (50:1) of embodiment 1210.2% malicious Fu Lin Evil frost
Poison fluorine phosphorus 10% ， Evil frost spirit 0.2%, lignosulfonates 1%, di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate 3.5%, polyvinyl alcohol 2.5%, acid red 0.5%, bentonite 5%, kaolin supplies 100%.Above-mentioned raw materials will be pulverized through airslide disintegrating mill, and be uniformly mixed, the clever seed treatment dry powder doses of obtained 10.2% malicious Fu Lin Evil frost.
Embodiment 1330.5% malicious Fu Lin famoxadone suspending agent (60:1)
Poison fluorine phosphorus 30% ， famoxadone 0.5%, triphen ethyl phenol APEO 3%, calcium dodecyl benzene sulfonate 1.5%, xanthans 0.2%, propane diols 1.9%, water supplies 100%.By above-mentioned raw materials abrading-ball 2 ~ 3 hours in ball crusher, then carry out high speed shear to certain particle diameter, i.e. obtained 30.5% malicious Fu Lin famoxadone suspending agent.
Embodiment 1411% malicious fluorine phosphorus SYP-Z048 suspending agent (10:1)
Poison fluorine phosphorus 10%, SYP-Z048 1%, two phenethyl phenol polyethenoxy ether 4%, Sodium Polyacrylate 8%, aluminium-magnesium silicate 1.5%, glycerine 4%, water supplies 100%.By above-mentioned raw materials abrading-ball 2 ~ 3 hours in ball crusher, then carry out high speed shear to certain particle diameter, i.e. obtained 11% malicious fluorine phosphorus SYP-Z048 suspending agent.
The embodiment 1521% malicious Fu Lin Evil clever suspending agent of frost (1:20)
Poison fluorine phosphorus 1% ， Evil frost spirit 20%, lignosulfonates 3%, di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate 4%, pectin 1.5%, isopropyl alcohol 3%, water supplies 100%.By above-mentioned raw materials abrading-ball 2 ~ 3 hours in ball crusher, then carry out high speed shear to certain particle diameter, i.e. the clever suspending agent of obtained 21% malicious Fu Lin Evil frost.
Embodiment 1610% malicious Fu Lin hymexazo suspension seed-coating agent (1:1)
Poison fluorine phosphorus 5%, hymexazo 5%, lignosulfonates 3%, phenethyl phenol polyethenoxy ether phosphate 3.5%, ethyl cellulose 2%, ethylene glycol 3%, water supplies 100%.By above-mentioned raw materials abrading-ball 2 ~ 3 hours in ball crusher, then carry out high speed shear to certain particle diameter, dressing, obtained 10% malicious Fu Lin hymexazo suspension seed-coating agent.
Embodiment 1711% malicious Fu Lin famoxadone suspension seed-coating agent (10:1)
Poison fluorine phosphorus 10% ， famoxadone 1%, acrylic acid and propionamide copolymer 2.5%, fatty alcohol-polyoxyethylene ether 3%, sodium carboxymethylcellulose 2%, ethylene glycol 3%, water supplies 100%.By above-mentioned raw materials abrading-ball 2 ~ 3 hours in ball crusher, then carry out high speed shear to certain particle diameter, dressing, obtained 11% malicious Fu Lin famoxadone suspension seed-coating agent.
Embodiment 1818% malicious fluorine phosphorus SYP-Z048 suspension seed-coating agent (1:5)
Poison fluorine phosphorus 3%, SYP-Z048 15%, calcium dodecyl benzene sulfonate 2%, condensation compound of alkyl phenol and epoxy ethane 4%, ethyl cellulose 2%, glycerine 4%, water supplies 100%.By above-mentioned raw materials abrading-ball 2 ~ 3 hours in ball crusher, then carry out high speed shear to certain particle diameter, dressing, obtained 18% malicious fluorine phosphorus SYP-Z048 suspension seed-coating agent.
Embodiment 196% malicious Fu Lin famoxadone ultra low volume liquids (5:1)
Poison fluorine phosphorus 5% ， famoxadone 1%, solvent naphtha 5%, cyclohexanone 20%, alkylphenol polyoxyethylene 6%, calcium dodecyl benzene sulfonate 2.3%, two wires oil subsidy foot 100%.After being uniformly mixed after above-mentioned raw materials is in mixing kettle, obtained 6% malicious Fu Lin famoxadone ultra low volume liquids.
