CN104367596A - Freeze-dried method for American cockroach - Google Patents
Freeze-dried method for American cockroach Download PDFInfo
- Publication number
- CN104367596A CN104367596A CN201410695241.2A CN201410695241A CN104367596A CN 104367596 A CN104367596 A CN 104367596A CN 201410695241 A CN201410695241 A CN 201410695241A CN 104367596 A CN104367596 A CN 104367596A
- Authority
- CN
- China
- Prior art keywords
- periplaneta americana
- freeze
- dry
- american cockroach
- distillation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a freeze-dried method for American cockroach. The method comprises the following steps: performing freeze-drying until sublimation is ended, taking out the American cockroach, sealing, packaging, thereby preparing the American cockroach. The energy consumption is low, the prepared American cockroach is difficult to break and high in activity, and the activity of the product is higher than that of freeze-dried American cockroach scalded to die in boiling water.
Description
Invention field
The present invention relates to medicine method for making, particularly the freeze drying process of a kind of periplaneta americana, belong to medical art.
Background technology
The large sickle in America (Periplaneta american) belongs to Insecta, and Fei Lian section, is commonly called as Blatta seu periplaneta.The large sickle in America sees Shennong's Herbal at first as medicinal, and for controlling, bloody sputum disease, cold and heat, removing mass are poly-, laryngopharynx numbness, endogenous cold loss of fecundity.At present with the large sickle in America for medicinal raw material, have the Chinese patent medicines such as rehabilitation is new, Xinmailong, liver dragon in market sale.
Traditional Chinese medicine drying has very long history in China, the Chinese herbal medicine of drying can keep certain medicinal ingredient and not easily putrid and deteriorated, the dry important measures as ensureing Chinese herbal medicine quality, it is a requisite technical process in Chinese herbal medicine processing, it is in close relations that dry and Chinese medicine is produced, and dry method will directly affect the quality of product.The drying means of the large sickle in existing document America, kills by soak with ethanol after seizure or boiling water scalds dead, dries or 60 DEG C of oven dry.
The freeze-drying process of prior art mainly can be divided into primary drying (sublimation drying), and redrying (adsorption stripping and dry) is to dry.The dry run pumpdown time is long, and energy consumption is high.The present invention in freeze dryer without redrying process.Energy consumption is low, can reduce by 50% through test of many times power consumption.
Further illustrate usefulness of the present invention below by pharmacodynamic study, test example is intended to further illustrate usefulness of the present invention, but not limitation of the present invention.
By the same a collection of periplaneta americana caught, process by the following method.
1) dry: kill by soak with ethanol, put sunlight place, dry;
2) dry: kill by soak with ethanol, dry following oven dry for 60 DEG C;
3) ethanol kills lyophilizing to the end that distils: kill by soak with ethanol, put in freeze dryer, be refrigerated to less than-20 DEG C, be evacuated to below drying chamber pressure 45Pa, subliming by heating, the temperature of distillation should control below 40 DEG C, when condenser temperature drops to the state before distillation, distillation terminates, and takes out, packs;
4) ethanol kills lyophilizing: kill by soak with ethanol, puts in freeze dryer, is refrigerated to less than-20 DEG C, is evacuated to below drying chamber pressure 45Pa, subliming by heating, the temperature of distillation should control below 40 DEG C, and the temperature of resolution phase controls below 45 DEG C, to dry, take out, pack.
5) boiling water scalds dead lyophilizing: scald with boiling water dead, put in freeze dryer, be refrigerated to less than-20 DEG C, be evacuated to below drying chamber pressure 45Pa, subliming by heating, the temperature of distillation should control below 40 DEG C, and the temperature of resolution phase controls below 45 DEG C, to dry, take out, pack.
One, the dry periplaneta americana friability of distinct methods compares
1, instrument friability somascope, analytical balance, hair-dryer.
2, inspection method
Before 2.1 adjusting instrument speed tests, the rotating speed of conditioning instrumentation is 25 turns ± 1 turn per minute, and setting test period is 4 minutes, and namely the total degree of rotary drum is 100 times.
The amount of taking of 2.2 test samples is tested at every turn and is taken whole test sample 10, blows away surperficial broken end, precise weighing with hair-dryer.
2.3 check
Test sample after above-mentioned weighed weight is put in cylinder, starts motor and rotate 100 times.After rotation terminates, check the cracked number of polypide, then blow away surperficial broken end with hair-dryer, accurate title, plants, and is the weight of less loss with the difference of the amount of taking, and calculates percentage ratio.
3, result, in table 1.
