CN104222118A - Bactericidal composition - Google Patents
Bactericidal composition Download PDFInfo
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- CN104222118A CN104222118A CN201410464753.8A CN201410464753A CN104222118A CN 104222118 A CN104222118 A CN 104222118A CN 201410464753 A CN201410464753 A CN 201410464753A CN 104222118 A CN104222118 A CN 104222118A
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- China
- Prior art keywords
- acid amides
- active component
- pyrrole bacterium
- fluorine pyrrole
- bacterium acid
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- 239000000203 mixture Substances 0.000 title claims abstract description 48
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 36
- 201000010099 disease Diseases 0.000 claims abstract description 35
- 229930182764 Polyoxin Natural products 0.000 claims abstract description 21
- YEBIHIICWDDQOL-YBHNRIQQSA-N polyoxin Polymers O[C@@H]1[C@H](O)[C@@H](C(C=O)N)O[C@H]1N1C(=O)NC(=O)C(C(O)=O)=C1 YEBIHIICWDDQOL-YBHNRIQQSA-N 0.000 claims abstract description 21
- 241000894006 Bacteria Species 0.000 claims description 78
- 150000001408 amides Chemical class 0.000 claims description 61
- WHDHEVMINMZADQ-UHFFFAOYSA-N [F].N1C=CC=C1 Chemical compound [F].N1C=CC=C1 WHDHEVMINMZADQ-UHFFFAOYSA-N 0.000 claims description 59
- 241000221785 Erysiphales Species 0.000 claims description 19
- 239000000375 suspending agent Substances 0.000 claims description 18
- 239000003094 microcapsule Substances 0.000 claims description 14
- 239000000839 emulsion Substances 0.000 claims description 12
- 206010039509 Scab Diseases 0.000 claims description 10
- 241000233679 Peronosporaceae Species 0.000 claims description 9
- 235000007164 Oryza sativa Nutrition 0.000 claims description 8
- 235000009566 rice Nutrition 0.000 claims description 8
- 239000004530 micro-emulsion Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 238000009736 wetting Methods 0.000 claims description 6
- 241001530056 Athelia rolfsii Species 0.000 claims description 5
- 206010027146 Melanoderma Diseases 0.000 claims description 5
- 206010064458 Penicilliosis Diseases 0.000 claims description 5
- 241000918585 Pythium aphanidermatum Species 0.000 claims description 5
- 241000221696 Sclerotinia sclerotiorum Species 0.000 claims description 5
- 230000035613 defoliation Effects 0.000 claims description 5
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 5
- 208000031968 Cadaver Diseases 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 239000005820 Prochloraz Substances 0.000 abstract description 22
- TVLSRXXIMLFWEO-UHFFFAOYSA-N prochloraz Chemical compound C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl TVLSRXXIMLFWEO-UHFFFAOYSA-N 0.000 abstract description 21
- 230000002195 synergetic effect Effects 0.000 abstract description 19
- 150000003839 salts Chemical class 0.000 abstract description 16
- 239000004480 active ingredient Substances 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 7
- 150000001875 compounds Chemical class 0.000 abstract description 4
- 239000005858 Triflumizole Substances 0.000 abstract description 3
- HSMVPDGQOIQYSR-KGENOOAVSA-N triflumizole Chemical compound C1=CN=CN1C(/COCCC)=N/C1=CC=C(Cl)C=C1C(F)(F)F HSMVPDGQOIQYSR-KGENOOAVSA-N 0.000 abstract description 3
- 239000005783 Fluopyram Substances 0.000 abstract description 2
- KVDJTXBXMWJJEF-UHFFFAOYSA-N fluopyram Chemical compound ClC1=CC(C(F)(F)F)=CN=C1CCNC(=O)C1=CC=CC=C1C(F)(F)F KVDJTXBXMWJJEF-UHFFFAOYSA-N 0.000 abstract description 2
- 238000001228 spectrum Methods 0.000 abstract description 2
- 238000009991 scouring Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 35
- 239000002131 composite material Substances 0.000 description 33
- 239000003814 drug Substances 0.000 description 28
- 230000003449 preventive effect Effects 0.000 description 22
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 17
- 150000003851 azoles Chemical class 0.000 description 17
- 229910052731 fluorine Inorganic materials 0.000 description 17
- 239000011737 fluorine Substances 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 239000000575 pesticide Substances 0.000 description 15
- 239000013530 defoamer Substances 0.000 description 14
- 239000002270 dispersing agent Substances 0.000 description 14
- 239000008367 deionised water Substances 0.000 description 12