Embodiment 2011% malicious fluorine phosphorus SYP-Z048 ultra low volume liquids (1:10)
Poison fluorine phosphorus 1%, SYP-Z048 10%, trimethylbenzene 10%, 1-METHYLPYRROLIDONE 10%, fatty alcohol-polyoxyethylene ether 4%, alkylphenol polyoxyethylene 3.5%, methyl oleate supplies 100%.After being uniformly mixed after above-mentioned raw materials is in mixing kettle, obtained 11% malicious fluorine phosphorus SYP-Z048 ultra low volume liquids.
Embodiment 215.5% malicious Fu Lin hymexazol granule (1:10)
Poison fluorine phosphorus 0.5% ， hymexazo 5%, naphthalenesulfonate formaldehyde condensation compound 2%, lauryl sodium sulfate 1.5%, ethyl cellulose 3%, ammonium chloride 5%, humic acid 10%, diatomite supplies 100%.Said components is mixed, pulverizes, stir after adding water-wet, then use screw extruder pelletizer granulation, sieve after drying and obtain 5.5% malicious fluorine phosphorus hymexazol granule.
Embodiment 220.5% malicious Fu Lin famoxadone granule (1:1)
Poison fluorine phosphorus 0.25% ， famoxadone 0.25%, lignosulfonates 2%, sodium butylnaphthalenesulfonate 2%, polyvinyl alcohol 2%, ammonium sulfate 8%, chitin 5%, urea supplies 100%.Said components is mixed, pulverizes, stir after adding water-wet, then use screw extruder pelletizer granulation, sieve after drying and obtain 0.5% malicious fluorine phosphorus famoxadone granule.
Embodiment 230.1% malicious fluorine phosphorus SYP-Z048 granule (1:1)
Poison fluorine phosphorus 0.05%, SYP-Z048 0.05%, Negel 1.5%, naphthalenesulfonate formaldehyde condensation compound 2%, polyvinyl alcohol 3%, ammonium sulfate 8%, urea supplies 100%.Said components is mixed, pulverizes, stir after adding water-wet, then use screw extruder pelletizer granulation, sieve after drying and obtain 0.1% malicious fluorine phosphorus SYP-Z048 granule.
The embodiment 241.2% malicious Fu Lin Evil clever granule of frost (1:5)
Poison fluorine phosphorus 0.2% ， Evil frost spirit 1%, Negel 4%, PO-EO block polyether 1%, sucrose 4%, ammonium dihydrogen phosphate (ADP) 10%, medium trace element 5%, urea supplies 100%.Said components is mixed, pulverizes, stir after adding water-wet, then use screw extruder pelletizer granulation, sieve after drying and obtain the clever granule of 1.2% malicious fluorine phosphorus Evil frost.
Toxicity Determination embodiment:
Following indoor biometrics test adopts the abundant method of Sun Yun to calculate co-toxicity coefficient (CTC) and evaluates mixed effect.
Toxicity index TI (B)=(EC of standard agent A
50the EC of ÷ B agent
50) × 100
Actual toxicity index ATI (AB)=(EC of A
50the EC of ÷ AB
50) × 100
Theoretical toxicity index TTI (AB)=TI (the A) × A percentage+TI (B) in the mixture × percentage of B in mixture
Actual measurement toxicity index (ATI)=(standard agent EC
50÷ reagent agent EC
50) × 100
In theoretical toxicity index (TTI)=A medicament toxicity index × mixture A percentage composition+B medicament toxicity index × mixture in the percentage composition of B
Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI) ÷ mixture] × 100
Evaluation criterion is: co-toxicity coefficient >=120 show as synergistic effect; Co-toxicity coefficient≤80 show as antagonism; 80< co-toxicity coefficient <120 shows as summation action.
Toxicity Determination embodiment one
The strains tested be kept on test tube slant is transferred on PDA flat board, in 28 DEG C of constant incubators, cultivate 3d, cut bacterium colony outer rim with the card punch of diameter 5mm and be prepared into bacterium cake, for subsequent use.
Mycelial growth rate assay method: by malicious fluorine Lin with the PDA culture medium flat plate of desired concn made respectively by hymexazo 2 kinds of bactericide, arranging not adding medicine is contrast, and each concentration repeats 4 times.Aseptically, bacterium cake is placed in pastille medium central authorities, is then placed in after 28 DEG C of incubators cultivate 72h, observe the growing state of strains tested under each bactericide different quality concentration, measure colony diameter by right-angled intersection method, represent bacterium colony size with mean, calculate relative inhibition.Application Excel software analysis, calculates the EC of each medicament
50, and calculate co-toxicity coefficient according to the abundant method of Sun Yun.Measurement result sees the following form 1
The Toxicity Determination result of table 1 control of plant bacterial wilt
From table 1 result of the test, malicious fluorine Lin Yu hymexazo by weight be 60:1 to 1:30 scope in the co-toxicity coefficient of composite control of plant bacterial wilt all more than 120, composite both showing have obvious synergistic function.Wherein, weight ratio is in the scope of 40:1 ~ 1:20, the co-toxicity coefficient of each process more than 150, synergy highly significant.
