CN105902577A - Low-sugar Cordyceps militaris oral tablet and preparation method thereof - Google Patents
Low-sugar Cordyceps militaris oral tablet and preparation method thereof Download PDFInfo
- Publication number
- CN105902577A CN105902577A CN201610221044.6A CN201610221044A CN105902577A CN 105902577 A CN105902577 A CN 105902577A CN 201610221044 A CN201610221044 A CN 201610221044A CN 105902577 A CN105902577 A CN 105902577A
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- Prior art keywords
- cordyceps militaris
- link
- water
- oral tablet
- decocting
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention provides a low-sugar Cordyceps militaris oral tablet and a preparation method thereof. The tablet does not contain most of polysaccharide components in Cordyceps militaris, and is prepared from a pure Cordyceps militaris component. The preparation method comprises the following steps: micro-crushing the Cordyceps militaris, removing polysaccharides, granulating the obtained powder, tabletting obtained granules, and disinfecting the obtained tablet. The tablet does not contain most of carbohydrates, belongs to a low sugar health product, is suitable for wide crowds to use, and is especially suitable for diabetic patients and lactase intolerant patients to take.
Description
Technical field
The present invention relates to Chinese medicine product technical field, be specifically related to a kind of low sugar Cordyceps militaris (L.) Link. oral tablet and preparation method thereof.
Background technology
Cordyceps militaris (L.) Link. is Ascomycotina, Ergota Zoopagales, Clavicipitaceae, the type sepecies of Cordyceps, and formal name used at school is
Cordycepsmilitaris, is the fungus with Pupa bombycis as host, equal with Cordyceps belongs to together, and chemical composition is basically identical,
Its antineoplastic component cordycepin content is higher than Cordyceps, is the new resource food of Ministry of Public Health approval, has antitumor, resists
The multiple efficacies such as viral, antibacterial, anti-inflammatory, slow down aging, raising immunity, is suitable for crowd extensive, is Cordyceps
Best succedaneum.
Cordyceps militaris (L.) Link. main active have cordycepin, cordycepic acid, Cordyceps polysaccharide, superoxide dismutase (SOD) and
Linoleic acid and palmitic acid etc., the content of its polysaccharide accounts for more than the 20% of Cordyceps dry weight.Which also limits diabetics
Take.
Summary of the invention
For solving the problems referred to above, the present invention provides a kind of low sugar Cordyceps militaris (L.) Link. oral tablet, and this tablet eliminates in Cordyceps militaris (L.) Link. exhausted
Most polysaccharide component, farthest remains content and the proportioning of other effective ingredient in Cordyceps militaris (L.) Link., and does not draws
Enter other composition outside Cordyceps militaris (L.) Link., can be taken by diabetics.
The technical solution adopted in the present invention is:
A kind of low sugar Cordyceps militaris (L.) Link. oral tablet, this tablet is solid tablet, for the Cordyceps militaris (L.) Link.sporophore to dry as raw material,
Extracted wet granulation after removing Cordyceps polysaccharide to form by decocting in water.
The Cordyceps militaris (L.) Link.sporophore of described drying carries out micronizing before decocting in water extracts.
The solid-liquid ratio that described decocting in water extracts is 1 (3-8), and decocting in water temperature is 95-100 DEG C, and the decocting in water time is 40-150min.