- 229910021641 deionized water Inorganic materials 0.000 description 12
- 239000012071 phase Substances 0.000 description 12
- 240000008067 Cucumis sativus Species 0.000 description 11
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 11
- 239000003995 emulsifying agent Substances 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- 239000000080 wetting agent Substances 0.000 description 10
- 230000002528 anti-freeze Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 239000002562 thickening agent Substances 0.000 description 9
- 241000209094 Oryza Species 0.000 description 7
- 241000209140 Triticum Species 0.000 description 7
- 235000021307 Triticum Nutrition 0.000 description 7
- 206010067482 No adverse event Diseases 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 238000011835 investigation Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 231100000820 toxicity test Toxicity 0.000 description 6
- 206010011732 Cyst Diseases 0.000 description 5
- 229910021380 Manganese Chloride Inorganic materials 0.000 description 5
- 239000008346 aqueous phase Substances 0.000 description 5
- 208000031513 cyst Diseases 0.000 description 5
- 229920002521 macromolecule Polymers 0.000 description 5
- 229940099607 manganese chloride Drugs 0.000 description 5
- 239000011565 manganese chloride Substances 0.000 description 5
- 241000223600 Alternaria Species 0.000 description 4
- 241000227653 Lycopersicon Species 0.000 description 4
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 4
- 235000014443 Pyrus communis Nutrition 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000003002 pH adjusting agent Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000003905 agrochemical Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
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- 239000011230 binding agent Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- OXOKTPUZOHPXSA-UHFFFAOYSA-L manganese(2+);n-propyl-n-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide;dichloride Chemical compound Cl[Mn]Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl OXOKTPUZOHPXSA-UHFFFAOYSA-L 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 150000002460 imidazoles Chemical class 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- -1 prochloraz zinc salt Chemical class 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 150000003432 sterols Chemical class 0.000 description 2
- 235000003702 sterols Nutrition 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- NDDVRXSINJWQDX-UHFFFAOYSA-N 1,2,2,3,3,4-hexafluoropyrrole Chemical compound FC=1C(C(N(C=1)F)(F)F)(F)F NDDVRXSINJWQDX-UHFFFAOYSA-N 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000010165 autogamy Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
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- 235000013339 cereals Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
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- 238000001035 drying Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- ZHNUHDYFZUAESO-UHFFFAOYSA-N formamide Substances NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
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- 239000003112 inhibitor Substances 0.000 description 1
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- 235000021374 legumes Nutrition 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
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- 150000004993 o-toluidines Chemical class 0.000 description 1
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Abstract
The invention discloses a bactericidal composition. The bactericidal composition contains an active ingredient A and an active ingredient B, wherein the active ingredient A is selected from fluopyram, the active ingredient B is selected from any one of the following compounds: prochloraz and the salts thereof, polyoxin and triflumizole, and the weight ratio of the active ingredient A to the active ingredient B is 1:80 to 60:1. The composition disclosed by the invention is high in activity on various diseases of various crops, has an obvious synergistic effect, and expands a bactericidal spectrum; moreover, the composition has the characteristics of low dosage, rainwater scouring resistance, and obvious synergy.
