CN104165497A - Honeysuckle freeze-drying method - Google Patents
Honeysuckle freeze-drying method Download PDFInfo
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- CN104165497A CN104165497A CN201410418395.7A CN201410418395A CN104165497A CN 104165497 A CN104165497 A CN 104165497A CN 201410418395 A CN201410418395 A CN 201410418395A CN 104165497 A CN104165497 A CN 104165497A
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- honeysuckle
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- distillation
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Abstract
The invention relates to a honeysuckle freeze-drying method. The honeysuckle free-drying method is characterized by comprising the step that freeze-drying is conducted until sublimation ends. In freeze-dried honeysuckle preparation, energy consumption is low, the appearance is good and the honeysuckle is not prone to breakage.
Description
Invention field
The present invention relates to medicine method for making, particularly the freeze drying process of a kind of honeysuckle, belongs to medical technical field.
Background technology
Honeysuckle (honeysuckle) is the bud of caprifoliaceae plant honeysuckle (LoniceraJaponica Thunb.), has the effects such as clearing heat and detoxicating, antiphlogistic antibacterial.Honeysuckle should be dried after plucking immediately, otherwise brown stain can occur color, and active ingredient also can reduce.Traditional drying means have dry in the shade, dry, oven dry etc.Mostly research is in recent years to utilize modern dry means to carry out the processing of honeysuckle, the report of existing honeysuckle microwave drying at present, freeze drying, the air-dry research such as dry.The rate of drying of microwave drying is fast, but parameter is wayward, cryodesiccated superior product quality, but drying time is long and cost is higher, and heated-air drying is simple to operate, but product quality is poor.
The freeze-drying process of prior art mainly can be divided into primary drying (lyophilization), and redrying (adsorption stripping and dry) is to dry.The dry run pumpdown time is long, and energy consumption is high.The present invention in freeze dryer without redrying process.Energy consumption is low, through test of many times power consumption, can reduce more than 50%.
Below by test, further illustrate usefulness of the present invention, test is intended to further illustrate usefulness of the present invention, but not limitation of the present invention.
To, with a collection of fresh honeysuckle, process by the following method.
1) dry: 60 ℃ are dried to dry.
2) dry: the thin stand on bamboo curtain splint of loosely dried.
3) freeze-drying: put in freeze dryer, be refrigerated to below-10 ℃, be evacuated to below drying chamber pressure 20Pa heating sublimation; Sublimation temperature is controlled at below 55 ℃, and distillation finishes, and the temperature of resolution phase is controlled at below 45 ℃, to dry, obtains.
4) freeze-drying to distillation finishes: the freeze drying process of a kind of honeysuckle, is characterized in that: get fresh honeysuckle, put in freeze dryer, be refrigerated to below-10 ℃, be evacuated to below drying chamber pressure 20Pa heating sublimation; Sublimation temperature is controlled at below 55 ℃, and distillation finishes, and obtains.
One, distinct methods drying leaching thing content comparison
Chemical composition of Chinese materia medica is complicated, mainly with decoction, takes, and clinical efficacy is the result of multicomponent comprehensive function, and content Chang Zuowei water-soluble and ethanol soluble extractives evaluates the comprehensive judge index of quality of medicinal material height.
Adopt one of < < Chinese pharmacopoeia > > version in 2010, appendix XA method is carried out water-soluble and assay ethanol soluble extractives.Wherein alcohol extract solvent adopts 70% ethanol.
The dry honeysuckle extract content of distinct methods the results are shown in Table 1 above.
Table 1 distinct methods is dried honeysuckle extract content measurement result.
| Sample | Dry | Dry | Freeze-drying | Freeze-drying to distillation finishes |
| Water extraction content (%) | 23.74 | 21.85 | 31.52 | 31.53 |
| Ethanol soluble extractives (%) | 20.37 | 19.81 | 27.44 | 27.43 |
Table 1 finds out, honeysuckle freeze-drying to distillation finishes and freeze-drying is water-soluble and the content of ethanol soluble extractives all higher than oven dry or dry, illustrate that freeze-drying honeysuckle of the present invention and freeze-drying traditional Chinese medicine honeysuckle quality are good, but energy consumption of the present invention is low.