The preparation method of above-mentioned low sugar Cordyceps militaris (L.) Link. oral tablet, comprises the following steps:
(1) Cordyceps militaris (L.) Link.sporophore taking drying is raw material, and micronizing obtains Cordyceps militaris (L.) Link. superfine powder；
(2) adding pure water in Cordyceps militaris (L.) Link. superfine powder, be warming up to 95-100 DEG C and carry out decocting in water extraction, water filters after carrying,
Obtain aqueous extract and water puies forward precipitation；Water carrying precipitation dry to constant weight, super micron mill is pulverized, is obtained water and carry superfine powder；
Water intaking extracting solution is concentrated into the 1/8-1/4 that condensate precursor is long-pending, and concentrated solution precipitates with edible ethanol, then filters and takes edible ethanol
Supernatant, concentrates standby, and concentration ratio specifically sees the concentration of concentrated solution, as long as meeting (3rd) step in theory to mix institute
Need the most permissible；
(3) water carries superfine powder mix according to mass ratio 3 (1-2) with edible ethanol supernatant concentrated solution, wet granulation；
(4) the Cordyceps militaris (L.) Link. granule obtained is put in 30-50 DEG C of baking oven and dry so that it is water content is below 5%；
(5) by the Cordyceps militaris (L.) Link. granulation dried, sterilizing, packaging, finished product low sugar Cordyceps militaris (L.) Link. oral tablet is obtained.
In described step (2), pure water addition is 3-8 times of Cordyceps militaris (L.) Link. superfine powder quality.
The time that in described step (2), decocting in water extracts is 40-150min.
In described step (2), the concentration of edible ethanol is 95%, and concentrated solution is 1 (4-8) with the volume ratio of edible ethanol.
The invention has the beneficial effects as follows:
(1) the Cordyceps militaris (L.) Link. tablet that the present invention provides eliminates overwhelming majority glucide in Cordyceps militaris (L.) Link. so that it is become a kind of low sugar
Health product, applicable crowd is more extensive, is particularly suited for the patient such as diabetics, lactose intolerance and takes.
(2) this Cordyceps sinensis tablet preparation method is simple, requires low to equipment, technology, it is easy to promotion and application.
(3) other adjunct ingredient any that this preparation method whole process is not introduced in addition to Cordyceps militaris (L.) Link., uses in Cordyceps sinensis tablet preparation process
Edible ethanol removed by the operation volatilization such as drying in follow-up processing technique, belong to pure natural without adding green food
Product, have stopped the side effect that various adjuvant brings.
(4) in this Cordyceps tablet producing technology isolated polysaccharide component due to and be not introduced into the organic reagent that is harmful to or its
Its chemical composition, it is also possible to continue purifies and separates, for food additive and the exploitation of health product, therefore this raw materials technology
Utilization rate is high, without industrial refuse, meets the standard of environmental protection.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further, but the present invention is not done any restriction by specific embodiment.
Embodiment 1:
The present embodiment low sugar Cordyceps militaris (L.) Link. oral tablet is solid tablet, for the Cordyceps militaris (L.) Link.sporophore to dry as raw material, passes through
Decocting in water extracts wet granulation after removing Cordyceps polysaccharide and forms.Concrete preparation process is as follows:
(1) Cordyceps militaris (L.) Link.sporophore taking drying is raw material, and micronizing obtains Cordyceps militaris (L.) Link. superfine powder；
(2) in Cordyceps militaris (L.) Link. superfine powder, add the pure water of 5 times of quality, be warming up to 100 DEG C and carry out decocting in water extraction 60min,
Water filters after carrying；Water puies forward precipitation and dries to constant weight, and super micron mill is pulverized, obtained water and carry superfine powder；Aqueous extract concentrates
To concentration 1/5, concentrated solution 95% edible ethanol precipitation of 5 times of volumes, filter and take edible ethanol supernatant, dense
It is reduced to the 1/8 standby of original volume；
(3) water carries superfine powder mix according to mass ratio 3:2 with edible ethanol supernatant concentrated solution, wet granulation；
(4) the Cordyceps militaris (L.) Link. granule obtained is put in 50 DEG C of baking ovens and dry so that it is water content is below 5%；
(5) by the Cordyceps militaris (L.) Link. granulation dried, sterilizing, packaging, finished product Cordyceps militaris (L.) Link. sheet is obtained.
