CN104379580A - (r)-硝呋太尔,其治疗感染的用途以及(r)和(s)-硝呋太尔的合成 - Google Patents

(r)-硝呋太尔,其治疗感染的用途以及(r)和(s)-硝呋太尔的合成 Download PDF

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Publication number
CN104379580A
CN104379580A CN201380022803.0A CN201380022803A CN104379580A CN 104379580 A CN104379580 A CN 104379580A CN 201380022803 A CN201380022803 A CN 201380022803A CN 104379580 A CN104379580 A CN 104379580A
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China
Prior art keywords
compound
nifuratel
preferred
methods according
reaction
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CN201380022803.0A
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English (en)
Chinese (zh)
Inventor
S·加利亚尔迪
A·孔松尼
F·美兰德
A·布尔盖罗尼
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Polichem SA
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Polichem SA
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Application filed by Polichem SA filed Critical Polichem SA
Publication of CN104379580A publication Critical patent/CN104379580A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C241/02—Preparation of hydrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201380022803.0A 2012-05-11 2013-03-13 (r)-硝呋太尔,其治疗感染的用途以及(r)和(s)-硝呋太尔的合成 Pending CN104379580A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12167640.7 2012-05-11
EP20120167640 EP2662371A1 (en) 2012-05-11 2012-05-11 (R)-Nifuratel and synthesis of (R) and (S)-Nifuratel
PCT/EP2013/055078 WO2013167295A1 (en) 2012-05-11 2013-03-13 (r) -nifuratel, its use for the treatment of infections and synthesis of (r) and (s) -nifuratel

Publications (1)

Publication Number Publication Date
CN104379580A true CN104379580A (zh) 2015-02-25

Family

ID=47846051

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380022803.0A Pending CN104379580A (zh) 2012-05-11 2013-03-13 (r)-硝呋太尔,其治疗感染的用途以及(r)和(s)-硝呋太尔的合成

Country Status (27)

Country Link
US (2) US9284306B2 (https=)
EP (2) EP2662371A1 (https=)
JP (1) JP2015515998A (https=)
KR (1) KR20150008871A (https=)
CN (1) CN104379580A (https=)
AU (1) AU2013258385A1 (https=)
BR (1) BR112014027953A2 (https=)
CA (1) CA2869827A1 (https=)
CL (1) CL2014002951A1 (https=)
CO (1) CO7131368A2 (https=)
CR (1) CR20140505A (https=)
DO (1) DOP2014000252A (https=)
EA (1) EA201492081A1 (https=)
EC (1) ECSP14026432A (https=)
GE (2) GEP201706626B (https=)
HK (1) HK1202539A1 (https=)
IL (1) IL235429A0 (https=)
IN (1) IN2014DN09256A (https=)
MA (1) MA20150279A1 (https=)
MX (1) MX2014013759A (https=)
NZ (1) NZ700752A (https=)
PE (1) PE20150167A1 (https=)
PH (2) PH12014502500B1 (https=)
SG (2) SG11201406447SA (https=)
TN (1) TN2014000430A1 (https=)
WO (1) WO2013167295A1 (https=)
ZA (1) ZA201407596B (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108254453A (zh) * 2016-12-28 2018-07-06 苏州电器科学研究院股份有限公司 一种有效测定塑料制品中邻苯二甲酸酯含量的检测方法
CN108760950A (zh) * 2018-04-25 2018-11-06 广州京诚检测技术有限公司 一种测定硝基呋喃代谢物的方法
CN110672765A (zh) * 2019-10-11 2020-01-10 温州海鹤药业有限公司 一种定量检测硝呋太尔中顺式异构体杂质的方法
CN112457304A (zh) * 2020-12-07 2021-03-09 中国药科大学 一种硝呋太尔的制备方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3684773B1 (en) 2017-09-20 2026-04-29 pH Pharma Co., Ltd. Thailanstatin analogs
CN111892557B (zh) * 2019-05-05 2022-11-08 河北圣泰材料股份有限公司 哌嗪类成膜离子液体的合成方法
CN113828243B (zh) * 2021-09-14 2022-06-28 南京南大药业有限责任公司 一种硝呋太尔制霉菌素栓制造方法及设备
KR20260012304A (ko) 2023-04-17 2026-01-26 피크 바이오, 인크. 항체 및 항체-약물 접합체 및 사용 방법 및 합성 공정 및 중간체
CN116947838B (zh) * 2023-07-25 2025-08-19 北京金城泰尔制药有限公司沧州分公司 高纯度硝呋太尔的生产方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB969126A (en) * 1962-08-01 1964-09-09 Polichimica Sap S P A Substituted oxazolidinones
CN101037434A (zh) * 2006-03-16 2007-09-19 韩志强 硝呋太尔的生产方法
CN101037435A (zh) * 2006-03-16 2007-09-19 韩志强 (s)－硝呋太尔,其制备方法和应用
CN101434584A (zh) * 2007-11-15 2009-05-20 中山大学 具有抗菌活性的手性噁唑烷酮类化合物
CN102395367A (zh) * 2009-04-20 2012-03-28 波利化学公司 硝呋太尔用于治疗由奇异菌属物种引起的感染的用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB969126A (en) * 1962-08-01 1964-09-09 Polichimica Sap S P A Substituted oxazolidinones
CN101037434A (zh) * 2006-03-16 2007-09-19 韩志强 硝呋太尔的生产方法
CN101037435A (zh) * 2006-03-16 2007-09-19 韩志强 (s)－硝呋太尔,其制备方法和应用
CN101434584A (zh) * 2007-11-15 2009-05-20 中山大学 具有抗菌活性的手性噁唑烷酮类化合物
CN102395367A (zh) * 2009-04-20 2012-03-28 波利化学公司 硝呋太尔用于治疗由奇异菌属物种引起的感染的用途