The dry periplaneta americana friability of table 1 distinct methods
| Shatter (individual) | Less loss amount (%) | |
| Dry | 2 | 5.37 |
| Dry | 3 | 5.49 |
| Ethanol kills lyophilizing to the end that distils | 2 | 7.32 |
| Ethanol kills lyophilizing | 10 | 30.54 |
| Boiling water scalds dead lyophilizing | 10 | 31.41 |
Table 1 result is known, and periplaneta americana of the present invention is lower than friability with lyophilizing periplaneta americana, and known antivibration wear resistant ability is strong, and product is non-friable, constant product quality.
Two, the dry periplaneta americana pharmacodynamics of distinct methods compares
1, the periplaneta americana of distinct methods drying is compared the protective effect that ethanol causes gastric mucosa damage.
Choose healthy SD rat, male and female half and half, weight 180-220g, be divided into matched group at random, dry periplaneta americana group, dry periplaneta americana group, the present invention dry periplaneta americana group, lyophilizing periplaneta americana group, boiling water scalds dead lyophilizing periplaneta americana group, totally 6 groups, often organize 10, every day gastric infusion 1 time, 1 2mg/kg, continuous 7 days, matched group gave equivalent distilled water.Before experiment, first fasting 48 h of rat, freely drinks water, after last administration, 1h every rat oral gavage dehydrated alcohol 1mL/ only, take off cervical vertebra after 1h and put to death animal, close cardia by clip, inject 1% formaldehyde 5mL from pylorus, folder closes pylorus again, put into 1% formalin and fix 10min, cut off coat of the stomach along greater gastric curvature, measure damaged length, as gastric mucosal damage index, and suppression ratio is calculated using damaged length (width is greater than 1 mm to be doubled) summation.The results are shown in Table 2.
Suppression ratio (%)=(matched group ulcer index one administration group ulcer index) ÷ matched group ulcer index × 100%.
The periplaneta americana of table 2 distinct methods drying is compared the protective effect that ethanol causes gastric mucosa damage
| Group | Dosage | Gastric mucosal damage index (mm) | Suppression ratio (%) |
| Matched group | 99.4±25.4 | ||
| Dry | 2mg/kg | 80.5±22.3 | 19.0 |
| Dry | 2mg/kg | 82.3±21.2 | 17.2 |
| Ethanol kills lyophilizing to the end that distils | 2mg/kg | 59.7±19.6 | 39.9 |
| Ethanol kills lyophilizing | 2mg/kg | 59.4±24.5 | 40.2 |
| Boiling water scalds dead lyophilizing | 2mg/kg | 84.8±20.4 | 14.7 |
Result shows, the periplaneta americana of distinct methods drying causes gastric mucosa damage to ethanol all has protective effect, scalds dead lyophilizing minimum with boiling water, periplaneta americana of the present invention and the protective effect of lyophilizing periplaneta americana the strongest.But it is low that energy consumption is compared in method of the present invention and lyophilizing, and product is non-friable.
Summary of the invention
The object of this invention is to provide the freeze drying process of a kind of periplaneta americana, the dry periplaneta americana of the method, energy consumption is low, non-friable, and Product Activity is high.
The present invention is achieved in that
A freeze drying process for periplaneta americana, is characterized in that: kill by soak with ethanol after seizure, puts in freeze dryer, is refrigerated to less than-10 DEG C, is evacuated to below drying chamber pressure 30Pa, subliming by heating; Sublimation temperature controls below 40 DEG C, and distillation terminates, and takes out, packs.
The freeze drying process of a kind of periplaneta americana of the present invention, is characterized in that: lyophilizing, to the end that distils, is taken out, packed.
The freeze drying process of a kind of periplaneta americana of the present invention, is characterized in that: distillation terminates a kind ofly to judge that 1. serviceability temperature Sensor monitoring temperature of charge is to judge whether the ice in material all distils by the following method; 2. condenser temperature drops to the state before distillation; 3. the pressure drop of freeze drying box is to the pressure close to cryoprobe.
So far complete the present invention, the present invention prepares periplaneta americana, and energy consumption is low, non-friable, and Product Activity is high, and scalds dead lyophilizing periplaneta americana higher than boiling water.