Description
The application is divisional application, and original application is the patent application " a kind of bactericidal composition " of Shaanxi Meibang Pesticide Co., Ltd., and the application number of original application is ︰ 201210239628.8, and original application day is 2012.07.11.
Technical field
The invention belongs to technical field of pesticide, relate to the application of a kind of bactericidal composition in crop pest.
Technical background
Fluorine pyrrole bacterium acid amides (Fluopyram) chemical name: N-{2-[the chloro-5-of 3-(trifluoromethyl)-2-pyridine radicals) ethyl] the fluoro-0-toluamide of-α, α, α-three, molecular formula: C
16h
11clF
6n
2o.It suppresses mitochondrial respiratory by hindering the electro transfer of succinate dehydrogenase in respiratory chain.Reaching the object controlling pathogenic bacteria by suppressing the several stage in the growth of pathogenic bacteria cycle, being mainly used in broad leaf crop being prevented and treated the microbial disease of ascus.
The salt of Prochloraz comprises prochloraz-manganese chloride complex, prochloraz nantokite, prochloraz zinc salt.
Prochloraz (Prochloraz) chemical name: N-propyl group-N-[α-(2,4,6-Trichlorophenoxy)-1H-imidazoles-1-formamide, molecular formula: C
15h
16cl
3n
3o
2.Imidazoles broad-spectrum germicide.The various crop disease caused for sac fungi and imperfect fungus has special efficacy.Effect is caused by suppressing the biosynthesis of sterol.Although do not have a systemic action, it has certain conductive performance.Prochloraz-manganese chloride complex (Prochloraz-manganese chloride complex) chemical name: N-propyl group-N-[2-(2,4,6-Trichlorophenoxy) ethyl]-1H imidazoles-1-formamide-manganese chloride, molecular formula: [C
15h
16cl
3n
3o
2] 4MnCl2.Imidazoles bactericide, with Prochloraz-manganese chloride compound for active ingredient, has special efficacy to the microbial various crop disease of ascus.
Polyoxin (Polyoxin) chemical name: peptide pyrimidine nucleoside, molecular formula: C
17h
25n
5o
14, broad-spectrum antibiotics class, has good Uptake and translocation effect, its mechanism of action is the chitinous biosynthesis of interference bacterial cell wall, germ tube contacts after medicament with mycelium, and local bulkiness breaks, overflow cell inclusion, and can not normal development, cause death, also have and suppress germ to produce spore and scab expansion effect, this medicine does not have toxicity to animal, does not have poisoning to plant.
Fluorine bacterium azoles (Triflumizole) chemical name: (E)-4-chloro-α, α, α-three fluoro-N-(1-imidazoles-1-base-α-the third oxygen ethylidene) o-toluidines fluorine bacterium azoles, molecular formula: C
15h
15n
3f
3clO.Sterol demethylation inhibitors, has the systemic fungicide of protection and therapeutic action.
In the real process of agricultural production, the problem that controlling disease the most easily produces is the generation of disease drug resistance.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistance disease.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really has the seldom composite of synergistic effect, especially synergistic effect clearly, very high composite just less of synergy ratio.Study through inventor, find fluorine pyrrole bacterium acid amides and Prochloraz or its salt, polyoxin, fluorine bacterium azoles mutually composite, there is good synergistic effect within the specific limits, and about fluorine pyrrole bacterium acid amides and Prochloraz or its salt, polyoxin, fluorine bacterium azoles relevant composite, there is not yet relevant report at home and abroad at present.