Embodiment 2:
The present embodiment low sugar Cordyceps militaris (L.) Link. oral tablet is solid tablet, for the Cordyceps militaris (L.) Link.sporophore to dry as raw material, passes through
Decocting in water extracts wet granulation after removing Cordyceps polysaccharide and forms.Concrete preparation process is as follows:
(1) Cordyceps militaris (L.) Link.sporophore taking drying is raw material, and micronizing obtains Cordyceps militaris (L.) Link. superfine powder；
(2) in Cordyceps militaris (L.) Link. superfine powder, add the pure water of 8 times of quality, be warming up to 95 DEG C and carry out decocting in water extraction 120min,
Water filters after carrying；Water puies forward precipitation and dries to constant weight, and super micron mill is pulverized, obtained water and carry superfine powder；Aqueous extract concentrates
To concentration 1/8, concentrated solution 95% edible ethanol precipitation of 8 times of volumes, filter and take edible ethanol supernatant, dense
It is reduced to the 1/10 standby of original volume；
(3) water carries superfine powder mix according to mass ratio 3:1.5 with edible ethanol supernatant concentrated solution, wet granulation；
(4) the Cordyceps militaris (L.) Link. granule obtained is put in 40 DEG C of baking ovens and dry so that it is water content is below 5%；
(5) by the Cordyceps militaris (L.) Link. granulation dried, sterilizing, packaging, finished product Cordyceps militaris (L.) Link. sheet is obtained.
Embodiment 3:
The present embodiment low sugar Cordyceps militaris (L.) Link. oral tablet is solid tablet, for the Cordyceps militaris (L.) Link.sporophore to dry as raw material, passes through
Decocting in water extracts wet granulation after removing Cordyceps polysaccharide and forms.Concrete preparation process is as follows:
(1) Cordyceps militaris (L.) Link.sporophore taking drying is raw material, and micronizing obtains Cordyceps militaris (L.) Link. superfine powder；
(2) in Cordyceps militaris (L.) Link. superfine powder, add the pure water of 3 times of quality, be warming up to 95 DEG C and carry out decocting in water extraction 120min,
Water filters after carrying；Water puies forward precipitation and dries to constant weight, and super micron mill is pulverized, obtained water and carry superfine powder；Aqueous extract concentrates
To concentration 1/4, concentrated solution 95% edible ethanol precipitation of 4 times of volumes, filter and take edible ethanol supernatant, dense
It is reduced to the 1/3 standby of original volume；
(3) water carries superfine powder mix according to mass ratio 3:1 with edible ethanol supernatant concentrated solution, wet granulation；
(4) the Cordyceps militaris (L.) Link. granule obtained is put in 40 DEG C of baking ovens and dry so that it is water content is below 5%；
(5) by the Cordyceps militaris (L.) Link. granulation dried, sterilizing, packaging, finished product Cordyceps militaris (L.) Link. sheet is obtained.
Character and the quality of the low sugar Cordyceps militaris (L.) Link. oral tablet preparing the various embodiments described above detect, and result is such as
Under:
Organoleptic indicator:
| Project | Index |
| Color and luster | In taupe |
| Taste, abnormal smells from the patient | There is this product distinctive taste abnormal smells from the patient, free from extraneous odour |
| Tissue morphology | Round sheet, consolidation |
| Impurity | Impurity without finding of naked eye |
According to the physicochemical and microbial index of state food standard detection Cordyceps polysaccharide sheet, result is as follows:
1) physical and chemical index:
| Project | Tablets detection refers to | GB |
| Moisture, % | ≤ mark 10 | ≤10 |
| Lead (in terms of Pb), mg/kg | ≤1.5 | ≤1.5 |
| Arsenic (in terms of As), mg/kg | ≤1.0 | ≤1.0 |
| Hydrargyrum (in terms of Hg), mg/kg | ≤0.3 | ≤0.3 |
2) microbiological indicator:
Claims (7)
1. a low sugar Cordyceps militaris (L.) Link. oral tablet, for solid tablet, it is characterised in that: for the Cordyceps militaris (L.) Link.sporophore to dry
For raw material, extracted after removing Cordyceps polysaccharide by decocting in water, wet granulation forms.