Detailed description of the invention
embodiment 1
Periplaneta americana kills by soak with ethanol after catching, put in freeze dryer, be refrigerated to-20 DEG C, be evacuated to drying chamber pressure 30Pa, subliming by heating, the temperature of distillation controls below 40 DEG C, when the ice judged in material with temperature sensor monitors temperature of charge all distils, distillation terminates, and takes out, packs.
embodiment 2
Periplaneta americana kills by soak with ethanol after catching, and puts in freeze dryer, is refrigerated to-28 DEG C, be evacuated to drying chamber pressure 50Pa, subliming by heating, the temperature of distillation controls at 50 DEG C, when condenser temperature drops to the state before distillation, distillation terminates, and takes out, packs.
embodiment 3
Periplaneta americana kills by soak with ethanol after catching, and puts in freeze dryer, puts in freeze dryer, be refrigerated to-32 DEG C, be evacuated to drying chamber pressure 50Pa, subliming by heating, the temperature of distillation controls at 50 DEG C, when the pressure drop of hothouse is to pressure close to cryoprobe, distillation terminates, and takes out, packs.
Claims (3)
1. a freeze drying process for periplaneta americana, is characterized in that: kill by soak with ethanol after seizure, puts in freeze dryer, is refrigerated to less than-10 DEG C, is evacuated to below drying chamber pressure 30Pa, subliming by heating; Sublimation temperature controls below 40 DEG C, and distillation terminates, and takes out, packs.
2. the freeze drying process of a kind of periplaneta americana according to claim 1, is characterized in that: lyophilizing, to the end that distils, is taken out, packed.
3. the freeze drying process of a kind of periplaneta americana according to claim 1, is characterized in that: distillation terminates a kind ofly to judge that 1. serviceability temperature Sensor monitoring temperature of charge is to judge whether the ice in material all distils by the following method; 2. condenser temperature drops to the state before distillation; 3. the pressure drop of freeze drying box is to the pressure close to cryoprobe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410695241.2A CN104367596A (en) | 2014-11-27 | 2014-11-27 | Freeze-dried method for American cockroach |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410695241.2A CN104367596A (en) | 2014-11-27 | 2014-11-27 | Freeze-dried method for American cockroach |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104367596A true CN104367596A (en) | 2015-02-25 |
Family
ID=52546957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410695241.2A Pending CN104367596A (en) | 2014-11-27 | 2014-11-27 | Freeze-dried method for American cockroach |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104367596A (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622911A (en) * | 2015-03-05 | 2015-05-20 | 济南康众医药科技开发有限公司 | Freeze-drying method of American cockroach |
| CN104622912A (en) * | 2015-03-05 | 2015-05-20 | 济南康众医药科技开发有限公司 | Pharmaceutical composition free of periplaneta Americana odor |
| CN104739878A (en) * | 2015-03-05 | 2015-07-01 | 济南康众医药科技开发有限公司 | Freeze-drying method of periplaneta americana |
| CN104739874A (en) * | 2015-03-05 | 2015-07-01 | 济南康众医药科技开发有限公司 | Method for freeze drying of leeches |
| CN104905053A (en) * | 2015-06-02 | 2015-09-16 | 安徽诺阳禽业有限公司 | Biological feed rich in cockroach powder and used for health duck and preparation method of biological feed |
| CN104905054A (en) * | 2015-06-02 | 2015-09-16 | 安徽诺阳禽业有限公司 | Special vegetable feed containing cockroach powder for poultry |
| CN104920850A (en) * | 2015-06-05 | 2015-09-23 | 安徽诺阳禽业有限公司 | High-nutrition biological feed being rich in cockroach powder and preparation method of high-nutrition biological feed |
| CN104957392A (en) * | 2015-06-02 | 2015-10-07 | 安徽诺阳禽业有限公司 | Egg-producing goose special feed rich in cockroach powder and preparation method thereof |
| CN104957391A (en) * | 2015-06-02 | 2015-10-07 | 安徽诺阳禽业有限公司 | Cockroach powder-rich egg-laying duck special feed |
| CN104982652A (en) * | 2015-06-02 | 2015-10-21 | 安徽诺阳禽业有限公司 | Processing method for food cockroach |
| CN104982692A (en) * | 2015-06-05 | 2015-10-21 | 安徽诺阳禽业有限公司 | Special meat goose feed rich in cockroach powder and preparing method thereof |
| CN104982691A (en) * | 2015-06-05 | 2015-10-21 | 安徽诺阳禽业有限公司 | Special young goose feed rich in cockroach powder and preparing method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104154709A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Drying method for radix tetrastigme |