Summary of the invention
The object of the invention is to propose a kind of to there is synergistic function, use cost is low, preventive effect is good bactericidal composition.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition, it is characterized in that containing active components A and active component B, active components A and active component B weight ratio are 1 ︰ 80 ~ 60 ︰ 1, described active components A is selected from fluorine pyrrole bacterium acid amides, and active component B is selected from any one compound following: Prochloraz or its salt, polyoxin, fluorine bacterium azoles; The preferred weight ratio of active components A and active component B is 1 ︰ 60 ~ 40 ︰ 1; The weight ratio being more preferably fluorine pyrrole bacterium acid amides and Prochloraz or its salt is 1 ︰ 40 ~ 10 ︰ 1, and the weight ratio of fluorine pyrrole bacterium acid amides and polyoxin is 1 ︰ 30 ~ 15 ︰ 1, and the weight ratio of fluorine pyrrole bacterium acid amides and fluorine bacterium azoles is 1 ︰ 30 ~ 20 ︰ 1; The weight ratio most preferably being fluorine pyrrole bacterium acid amides and Prochloraz or its salt is 1 ︰ 15 ~ 5 ︰ 1, and the weight ratio of fluorine pyrrole bacterium acid amides and polyoxin is 1 ︰ 10 ~ 5 ︰ 1, and the weight ratio of fluorine pyrrole bacterium acid amides and fluorine bacterium azoles is 1 ︰ 15 ~ 10 ︰ 1.
Described bactericidal composition is for preventing and treating the disease of crops, and described crops comprise cereal crops, legume crop, fiber crop, sugar [yielding, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crop, flower crop, medicinal crop, crop, green manure pasture crop; Described disease comprises powdery mildew, scab, rust, anthracnose, epidemic disease, leaf spot, brown spot, graywall, black spot, bakanae disease, rice blast, blossom-end rot, crown rot, green mould, penicilliosis, downy mildew, leaf mold, stalk break, spot defoliation, damping off, banded sclerotial blight.
In the present composition, the content of active component depends on amount of application when being used alone, and also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, simultaneously also relevant with target disease.In usual composition, the weight percentage of active component is 1% ~ 90% of gross weight, is preferably 5% ~ 80%.According to different preparation types, active component content scope is different.Usually, liquid preparation contains the active substance of by weight 1% ~ 60%, is preferably 5% ~ 50%; Solid pharmaceutical preparation contains the active substance of by weight 5% ~ 80%, is preferably 10% ~ 80%.
At least containing a kind of surfactant in bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 2% ~ 30% of total formulation weight amount, and surplus is solid or liquid diluent.
Surfactant selected by bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, thickener or defoamer.According to different dosage form, in preparation, stabilizing agent known in those skilled in the art, antifreeze etc. can also be contained.
Bactericidal composition of the present invention can by user before use through diluting or directly using.Its preparation can be prepared by processing method known in those skilled in the art, after mixing, then adds surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, defoamer etc. by active component with liquid flux or solid carrier.
Bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein preferred dosage form is wetting powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent, can also make aqua, soluble liquid.
Composition comprises following component and content when making wetting powder: active components A 0.1% ~ 60%, active component B 0.1% ~ 80%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, filler surplus.
Composition comprises following component and content when making water dispersible granules: active components A 0.1% ~ 60%, active component B 0.1% ~ 80%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, disintegrant 1% ~ 10%, binding agent 0 ~ 8%, filler surplus.
Composition comprises following component and content when making suspending agent: active components A 0.1% ~ 50%, active component B 0.1% ~ 50%, dispersant 1% ~ 10%, wetting agent 1% ~ 10%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, antifreeze 0 ~ 8%, deionized water add to 100%.
Composition comprises following component and content when making suspension emulsion: active components A 0.1% ~ 50%, active component B 0.1% ~ 50%, emulsifier 1% ~ 10%, dispersant 1% ~ 10%, solvent 1% ~ 20%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, antifreeze 0 ~ 8%, deionized water add to 100%.
Composition comprises following component and content when making microemulsion: active components A 0.1% ~ 50%, active component B0.1% ~ 50%, emulsifier 3% ~ 25%, solvent 1% ~ 20%, antifreeze 0 ~ 8%, defoamer 0.01% ~ 2%, deionized water add to 100%.
