CN104367481A - Processing technology for cefcapene pivoxil hydrochloride - Google Patents

Processing technology for cefcapene pivoxil hydrochloride Download PDF

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Publication number
CN104367481A
CN104367481A CN201410481476.1A CN201410481476A CN104367481A CN 104367481 A CN104367481 A CN 104367481A CN 201410481476 A CN201410481476 A CN 201410481476A CN 104367481 A CN104367481 A CN 104367481A
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China
Prior art keywords
process
coating
materials
hydrochloride
processing technology
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CN201410481476.1A
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Chinese (zh)
Inventor
沈千万
周璇
刘萍
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四川制药制剂有限公司
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Priority to CN201410481476.1A priority Critical patent/CN104367481A/en
Publication of CN104367481A publication Critical patent/CN104367481A/en

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Abstract

The invention discloses a processing technology for cefcapene pivoxil hydrochloride. The processing technology comprises the steps that firstly, raw materials and auxiliary materials are dried, and the water content of the raw materials and the water content of the auxiliary materials are made to be lower than or equal to 3.0%; the raw materials and the auxiliary materials are screened through a 100-mesh screen and then mixed, dry granulation is conducted, tabletting is conducted, and products are obtained after coating is conducted. By means of the processing technology, the pharmaceutical preparation good in quality and stability, smooth in tablet face and even in color can be obtained.

Description

盐酸头孢卡品酯的加工工艺 Process card product ester Hydrochloride,

技术领域 FIELD

[0001] 本发明涉及医药领域,具体地,涉及盐酸头孢卡品酯的加工工艺。 [0001] The present invention relates to the field of medicine, particularly, to a card processing products cephem ester hydrochloride.

背景技术 Background technique

[0002] 盐酸头孢卡品酯用于治疗由敏感菌引起的表皮感染、皮肤深部感染、慢性脓皮症、外伤、烫伤及手术创伤等伤口的继发感染、乳腺炎、肛门周围浓重、咽炎、喉炎、牙组织感染、牙周炎等。 [0002] cefcapene pivoxil hydrochloride for the treatment of infections caused by susceptible strains of the skin, deep skin infection, secondary infection of chronic pyoderma, trauma, burns and surgical trauma wounds, mastitis, thick around the anus, pharyngitis, laryngitis, dental tissue infections, periodontitis. 目前盐酸头孢卡品酯因口服方便一般采用片剂。 Currently cephalosporin ester hydrochloride card products commonly used because for convenient oral tablets. 但是盐酸头孢卡品酯微溶于乙醇,几乎不溶于水,如何提高其溶解度、增加片剂的溶出度一直都是制药制剂上密切关注的课题。 However cephalosporin ester hydrochloride card ethanol-soluble product, almost insoluble in water, how to improve their solubility, dissolution rate increased problem has been the pharmaceutical tablet formulation is closely.

[0003] 对于如何加工完成一个质量好的盐酸头孢卡品酯的制剂,几乎没有盐酸头孢卡品酯的加工工艺相关报道。 [0003] How the finished formulation for a good quality of cefcapene pivoxil hydrochloride, almost no ester hydrochloride cefcapene process reports.

发明内容 SUMMARY

[0004] 本发明所要解决的技术问题是提供一种盐酸头孢卡品的加工工艺,该加工工艺能够得到一种质量好的、稳定性好、片面光滑、色泽均匀的制药制剂。 [0004] The present invention solves the technical problem is to provide a cefcapene hydrochloride of process, the process can be one kind of good quality, good stability, smooth-sided, uniform color pharmaceutical formulation.

[0005] 本发明解决上述问题所采用的技术方案是: [0005] aspect of the present invention to solve the above problems is adopted:

盐酸头孢卡品酯的加工工艺,包括以下步骤: Cephalosporin ester hydrochloride product card processing, comprising the steps of:

(1)干燥原料和辅料,使得原料和辅料的水分含量彡3.0% ; (1) dried raw materials and accessories, such that the moisture content of the raw and auxiliary materials San 3.0%;

(2)将原料和辅料进行100目过筛处理; (2) the raw materials and accessories for processing 100 mesh sieve;

(3)将原料和辅料进行混粉处理; (3) mixing the starting materials and components for powder treatment;

(4)将经混粉处理的原料和辅料干法制成颗粒,控制整理水分含量彡3.6% ; (4) and auxiliary raw materials by mixing the dry powder processed to form a granulate, controls the finisher San 3.6% moisture content;

(5)压片后包衣。 (5) coating the tablet.

[0006] 所述步骤(4)中的整粒的颗粒大小为40目。 [0006] The particle size of the step (4) of the sieved 40 mesh.

[0007] 所述包衣为将片芯放入包衣锅内加热,进风温度为75°C,包衣锅转速4转/分。 [0007] The coating of the tablet cores into a coating pan heated inlet air temperature of 75 ° C, a pan speed of 4 rpm / min.

[0008] 所述包衣的排风温度为30°C。 [0008] The coating exhaust temperature 30 ° C.

[0009] 所述包衣温度为35°C。 [0009] The coating temperature is 35 ° C.

[0010] 综上,本发明的有益效果是: [0010] In summary, the advantages are:

本发明得到一种质量好的、稳定性好、片面光滑、色泽均匀的制药制剂。 A quality-of the present invention is to obtain a good, stable, smooth-sided, uniform color pharmaceutical formulation.

具体实施方式 Detailed ways

[0011] 下面结合实施例,对本发明作进一步地的详细说明,但本发明的实施方式不限于此。 [0011] below with reference to embodiments of the present invention will be further described in detail, but the embodiment of the present invention is not limited thereto.