-
2014
- 2014-11-27 CN CN201410695241.2A patent/CN104367596A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104154709A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Drying method for radix tetrastigme |
Non-Patent Citations (2)
| Title |
|---|
| 何佳奇等: "动物药在制剂学研究方面的新进展", 《中华中医药学刊》 * |
| 湖南省食品药品监督管理局: "《湖南省中药材标准（2009年版）》", 28 February 2010, 湖南科学技术出版社 * |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622911A (en) * | 2015-03-05 | 2015-05-20 | 济南康众医药科技开发有限公司 | Freeze-drying method of American cockroach |
| CN104622912A (en) * | 2015-03-05 | 2015-05-20 | 济南康众医药科技开发有限公司 | Pharmaceutical composition free of periplaneta Americana odor |
| CN104739878A (en) * | 2015-03-05 | 2015-07-01 | 济南康众医药科技开发有限公司 | Freeze-drying method of periplaneta americana |
| CN104739874A (en) * | 2015-03-05 | 2015-07-01 | 济南康众医药科技开发有限公司 | Method for freeze drying of leeches |
| CN104905053A (en) * | 2015-06-02 | 2015-09-16 | 安徽诺阳禽业有限公司 | Biological feed rich in cockroach powder and used for health duck and preparation method of biological feed |
| CN104905054A (en) * | 2015-06-02 | 2015-09-16 | 安徽诺阳禽业有限公司 | Special vegetable feed containing cockroach powder for poultry |
| CN104957392A (en) * | 2015-06-02 | 2015-10-07 | 安徽诺阳禽业有限公司 | Egg-producing goose special feed rich in cockroach powder and preparation method thereof |
| CN104957391A (en) * | 2015-06-02 | 2015-10-07 | 安徽诺阳禽业有限公司 | Cockroach powder-rich egg-laying duck special feed |
| CN104982652A (en) * | 2015-06-02 | 2015-10-21 | 安徽诺阳禽业有限公司 | Processing method for food cockroach |
| CN104920850A (en) * | 2015-06-05 | 2015-09-23 | 安徽诺阳禽业有限公司 | High-nutrition biological feed being rich in cockroach powder and preparation method of high-nutrition biological feed |
| CN104982692A (en) * | 2015-06-05 | 2015-10-21 | 安徽诺阳禽业有限公司 | Special meat goose feed rich in cockroach powder and preparing method thereof |
| CN104982691A (en) * | 2015-06-05 | 2015-10-21 | 安徽诺阳禽业有限公司 | Special young goose feed rich in cockroach powder and preparing method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104367596A (en) | Freeze-dried method for American cockroach | |
| WO2008137164A1 (en) | Edible thin film strips and process for making | |
| CN104367595A (en) | Application of American cockroach dried by different methods in preparation of medicines | |
| Sharma et al. | Comparative phytochemistry, antioxidant, antidiabetic, and anti-inflammatory activities of traditionally used Ocimum basilicum L. Ocimum gratissimum L., and Ocimum tenuiflorum L. | |
| CN102845690A (en) | Hawthorn freeze-dried whole fruit and preparation method thereof | |
| CN102274270B (en) | Processing process for emblic leafflower fruit serving as Chinese medicine | |
| CN102266492B (en) | Method for processing dendrobium huoshanense plant dry product | |
| CN103954100B (en) | The application of Refrigeration Technique in Hericium erinaceus is dry | |
| CN103623250B (en) | Preparation technology of active freeze-dried rhizoma gastrodiae | |
| CN103947743A (en) | Drying method of hericium erinaceus | |
| CN102908379A (en) | Multi-index quality-control based fresh platycodon grandiflorum medicinal slice processing method | |
| CN104147118A (en) | Freeze-drying method of radix scutellariae | |
| CN104147221B (en) | Freeze-drying method of rehamnnia glutinosa | |
| CN103977033A (en) | Hericium erinaceus drying method | |
| CN104382945A (en) | Method for freeze-drying anti-ulcer periplaneta americana | |
| CN104622911A (en) | Freeze-drying method of American cockroach | |
| CN104165497A (en) | Honeysuckle freeze-drying method | |
| CN104154709A (en) | Drying method for radix tetrastigme | |
| CN103134273A (en) | Drying method for blood nourishing and brain refreshing pill extractive | |
| CN104180614A (en) | Freeze-drying method for roots of red-rooted salvia | |
| CN104739874A (en) | Method for freeze drying of leeches | |
| CN104739878A (en) | Freeze-drying method of periplaneta americana | |
| CN104147059A (en) | Drying method of penthorum chinense pursh | |
| Anadani et al. | Vacuum freeze drying of Aloe vera fillets | |
| CN104180619A (en) | Scutellaria baicalensis drying method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: 250014 Ji'nan, Shandong, Lixia District, No. ten road 17079, three, 17D Applicant after: Shandong Zhonghong Kang Pharmaceutical Technology Development Co Ltd Address before: 250014 No. 4, West building, Shandong Academy of Sciences, 19 Shandong Road, Lixia Road, Lixia District, Shandong Applicant before: Jinan Kangzhong Medicin Science & Technology Co., Ltd. |
|
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150225 |