Composition comprises following component and content when making aqueous emulsion: active components A 0.1% ~ 50%, active component B 0.1% ~ 50%, solvent 1% ~ 20%, emulsifier 1% ~ 12%, antifreeze 0 ~ 8%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, deionized water add to 100%.
Composition comprises following component and content when making microcapsule suspending agent: active components A 0.1% ~ 50%, active component B0.1% ~ 50%, macromolecule cyst material 1% ~ 10%, dispersant 2% ~ 10%, solvent 1% ~ 10%, emulsifier 1% ~ 7%, pH adjusting agent 0.01% ~ 5%, defoamer 0.01% ~ 2%, deionized water add to 100%.
Composition comprises following component and content when making microcapsule suspension-suspendinagent agent: active components A 0.1% ~ 50%, active component B0.1% ~ 50%, macromolecule cyst material 1% ~ 12%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, solvent 1% ~ 15%, emulsifier 1% ~ 8%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, pH adjusting agent 0.01% ~ 5%, deionized water add to 100%.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension-suspendinagent agent the key technical indexes of the present invention:
The invention has the advantages that: (1) present composition has good synergy and lasting effect within the specific limits, and preventive effect is higher than single dose; (2) pesticide usage amount reduces, and reduces the residual quantity of agricultural chemicals on crop, alleviates environmental pollution; (3) fungicidal spectrum is expanded, to multiple diseases as powdery mildew, scab, rust, anthracnose, epidemic disease, leaf spot, brown spot, graywall, black spot, bakanae disease, rice blast, blossom-end rot, crown rot, green mould, penicilliosis, downy mildew, leaf mold, stalk break, spot defoliation, damping off, banded sclerotial blight have greater activity.
Embodiment
Below in conjunction with embodiment to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Example 1 ~ 9 wetting powder
By fluorine pyrrole bacterium acid amides, active component B, dispersant, wetting agent, filler mixing, mix in mixed cylinder, mix again after airslide disintegrating mill is pulverized, namely can be made into wetting powder product of the present invention.Specifically in table 1.
The each component of table 1 example 1 ~ 9 and content
Example 10 ~ 18 water dispersible granules
Fluorine pyrrole bacterium acid amides, active component B, dispersant, wetting agent, disintegrant, filler are obtained together the particle diameter needed through air-flow crushing, then add other auxiliary agents such as binding agent (can add and can not add), obtain granulation materials.Item is quantitatively sent in fluidized bed granulating dryer through granulating and after drying, obtaining water dispersible granules product of the present invention.Specifically in table 2.
The each component of table 2 example 10 ~ 18 and content
Prochloraz in table 1 to table 2 or its salt, polyoxin, fluorine bacterium azoles are exchanged, can novel formulation be obtained.
Example 19 ~ 27 suspending agent
Dispersant, wetting agent, thickener (can add and can not add), defoamer, antifreeze (can add and can not add) are mixed through high speed shear, add fluorine pyrrole bacterium acid amides, active component B, surplus is supplied by deionized water, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, obtained suspending agent product of the present invention.Specifically in table 3.
The each component of table 3 example 19 ~ 27 and content
Example 28 ~ 32 suspension emulsion
Dispersant, defoamer, thickener (can add and can not add), antifreeze (can add and can not add), deionized water are mixed through high speed shear, add fluorine pyrrole bacterium acid amides, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, obtained fluorine pyrrole bacterium amide suspending agents, then by active component B, solvent, emulsifier and the direct emulsification of various auxiliary agent high speed agitators in suspending agent, obtained suspension emulsion product of the present invention.Specifically in table 4.
The each component of table 4 example 28 ~ 32 and content
Example 33 ~ 41 aqueous emulsion
Fluorine pyrrole bacterium acid amides, active component B, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase; Deionized water, antifreeze (can add and can not add), thickener (can add and can not add), defoamer are mixed, becomes homogeneous aqueous phase.Under high velocity agitation, aqueous phase is added oil phase, obtained aqueous emulsion product of the present invention.Specifically in table 5.