Toxicity Determination embodiment two
Adopt mycelial growth rate method.After being melted by medium, be cooled to about 45 DEG C, be made into respectively content of dispersion be 1,10,100,1000 μ g/ml containing medium, pouring diameter after shaking up into is in the sterilising medium ware of 9cm, every ware 10ml.Being 5mm card punch with diameter gets bacterium cake access pastille culture medium flat plate central authorities by beating for examination bacterial classification of having activated, is placed in 28 DEG C of constant incubators.After cultivating 5d, just cover with mycelia in contrast culture dish, measure colony diameter by right-angled intersection method, calculate mycelia relative inhibition.Relative inhibition (%)=(contrast bacterium colony average diameter-process bacterium colony average diameter)/contrast bacterium colony average diameter × 100.Often process repetition 4 times, replace pesticide-treated for contrast with sterile water, the result of gained adopts Excel software analysis, calculates the EC of each medicament
50, and calculate co-toxicity coefficient according to the abundant method of Sun Yun.Measurement result sees the following form 2
The Toxicity Determination result of tomato late blight prevented and treated by table 2
As seen from the data in Table 2, malicious fluorine Lin Yu famoxadone by weight be 60:1 to 1:30 scope in the co-toxicity coefficient of composite control tomato late blight all more than 120, composite both showing have synergistic function.Wherein, malicious fluorine phosphorus and famoxadone by weight be 40:1 ~ 1:20 scope in, the co-toxicity coefficient respectively processed more than 150, synergy highly significant.
The Toxicity Determination result of tomato late blight prevented and treated by table 3
As seen from the data in Table 3, the spirit of malicious fluorine Lin Yu Evil frost by weight be 60:1 to 1:30 scope in the co-toxicity coefficient of composite control tomato late blight all more than 120, composite both showing have obvious synergistic function.Wherein, when in the scope that weight ratio is 40:1 ~ 1:20, the co-toxicity coefficient of each process more than 140, synergy highly significant.
Toxicity Determination embodiment three
Test method: to feed plant hopper with diseased plant, makes plant hopper be with poison, is with malicious rate about 35% after testing.Potted plant healthy rice strain, for connecing worm.
When rice shoot grows to 1 leaf 1 heart ~ 2 leaf 1 heart, carry out inoculated identification.Every alms bowl cover is with translucent cover, and top gauze seals, and calculating by every seedling 5 small brown rice planthoppers needs worm amount, accesses for 2 ~ 3 small brown rice planthopper in ages (being with malicious rate about 35%).Expelling parasite every day 2 times, makes tested rice seedling evenly by poison.After 48h, evenly sprayed by the medicament preparing variable concentrations in on examination seedling, often process and repeat for 4 times, the seedling of each process grows morbidity under natural lighting condition.Test establishes the process not containing medicament as blank.Deng blank morbidity about 50% time, classification investigation incidence, calculate inhibiting rate, use EC
50value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient, and measurement result is in table 4:
The Toxicity Determination result of table 4 water prevention rice black streak dwarf
The Toxicity Determination result of table 5 water prevention rice black streak dwarf
From table 4-5 data, malicious fluorine phosphorus respectively with SYP-Z048, hymexazo by weight be 60:1 to 1:30 scope in the co-toxicity coefficient of composite water prevention rice black streak dwarf all more than 120, composite both showing have obvious synergistic function.Wherein, when in the scope that weight ratio is 40:1 ~ 1:20, the co-toxicity coefficient of each process more than 140, synergy highly significant.
land for growing field crops test examples
In order to clear and definite malicious fluorine Lin Yu oxazole series bactericidal agent is as the control efficiency of hymexazo, famoxadone, the composite various crop pest of SYP-Z048, Evil frost spirit, and composite use whether synergy and synergy whether obvious, present invention applicant at home different regions has carried out a large amount of field trials.Illustrate with several fields embodiment below.Wetting powder is wettable powder.
Contrast medicament 1:30% poison fluorine phosphorus wetting powder, registration card number LS20130359, Guangxi Tianyuan Biochemical Co., Ltd. produces.
