CN103316092A - Preparation technology of Jindan tablets - Google Patents
Preparation technology of Jindan tablets Download PDFInfo
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- CN103316092A CN103316092A CN201310260066XA CN201310260066A CN103316092A CN 103316092 A CN103316092 A CN 103316092A CN 201310260066X A CN201310260066X A CN 201310260066XA CN 201310260066 A CN201310260066 A CN 201310260066A CN 103316092 A CN103316092 A CN 103316092A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 238000005516 engineering process Methods 0.000 title claims abstract description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 63
- 239000011248 coating agent Substances 0.000 claims abstract description 33
- 238000000576 coating method Methods 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000003814 drug Substances 0.000 claims abstract description 20
- 239000000463 material Substances 0.000 claims abstract description 19
- 238000001035 drying Methods 0.000 claims abstract description 9
- 239000000284 extract Substances 0.000 claims description 28
- 239000012567 medical material Substances 0.000 claims description 24
- 239000008187 granular material Substances 0.000 claims description 21
- 241000282894 Sus scrofa domesticus Species 0.000 claims description 19
- 239000002674 ointment Substances 0.000 claims description 19
- 238000000605 extraction Methods 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 12
- 239000007921 spray Substances 0.000 claims description 12
- 238000002481 ethanol extraction Methods 0.000 claims description 8
- 238000003809 water extraction Methods 0.000 claims description 8
- 230000001476 alcoholic effect Effects 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 7
- 238000007907 direct compression Methods 0.000 claims description 2
- 239000007888 film coating Substances 0.000 claims description 2
- 238000009501 film coating Methods 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 239000000314 lubricant Substances 0.000 claims description 2
- 238000001694 spray drying Methods 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 235000016811 Biondella Nutrition 0.000 abstract 1
- 241001571764 Lysimachia christinae Species 0.000 abstract 1
- 241001648835 Polygonum cuspidatum Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 241001530209 Swertia Species 0.000 abstract 1
- 238000000034 method Methods 0.000 description 22
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 6
- 241001071795 Gentiana Species 0.000 description 5
- 241000612166 Lysimachia Species 0.000 description 5
- 238000007664 blowing Methods 0.000 description 5
- 238000002386 leaching Methods 0.000 description 5
- 235000019359 magnesium stearate Nutrition 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- 238000005507 spraying Methods 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 239000010409 thin film Substances 0.000 description 5
- 210000000941 bile Anatomy 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- SQFSKOYWJBQGKQ-UHFFFAOYSA-N kaempferide Chemical compound C1=CC(OC)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 SQFSKOYWJBQGKQ-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 3
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 3
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 3
- 229960001285 quercetin Drugs 0.000 description 3
- 235000005875 quercetin Nutrition 0.000 description 3
- HSTZMXCBWJGKHG-UHFFFAOYSA-N (E)-piceid Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=CC(C=CC=2C=CC(O)=CC=2)=C1 HSTZMXCBWJGKHG-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 150000002338 glycosides Chemical class 0.000 description 2
- 229960003764 polydatin Drugs 0.000 description 2
- HSTZMXCBWJGKHG-CUYWLFDKSA-N trans-piceid Polymers O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(\C=C\C=2C=CC(O)=CC=2)=C1 HSTZMXCBWJGKHG-CUYWLFDKSA-N 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000001989 choleretic effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000005070 sphincter Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a preparation technology of Jindan tablets. The preparation technology of Jindan tablets comprises the following steps of: extracting medicinal materials, drying, granulating, tabletting, coating and packaging, wherein in the step of extracting medicinal materials, lysimachia christinae Hance, felwort and polygonum cuspidatum are firstly extracted by alcohol, then water is added into extracted medicinal material residues, and the residues are decocted for extracting, thereby extracting water-soluble components and alcohol-soluble components in main components of medicaments comprehensively through the extracting step, achieving the aim of utilizing the medicament raw materials fully, and improving the utilization ratio of the materials.
Description
Technical field
The invention discloses a kind of preparation technology of JINDAN PIAN, belong to technical field of traditional Chinese medicine pharmacy.
