CN103134273A - Drying method for blood nourishing and brain refreshing pill extractive - Google Patents
Drying method for blood nourishing and brain refreshing pill extractive Download PDFInfo
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- CN103134273A CN103134273A CN2011103764371A CN201110376437A CN103134273A CN 103134273 A CN103134273 A CN 103134273A CN 2011103764371 A CN2011103764371 A CN 2011103764371A CN 201110376437 A CN201110376437 A CN 201110376437A CN 103134273 A CN103134273 A CN 103134273A
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Abstract
The invention relates to a drying method for blood nourishing and brain refreshing pill extractive. The technical solution includes that blood nourishing and brain refreshing extract is weighed and placed on drying bands of a vacuum low temperature continuous band dryer, drying conditions are set, the drying conditions include that set temperature of a first level plate is 60-130 DEG C, set temperature of a second level plate is 50-90 DEG C, set temperature of a third level plate is 10-60 DEG C, and vacuum degree is -0.08--0.1 Mpa, and dried material is obtained.
Description
Technical field:
The present invention relates to a kind of drying means of Chinese medical concrete, particularly a kind of drying means of blood-nourishing and brain-refreshing extract of bolus.
Background technology:
The blood-nourishing and brain-refreshing ball is the modern Chinese herbal medicine preparation of Tianjin Tasly Pharmaceutical Co., Ltd's development, formed by the 11 flavor Chinese medicines such as Radix Angelicae Sinensis, Ligusticum wallichii, the root of herbaceous peony, reticulate millettia, cassia seed, corydalis tuber, and after modern high tech method extracts, add suitable auxiliary material, a kind of pill of making.It is fast that said preparation has an active ingredient stripping, the bioavilability advantages of higher.The blood-nourishing and brain-refreshing ball has the flat liver of nourishing blood, and effect promoting blood circulation and removing obstruction in channels can be used for the headache of deficiency of blood liver due to high, staggers, the illness such as dysphoria, insomnia and dreamful sleep, has clinically significant curative effect.The blood-nourishing and brain-refreshing ball is prepared as follows:
Medicinal material adds solvent and extracts 2 times, and extract is concentrated, and alcohol precipitation (or directly concentrated) gets medicinal extract.
The preparation of ball adopts the galenic pharmacy routine techniques to be prepared into.
Chinese medical concrete, drying means has multiple, mainly contains, boulton process, the hot drying method of baking oven, micro-wave drying method, the infra-red drying method, spray drying process, freeze-drying etc., the very bad solution of dry problem of some Chinese medical concrete, it is together dry that some need to add auxiliary material.
Chinese medical concrete is why difficult dry, is generally because contain oligosaccharides in medicinal material or compound sugar is more, and as the ratio of rhizome medicinal material of flower class, fruit class, quality plumpness etc., though alcohol precipitation or membrane filtration can not be removed, very easily softening because being heated when dry, moisture absorption is clamminess.Low temperature drying or dehumidifying may have effect, but are not hundred-percent effective, and to pulverize be because of the heat production deliquescing, or specific area increases, and wettability power increases.Increasing the auxiliary material amount is a way, but can cause dose to increase.
The former drying means of blood-nourishing and brain-refreshing extract of bolus adopts the vacuum drying chamber drying process, and man-hour is long, and the medicinal extract of average every dry 46.6kg approximately need be with 58.5 hours, and drying efficiency is low; Composition Paeoniflorin, forulic acid belong to heat-sensitive materials, long high temperature drying, and content loss is larger, paeoniflorin content loss 7.2%, forulic acid loss 54.3%.
Summary of the invention:
The invention provides the vacuum and low temperature continuous band and do technical finesse blood-nourishing and brain-refreshing medicinal extract, obtained good effect.Vacuum and low temperature continuous band of the present invention is done technology can make the inner porosity and looseness shape that forms of dried product, original material properties of retained product, and outward appearance is good, owing to being vacuum dehydrating at lower temperature, therefore can satisfy the processing request of very big part heat sensitive material; Be fit to the drying of the materials such as spray-drying and the insoluble high viscosity of vacuum drying oven, high fat, high-carbohydrate, and can well keep product stability and uniformity in batches; It has broken through the technical barrier of the continuous feeding and discharging under the vacuum state, makes static drying successfully be converted into dynamic drying, when having increased substantially dried product output, makes production cost descend comprehensively.