Two, the dry total appearance character comparison of honeysuckle of distinct methods
The results are shown in Table 2.
Table 2 distinct methods is dried honeysuckle appearance character result
| Sample | Dry | Dry | Freeze-drying | Freeze-drying to distillation finishes |
| Color | Faint yellow, occasionally have yellowish green alternate | Yellow, occasionally has brown alternate | Faint yellow, white is alternate | Faint yellow, white is alternate |
| Fragrance | Delicate fragrance is lighter | Delicate fragrance is lighter | Delicate fragrance is denseer | Delicate fragrance is denseer |
| Quality | Bud is fuller, and the ripe flower sense of tool, slightly rolls up | Bud is not full, and the raw flower sense of tool, rolls up obviously | Bud is full, and tool is raw flower sense obviously, without rolling up | Bud is full, and tool is raw flower sense obviously, without rolling up |
Table 2 result is known, freeze-drying and freeze-drying are better to the honeysuckle finished product appearance character that distillation finishes gained.
Three, the dry honeysuckle friability comparison of distinct methods
1, inspection method
Get respectively 10 of the dry honeysuckles of distinct methods, pack in polybag, put 1m place, freely fall, 10 times repeatedly, check cracked number of each test sample.
2, result, is shown in 3.
Table 3 distinct methods is dried honeysuckle friability result (%)
| Sample | Dry | Dry | Freeze-drying | Freeze-drying to distillation finishes |
| Cracked number | 5 | 4 | 7 | 4 |
Table 3 result is known, and honeysuckle friability of the present invention is low, and product is non-friable, and known storage, transportation easily keep shape, constant product quality.
Summary of the invention
The freeze drying process that the object of this invention is to provide a kind of honeysuckle, the method is dried honeysuckle, and energy consumption is low, and appearance character is good, non-friable.
The object of the present invention is achieved like this:
A freeze drying process for honeysuckle, is characterized in that: get fresh honeysuckle, put in freeze dryer, be refrigerated to below-10 ℃, be evacuated to below drying chamber pressure 30Pa heating sublimation; Sublimation temperature is controlled at below 40 ℃, and distillation finishes, and obtains.
The freeze drying process of a kind of honeysuckle of the present invention, is characterized in that: freeze-drying to distillation finishes.
The freeze drying process of a kind of honeysuckle of the present invention, is characterized in that: a kind of judgement of distillation in finishing by the following method 1. serviceability temperature Sensor monitoring temperature of charge judge whether the ice in material all distils; 2. condenser temperature drops to the state before distillation; 3. the pressure drop of freeze drying box is to the pressure that approaches freezer unit.
So far completed the present invention, the present invention prepares freeze-drying honeysuckle, and energy consumption is low, and appearance character is good, non-friable.
The specific embodiment
embodiment 1
Fresh honeysuckle, puts in freeze dryer, is refrigerated to-20 ℃, is evacuated to drying chamber pressure 30Pa, heating sublimation, and the temperature of distillation is controlled at below 40 ℃, and when all distilling with the ice in temperature sensor monitors temperature of charge judgement material, distillation finishes, and obtains.
embodiment 2
Fresh honeysuckle, puts in freeze dryer, is refrigerated to-28 ℃, is evacuated to drying chamber pressure 50Pa, heating sublimation, and the temperature of distillation is controlled at 50 ℃, the state before condenser temperature drops to distillation, distillation finishes, and obtains.
embodiment 3
Fresh honeysuckle, puts in freeze dryer, puts in freeze dryer, is refrigerated to-32 ℃, is evacuated to drying chamber pressure 50Pa, heating sublimation, and the temperature of distillation is controlled at 50 ℃, and when the pressure drop of hothouse is when approaching the pressure of freezer unit, distillation finishes, and obtains.
embodiment 4
Fresh honeysuckle, puts in freeze dryer, is refrigerated to-10 ℃, is evacuated to drying chamber pressure 30Pa, heating sublimation, and the temperature of distillation is controlled at below 40 ℃, and when all distilling with the ice in temperature sensor monitors temperature of charge judgement material, distillation finishes, and obtains.