Background technology
JINDAN PIAN has anti-inflammation, relieving spasm to stop pain, the effects such as function of gallbladder promoting relieving constipation.Main component Radix Gentianae wherein, Herba Lysimachiae have anti-inflammation, the effects such as heat clearing away.Herba Lysimachiae can promote sphincter muscle of bile duct lax, increases bile secretion, improves drug concentration in bile, and choleretic effect is arranged.Rhizoma Polygoni Cuspidati can suppress intestinal antidromicity antibacterial to be infected, and Fel Sus domestica unguentum can impel bile to become solution state, to correct the bile pathological change.
The processing step that adopted when present stage, the Chinese medicine JINDAN PIAN was produced comprises extraction, drying, granulation, tabletting, coating, packaging step.Generally all be with the Herba Lysimachiae ethanol extraction in the extraction step, then Radix Gentianae, Rhizoma Polygoni Cuspidati water extraction are condensed into extractum with the extracting solution merging.But water-soluble components is not only arranged in Herba Lysimachiae, Radix Gentianae, the Rhizoma Polygoni Cuspidati, pure soluble constituent is also arranged.So, alone water or ethanol extraction, active ingredient is extracted not exclusively.The water-soluble components flavonoid is arranged in the Herba Lysimachiae, also have the glycoside such as Quercetin to be insoluble in water and to be dissolved in ethanol.The flavonoid composition is arranged in the Rhizoma Polygoni Cuspidati, but Anthraquinones is insoluble in water.The bitter glycoside composition that Radix Gentianae is insoluble in water reaches 7.3%.Therefore, the used extracting method of production JINDAN PIAN so that the effective ingredient in the medical material can not get abundant extraction, has reduced the utilization rate of medical material at present, has caused waste.
Summary of the invention
Goal of the invention is in order to overcome above the deficiencies in the prior art, the invention provides a kind of preparation method of JINDAN PIAN, when medicinal material extract, Herba Lysimachiae, Radix Gentianae, Rhizoma Polygoni Cuspidati are used water extraction after with 60% ethanol extraction again, extract with the full composition that reaches these three kinds of medical materials, take full advantage of the effective ingredient in the medical material, improve curative effect.
To achieve these goals, the present invention is by the following technical solutions:
A kind of preparation technology of Chinese medicine JINDAN PIAN may further comprise the steps:
(1) medicinal material extract: Herba Lysimachiae, Radix Gentianae, Rhizoma Polygoni Cuspidati are used respectively ethanol extraction three times, Fel Sus domestica unguentum with ethanol extraction once, the alcoholic solution that merges backflow and Fel Sus domestica unguentum, medical material residue after the extraction decocts with water twice again, filter, concentrated, alcohol extract and water extraction concentrated solution are merged, be condensed into extractum;
(2) drying: extractum is formed fine powder by spray drying;
(3) granulate: fine powder is made by granulator can be for the granule of tabletting;
(4) tabletting: granule is added direct compression behind the lubricant, obtain plain sheet;
(5) coating: the JINDAN PIAN element sheet that presses is placed in the high-efficiency coating pot, film coating, the coating gain in weight is 2%-5%, and get final product.
The weight of the used ethanol of medicinal material extract in the step (1) is respectively 5-10 times of corresponding medical material Herba Lysimachiae weight, and the 3-7 of Radix Gentianae weight times, the 3-7 of Rhizoma Polygoni Cuspidati weight times, the 2-3 of Fel Sus domestica unguentum weight doubly.
Used ethanol is the ethanol of content 60%, and extracting mode is reflux, extract,, and wherein for the first time extraction time is 2-3 hour, and second, third time extraction time is 1-2 hour, has extracted rear merging backflow and Fel Sus domestica unguentum alcohol extract, obtains alcohol extract; In the above-mentioned steps, alcohol extract is Recycled ethanol further also.
The preparation technology of described Chinese medicine JINDAN PIAN, the medical material residue decocts with water 5-8 that twice used water yield be respectively the medical material amount doubly and 4-6 times.
The preparation technology of described Chinese medicine JINDAN PIAN after wherein decocting boils filters medicinal liquid, and being concentrated into Baume degrees is 5-8 ° of Be, and temperature is 60-80 ℃.
The preparation technology of described Chinese medicine JINDAN PIAN, it is 12-18 ° of Be that alcohol extract and water extraction concentrated solution are incorporated into Baume degrees, temperature is 60-80 ℃.