The each component of table 5 example 33 ~ 41 and content
Prochloraz, polyoxin, fluorine bacterium azoles in table 3 to table 5 are exchanged, can novel formulation be obtained.
Example 42 ~ 44 microemulsion
Fluorine pyrrole bacterium acid amides, active component B are dissolved in and are equipped with in the homogenizer of solvent, emulsifier, antifreeze (can add and can not add), defoamer are joined in the homogenizer that above-mentioned solution is housed, give strong mixing after supplying surplus by deionized water and homogenize, finally obtain the microemulsion product of the present invention that clear appearance is transparent.Specifically in table 6.
The each component of table 6 example 42 ~ 44 and content
Example 45 ~ 47 microcapsule suspending agent
By fluorine pyrrole bacterium acid amides, active component B, macromolecule cyst material, solvent, make to be dissolved into homogeneous oil phase, in a shear condition, oil phase is joined in the aqueous phase solution containing emulsifier, pH adjusting agent, dispersant, defoamer, surplus is supplied by deionized water, bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, makes the finely disseminated microcapsule suspending agent product of the present composition.Specifically in table 7.
The each component of table 7 example 45 ~ 47 and content
Example 48 ~ 50 microcapsule suspension-suspendinagent agent
By active component B, macromolecule cyst material, solvent, make to be dissolved into homogeneous oil phase, oil phase is joined in a shear condition in the aqueous phase solution containing emulsifier, pH adjusting agent, make finely disseminated microcapsule suspending agent.Dispersant, wetting agent, defoamer, thickener (can add and can not add) are mixed through high speed shear, add fluorine pyrrole bacterium acid amides, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, obtained suspending agent, then join in the aqueous phase solution of micro-capsule suspension by suspending agent, deionized water supplies surplus, makes the finely disseminated microcapsule suspension-suspendinagent agent product of the present composition.Specifically in table 8.
The each component of table 8 example 48 ~ 50 and content
The embodiment of the present invention is the method adopting Toxicity Determination and field trial to combine.First pass through Toxicity Determination, synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carry out field trial.
Test method: determine that after the effective inhibition concentration scope of each medicament, medicament establishes 5 dosage process respectively by active constituent content through prerun, if clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure medicament to the virulence of crop germ.Measure colony diameter by right-angled intersection method after 72h, calculate each process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/L) converts logarithm value (x) to, try to achieve virulence regression equation (y=a+bx) with method of least squares, and calculate the EC of often kind of medicament thus
50value.Calculate two medicament different ratio synergies ratio (SR) according to Wadley method, SR < 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action simultaneously, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active components A and the ratio of active component B shared by combination; A is fluorine pyrrole bacterium acid amides; B choosing is to the one in Prochloraz or its salt, polyoxin, fluorine bacterium azoles.
Application Example two:
For examination disease: bakanae disease of rice; Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine pyrrole bacterium acid amides and Prochloraz or the former medicine of its salt and the two different ratio mixture.
Toxicity test result
Table 9 fluorine pyrrole bacterium acid amides and Prochloraz or the composite toxicity test analysis of results table to bakanae disease of rice of its salt
As shown in Table 9, the proportioning of fluorine pyrrole bacterium acid amides and Prochloraz or the composite water prevention rice bakanae disease of its salt is when 1 ︰ 80 ~ 60 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 80 ~ 60 ︰ 1 scope all shows synergistic effect, when the proportioning of fluorine pyrrole bacterium acid amides and Prochloraz or its salt is at 1 ︰ 40 ~ 10 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.30.Optimum ratio through test discovery fluorine pyrrole bacterium acid amides and Prochloraz or its salt is 10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:15,1:20,1:25,1:30,1:35,1:40, especially when fluorine pyrrole bacterium acid amides and Prochloraz or its salt weight ratio are 1:4, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example three:
For examination disease: wheat powdery mildew; Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine pyrrole bacterium acid amides and the former medicine of polyoxin and the two different ratio mixture.