Low sugar Cordyceps militaris (L.) Link. oral tablet the most according to claim 1, it is characterised in that: Cordyceps militaris (L.) Link. of described drying
Entity carries out micronizing before decocting in water extracts.
Low sugar Cordyceps militaris (L.) Link. oral tablet the most according to claim 1, it is characterised in that: the feed liquid that described decocting in water extracts
Ratio is 1 (3-8), and decocting in water temperature is 95-100 DEG C, and the decocting in water time is 40-150min.
4. the preparation method of the low sugar Cordyceps militaris (L.) Link. oral tablet described in claim 1, it is characterised in that comprise the following steps:
(1) Cordyceps militaris (L.) Link.sporophore taking drying is raw material, and micronizing obtains Cordyceps militaris (L.) Link. superfine powder；
(2) adding pure water in Cordyceps militaris (L.) Link. superfine powder, be warming up to 95-100 DEG C and carry out decocting in water extraction, water filters after carrying,
Obtain aqueous extract and water puies forward precipitation；Water carries precipitation dry to constant weight, then micronizing, obtain water and carry superfine powder；Take
Aqueous extract is concentrated into the 1/8-1/4 that condensate precursor is long-pending, and concentrated solution precipitates with edible ethanol, then filters, takes edible ethanol
Supernatant, concentrates standby；
(3) water carries superfine powder mix according to mass ratio 3 (1-2) with edible ethanol supernatant concentrated solution, wet granulation；
(4) the Cordyceps militaris (L.) Link. granule obtained is put in 30-50 DEG C of baking oven and dry so that it is water content is below 5%；
(5) by the Cordyceps militaris (L.) Link. granulation dried, sterilizing, packaging, finished product low sugar Cordyceps militaris (L.) Link. oral tablet is obtained.
The preparation method of low sugar Cordyceps militaris (L.) Link. oral tablet the most according to claim 4, it is characterised in that: described step
(2) in, pure water addition is 3-8 times of Cordyceps militaris (L.) Link. superfine powder quality.
The preparation method of low sugar Cordyceps militaris (L.) Link. oral tablet the most according to claim 4, it is characterised in that: described step
(2) time that in, decocting in water extracts is 40-150min.
The preparation method of low sugar Cordyceps militaris (L.) Link. oral tablet the most according to claim 4, it is characterised in that: described step
(2) in, the concentration of edible ethanol is 95%, and concentrated solution is 1 (4-8) with the volume ratio of edible ethanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610221044.6A CN105902577A (en) | 2016-04-10 | 2016-04-10 | Low-sugar Cordyceps militaris oral tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610221044.6A CN105902577A (en) | 2016-04-10 | 2016-04-10 | Low-sugar Cordyceps militaris oral tablet and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN105902577A true CN105902577A (en) | 2016-08-31 |
Family
ID=56745008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610221044.6A Pending CN105902577A (en) | 2016-04-10 | 2016-04-10 | Low-sugar Cordyceps militaris oral tablet and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106721853A (en) * | 2017-01-24 | 2017-05-31 | 北京首诚航天农业生物科技有限公司 | A kind of Cordyceps militaris solid beverage composition and preparation method thereof |
| CN112190602A (en) * | 2020-10-27 | 2021-01-08 | 苏州家和蚕业生物科技有限公司 | Preparation method of silkworm chrysalis cordyceps sinensis tablets |
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2016
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| CN103599138A (en) * | 2013-11-22 | 2014-02-26 | 宁波广发文博生物科技有限公司 | Cordyceps militaris extract lozenge |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106721853A (en) * | 2017-01-24 | 2017-05-31 | 北京首诚航天农业生物科技有限公司 | A kind of Cordyceps militaris solid beverage composition and preparation method thereof |
| CN112190602A (en) * | 2020-10-27 | 2021-01-08 | 苏州家和蚕业生物科技有限公司 | Preparation method of silkworm chrysalis cordyceps sinensis tablets |
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Application publication date: 20160831 |