The preparation technology of described Chinese medicine JINDAN PIAN, spray dryer inlet temperature are 180～220 ℃, and outlet temperature is 90～110 ℃.
The preparation technology of described Chinese medicine JINDAN PIAN, granulator inlet temperature are 60～110 ℃, and the transfusion frequency values is 35～50HZ.
Beneficial effect
In extraction step, Herba Lysimachiae, Radix Gentianae, Rhizoma Polygoni Cuspidati are used water extraction after with ethanol extraction again, the full composition that reaches these three kinds of medical material effective ingredient extracts, so that the effective ingredient in the medical material is fully used, the JINDAN PIAN of using the present invention to make is compared with the JINDAN PIAN that traditional method makes, the total content of Quercetin and kaempferide has improved more than 60%, Determination of Polydatin has improved 42.8%, and the content of Radix Gentianae hardship also is significantly improved.
The specific embodiment:
Embodiment 1
The preparation method of JINDAN PIAN may further comprise the steps:
(1) medicinal material extract: by weight, with 60 parts of Herba Lysimachiaes, 10 parts of Radix Gentianaes, 20 parts of usefulness of Rhizoma Polygoni Cuspidati, 60% alcohol reflux three times (add amount of alcohol and be about respectively 5 times, 3 times, 3 times of medical material amount), 3 hours for the first time, second and third time each 2 hours, alcoholic solution (1 part of the Fel Sus domestica unguentum that merges backflow and Fel Sus domestica unguentum, add 2 times of extractions of ethanol), Recycled ethanol obtains alcohol extract.Herba Lysimachiae, Radix Gentianae, Rhizoma Polygoni Cuspidati residue are decocted with water secondary (amount of water is about respectively 5 times of medical material amounts, 4 times of amounts), each 2 hours, medicinal liquid filters, be concentrated into Baume degrees and be about 5 ° of Be, temperature 60 C, precipitation is more than 24 hours, and the mixed liquor of leaching supernatant and alcohol extract merging is concentrated into Baume degrees and is about 12 ° Be(60 ℃) extractum.
(2) drying: clear paste is spray dried to fine powder.The spray dryer inlet temperature is 180 ℃, and outlet temperature is 90 ℃.
(3) granulate: but the magnesium stearate of fine powder and 1% is directly made the granule of tabletting with one-step-granulating method.The one-step-granulating method inlet temperature is 90 ℃, and the transfusion frequency values is 35HZ.
(4) tabletting: with the granule tabletting, punch die φ 10mm scrobicula checks that every 15 minutes average sheet is heavy once, checks hardness, outward appearance etc. simultaneously in the tabletting process.
(5) coating: get qualified JINDAN PIAN element sheet, set high in the effect coating pan, start seed-coating machine, exhaust blower and hot-air blower, elder generation's blowing hot-air pre-phlogiston sheet to 40 ℃, then start spraying system, film-coat liquid is sprayed onto the tablet surface equably, the coating temperature is 50～60 ℃, until sprayed till whole thin film dress materials, the coating weightening finish is 2%.
Embodiment 2
The preparation method of JINDAN PIAN may further comprise the steps:
(1) medicinal material extract: with 60 parts of Herba Lysimachiaes, 10 parts of Radix Gentianaes, 20 parts of usefulness of Rhizoma Polygoni Cuspidati, 60% alcohol reflux three times (add amount of alcohol and be about respectively 6 times, 4 times, 4 times of medical material amount), 3 hours for the first time, second and third time each 1 hour, alcoholic solution (1 part of the Fel Sus domestica unguentum that merges backflow and Fel Sus domestica unguentum, add 3 times of extractions of ethanol), Recycled ethanol.Herba Lysimachiae, Radix Gentianae, Rhizoma Polygoni Cuspidati residue are decocted with water secondary (amount of water is about respectively 6 times of medical material amounts, 5 times of amounts), each 2 hours, medicinal liquid filters, be concentrated into Baume degrees and be about 6 ° Be(60 ℃), precipitation is more than 24 hours, the mixed liquor of leaching supernatant and alcohol extract merges, and is concentrated into Baume degrees and is about 14 ° Be(60 ℃) clear paste.
