CN104370922A - 有机化合物 - Google Patents
有机化合物 Download PDFInfo
- Publication number
- CN104370922A CN104370922A CN201410545520.0A CN201410545520A CN104370922A CN 104370922 A CN104370922 A CN 104370922A CN 201410545520 A CN201410545520 A CN 201410545520A CN 104370922 A CN104370922 A CN 104370922A
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- compound
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- disease
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- 0 CCC(C)(***)C(C)N(C(C1C(N2C)=O)N(*)*)NC1N1C2=N[C@@]2[C@]1CCC2 Chemical compound CCC(C)(***)C(C)N(C(C1C(N2C)=O)N(*)*)NC1N1C2=N[C@@]2[C@]1CCC2 0.000 description 5
- SJSNVFOJVPFYIA-BWSUQSFDSA-N CC(C=C)NN[C@H](CCC1)[C@H]1NC(/C(/C)=C(/NCc1ccccc1)\NC(c(cc1)ccc1-c(cc1)ncc1F)Br)=N Chemical compound CC(C=C)NN[C@H](CCC1)[C@H]1NC(/C(/C)=C(/NCc1ccccc1)\NC(c(cc1)ccc1-c(cc1)ncc1F)Br)=N SJSNVFOJVPFYIA-BWSUQSFDSA-N 0.000 description 1
- PCMLXAWFTZRKFN-CHENDWDOSA-N CN(C1=N[C@H](CCC2)[C@H]2N1C(/C1=C(\NCc(cc2)cc(F)c2C(C(F)(F)F)=O)/Nc2ccccc2)=N)C1=O Chemical compound CN(C1=N[C@H](CCC2)[C@H]2N1C(/C1=C(\NCc(cc2)cc(F)c2C(C(F)(F)F)=O)/Nc2ccccc2)=N)C1=O PCMLXAWFTZRKFN-CHENDWDOSA-N 0.000 description 1
- QXWRLKNLXIQZRI-UXHICEINSA-N CN(C1=N[C@H](CCC2)[C@H]2N1C(NCCc1ccc(C(F)(F)F)cc1)=C1C(Nc2ccccc2)=N)C1=O Chemical compound CN(C1=N[C@H](CCC2)[C@H]2N1C(NCCc1ccc(C(F)(F)F)cc1)=C1C(Nc2ccccc2)=N)C1=O QXWRLKNLXIQZRI-UXHICEINSA-N 0.000 description 1
- MXCUPQYJOGSMLA-VKJRYQNVSA-N CN(C1=N[C@H](CCC2)[C@H]2N1c1n[n](Cc(cc2)ccc2-c2nccc(-c3cccc(Nc([n](Cc(cc4)ccc4C(O)=O)nc4N5C(N6C)=N[C@H]7[C@@H]5CCC7)c4C6=O)c3)c2)c(Nc2ccccc2)c11)C1=O Chemical compound CN(C1=N[C@H](CCC2)[C@H]2N1c1n[n](Cc(cc2)ccc2-c2nccc(-c3cccc(Nc([n](Cc(cc4)ccc4C(O)=O)nc4N5C(N6C)=N[C@H]7[C@@H]5CCC7)c4C6=O)c3)c2)c(Nc2ccccc2)c11)C1=O MXCUPQYJOGSMLA-VKJRYQNVSA-N 0.000 description 1
- WKWVOJIMSHYRFC-UXHICEINSA-N CN(C1=N[C@H](CCC2)[C@H]2N1c1n[n](Cc(cc2)ccc2C(OC)=O)c(Nc2ccccc2)c11)C1=O Chemical compound CN(C1=N[C@H](CCC2)[C@H]2N1c1n[n](Cc(cc2)ccc2C(OC)=O)c(Nc2ccccc2)c11)C1=O WKWVOJIMSHYRFC-UXHICEINSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Transplantation (AREA)
Abstract
Description
Claims (24)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1204007P | 2007-12-06 | 2007-12-06 | |
US61/012,040 | 2007-12-06 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008801262362A Division CN101970444A (zh) | 2007-12-06 | 2008-12-06 | 有机化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN104370922A true CN104370922A (zh) | 2015-02-25 |
Family
ID=40755776
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410545499.4A Pending CN104370920A (zh) | 2007-12-06 | 2008-12-06 | 有机化合物 |
CN201410545406.8A Pending CN104370918A (zh) | 2007-12-06 | 2008-12-06 | 有机化合物 |
CN201410545375.6A Pending CN104402893A (zh) | 2007-12-06 | 2008-12-06 | 有机化合物 |
CN201410545509.4A Pending CN104370921A (zh) | 2007-12-06 | 2008-12-06 | 有机化合物 |
CN2008801262362A Pending CN101970444A (zh) | 2007-12-06 | 2008-12-06 | 有机化合物 |
CN201410545465.5A Pending CN104370919A (zh) | 2007-12-06 | 2008-12-06 | 有机化合物 |
CN201410545520.0A Pending CN104370922A (zh) | 2007-12-06 | 2008-12-06 | 有机化合物 |
Family Applications Before (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410545499.4A Pending CN104370920A (zh) | 2007-12-06 | 2008-12-06 | 有机化合物 |