Toxicity test result
Table 10 fluorine pyrrole bacterium acid amides and the composite toxicity test analysis of results table to wheat powdery mildew of polyoxin
As shown in Table 10, the proportioning of fluorine pyrrole bacterium acid amides and the composite control wheat powdery mildew of polyoxin is when 1 ︰ 80 ~ 60 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 80 ~ 60 ︰ 1 scope all shows synergistic effect, when the proportioning of fluorine pyrrole bacterium acid amides and polyoxin is at 1 ︰ 30 ~ 15 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.25.Optimum ratio through test discovery fluorine pyrrole bacterium acid amides and polyoxin is 15:1,10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:15,1:20,1:25,1:30, especially when fluorine pyrrole bacterium acid amides and polyoxin weight ratio are 1:2, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example four:
For examination disease: powdery mildew of cucumber; Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine pyrrole bacterium acid amides and the former medicine of fluorine bacterium azoles and the two different ratio mixture.
Toxicity test result
Table 11 fluorine pyrrole bacterium acid amides and the composite toxicity test analysis of results table to powdery mildew of cucumber of fluorine bacterium azoles
As shown in Table 11, fluorine pyrrole bacterium acid amides and the composite proportioning of preventing and treating powdery mildew of cucumber of fluorine bacterium azoles are when 1 ︰ 80 ~ 60 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 80 ~ 60 ︰ 1 scope all shows synergistic effect, when the proportioning of fluorine pyrrole bacterium acid amides and fluorine bacterium azoles is at 1 ︰ 30 ~ 20 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.25.Optimum ratio through test discovery fluorine pyrrole bacterium acid amides and fluorine bacterium azoles is 20:1,15:1,10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,2:3,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:15,1:20,1:25,1:30, especially when fluorine pyrrole bacterium acid amides and fluorine bacterium azoles weight ratio are 2:3, synergy ratio is maximum, and synergistic effect is the most obvious.
Through test find: fluorine pyrrole bacterium acid amides and active component B composite after have obvious synergistic effect to the control of powdery mildew, scab, rust, anthracnose, epidemic disease, leaf spot, brown spot, graywall, black spot, bakanae disease, rice blast, blossom-end rot, crown rot, green mould, penicilliosis, downy mildew, leaf mold, stalk break, spot defoliation, damping off, banded sclerotial blight, synergy ratio is all more than 1.50.
Test of pesticide effectiveness part
Test medicine is researched and developed by Shaanxi Meibang Pesticide Co., Ltd., is provided.Contrast medicament: 30% fluorine pyrrole bacterium amide suspending agents (autogamy), 20% Prochloraz microemulsion (commercial), 10% Wettable polyoxin powder (commercial), 30% triflumizole wettable powder (commercial).