Contrast medicament 2:70% hymexazo wetting powder, registration card number PD20110451, Shaanxi Meibang Pesticide Co., Ltd.;
Contrast medicament 3:30% famoxadone wettable powder, self-control;
Contrast medicament 4:25% SYP-Z048 missible oil, registration card number PD20080774, Shenyang Sciencreat Chemicals Co., Ltd..
The clever wettable powder of contrast medicament 5:15% Evil frost, self-control.
Field trial embodiment one:
Test method: according to " NY/T1464.32-2010 pesticide field efficacy medicine test criterion the 32nd part: bactericidal agent for preventing and treating bacterial wilt of tomato ", begins to carry out first time when seeing diseased plant and fills with root dispenser, interval 7 days second time dispenser.Before dispenser and after second time medicine 7 days, 14 Tian Mei communities investigate whole plant respectively, record total strain number and diseased plant number, calculate 7 days, 14 days diseased plant rate and preventive effect after second time medicine, the results are shown in Table 6:
The field test results of table 6 control of plant bacterial wilt
From result of the test table 6, when usage amount is less, during pesticidal preparations control of plant bacterial wilt of the present invention, preventive effect (the active ingredient dosage 12g/667m of 7d after second time medicine
2) respectively than single dose poison fluorine phosphorus (active ingredient dosage 15g/667m
2) Ji hymexazo (active ingredient dosage 30g/667m
2) preventive effect height 24.17-34.91%, 35.00-45.75%; And still can reach the preventive effect of more than 84% at 14d, the lasting period is long.
Field trial embodiment two:
Test method: according to " GB/T17980.31-2000 pesticide field efficacy medicine test criterion (one) bactericidal agent for preventing and treating early blight of tomato and late blight ".First time spray pesticide is carried out, interval 7 days second time dispenser when disease just occurs.Within 7 days, 14 days, carry out classification investigation respectively before dispenser and after second time medicine, 7 days, 14 days disease indexs and preventive effect after calculating second time medicine, the results are shown in Table 7:
The field test results of tomato late blight prevented and treated by table 7
From result of the test table 7, when usage amount is less, pesticidal preparations control tomato late blight of the present invention, preventive effect (the active ingredient dosage 4g/667m of 7d after second time medicine
2) respectively than single dose poison fluorine phosphorus (active ingredient dosage 18g/667m
2) Ji famoxadone (active ingredient dosage 6g/667m
2) preventive effect height 38.06%-41.90%, 20.99%-24.83%; And still can reach the preventive effect of more than 85% at 14d, the lasting period is long.
From result of the test table 7 also, when usage amount is less, pesticidal preparations control tomato late blight of the present invention, preventive effect (the active ingredient dosage 4g/667m of 7d after second time medicine
2) respectively than single dose poison fluorine phosphorus (active ingredient dosage 18g/667m
2) Ji Evil frost spirit (active ingredient dosage 10g/667m
2) preventive effect height 39.14%-41.07%, 32.70%-34.63%; And still can reach the preventive effect of more than 87% at 14d, the lasting period is long.
Field trial embodiment three:
Test method and computational methods: the test method with reference to agricultural [technology service centre of tourist resources in 2011 " southern rice black-streaked dwarf disease remedies Chemicals test " performs, first time spray pesticide is carried out when southern rice black-streaked dwarf disease aobvious disease, once every medication in 7 days later, dispenser three times altogether, every mu of water consumption is 60kg.After third time medicine, 10 days and paddy rice full heading time are investigated respectively, record total strain number and aobvious disease strain number, calculate the incidence of disease and preventive effect, the results are shown in Table 8:
The field test results of table 8 water prevention rice black streak dwarf
From result of the test table 8, when usage amount is lower than single dose, malicious fluorine phosphorus and the composite water prevention rice black streak dwarf of SYP-Z048, control efficiency (the active ingredient dosage 10g/667m of 10d after medicine
2) respectively than single dose poison fluorine phosphorus (active ingredient dosage 12g/667m
2) and SYP-Z048 (active ingredient dosage 30g/667m
2) preventive effect height 21.43%-22.32%, 34.81%-35.70%; And still can reach the preventive effect of more than 84% at 14d, the lasting period is long.
Claims (9)
1. a complex composition for toxic fluorine phosphorus and oxazole series bactericidal agent, is characterized in that, described complex composition is made up of malicious fluorine phosphorus and oxazole series bactericidal agent; Wherein, malicious fluorine Lin is with the weight ratio of oxazole series bactericidal agent is 60:1 to 1:30.