[0012] 实施例1 [0012] Example 1

盐酸头孢卡品酯的加工工艺,包括以下步骤: Cephalosporin ester hydrochloride product card processing, comprising the steps of:

(6)干燥原料和辅料,使得原料和辅料的水分含量彡3.0% ; (6) drying the raw material and auxiliary materials, such that the moisture content of the raw and auxiliary materials San 3.0%;

(7)将原料和辅料进行100目过筛处理; (8)将原料和辅料进行混粉处理; (7) The raw materials and accessories for processing 100 mesh sieve; (8) for mixing the raw materials and powder processing;

(9)将经混粉处理的原料和辅料干法制成颗粒,控制整理水分含量彡3.6% ; (9) and auxiliary raw material mixed powder treated by the dry method into particles, controls the finisher San 3.6% moisture content;

(10)压片后包衣。 (10) coated after tabletting.

[0013] 所述步骤(4)中的整粒的颗粒大小为40目。 [0013] The particle size of the step (4) of the sieved 40 mesh.

[0014] 所述包衣为将片芯放入包衣锅内加热,进风温度为75°C,包衣锅转速4转/分。 [0014] The coating of the tablet cores into a coating pan heated inlet air temperature of 75 ° C, a pan speed of 4 rpm / min.

[0015] 所述包衣的排风温度为30°C。 [0015] The coating exhaust temperature 30 ° C.

[0016] 所述包衣温度为35°C。 The [0016] coating temperature of 35 ° C.

[0017] 如上所述,可较好的实现本发明。 [0017] As described above, the present invention can be better realized.

Claims (5)

1.盐酸头孢卡品酯的加工工艺,其特征在于,包括以下步骤: 干燥原料和辅料,使得原料和辅料的水分含量< 3.0% ; 将原料和辅料进行100目过筛处理; 将原料和辅料进行混粉处理; 将经混粉处理的原料和辅料干法制成颗粒,控制整理水分含量< 3.6% ; 压片后包衣。 1. Process of cefcapene pivoxil hydrochloride, characterized by comprising the steps of: drying and raw materials, so the moisture content of the raw materials and <3.0%; starting materials and components for the 100 mesh sieve process; the raw material and auxiliary materials for powder mixing process; and auxiliary raw material powder by mixing a dry process to form a granulate, controls the finisher moisture content <3.6%; after compression coating.
2.根据权利要求1所述的盐酸头孢卡品酯的加工工艺,其特征在于,所述步骤(4)中的整粒的颗粒大小为40目。 The process cephem ester hydrochloride card product according to claim 1, wherein the particle size of the whole (4) in the step 40 mesh.
3.根据权利要求1所述的盐酸头孢卡品酯的加工工艺,其特征在于,所述包衣为将片芯放入包衣锅内加热,进风温度为75°C,包衣锅转速4转/分。 The process cephem ester hydrochloride card product according to claim 1, wherein said coating is a tablet cores into a coating pan heated inlet air temperature of 75 ° C, a pan rotation speed 4 rev / min.
4.根据权利要求1所述的盐酸头孢卡品酯的加工工艺,其特征在于,所述包衣的排风温度为30°C。 The process cephem ester hydrochloride card product according to claim 1, wherein the coating exhaust temperature 30 ° C.
5.根据权利要求1所述的盐酸头孢卡品酯的加工工艺,其特征在于,所述包衣温度为35。 Process according to claim cefcapene pivoxil hydrochloride of claim 1, wherein the coating temperature is 35. . .
CN201410481476.1A 2014-09-21 2014-09-21 Processing technology for cefcapene pivoxil hydrochloride CN104367481A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002356427A (en) * 2001-05-30 2002-12-13 Shionogi & Co Ltd β-LACTAMASE INHIBITOR
CN101670485A (en) * 2000-09-13 2010-03-17 浜松光子学株式会社 Laser processing method and laser processing apparatus
WO2010056827A1 (en) * 2008-11-13 2010-05-20 Protez Pharmaceuticals, Inc. Beta-lactamase inhibitors
CN102138923A (en) * 2011-02-01 2011-08-03 石药集团中奇制药技术(石家庄)有限公司 Cefcapene pivoxil hydrochloride composition and preparation method thereof
CN102138922A (en) * 2011-02-01 2011-08-03 石药集团中奇制药技术(石家庄)有限公司 Cefcapene pivoxil hydrochloride composition and preparation method thereof
CN103316092A (en) * 2013-06-25 2013-09-25 江苏七O七天然制药有限公司 Preparation technology of Jindan tablets

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101670485A (en) * 2000-09-13 2010-03-17 浜松光子学株式会社 Laser processing method and laser processing apparatus
JP2002356427A (en) * 2001-05-30 2002-12-13 Shionogi & Co Ltd β-LACTAMASE INHIBITOR
WO2010056827A1 (en) * 2008-11-13 2010-05-20 Protez Pharmaceuticals, Inc. Beta-lactamase inhibitors
CN102138923A (en) * 2011-02-01 2011-08-03 石药集团中奇制药技术(石家庄)有限公司 Cefcapene pivoxil hydrochloride composition and preparation method thereof
CN102138922A (en) * 2011-02-01 2011-08-03 石药集团中奇制药技术(石家庄)有限公司 Cefcapene pivoxil hydrochloride composition and preparation method thereof
CN103316092A (en) * 2013-06-25 2013-09-25 江苏七O七天然制药有限公司 Preparation technology of Jindan tablets

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
雷秀珍: "盐酸头孢卡品酯片的研制及质量研究", 《海峡药学》 *

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