Application Example five fluorine pyrrole bacterium acid amides and active component B and compositely prevent and treat the powdery mildew of cucumber test of pesticide effectiveness
This test arrangement is in Jingyang County, Shaanxi Province, and the investigation powdery mildew of cucumber state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after last dispenser 7 days, 15 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 12 fluorine pyrrole bacterium acid amides and active component B and compositely prevent and treat the powdery mildew of cucumber test of pesticide effectiveness
As can be seen from Table 12, fluorine pyrrole bacterium acid amides and active component B composite after effectively can prevent and treat powdery mildew of cucumber, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example hexafluoro pyrrole bacterium acid amides and active component B and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
This test arrangement is in Xianyang, Shanxi province city, and the investigation alternaria leaf spot of apple state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after last dispenser 10 days, 30 days, 45 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 13 fluorine pyrrole bacterium acid amides and active component B and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
As can be seen from Table 13, fluorine pyrrole bacterium acid amides and active component B composite after effectively can prevent and treat alternaria leaf spot of apple, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example seven fluorine pyrrole bacterium acid amides and active component B and the composite control wheat powdery mildew test of pesticide effectiveness thereof
This test arrangement is at Shaanxi Province's Weinan City, and the investigation wheat powdery mildew state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after last dispenser 7 days, 15 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 14 fluorine pyrrole bacterium acid amides and active component B and the composite control wheat powdery mildew test of pesticide effectiveness thereof
As can be seen from Table 14, fluorine pyrrole bacterium acid amides and active component B composite after effectively can prevent and treat wheat powdery mildew, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example octafluoro pyrrole bacterium acid amides and active component B and the composite control pear scab test of pesticide effectiveness thereof
This test arrangement is in Xianyang, Shanxi province city, and the investigation pear scab state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after last dispenser 10 days, 30 days, 45 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 15 fluorine pyrrole bacterium acid amides and active component B and the composite control pear scab test of pesticide effectiveness thereof
As can be seen from Table 15, fluorine pyrrole bacterium acid amides and active component B composite after effectively can prevent and treat pear scab, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example nine fluorine pyrrole bacterium acid amides and active component B and the composite control tomato blight test of pesticide effectiveness thereof
This test arrangement is at Xian District, Shanxi Province suburban area, and the investigation tomato blight state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after last dispenser 7 days, 15 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 16 fluorine pyrrole bacterium acid amides and active component B and the composite control tomato blight test of pesticide effectiveness thereof
As can be seen from Table 16, fluorine pyrrole bacterium acid amides and active component B composite after effectively can prevent and treat tomato blight, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten fluorine pyrrole bacterium acid amides and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
This test arrangement is in Jingyang County, Shaanxi Province, and the investigation cucumber downy mildew state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after last dispenser 10 days, 30 days, 45 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 17 fluorine pyrrole bacterium acid amides and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 17, fluorine pyrrole bacterium acid amides and active component B composite after effectively can prevent and treat cucumber downy mildew, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
After draw through tests different local throughout the country, fluorine pyrrole bacterium acid amides and Prochloraz or its salt, polyoxin, the composite rear preventive effect to Common Diseases such as the powdery mildew in various crop, scab, rust, anthracnose, epidemic disease, leaf spot, brown spot, graywall, black spot, bakanae disease, rice blast, blossom-end rot, crown rot, green mould, penicilliosis, downy mildew, leaf mold, stalk break, spot defoliation, damping off, banded sclerotial blights of fluorine bacterium azoles are all more than 95%, be better than single dose preventive effect, synergistic effect is obvious.
| Consult people | Zhong Long army | Zhao Jiao | Liang Xiaojuan |
| Mark | 10 | 9.5 | 9.8 |
Claims (6)
1. a bactericidal composition, is characterized in that: effective active composition is active components A and active component B, and active components A and active component B weight ratio are 1 ︰ 80 ~ 60 ︰ 1, and described active components A is fluorine pyrrole bacterium acid amides, and active component B is polyoxin.
2. bactericidal composition according to claim 1, is characterized in that: the weight ratio of active components A and active component B is 1 ︰ 60 ~ 40 ︰ 1.
3. bactericidal composition according to claim 2, is characterized in that: the weight ratio of fluorine pyrrole bacterium acid amides and polyoxin is 1 ︰ 30 ~ 15 ︰ 1.
4. according to the bactericidal composition in claims 1 to 3 described in any one, it is characterized in that: composition makes wetting powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
5. bactericidal composition according to claim 4 is for preventing and treating the application of corps diseases.
6. application according to claim 5, is characterized in that: described disease comprises powdery mildew, scab, rust, anthracnose, epidemic disease, leaf spot, brown spot, graywall, black spot, bakanae disease, rice blast, blossom-end rot, crown rot, green mould, penicilliosis, downy mildew, leaf mold, stalk break, spot defoliation, damping off, banded sclerotial blight.
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