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108254453A (zh) * 2016-12-28 2018-07-06 苏州电器科学研究院股份有限公司 一种有效测定塑料制品中邻苯二甲酸酯含量的检测方法
CN108760950A (zh) * 2018-04-25 2018-11-06 广州京诚检测技术有限公司 一种测定硝基呋喃代谢物的方法
CN108760950B (zh) * 2018-04-25 2022-07-15 国检测试控股集团京诚检测有限公司 一种测定硝基呋喃代谢物的方法
CN110672765A (zh) * 2019-10-11 2020-01-10 温州海鹤药业有限公司 一种定量检测硝呋太尔中顺式异构体杂质的方法
CN112457304A (zh) * 2020-12-07 2021-03-09 中国药科大学 一种硝呋太尔的制备方法
CN112457304B (zh) * 2020-12-07 2022-03-11 中国药科大学 一种硝呋太尔的制备方法

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Publication number Publication date
PE20150167A1 (es) 2015-02-07
CA2869827A1 (en) 2013-11-14
US9284306B2 (en) 2016-03-15
EA201492081A1 (ru) 2015-06-30
GEP201706626B (en) 2017-02-10
WO2013167295A1 (en) 2013-11-14
NZ700752A (en) 2016-02-26
KR20150008871A (ko) 2015-01-23
IN2014DN09256A (https=) 2015-07-10
EP2847189A1 (en) 2015-03-18
ZA201407596B (en) 2016-05-25
SG10201608485XA (en) 2016-12-29
IL235429A0 (en) 2014-12-31
JP2015515998A (ja) 2015-06-04
MA20150279A1 (fr) 2015-08-31
PH12014502500A1 (en) 2014-12-15
DOP2014000252A (es) 2014-12-31
BR112014027953A2 (pt) 2018-02-06
CL2014002951A1 (es) 2014-12-26
PH12015502241A1 (en) 2016-08-15
PH12014502500B1 (en) 2014-12-15
AU2013258385A1 (en) 2014-10-30
EP2662371A1 (en) 2013-11-13
GEP201606595B (en) 2017-01-10
CR20140505A (es) 2015-02-06
MX2014013759A (es) 2015-08-07
US9067927B2 (en) 2015-06-30
US20150119431A1 (en) 2015-04-30
HK1202539A1 (en) 2015-10-02
CO7131368A2 (es) 2014-12-01
TN2014000430A1 (en) 2016-03-30
SG11201406447SA (en) 2014-11-27
ECSP14026432A (es) 2015-09-30
US20150148547A1 (en) 2015-05-28

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Application publication date: 20150225