(2) drying: clear paste is spray dried to fine powder.The spray dryer inlet temperature is 190 ℃, and outlet temperature is 100 ℃.
(3) granulate: but the magnesium stearate of fine powder and 1% is directly made the granule of tabletting with one-step-granulating method.The one-step-granulating method inlet temperature is 100 ℃, and the transfusion frequency values is 40HZ.
(4) tabletting: with the granule tabletting, punch die φ 10mm scrobicula checks that every 15 minutes average sheet is heavy once, checks hardness, outward appearance etc. simultaneously in the tabletting process.
(5) coating: get qualified JINDAN PIAN element sheet, set high in the effect coating pan, start seed-coating machine, exhaust blower and hot-air blower, elder generation's blowing hot-air pre-phlogiston sheet to 40 ℃, then start spraying system, film-coat liquid is sprayed onto the tablet surface equably, the coating temperature is 50～60 ℃, until sprayed till whole thin film dress materials, the coating weightening finish is 3%.
Embodiment 3
The preparation method of JINDAN PIAN may further comprise the steps:
(1) medicinal material extract: with 50 parts of Herba Lysimachiaes, 8 parts of Radix Gentianaes, 15 parts of usefulness of Rhizoma Polygoni Cuspidati, 60% alcohol reflux three times (add amount of alcohol and be about respectively 7 times, 5 times, 5 times of medical material amount), 2 hours for the first time, second and third time each 1 hour, alcoholic solution (1 part of the Fel Sus domestica unguentum that merges backflow and Fel Sus domestica unguentum, add 2 times of extractions of ethanol), Recycled ethanol.Herba Lysimachiae, Radix Gentianae, Rhizoma Polygoni Cuspidati residue are decocted with water secondary (amount of water is about respectively 6 times of medical material amounts, 5 times of amounts), each 2 hours, medicinal liquid filters, be concentrated into Baume degrees and be about 6 ° Be(80 ℃), precipitation is more than 24 hours, the mixed liquor of leaching supernatant and alcohol extract merges, and is concentrated into Baume degrees and is about 15 ° Be(80 ℃) clear paste.
(2) drying: clear paste is spray dried to fine powder.The spray dryer inlet temperature is 210 ℃, and outlet temperature is 95 ℃.
(3) granulate: but the magnesium stearate of fine powder and 1% is directly made the granule of tabletting with one-step-granulating method.The one-step-granulating method inlet temperature is 85 ℃, and the transfusion frequency values is 50HZ.
(4) tabletting: with the granule tabletting, punch die φ 10mm scrobicula checks that every 15 minutes average sheet is heavy once, checks hardness, outward appearance etc. simultaneously in the tabletting process.
(5) coating: get qualified JINDAN PIAN element sheet, set high in the effect coating pan, start seed-coating machine, exhaust blower and hot-air blower, elder generation's blowing hot-air pre-phlogiston sheet to 40 ℃, then start spraying system, film-coat liquid is sprayed onto the tablet surface equably, the coating temperature is 50～60 ℃, until sprayed till whole thin film dress materials, the coating weightening finish is 3%.
Embodiment 4
The preparation method of JINDAN PIAN may further comprise the steps:
(1) medicinal material extract: with 70 parts of Herba Lysimachiaes, 10 parts of Radix Gentianaes, 25 parts of usefulness of Rhizoma Polygoni Cuspidati, 60% alcohol reflux three times (add amount of alcohol and be about respectively 7 times, 5 times, 5 times of medical material amount), 2 hours for the first time, second and third time each 1 hour, alcoholic solution (1 part of the Fel Sus domestica unguentum that merges backflow and Fel Sus domestica unguentum, add 3 times of extractions of ethanol), Recycled ethanol.Herba Lysimachiae, Radix Gentianae, Rhizoma Polygoni Cuspidati residue are decocted with water secondary (amount of water is about respectively 6 times of medical material amounts, 5 times of amounts), each 2 hours, medicinal liquid filters, be concentrated into Baume degrees and be about 7 ° Be(80 ℃), precipitation is more than 24 hours, the mixed liquor of leaching supernatant and alcohol extract merges, and is concentrated into Baume degrees and is about 17 ° Be(80 ℃) clear paste.
(2) drying: clear paste is spray dried to fine powder.The spray dryer inlet temperature is 200 ℃, and outlet temperature is 95 ℃.