Adopt the vacuum and low temperature continuous band to do technology (vacuum and low temperature continuous drier, model: FJ100-2, Shanghai Minjie Machinery Co. Ltd.), blood-nourishing and brain-refreshing medicinal extract is coated on the crawler belt of continuous operation equably, adjust the crawler belt speed of service, drying efficiency is high, and production capacity increases by 8 times; The relative heated time of material is short, has effectively protected the thermal sensitivity composition, and the forulic acid rate of transform is 92.67%, the Paeoniflorin rate of transform 95.98%.
Blood-nourishing and brain-refreshing medicinal extract of the present invention extracts the extract that obtains for producing in blood-nourishing and brain-refreshing preparation process from blood-nourishing and brain-refreshing 11 flavor Chinese medicines, can be liquid extract, or rare medicinal extract, namely contains the extract than juicy or solvent composition, the extract of non-drying.Blood-nourishing and brain-refreshing medicinal extract of the present invention, its extracting method is prior art, adopt prior art to extract the medicinal extract that obtains as water extraction and alcohol precipitation method, the medicinal extract that water extraction obtains, the medicinal extract that the medicinal extract that alcohol extracting method obtains or ethanol extract from water precipitation obtain, no matter adopt any method, as long as the medicinal extract that obtains from blood-nourishing and brain-refreshing 11 flavor medicinal material extract all belongs to category of the present invention, the medicinal extract that obtains in preferred above-mentioned blood-nourishing and brain-refreshing granules preparation process.
Technical Solving of the present invention is as follows:
Take blood-nourishing and brain-refreshing medicinal extract, coat continuously on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, condition is :-130 ℃ of 60 ℃ of step design temperatures, 10 ℃-60 ℃ of two-90 ℃ of 50 ℃ of step design temperatures, three step design temperatures, vacuum-0.08--0.1Mpa receives to get dry thing.
Preferred drying condition of the present invention is:
95-130 ℃ of preferred one-level plate temperature, 60-90 ℃ of secondary plate temperature, 10 ℃ of-50 ℃ of vacuum-0.08--0.1Mpa of three grades of plate temperatures,
Can guarantee to improve the forulic acid rate of transform and the Paeoniflorin rate of transform when dry powder moisture is up to standard, solve the destroyed problem of dry run Chinese traditional medicine active ingredient.
Most preferably 110 ℃ of one-level plate temperatures, 40 ℃ of 70 ℃, three grades plate temperatures of secondary plate temperature; In the time of can guaranteeing during vacuum-0.1Mpa that in dry powder, moisture is 5.53%, the forulic acid rate of transform rises to 90.53%, and the Paeoniflorin rate of transform rises to 98.00%
The present invention compared to the prior art, the Contrast on effect situation is as follows:
| Project | Vacuum drying chamber is dry | The vacuum and low temperature continuous band is dry |
| Drying process man-hour (medicinal extract of 46.6kg) | 58.5 hour | 6.6 hour |
| The Paeoniflorin rate of transform | 92.8％ | 95.98％ |
| The forulic acid rate of transform | 45.7％ | 92.67％ |
1, experimental program:
Investigate different baking temperatures, on the impact of the quality of dry extract.