2. toxic fluorine Lin according to claim 1 is with the complex composition of oxazole series bactericidal agent, it is characterized in that, Suo Shu oxazole series bactericidal agent is hymexazo, famoxadone, any one in the spirit of SYP-Z048, Evil frost.
3. toxic fluorine Lin according to claim 1 is with the complex composition of oxazole series bactericidal agent, it is characterized in that, described malicious fluorine Lin is with the weight ratio of oxazole series bactericidal agent is 40:1 to 1:20.
4. a pesticidal preparations, is characterized in that, described pesticidal preparations comprises acceptable auxiliary material on complex composition described in any one of claims 1 to 3 and agricultural chemicals, is then prepared into the pesticidal preparations for preventing and treating agricultural disease.
5. pesticidal preparations according to claim 4, is characterized in that, described complex composition accounts for 0.1% ~ 80% of described pesticidal preparations gross weight.
6. pesticidal preparations according to claim 5, is characterized in that, described complex composition accounts for 5% ~ 50% of described pesticidal preparations gross weight.
7. pesticidal preparations according to claim 4, is characterized in that, the formulation of described pesticidal preparations is wettable powder, water dispersible granules, seed treatment dry powder doses, suspending agent, suspension seed-coating agent, ultra low volume liquids, granule.
8. pesticidal preparations according to claim 4, is characterized in that, on described agricultural chemicals, acceptable auxiliary material is the mixture of a kind of and auxiliary agent in filler, solvent.
9. the application of the pesticidal preparations as described in as arbitrary in claim 4-8, is characterized in that, described pesticidal preparations is used for controlling plant diseases.
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| CN201510466398.2A CN105052995B (en) | 2015-07-31 | 2015-07-31 | A kind of complex composition and preparation containing toxic fluoride phosphate and oxazole series bactericidal agent |
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| CN201510466398.2A CN105052995B (en) | 2015-07-31 | 2015-07-31 | A kind of complex composition and preparation containing toxic fluoride phosphate and oxazole series bactericidal agent |
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| CN105052995A true CN105052995A (en) | 2015-11-18 |
| CN105052995B CN105052995B (en) | 2017-06-06 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106857550A (en) * | 2015-12-11 | 2017-06-20 | 沈阳中化农药化工研发有限公司 | It is a kind of containing the bactericide for stablizing component |
| CN106982844A (en) * | 2017-05-13 | 2017-07-28 | 南京高正农用化工有限公司 | A kind of agricultural bactericidal composition of Bao Han famoxadones and hymexazol |
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| CN1687088A (en) * | 2005-04-04 | 2005-10-26 | 贵州大学 | N-substituted benzothiazolyl-1-substituted phenyl-0,0-dialkyl-alpha-amino phosphonate ester derivatives preparation and application |
| CN102715187A (en) * | 2012-06-27 | 2012-10-10 | 广西田园生化股份有限公司 | Sterilization composition containing Dufulin and strobilurins |
| CN102726444A (en) * | 2012-06-27 | 2012-10-17 | 广西田园生化股份有限公司 | Sterilization composition containing Dufulin |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1687088A (en) * | 2005-04-04 | 2005-10-26 | 贵州大学 | N-substituted benzothiazolyl-1-substituted phenyl-0,0-dialkyl-alpha-amino phosphonate ester derivatives preparation and application |
| CN102715187A (en) * | 2012-06-27 | 2012-10-10 | 广西田园生化股份有限公司 | Sterilization composition containing Dufulin and strobilurins |
| CN102726444A (en) * | 2012-06-27 | 2012-10-17 | 广西田园生化股份有限公司 | Sterilization composition containing Dufulin |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106857550A (en) * | 2015-12-11 | 2017-06-20 | 沈阳中化农药化工研发有限公司 | It is a kind of containing the bactericide for stablizing component |
| CN106857550B (en) * | 2015-12-11 | 2019-11-12 | 沈阳中化农药化工研发有限公司 | It is a kind of containing the fungicide for stablizing component |
| CN106982844A (en) * | 2017-05-13 | 2017-07-28 | 南京高正农用化工有限公司 | A kind of agricultural bactericidal composition of Bao Han famoxadones and hymexazol |
| CN106982844B (en) * | 2017-05-13 | 2018-09-14 | 南京高正农用化工有限公司 | A kind of agricultural bactericidal composition of Bao Han famoxadones and hymexazol |
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| CN105052995B (en) | 2017-06-06 |
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