(3) granulate: but the magnesium stearate of fine powder and 1% is directly made the granule of tabletting with one-step-granulating method.The one-step-granulating method inlet temperature is 75 ℃, and the transfusion frequency values is 40HZ.
(4) tabletting: with the granule tabletting, punch die φ 10mm scrobicula checks that every 15 minutes average sheet is heavy once, checks hardness, outward appearance etc. simultaneously in the tabletting process.
(5) coating: get qualified JINDAN PIAN element sheet, set high in the effect coating pan, start seed-coating machine, exhaust blower and hot-air blower, elder generation's blowing hot-air pre-phlogiston sheet to 40 ℃, then start spraying system, film-coat liquid is sprayed onto the tablet surface equably, the coating temperature is 50～60 ℃, until sprayed till whole thin film dress materials, the coating weightening finish is 4%.
Embodiment 5
The preparation method of JINDAN PIAN may further comprise the steps:
(1) medicinal material extract: with 60 parts of Herba Lysimachiaes, 10 parts of Radix Gentianaes, 20 parts of usefulness of Rhizoma Polygoni Cuspidati, 60% alcohol reflux three times (add amount of alcohol and be about respectively 10 times, 7 times, 7 times of medical material amount), 2 hours for the first time, second and third time each 1 hour, alcoholic solution (1 part of the Fel Sus domestica unguentum that merges backflow and Fel Sus domestica unguentum, add 3 times of extractions of ethanol), Recycled ethanol.Herba Lysimachiae, Radix Gentianae, Rhizoma Polygoni Cuspidati residue are decocted with water secondary (amount of water is about respectively 8 times of medical material amounts, 6 times of amounts), each 2 hours, medicinal liquid filters, be concentrated into Baume degrees and be about 8 ° Be(70 ℃), precipitation is more than 24 hours, the mixed liquor of leaching supernatant and alcohol extract merges, and is concentrated into Baume degrees and is about 18 ° Be(70 ℃) clear paste.
(2) drying: clear paste is spray dried to fine powder.The spray dryer inlet temperature is 220 ℃, and outlet temperature is 90 ℃.
(3) granulate: but the magnesium stearate of fine powder and 1% is directly made the granule of tabletting with one-step-granulating method.The one-step-granulating method inlet temperature is 110 ℃, and the transfusion frequency values is 50HZ.
(4) tabletting: with the granule tabletting, punch die φ 10mm scrobicula checks that every 15 minutes average sheet is heavy once, checks hardness, outward appearance etc. simultaneously in the tabletting process.
(5) coating: get qualified JINDAN PIAN element sheet, set high in the effect coating pan, start seed-coating machine, exhaust blower and hot-air blower, elder generation's blowing hot-air pre-phlogiston sheet to 40 ℃, then start spraying system, film-coat liquid is sprayed onto the tablet surface equably, the coating temperature is 50～60 ℃, until sprayed till whole thin film dress materials, the coating weightening finish is 5%.
Get extracting method of the present invention and make the JINDAN PIAN effective substance content that JINDAN PIAN and existing traditional method make and compare test, concrete data see Table 1.Detection method is referring to research " Shandong medicine thing " the 29th volume the 3rd phase author Chen Xiaofeng, Yang Yanfei in 2010 of JINDAN capsule quality standard.
Table 1 JINDAN PIAN of the present invention and traditional method make the contrast of JINDAN PIAN active constituent content
Can be found out by above test data, the JINDAN PIAN of using the present invention to make is compared with the JINDAN PIAN that traditional method makes, the total content of Quercetin and kaempferide has improved more than 60%, Determination of Polydatin has improved 42.8%, and the content of Radix Gentianae hardship also is significantly improved, therefore the present invention's technique of preparing JINDAN PIAN can effectively utilize raw material, improves curative effect, has reduced accordingly cost.