| The laboratory sample lot number | 20110801 | 20110802 | 20110803 | 20110804 | 20110805 |
| Baking temperature (one-level/secondary) ℃ | 60/50 | 80/60 | 95/60 | 110/70 | 130/90 |
2, experimental result
3, experiment conclusion:
3.1 by investigating the dried baking temperature of different vacuum and low temperature continuous bands to the quality influence of blood-nourishing and brain-refreshing extract as seen: the baking temperature one-level is 60 ℃-130 ℃, and secondary is 50 ℃-90 ℃, three-60 ℃ of 10 ℃ of step design temperatures, vacuum-0.08-0.1Mpa; 95-130 ℃ of preferred one-level plate temperature, 60-90 ℃ of secondary plate temperature, 10 ℃-50 ℃ of three step design temperatures; Most preferably 110 ℃ of one-level plate temperatures, 70 ℃ of secondary plate temperatures, 40 ℃ of three step design temperatures, vacuum-0.1Mpa; The extract dry effect is better with this understanding, and the forulic acid rate of transform on average rises to 92.67%, and the Paeoniflorin rate of transform is average 95.98%, and the vacuum and low temperature continuous band is done the rate of transform that drying can obviously improve temperature-sensitive composition forulic acid, Paeoniflorin.
3.2 calculate by production lot 46.6kg medicinal extract, the dried drying process of vacuum and low temperature continuous band needs 6.6 hours, vacuum drying chamber is dry needs 58.5 hours, and drying efficiency has improved 8 times.
3.3, this technique has the continuity of production, drying, cooling, pulverizing, a step are completed, and whole process is airtight simultaneously, is in vacuum state, the moisture absorption risk of having evaded the exposed placement of dry thing room temperature has been evaded dry extract and has been pulverized separately the yield losses that brings.
The specific embodiment:
Further illustrate by the following examples the present invention, but not as limitation of the present invention.
Embodiment 1
With blood-nourishing and brain-refreshing medicinal extract, be placed on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, condition is: 70 ℃ of step design temperatures, two 55 ℃ of step design temperatures, 40 ℃ of three step design temperatures, vacuum-0.08Mpa get dry thing through super-dry.
Embodiment 2
With blood-nourishing and brain-refreshing medicinal extract, be placed on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, condition is: 90 ℃ of step design temperatures, two 65 ℃ of step design temperatures, 50 ℃ of three step design temperatures, vacuum-0.1Mpa get dry thing through super-dry.
Embodiment 3
With blood-nourishing and brain-refreshing medicinal extract, be placed on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, condition is: 120 ℃ of step design temperatures, two 75 ℃ of step design temperatures, 35 ℃ of three step design temperatures, vacuum-0.09Mpa get dry thing through super-dry.
Embodiment 4
With blood-nourishing and brain-refreshing medicinal extract, be placed on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, condition is: 100 ℃ of step design temperatures, two 65 ℃ of step design temperatures, 30 ℃ of three step design temperatures, vacuum-0.1Mpa get dry thing through super-dry.
Embodiment 5
With blood-nourishing and brain-refreshing medicinal extract, be placed on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, condition is: 105 ℃ of step design temperatures, two 75 ℃ of step design temperatures, three 39 ℃ of step design temperatures, vacuum-0.1Mpa get dry thing through super-dry.
Embodiment 6
With blood-nourishing and brain-refreshing medicinal extract, be placed on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, condition is: 115 ℃ of step design temperatures, two 70 ℃ of step design temperatures, three 41 ℃ of step design temperatures, vacuum-0.1Mpa get dry thing through super-dry.
Embodiment 7
With 9.49kg blood-nourishing and brain-refreshing medicinal extract, be placed on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, condition is: 60 ℃ of step design temperatures, two 50 ℃ of step design temperatures, three 60 ℃ of step design temperatures, vacuum-0.1Mpa, crawler belt speed 10HZ get dry thing through super-dry.
Embodiment 8
With 11.05kg blood-nourishing and brain-refreshing medicinal extract, be placed on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, condition is: 80 ℃ of step design temperatures, two 60 ℃ of step design temperatures, three 35 ℃ of step design temperatures, vacuum-0.08Mpa, crawler belt speed 10HZ get dry thing through super-dry.
Embodiment 9
With 9.95kg blood-nourishing and brain-refreshing medicinal extract, be placed on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, condition is: 95 ℃ of step design temperatures, two 60 ℃ of step design temperatures, three 50 ℃ of step design temperatures, vacuum-0.09Mpa, crawler belt speed 10HZ get dry thing through super-dry.