CN201410545406.8A Pending CN104370918A (zh) | 2007-12-06 | 2008-12-06 | 有机化合物 |
CN201410545375.6A Pending CN104402893A (zh) | 2007-12-06 | 2008-12-06 | 有机化合物 |
CN201410545509.4A Pending CN104370921A (zh) | 2007-12-06 | 2008-12-06 | 有机化合物 |
CN2008801262362A Pending CN101970444A (zh) | 2007-12-06 | 2008-12-06 | 有机化合物 |
CN201410545465.5A Pending CN104370919A (zh) | 2007-12-06 | 2008-12-06 | 有机化合物 |
Country Status (17)
Country | Link |
---|---|
US (3) | US8273751B2 (zh) |
EP (3) | EP2698160A3 (zh) |
JP (4) | JP5068857B2 (zh) |
KR (2) | KR101227738B1 (zh) |
CN (7) | CN104370920A (zh) |
AU (1) | AU2008335811B2 (zh) |
CA (2) | CA2845454C (zh) |
DK (1) | DK2240490T3 (zh) |
ES (1) | ES2436780T3 (zh) |
HK (6) | HK1207627A1 (zh) |
HR (1) | HRP20131073T1 (zh) |
IL (2) | IL206096A (zh) |
MX (1) | MX2010006212A (zh) |
PL (1) | PL2240490T3 (zh) |
PT (1) | PT2240490E (zh) |
SI (1) | SI2240490T1 (zh) |
WO (1) | WO2009075784A1 (zh) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002324846B2 (en) | 2001-08-31 | 2007-05-10 | Childrens Hospital Medical Center | Phosphodiesterase activity and regulation of phosphodiesterase 1-B-mediated signaling in brain |
BRPI0611095B8 (pt) * | 2005-06-06 | 2021-05-25 | Intracellular Therapies Inc | compostos inibidores de pde1, composição farmacêutica compreendendo-os, usos dos mesmos como inibidores de pde1 para o tratamento de doenças relacionadas, tal como doença de parkinson e deficiência cognitiva, e métodos para produção dos ditos compostos |
MX2008015489A (es) | 2006-06-06 | 2009-01-13 | Intra Cellular Therapies Inc | Compuestos organicos. |
JP2010509399A (ja) * | 2006-11-13 | 2010-03-25 | イントラ−セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
US9006258B2 (en) | 2006-12-05 | 2015-04-14 | Intra-Cellular Therapies, Inc. | Method of treating female sexual dysfunction with a PDE1 inhibitor |
ES2588238T3 (es) * | 2007-12-06 | 2016-10-31 | Intra-Cellular Therapies, Inc. | Derivados de pirazolopirimidin-4,6-diona y su uso como producto farmacéutico |
CN104370920A (zh) | 2007-12-06 | 2015-02-25 | 武田药品工业株式会社 | 有机化合物 |
EP2370080A1 (en) * | 2008-12-02 | 2011-10-05 | University of Utah Research Foundation | Pde1 as a target therapeutic in heart disease |
KR20110103949A (ko) | 2008-12-06 | 2011-09-21 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
US8536159B2 (en) | 2008-12-06 | 2013-09-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
KR20110096032A (ko) | 2008-12-06 | 2011-08-26 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
MA32939B1 (fr) | 2008-12-06 | 2012-01-02 | Intra Cellular Therapies Inc | Composes organiques |
AU2009322905A1 (en) | 2008-12-06 | 2010-06-10 | Intra-Cellular Therapies, Inc. | Organic compounds |
US8859564B2 (en) | 2008-12-06 | 2014-10-14 | Intra-Cellular Therapies, Inc. | Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione derivatives useful as inhibitors of phosphodiesterase 1 |
US11464781B2 (en) | 2009-02-25 | 2022-10-11 | Intra-Cellular Therapies, Inc. | PDE1 inhibitors for ophthalmic disorders |
WO2010132127A1 (en) * | 2009-05-13 | 2010-11-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
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