Claims (8)
1. the preparation technology of a Chinese medicine JINDAN PIAN is characterized in that, may further comprise the steps:
(1) medicinal material extract: Herba Lysimachiae, Radix Gentianae, Rhizoma Polygoni Cuspidati are used respectively ethanol extraction three times, Fel Sus domestica unguentum with ethanol extraction once, the alcoholic solution that merges backflow and Fel Sus domestica unguentum, medical material residue after the extraction decocts with water twice again, filter, concentrated, alcohol extract and water extraction concentrated solution are merged, be condensed into extractum;
(2) drying: extractum is formed fine powder by spray drying;
(3) granulate: fine powder is made by granulator can be for the granule of tabletting;
(4) tabletting: granule is added direct compression behind the lubricant, obtain plain sheet;
(5) coating: the JINDAN PIAN element sheet that presses is placed in the high-efficiency coating pot, film coating, the coating gain in weight is 2%-5%, and get final product.
2. the preparation technology of Chinese medicine JINDAN PIAN according to claim 1 is characterized in that, the 5-10 that the weight of used ethanol is respectively corresponding medical material Herba Lysimachiae weight during medicinal material extract doubly, the 3-7 of Radix Gentianae weight doubly, the 3-7 of Rhizoma Polygoni Cuspidati weight doubly, the 2-3 of Fel Sus domestica unguentum is doubly.
3. the preparation technology of Chinese medicine JINDAN PIAN according to claim 1, it is characterized in that, used ethanol is the ethanol of content 60%, extracting mode is reflux, extract,, wherein extraction time is 2-3 hour for the first time, second, third time extraction time is 1-2 hour, has extracted rear merging backflow and Fel Sus domestica unguentum alcohol extract, Recycled ethanol.
4. the preparation technology of Chinese medicine JINDAN PIAN according to claim 1 is characterized in that, the medical material residue decocts with water 5-8 that twice used water yield be respectively the medical material amount doubly and 4-6 times.
5. the preparation technology of Chinese medicine JINDAN PIAN according to claim 1 is characterized in that, after decocting boils medicinal liquid is filtered, and being concentrated into Baume degrees is 5-8 ° of Be, and temperature is 60-80 ℃.
6. the preparation technology of Chinese medicine JINDAN PIAN according to claim 1 is characterized in that, it is 12-18 ° of Be that alcohol extract and water extraction concentrated solution are incorporated into Baume degrees, and temperature is 60-80 ℃.
7. the preparation technology of Chinese medicine JINDAN PIAN according to claim 1 is characterized in that, the spray dryer inlet temperature is 180～220 ℃, and outlet temperature is 90～110 ℃.
8. the preparation technology of Chinese medicine JINDAN PIAN according to claim 1 is characterized in that, the granulator inlet temperature is 60～110 ℃, and the transfusion frequency values is 35～50HZ.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367481A (en) * | 2014-09-21 | 2015-02-25 | 四川制药制剂有限公司 | Processing technology for cefcapene pivoxil hydrochloride |
| CN106266130A (en) * | 2016-08-23 | 2017-01-04 | 刘军 | Fast-acting antiphlogistic, ethoxybenzamide Chinese patent medicine preparation |
| CN112353851A (en) * | 2020-11-10 | 2021-02-12 | 江苏七〇七天然制药有限公司 | Jindan capsule and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1363309A (en) * | 2001-01-10 | 2002-08-14 | 杨孟君 | Nano medicine 'jintan' and its preparing process |
| CN1724011A (en) * | 2005-07-04 | 2006-01-25 | 山东省医学科学院药物研究所 | A kind of 'Jindan ' soft capsule and preparation method thereof |
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2013
- 2013-06-25 CN CN201310260066.XA patent/CN103316092B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1363309A (en) * | 2001-01-10 | 2002-08-14 | 杨孟君 | Nano medicine 'jintan' and its preparing process |
| CN1724011A (en) * | 2005-07-04 | 2006-01-25 | 山东省医学科学院药物研究所 | A kind of 'Jindan ' soft capsule and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367481A (en) * | 2014-09-21 | 2015-02-25 | 四川制药制剂有限公司 | Processing technology for cefcapene pivoxil hydrochloride |
| CN106266130A (en) * | 2016-08-23 | 2017-01-04 | 刘军 | Fast-acting antiphlogistic, ethoxybenzamide Chinese patent medicine preparation |
| CN112353851A (en) * | 2020-11-10 | 2021-02-12 | 江苏七〇七天然制药有限公司 | Jindan capsule and preparation method thereof |
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| CN103316092B (en) | 2015-10-21 |
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