Embodiment 10
With 10.1kg blood-nourishing and brain-refreshing medicinal extract, be placed on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, condition is: 110 ℃ of step design temperatures, two 70 ℃ of step design temperatures, three 40 ℃ of step design temperatures, vacuum-0.1Mpa crawler belt speed 11HZ get dry thing through super-dry.
Embodiment 11
With 10kg blood-nourishing and brain-refreshing medicinal extract, be placed on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, condition is: 130 ℃ of step design temperatures, two 90 ℃ of step design temperatures, three 10 ℃ of step design temperatures, vacuum-0.08Mpa, crawler belt speed 11HZ get dry thing through super-dry.
Claims (4)
1. the drying means of a blood-nourishing and brain-refreshing extract of bolus, it is characterized in that, step is as follows: get blood-nourishing and brain-refreshing medicinal extract, coat continuously on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, and condition is :-130 ℃ of 60 ℃ of step design temperatures, 10 ℃-60 ℃ of two-90 ℃ of 50 ℃ of step design temperatures, three step design temperatures, vacuum-0.08--0.1Mpa gets dry thing.
2. according to claim 1 drying means, it is characterized in that, step is as follows: get blood-nourishing and brain-refreshing medicinal extract, coat continuously on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, and condition is :-130 ℃ of 95 ℃ of step design temperatures, 10 ℃-50 ℃ of two-90 ℃ of 60 ℃ of step design temperatures, three step design temperatures, vacuum-0.08--0.1Mpa gets dry thing.
3. according to claim 1 drying means, it is characterized in that, step is as follows: get blood-nourishing and brain-refreshing medicinal extract, coat continuously on the dry zone of the dried drying machine of vacuum and low temperature continuous band, drying condition is set, condition is: 110 ℃ of step design temperatures, two 70 ℃ of step design temperatures, three 40 ℃ of step design temperatures, vacuum-0.1Mpa gets dry thing.
4. the drying means of claim 1, is characterized in that, blood-nourishing and brain-refreshing medicinal extract wherein is prepared as follows: medicinal material adds solvent and extracts, and extract is concentrated, and alcohol precipitation (or directly concentrated) gets medicinal extract.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103900354A (en) * | 2014-04-14 | 2014-07-02 | 天津中新药业集团股份有限公司达仁堂制药厂 | Improved drying production method for lung cleaning anti-inflammatory pills |
| CN105043029A (en) * | 2015-08-20 | 2015-11-11 | 倪勤华 | Drying method for Chinese medical extract |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1927229A (en) * | 2006-08-30 | 2007-03-14 | 浙江大学 | Method and device for producing poriferous and loose dry product of traditional Chinese medicine concrete |
| CN101259157A (en) * | 2007-03-08 | 2008-09-10 | 天津天士力现代中药资源有限公司 | Chinese medicine kudzu root extract new drying technique method |
| CN101703613A (en) * | 2009-11-03 | 2010-05-12 | 四川美大康药业股份有限公司 | Preparation method of rehmannia leaf total glycoside extract dry product |
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2011
- 2011-11-23 CN CN2011103764371A patent/CN103134273A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1927229A (en) * | 2006-08-30 | 2007-03-14 | 浙江大学 | Method and device for producing poriferous and loose dry product of traditional Chinese medicine concrete |
| CN101259157A (en) * | 2007-03-08 | 2008-09-10 | 天津天士力现代中药资源有限公司 | Chinese medicine kudzu root extract new drying technique method |
| CN101703613A (en) * | 2009-11-03 | 2010-05-12 | 四川美大康药业股份有限公司 | Preparation method of rehmannia leaf total glycoside extract dry product |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103900354A (en) * | 2014-04-14 | 2014-07-02 | 天津中新药业集团股份有限公司达仁堂制药厂 | Improved drying production method for lung cleaning anti-inflammatory pills |
| CN105043029A (en) * | 2015-08-20 | 2015-11-11 | 倪勤华 | Drying method for Chinese medical extract |
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Application publication date: 20130605 |