Claims (3)
1. a freeze drying process for honeysuckle, is characterized in that: get fresh honeysuckle, put in freeze dryer, be refrigerated to below-10 ℃, be evacuated to below drying chamber pressure 30Pa heating sublimation; Sublimation temperature is controlled at below 40 ℃, and distillation finishes, and obtains.
2. according to the freeze drying process of a kind of honeysuckle of claim 1, it is characterized in that: freeze-drying to distillation finishes.
3. according to the freeze drying process of a kind of honeysuckle of claim 1, it is characterized in that: a kind of judgement of distillation in finishing by the following method 1. serviceability temperature Sensor monitoring temperature of charge judge whether the ice in material all distils; 2. condenser temperature drops to the state before distillation; 3. the pressure drop of freeze drying box is to the pressure that approaches freezer unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410418395.7A CN104165497A (en) | 2014-08-25 | 2014-08-25 | Honeysuckle freeze-drying method |
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| CN201410418395.7A CN104165497A (en) | 2014-08-25 | 2014-08-25 | Honeysuckle freeze-drying method |
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| CN104165497A true CN104165497A (en) | 2014-11-26 |
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| CN201410418395.7A Pending CN104165497A (en) | 2014-08-25 | 2014-08-25 | Honeysuckle freeze-drying method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106643006A (en) * | 2016-12-21 | 2017-05-10 | 吴青业 | Freezing and drying preparation method and application of pomelo fruits |
Citations (8)
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|---|---|---|---|---|
| US3835550A (en) * | 1972-08-21 | 1974-09-17 | K Kaneko | Freeze-drying process for producing a dry plant |
| FR2553873A1 (en) * | 1983-10-19 | 1985-04-26 | Allorge Lucile | Method for drying, stabilising, decontaminating and de-infesting medicinal or seasoning plants using a microwave oven |
| CN103055098A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Freeze-dried yam for preventing and treating cancer |
| CN103054917A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Application for freeze-dried purslane in medicine preparation |
| CN103285063A (en) * | 2013-05-15 | 2013-09-11 | 孙玉平 | Preparation method of honeysuckle extract |
| US20130316028A1 (en) * | 2011-02-15 | 2013-11-28 | Alberta Berendina Buring | Freeze dried extract of parkia, preferably of parkia speciosa beans for treatment of diseases such as diabetes mellitus type 2 |
| CN103822442A (en) * | 2014-02-17 | 2014-05-28 | 河南科技大学 | Method for drying honeysuckles |
| CN103948652A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Method for drying lucid ganoderma |
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2014
- 2014-08-25 CN CN201410418395.7A patent/CN104165497A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3835550A (en) * | 1972-08-21 | 1974-09-17 | K Kaneko | Freeze-drying process for producing a dry plant |
| FR2553873A1 (en) * | 1983-10-19 | 1985-04-26 | Allorge Lucile | Method for drying, stabilising, decontaminating and de-infesting medicinal or seasoning plants using a microwave oven |
| US20130316028A1 (en) * | 2011-02-15 | 2013-11-28 | Alberta Berendina Buring | Freeze dried extract of parkia, preferably of parkia speciosa beans for treatment of diseases such as diabetes mellitus type 2 |
| CN103055098A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Freeze-dried yam for preventing and treating cancer |
| CN103054917A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Application for freeze-dried purslane in medicine preparation |
| CN103285063A (en) * | 2013-05-15 | 2013-09-11 | 孙玉平 | Preparation method of honeysuckle extract |
| CN103822442A (en) * | 2014-02-17 | 2014-05-28 | 河南科技大学 | Method for drying honeysuckles |
| CN103948652A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Method for drying lucid ganoderma |
Non-Patent Citations (2)
| Title |
|---|
| 李世传等: "不同干燥方法对金银花叶成分和抑菌效果的影响", 《中国食品学报》 * |
| 闫家福等: "冷冻干燥技术及其在中药研究中的应用", 《中国实验方剂学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106643006A (en) * | 2016-12-21 | 2017-05-10 | 吴青业 | Freezing and drying preparation method and application of pomelo fruits |
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Application publication date: 20141126 |